Clinical trials
Chronic Heart Failure clinical trials
Below are recruiting chronic heart failure clinical trials, each written for real people, not researchers. We’re tracking 385 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT02966665RecruitingPhase 1
Testing blood vessel function in people of different health conditions
This early study measures how well your blood vessels work using tests that may include MRI. It compares healthy people with people who have conditions like COPD, pulmonary arterial hypertension, heart failure, or high blood pressure, to better understand “vascular function” in health and disease.
Salt Lake City, UtahAges 18 years+ - NCT05519046Recruiting
Test a heart pacing treatment for Chagas-related heart failure
This study looks at a heart treatment called cardiac contractility modulation in people with Chagas heart disease who have moderate symptoms and weak heart pumping. It aims to see whether this therapy improves heart function and related outcomes in the right patients.
São Paulo, São PauloAges 18–75 - NCT07270718Recruiting
Beetroot powder for blood pressure in men with hypertension
This trial tests whether taking 20 grams of beetroot powder daily can help lower blood pressure and improve blood flow in men who already have high blood pressure under control with medication. Beetroot is rich in nitrates, which may relax blood vessels.
MoscowAges 18–60 - NCT06082063RecruitingPhase 3
Reducing heart disease risk in type 1 diabetes
This trial tests a combination of treatments to lower the risk of heart disease and kidney problems in people with type 1 diabetes who already have some complications or higher risk. If you qualify, you will receive extra care aimed at preventing heart attacks, strokes, and kidney failure.
CopenhagenAges 40–90 - NCT06726109Recruiting
FOCUS study on acute heart failure
This trial is studying patients admitted to the hospital for acute heart failure. It will collect information to better understand and treat people with low heart pumping strength (ejection fraction less than 40%) and fluid retention.
Genk, BelgiumAges Any age - NCT06150950Recruiting
Exercise rehab for Fontan failure
This trial tests if a supervised exercise program (cardiac rehabilitation) can help people who have had a Fontan procedure and are now experiencing heart failure symptoms. It aims to improve your strength, stamina, and overall well-being.
Stanford, CaliforniaAges 18 years+ - NCT06903559RecruitingPhase 1/Phase 2
Roxadustat for heart and nutrition in dialysis patients
This study tests whether roxadustat can help improve heart health, nutrition, and reduce inflammation in people on hemodialysis. It may offer a new treatment option for anemia related to kidney disease.
Al Mansurah, DakahliyaAges 18 years+ - NCT06332391Recruiting
Paced heart rate increase for heart conditioning
This trial tests whether a special pacing pattern can strengthen your heart's pumping ability. You may qualify if you have heart failure with a low ejection fraction and already have a pacemaker or defibrillator with an atrial lead.
Iowa City, IowaAges 18–120 - NCT05952999Enrolling by invitation
Studying Hospital-At-Home care done from home
This trial looks at how well a “Hospital at Home” program works when people start from the emergency department or are already in the hospital and can be cared for at home. It may help teams improve care at home for certain medical conditions and situations.
Peoria, IllinoisAges 18 years+ - NCT06218199RecruitingPhase 4
Diuretics vs. blood pressure meds for HeartLogic alerts
This trial compares two treatments—diuretics (water pills) and a blood pressure medication called sacubitril/valsartan—to see which works better when your heart device sends an alert. It's for people with a Boston Scientific heart device that has HeartLogic alerting turned on.
Huntsville, AlabamaAges 19 years+ - NCT06570473RecruitingPhase 2
RV failure treatment trial for pulmonary hypertension patients
This trial is testing two heart medications, empagliflozin and ranolazine, to see if they can improve right heart function in people with pulmonary hypertension and right ventricular failure. Participants will monitor their symptoms using a smartphone or tablet.
Calgary, AlbertaAges 18 years+ - NCT07099859RecruitingPhase 4
Losartan after aortic valve surgery for severe leakage
This trial tests if the drug losartan can help the heart recover better after surgery to replace a leaky aortic valve. It may reduce strain on the heart and improve long-term outcomes.
São Paulo, São PauloAges 18–85 - NCT06583395Enrolling by invitation
Meditation retreat study with fitness tracker
This trial studies people attending a 7-day meditation retreat to see how meditation affects well-being. You will wear a fitness tracker and answer surveys.
Palm Desert, CaliforniaAges 21 years+ - NCT06595147Recruiting
Exercise for heart health in breast cancer survivors
This study tests if a 12-week exercise program improves heart health in women over 60 who have finished treatment for early-stage breast cancer. You will be placed in either an aerobic exercise group or a stretching group to see which helps your heart more.
Edmonton, AlbertaAges 60 years+ - NCT06108076RecruitingEarly Phase 1
Oral ketones for heart failure and diabetes
This study tests whether taking a special oral ketone supplement can help people with both heart failure and diabetes. It looks at both short-term and long-term effects on heart function and blood sugar control.
San Antonio, TexasAges 18–80 - NCT06645691RecruitingPhase 2
Heart and metabolic imaging study using a special MRI scan
This study tests a new MRI method that uses a safe, natural substance (pyruvate) to take detailed pictures of the heart and metabolism. It may help doctors better understand heart disease, diabetes, and related conditions.
SingaporeAges 21–99 - NCT04666454RecruitingPhase 4
Medication trial for broken heart (Takotsubo) syndrome
This trial tests an optimized medication approach for people diagnosed with Takotsubo (“broken heart”) syndrome. It may help clinicians find a safer and more effective treatment plan after this heart condition.
AarhusAges 18 years+ - NCT03398369Recruiting
Imaging study to guide heart failure device treatment
This study uses advanced heart imaging to better understand heart function in people who may benefit from a cardiac resynchronization therapy (CRT) device. It aims to find ways to improve how doctors choose treatment and tailor care.
Charlottesville, VirginiaAges 20–90 - NCT05028686Recruiting
Using blood tests and AI to predict heart failure readmissions
This study looks at hospital and emergency patients with heart failure and uses “omics” (advanced lab data from the body) plus statistics and artificial intelligence to predict who is likely to return to the hospital soon. If it works, it could help doctors better plan follow-up care to reduce repeat hospital visits.
Toronto, OntarioAges 18–105 - NCT06142474RecruitingPhase 3
SGLT2 inhibitors for heart failure patients during ventilator weaning
This trial tests a heart failure medication (SGLT2 inhibitor) to help people with heart failure who are on a breathing machine (ventilator) get better and come off the machine faster. It is for patients with a specific type of heart failure where the heart pumps weakly (EF ≤ 40%).
TaipeiAges 20 years+ - NCT06356727Recruiting
Blood vessel health test for heart recovery
This study checks if tiny blood vessel problems in the heart affect how well the heart muscle recovers after being weak. It uses special imaging during a routine heart catheterization to look at these small vessels.
FerraraAges 18–85 - NCT06208007Recruiting
Predicting heart failure with stiff arteries
This study looks at whether stiffer arteries can help predict a type of heart failure where the heart doesn't relax properly (HFpEF). It's for people who have risk factors like high blood pressure, diabetes, or being older, and who may have early signs of heart trouble.
Göttingen, Lower SaxonyAges 18 years+ - NCT07750873RecruitingPhase 2
Study of an investigational medicine for heart failure with reduced pumping function
This trial tests an investigational medicine called CRD-4730 (taken as a pill) to see if it can improve heart function and symptoms in people with heart failure and a reduced pumping ability. It may help you feel better and slow the progression of your condition.
Pasadena, CaliforniaAges 18–85 - NCT06646601Recruiting
Garden-based program for heart and stroke recovery
This trial tests a preventive program that uses a therapeutic garden to help people with heart or blood vessel conditions. It looks at whether patients find the program helpful and easy to take part in.
GapAges 18 years+
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Common questions
- Are there clinical trials for chronic heart failure?
- Yes. Clin2 currently lists 385 recruiting chronic heart failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic heart failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic heart failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.