Clinical trials
Chronic Heart Failure clinical trials
Below are recruiting chronic heart failure clinical trials, each written for real people, not researchers. We’re tracking 385 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07656454RecruitingPhase 1
Comparing two ways to give CDR132L in healthy volunteers
This study measures how well the drug CDR132L enters the blood when injected under the skin, compared to injection into a vein. It is done in healthy volunteers to find the best way to give the drug.
BerlinAges 18–55 - NCT07643818Enrolling by invitationPhase 2
Intravenous iron for heart failure patients with low iron
This study tests whether giving intravenous iron improves symptoms, quality of life, and exercise ability in people with heart failure and low iron levels. Participants will receive iron infusions and be monitored over time to see if their condition improves.
Saint HelierAges 18 years+ - NCT07632586Recruiting
First-in-Human Heart Pump Implant Study
This trial tests a new tiny heart pump called the Icoms Flowmaker for patients with severe heart failure who cannot have a standard heart pump. The device may help your heart pump blood better and improve your ability to do daily activities.
PragueAges 18–80 - NCT02856620Recruiting
Study heart function and frailty in people with aortic valve narrowing
This study looks at how heart mechanics, blood markers, and frailty relate to symptoms and heart measurements in people with aortic stenosis (a stiff, narrowed heart valve). It may help doctors better understand who is at higher risk and how disease changes over time.
Montreal, QuebecAges 18 years+ - NCT05760924Recruiting
Testing a new heart pacing method for CRT nonresponders
This trial tests whether a different pacing approach called left bundle branch pacing can improve outcomes and heart structure changes in people who did not improve with standard biventricular CRT. It may help some patients with ongoing heart failure symptoms and weak heart pumping.
TomskAges 18–80 - NCT07611084Recruiting
Atrial Fibrillation Study in Older Adults in Rural China
This study follows older adults in rural China who have atrial fibrillation (an irregular heart rhythm) to better understand the condition and screen for heart failure. Researchers want to learn more about how these conditions affect people in rural communities.
Taizhou, JiangsuAges 65–80 - NCT07601867Recruiting
Dapagliflozin to improve heart function after bypass surgery
This trial tests whether a diabetes medication called dapagliflozin can help improve how well the right side of your heart works after off-pump coronary artery bypass grafting surgery (a way to reroute blood around blocked heart arteries). The goal is to see if this drug reduces strain on your heart during recovery.
Pyatigorsk, Stavropol KrayAges 18 years+ - NCT07493915Recruiting
Personalized rehab for veterans with heart failure with preserved ejection fraction
This study tests a tailored exercise program for veterans who have heart failure with preserved ejection fraction (HFpEF). It aims to see if a personalized rehab plan can improve your heart function and quality of life.
Columbia, South CarolinaAges 18 years+ - NCT07482943RecruitingPhase 4
Dapagliflozin for heart function after Fontan procedure
This trial tests whether dapagliflozin, a diabetes drug that also helps the heart, can improve exercise ability and heart function in people who have had the Fontan procedure for a single ventricle heart defect.
Hong KongAges 12 years+ - NCT07413198Recruiting
Combined home and clinic exercise coaching for heart failure
This trial tests a program that combines home-based and clinic-based exercise coaching to help people with heart failure get more active. It aims to improve health and quality of life.
Winston-Salem, North CarolinaAges 55 years+ - NCT07403669Recruiting
Heart, kidney, and metabolic health assessment study
This trial offers a health assessment and empowerment program for adults who have heart, kidney, or metabolic conditions like diabetes or heart disease. It aims to help you better manage your health.
Chandler, ArizonaAges 18 years+ - NCT07385417Recruiting
Early AF treatment for heart failure with preserved pumping function
This study tests using a new electrical pulse treatment for atrial fibrillation (AF) early on, in people who also have a type of heart failure where the heart pumps normally but is stiff. The goal is to see if this treatment helps manage both conditions better.
Frankfurt am MainAges 18–80 - NCT07324772Recruiting
Exercise program to improve symptoms in atrial fibrillation and heart failure
This study tests if starting a supervised exercise program can help older adults with both atrial fibrillation and a type of heart failure called HFpEF feel better and have a better quality of life. You'll be asked to join exercise sessions and have regular check-ins to see how you're doing.
Chicago, IllinoisAges 60–99 - NCT06378632Recruiting
Heart failure monitoring app study
This study tests a smartphone app that listens to your voice to detect early signs of heart failure worsening. It aims to help you avoid hospital stays by catching problems sooner.
Fairhope, AlabamaAges 22 years+ - NCT07252856Recruiting
Digital support for heart rehab (phase III)
This trial tests a digital tool to help people with heart disease continue their cardiac rehabilitation at home during the maintenance phase. It's for people who have already completed the earlier rehab phase and are ready for long-term support.
LeuvenAges 18 years+ - NCT07251361Enrolling by invitation
Exercise program for heart failure with preserved ejection fraction
This study tests whether a special exercise program that combines different types of training (like aerobic, strength, and balance) can improve heart and muscle function, daily abilities, and quality of life in people with heart failure with preserved ejection fraction (HFpEF). You may benefit if your heart failure is stable and you are able to exercise safely.
Pamplona, NavarreAges 18 years+ - NCT07210606RecruitingPhase 4
Sleep apnea treatment study for veterans with heart failure
This study looks at how well a medicine called trazodone might help treat central sleep apnea in veterans who also have heart failure. It aims to improve sleep and breathing, which may help you feel better.
Detroit, MichiganAges 18 years+ - NCT07207811RecruitingPhase 3
Coramitug for heart failure caused by ATTR amyloidosis
This trial tests a new medicine called Coramitug for people with heart failure due to ATTR amyloidosis, a condition where abnormal proteins build up in the heart. The study aims to see if Coramitug can improve heart function and quality of life.
Phoenix, ArizonaAges 18 years+ - NCT07147114RecruitingPhase 4
Combined macitentan and dapagliflozin for heart failure with lung high blood pressure
This trial tests whether adding two medications—macitentan and dapagliflozin—together is safe and effective for people with heart failure and a certain type of high blood pressure in the lungs. It might help improve your symptoms and daily function.
BusanAges 19 years+ - NCT07118488Recruiting
New ablation approach for persistent atrial fibrillation with heart issues
This study tests a new way to treat long-lasting atrial fibrillation using focused energy (pulse field ablation) guided by special heart mapping. It may help people who have not improved with medications or have other heart problems like heart failure.
Madrid, MadridAges 18–80 - NCT07094919Recruiting
Corheart 6 heart pump long-term study
This study follows people who have already received the Corheart 6 heart pump to see how well it works over time. You may qualify if you have severe heart failure that doesn't improve with standard treatments and you got the pump after October 1, 2021.
Shenzhen, GuangdongAges 18 years+ - NCT05712824Recruiting
Device to measure left-heart pressure in advanced heart failure
This trial tests a wirelessly implanted device that measures pressure in the left upper heart chamber (left atrial pressure) in people with advanced heart failure. By tracking that pressure, researchers hope to better understand disease status and guide care.
Tbilisi, GeorgiaAges 22–88 - NCT06147336Recruiting
Testing the V-Lap system for heart failure monitoring
This trial tests a new device called V-Lap that is placed in the heart to monitor pressure. It may help doctors better manage heart failure and reduce hospital stays. Researchers want to see if it works well in people with mild to moderate heart failure.
Boston, MassachusettsAges 22–88 - NCT07022067Recruiting
Smartphone study for chronic coronary syndrome
This study tests if a smartphone app can help people with a chronic heart condition called coronary syndrome. It aims to make care easier and track symptoms at home.
Milan, ItalyAges 18 years+
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Common questions
- Are there clinical trials for chronic heart failure?
- Yes. Clin2 currently lists 385 recruiting chronic heart failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic heart failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic heart failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.