Clinical trials
Cognitive Dysfunction clinical trials
Below are recruiting cognitive dysfunction clinical trials, each written for real people, not researchers. We’re tracking 145 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06702488RecruitingPhase 1
Dexmedetomidine and magnesium to protect thinking after surgery in seniors
This study tests whether adding two drugs, dexmedetomidine and magnesium sulfate, during anesthesia can help older adults keep their thinking and memory sharp after open abdominal surgery. It aims to reduce the risk of confusion or memory problems that sometimes happen after surgery.
Al FayyumAges 60–80 - NCT07589348Recruiting
Brain Function After Gynecologic Surgery
This study measures whether women experience changes in thinking and memory after having gynecologic surgery (removal of uterus and/or ovaries). Researchers want to understand how anesthesia and surgery affect the brain and identify who might be at risk.
İzmit, KocaeliAges 18 years+ - NCT07563777Recruiting
Long-term study of human aging and health
This is a long-term research study that follows people over time to understand how humans age. Researchers will collect information about your health and lifestyle to learn what helps people stay healthier as they get older.
Boulder, ColoradoAges 18 years+ - NCT06761573Recruiting
Study on brain activity and confusion after head and neck surgery
This trial measures brain signals to see if they can predict confusion (delirium) after surgery. It may help identify patients at higher risk so they can get extra care.
BolognaAges 18–90 - NCT05715710Recruiting
MRI and brain vein pattern study for memory and thinking problems
This study looks at whether certain deep brain veins seen on MRI are linked to thinking and memory problems in people with small-vessel brain disease. It compares brain scan findings with cognitive (thinking) testing to better understand what may drive cognitive dysfunction.
Zigong, SichuanAges 50–85 - NCT07447050RecruitingPhase 2
Riluzole to Prevent Chemo-Related Cognitive Problems
This pilot study tests whether the drug riluzole can help prevent the thinking and memory problems (often called 'chemobrain') that some people experience during chemotherapy. If you are about to start a chemo regimen containing an anthracycline or platinum drug, you may be able to join.
Orange, CaliforniaAges 18 years+ - NCT07396532Recruiting
iPad messages to prevent delirium after hip fracture surgery
This trial tests if audio-recorded messages played on an iPad can help prevent confusion (delirium) after hip fracture surgery in older adults. It is for people aged 60 and older who do not have a history of memory or thinking problems.
SingaporeAges 60 years+ - NCT06021197RecruitingPhase 2
NMDA-enhancing treatment for cognitive symptoms in schizophrenia
This study tests a new treatment that may help with thinking and memory problems in people with schizophrenia. It is for people whose schizophrenia symptoms are stable and who are already on a steady medication.
TaichungAges 18–65 - NCT07254234Recruiting
Eye scans to detect Alzheimer's-related proteins
This study uses a special eye scan to look for abnormal protein deposits in the retina, which may be linked to Alzheimer's disease. It is for people who are generally healthy but have mild memory concerns or mild cognitive impairment.
Abu DhabiAges 55 years+ - NCT07245186Enrolling by invitation
Healthy living program for kidney decline
This study tests a program to help people with chronic kidney disease (CKD) stay healthy through diet tracking and other proactive steps. It focuses on people whose kidney function has declined but who are not yet on dialysis.
Shanghai, Shanghai MunicipalityAges 18–90 - NCT06423547Recruiting
Predicting confusion after surgery in older adults
This study looks at older patients (65 and older) who have had surgery and anesthesia. It aims to find who is at risk for confusion (delirium) and memory problems afterward. The goal is to help doctors prevent these issues.
BeijingAges 65–100 - NCT07226219RecruitingPhase 1
Medication to help attention in children with sickle cell disease
This study tests whether a common medication called methylphenidate (often used for ADHD) can help children with sickle cell disease who have attention or memory problems. If the child qualifies, the study may offer a new way to improve focus and daily functioning.
Memphis, TennesseeAges 8–17 - NCT07220512Recruiting
Exercise help for ovarian, fallopian, or endometrial cancer
This trial tests a special exercise program during chemotherapy before surgery. It may help patients with certain gynecologic cancers get stronger and better prepared for treatment.
Winston-Salem, North CarolinaAges 55 years+ - NCT06817239Recruiting
Low-dose esketamine for preventing confusion after surgery in older adults
This study tests whether a low dose of the medicine esketamine can help prevent confusion after surgery in older adults at higher risk. You may qualify if you are 65 or older, planning a major non-cardiac surgery, and have certain health conditions like high blood pressure or diabetes.
Fuzhou, FujianAges 65–90 - NCT05990790RecruitingPhase 4
Comparing anesthetics and their effect on confusion after surgery
This study compares three different anesthesia medicines to see which one might lower the chance of confusion or delirium after major surgery. If you are 65 or older and having a long, planned non-heart surgery, this trial could help determine the safest option for you.
InnsbruckAges 65 years+ - NCT06136546RecruitingPhase 2
Infliximab for depression with cognitive problems
This trial tests if a medicine called infliximab, given through an IV, can help improve thinking and memory problems in people with moderate to severe depression who also have high inflammation levels. It aims to see if lowering inflammation can ease both mood and cognitive symptoms.
Boston, MassachusettsAges 25–50 - NCT07102927Recruiting
Virtual reality training for stroke patients with neglect
This trial tests whether virtual reality exercises can help people with right-brain stroke overcome 'neglect' (trouble noticing things on their left side). It aims to improve daily function and quality of life.
SeoulAges 19–99 - NCT06972004Enrolling by invitation
Preventing loss of independence through exercise for veterans
This study tests a gentle exercise program for veterans living in VA community living centers. The program is designed to help residents with memory problems stay independent, move better, and feel better. Staff at the center will be trained to lead the classes.
San Francisco, CaliforniaAges 18 years+ - NCT06817395Recruiting
Thinking and memory in chronic ITP
This study looks at whether chronic or persistent immune thrombocytopenia (ITP) affects thinking and memory. If you have had low platelet counts for 3 months or more and have been treated for ITP, you may help researchers understand how the condition can impact the brain.
Boston, MassachusettsAges 18 years+ - NCT06775964RecruitingPhase 1/Phase 2
Stem cell therapy for early Alzheimer's disease
This trial tests a stem cell treatment for people with early-stage Alzheimer's disease. It aims to see if the treatment can help slow memory loss or other symptoms. You must have a specific blood test showing inflammation in the body to qualify.
Houston, TexasAges 60–80 - NCT06572332Enrolling by invitation
Brain scan study for sleep in older Chinese adults
This study uses brain scans to understand sleep problems in older Chinese adults. If you are 60+ and have trouble sleeping, you may help researchers find better ways to improve sleep.
Hong KongAges 50–90 - NCT06133842Recruiting
Brain blood flow and confusion after surgery study
This trial looks at how well the brain controls its own blood flow during non-cardiac surgeries. It aims to see if problems with this regulation are linked to confusion after surgery (delirium).
Boston, MassachusettsAges 60 years+ - NCT06042699Recruiting
Iron deficiency and scoliosis study for teens and young adults
This study tests whether giving iron supplements before spinal fusion surgery can help kids with low iron levels. It aims to understand iron deficiency in young people with scoliosis and improve their surgical outcomes.
New York, New YorkAges 10–26 - NCT02832193Recruiting
Uses past anesthesia test data to study memory after surgery
This study looks back at information already collected around elective surgery to understand how anesthesia and surgery may affect thinking and memory (sometimes called POCD). It mainly uses records and questionnaires rather than adding a new treatment.
BerlinAges 18–100
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Common questions
- Are there clinical trials for cognitive dysfunction?
- Yes. Clin2 currently lists 145 recruiting cognitive dysfunction studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cognitive dysfunction trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cognitive dysfunction trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.