Clinical trials
Cognitive clinical trials
Below are recruiting cognitive clinical trials, each written for real people, not researchers. We’re tracking 1,981 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04855630Recruiting
Sleep and exercise study for memory changes
This study tests whether improving sleep and increasing exercise can help people with mild memory changes. You'll wear a Fitbit and a sleep headband and use a stationary bike.
Miami, FloridaAges 55–80 - NCT04856410Enrolling by invitation
Spaceflight cognitive testing using MRI brain scans
This study looks at how long-duration space travel affects thinking skills, especially memory and spatial navigation, and what changes happen in the brain. It compares astronauts with healthy volunteer “astronaut surrogates” and uses MRI scans to measure brain function.
Philadelphia, PennsylvaniaAges Any age - NCT04897334Recruiting
Brain stimulation plus rehab to improve thinking after stroke
This study tests whether a noninvasive brain stimulation treatment, combined with rehabilitation, can improve thinking and other “neurocognition” problems after a recent stroke. It may help people whose thinking has been affected by stroke within the past month.
Philadelphia, PennsylvaniaAges 18–90 - NCT04701177Enrolling by invitation
Smartphone-based study of brain biomarkers in memory clinic patients
This observational study follows people with (or at risk for) Alzheimer’s-related brain changes and a comparison group without them. It uses clinic visits, cognitive testing, questionnaires, and possibly a spinal fluid test to better understand brain biomarkers and how they relate to thinking and daily life.
Corfu, CorfuAges 45 years+ - NCT04765137RecruitingPhase 2
Atorvastatin to improve brain blood flow in mild memory decline
This Phase 2 study tests whether the cholesterol medicine atorvastatin can improve how well blood vessels in the brain respond in people with mild cognitive impairment (MCI). It may help brain circulation and possibly slow thinking and memory problems.
Baltimore, MarylandAges 60–95 - NCT04632628Recruiting
Online sleep coaching for insomnia in dementia caregivers
This trial tests an online form of cognitive behavioral therapy (a structured skills-based program) to improve insomnia for people caring for someone with dementia. It may help reduce trouble falling asleep, staying asleep, or waking too early.
Columbia, MissouriAges 18 years+ - NCT04520139RecruitingPhase 1/Phase 2
NAC to help prevent chemo brain fog in ovarian cancer
This Phase 1/2 study tests whether taking NAC (a supplement medicine) can help prevent or reduce memory and thinking problems after platinum chemotherapy. It targets people with advanced ovarian, fallopian tube, or primary peritoneal cancer who are starting at least six cycles of platinum-based treatment.
Orange, CaliforniaAges 18 years+ - NCT03036319Recruiting
Neurorehabilitation study for thinking and memory changes
This study looks at neurorehabilitation approaches for people age 50 and older who report trouble with thinking or memory. It may help researchers understand how to support cognitive functioning during recovery or daily life.
Ann Arbor, MichiganAges 50 years+ - NCT04433455Recruiting
Brain and thinking health in hemodialysis patients
This study looks at how blood vessel problems in the brain and thinking (cognition) are related in people who are on long-term hemodialysis for kidney failure. By joining, you help doctors learn how to better protect brain health in dialysis patients.
Shanghai, Shanghai MunicipalityAges 50–85 - NCT04373564RecruitingPhase 4
Tracking brain and movement changes after repeated MRI contrast
This study looks at whether getting the MRI contrast dye multiple times over 5 years affects body movement and thinking skills. It compares people who had the dye repeatedly with people who have little or no exposure, using brain MRI scans and regular mental and movement testing.
Scottsdale, ArizonaAges 18–64 - NCT04335994Recruiting
Home sleep testing for people with memory trouble
This study looks at how well home sleep apnea testing works for people with cognitive impairment (memory/thinking problems) to help improve outcomes. You may be asked to do a home sleep test (and possibly an in-lab test) and will involve a caregiver if needed.
Toronto, OntarioAges Any age - NCT04297020Recruiting
Checking brain health in breast cancer survivors
This study looks at differences in brain function in people who have had breast cancer, compared with certain people without that history. It’s testing how brain health changes after breast cancer and relates to mood, thinking, and daily functioning.
Los Angeles, CaliforniaAges 35–65 - NCT04343157RecruitingPhase 2
Image-guided radiation for brain tumors that protects thinking
This trial tests a special type of radiation therapy for brain tumors that aims to protect your memory and thinking skills. It may be an option if you have certain brain tumors or a small number of brain metastases.
San Diego, CaliforniaAges 18 years+ - NCT04165460Enrolling by invitation
CBT programs for anxiety and coping in cervical cancer
This study tests two structured talk-therapy programs (cognitive-behavioral therapy) to help people with cervical cancer manage anxiety, depression symptoms, and unhelpful coping skills. It also looks at the role of a main caregiver during care planning and support.
Mexico City, TlalpanAges 18 years+ - NCT04240665Enrolling by invitation
Test a digital notebook for memory problems
This study tests a digital “memory notebook” to help people who have early memory concerns keep track and report changes over time. It may be useful if you’re having mild memory issues and can complete surveys with a study partner.
Sacramento, CaliforniaAges 60 years+ - NCT04123314RecruitingEarly Phase 1
Psilocybin study for depression in mild memory or early Alzheimer’s
This early-phase study tests whether psilocybin (a psychedelic substance) can help with depression in people who have mild memory problems or early Alzheimer’s. The trial also closely monitors safety, thinking changes, mood, and blood pressure before and after dosing.
Baltimore, MarylandAges 18–85 - NCT04106713Recruiting
Understanding change across different psychotherapies for anxiety and depression
This study looks at how people change during different types of psychotherapy for anxiety and depression. It aims to understand which treatments work best for different people.
Singapore, SingaporeAges 18–99 - NCT03094312Recruiting
Check how a seizure-brain procedure affects thinking after surgery
This study looks at whether a special brain-recording procedure for difficult-to-control seizures changes a person’s memory, thinking, or other brain skills afterward. It may help doctors understand risks and plan care for people undergoing the procedure.
BronAges 18–65 - NCT03906435Recruiting
Cognitive therapy to prevent problems for very premature NICU babies
This study offers a counseling approach to help prevent “Vulnerable Child Syndrome” in babies born very early and cared for in the NICU. It focuses on support during the early months after birth and compares outcomes for families getting the therapy versus usual support.
Dallas, TexasAges Any age - NCT03971487RecruitingPhase 1/Phase 2
Ocrelizumab for psychosis linked to an overactive immune system
This Phase 1/2 study tests ocrelizumab, a medicine that affects parts of the immune system, to see if it can improve psychosis symptoms in people with schizophrenia-spectrum disorders. It’s mainly for younger adults with ongoing psychosis and evidence that the symptoms began early in life, with certain infection/vaccine safety requirements.
Houston, TexasAges 18–35 - NCT03836950RecruitingPhase 1/Phase 2
Brain stimulation to improve thinking in Parkinson’s
This trial studies a noninvasive treatment called rTMS to help improve thinking and memory in people with Parkinson’s who have mild cognitive problems. It may help strengthen brain function, but it also has strict safety and eligibility rules to protect against seizure and metal-related risks.
Chicago, IllinoisAges 50 years+ - NCT03769259Enrolling by invitation
Therapy for recent suicidal thoughts or attempts
This study tests a brief counseling approach based on cognitive behavioral therapy to help people who are dealing with suicidal thoughts or a recent suicide attempt. It’s offered in outpatient care and aims to see whether this shorter therapy works for improving safety and coping.
Jacksonville, North CarolinaAges 18 years+ - NCT03653156Recruiting
Aging and brain study for mild memory loss and dementia
This study checks how age affects memory and thinking, and compares people with mild memory problems, Alzheimer’s disease types, vascular dementia, and healthy controls. You may help researchers understand brain changes using thinking tests, MRI scans, and blood or spinal fluid tests.
Hefei, AnhuiAges 18 years+ - NCT03582709Enrolling by invitation
Study how sitting time affects kids’ thinking and heart health
This study looks at how much children sit each day and how it relates to thinking skills and cardiovascular (heart and blood vessel) health. It may help researchers understand which lifestyle patterns are linked to better or worse health outcomes in children.
Ages 7–12
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Common questions
- Are there clinical trials for cognitive?
- Yes. Clin2 currently lists 1,981 recruiting cognitive studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cognitive trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cognitive trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.