Clinical trials
Critical Illness clinical trials
Below are recruiting critical illness clinical trials, each written for real people, not researchers. We’re tracking 336 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07108179Enrolling by invitation
Continuous glucose monitor accuracy in ICU patients
This trial tests a continuous glucose monitoring system for people in the intensive care unit (ICU). It checks how well the device measures blood sugar and if it can help predict outcomes for critically ill patients.
Changsha, changshaAges 18 years+ - NCT07059988Recruiting
How the body makes energy in critical illness
This study looks at how the body produces energy in critically ill patients on breathing machines. It compares energy production between ICU patients and healthy volunteers to find better ways to support recovery.
StockholmAges 18 years+ - NCT07032870Recruiting
Ultrasound reliability study in ICU patients
This study checks how reliably different physical therapists can measure muscles and nerves using ultrasound in patients who are awake and stable in the intensive care unit (ICU). It aims to improve muscle assessment techniques for critically ill adults.
Santiago, Metropolitan RegionAges 18 years+ - NCT06533787Recruiting
Heart ultrasound in sick newborns in the NICU
This study tests how using a heart ultrasound (echocardiography) can help doctors better manage care for very sick newborns in the NICU. It may help guide treatment for babies who are unstable, regardless of their weight or how early they were born.
SohagAges 2 hours–4 weeks - NCT06751043Recruiting
Testing if fasting before a procedure is needed in ICU patients
This trial tests whether not eating before a procedure (called preoperative fasting) is better than fasting in ICU patients who are already receiving tube feedings. It aims to find out if skipping the fast can help you without causing extra risks.
Palo Alto, CaliforniaAges 18 years+ - NCT04475666Recruiting
Protein replacement through tube feeding in ICU patients
This study tests whether giving a different protein through tube feeding can help critically ill adults in the ICU. You may be eligible if you are already receiving nutrition through a stomach or gut tube and are on a breathing machine.
Jeddah, JeddahAges 18 years+ - NCT05829317RecruitingPhase 4
Magnesium to prevent new atrial fibrillation in ICU patients
This trial tests whether giving magnesium can lower the chance of developing new irregular heartbeat (atrial fibrillation) in critically ill adults in the ICU. If you are at risk but do not already have this rhythm issue, magnesium may help prevent it.
Hamilton, OntarioAges 18 years+ - NCT04608630RecruitingPhase 2
Preventing bone loss in ICU patients with anti-bone drugs
This Phase 2 study tests whether zoledronic acid or denosumab can prevent bone thinning in critically ill adults after staying in the ICU. It may help reduce the risk of future bone fractures if your body is at higher risk during and after critical illness.
Sydney, New South WalesAges 50 years+ - NCT07585578Recruiting
Understanding long-term effects after critical illness
This study looks at how chronic critical illness affects patients' thinking, physical abilities, and emotional well-being after leaving the intensive care unit. It may help improve care and support for people who are still dependent on hospital care.
Huaibei, AnhuiAges 18 years+ - NCT07680816Recruiting
Study of gamma delta T cells in critically ill patients
This study looks at a type of immune cell called gamma delta T cells in patients who are very sick in the ICU, including those with and without sepsis. The goal is to understand how these cells work differently in these patients, which could help find better treatments.
Wuhan, Outside of the USAges 18–80 - NCT06220825Recruiting
Breathing support practices in critically ill children
This trial looks at how doctors manage breathing support for children in the intensive care unit. It may help improve care for kids who need help breathing.
GroningenAges Up to 18 years - NCT04580680Recruiting
Testing a blood-filter treatment in critically ill ICU patients
This study looks at an add-on blood-filter treatment used in the ICU to help remove harmful substances like waste products, inflammation signals, or toxins from the blood. Results may help doctors understand whether this approach improves care and how it should be used.
FlorenceAges Any age - NCT06923462Recruiting
VoiceLove app for ICU patients on a ventilator
This study tests a special app called VoiceLove that helps patients in the ICU who are on a breathing machine communicate with their family and care team. The goal is to reduce confusion and improve connection and satisfaction for everyone involved.
Nashville, TennesseeAges 18 years+ - NCT05850962Recruiting
Personalized blood pressure targets for ICU shock care
This study compares individualized blood pressure goals versus the usual (standard) targets for adults in the ICU with shock. The aim is to see whether tailored blood pressure treatment can improve outcomes by better matching each person’s needs.
Newcastle, New South WalesAges 40 years+ - NCT07430969Recruiting
Muscle Stimulation and Amino Acids for ICU Patients on Ventilators
This trial tests whether giving muscle stimulation and amino acids can help patients in the ICU who are on a breathing machine to maintain their muscle protein. The study aims to prevent muscle wasting during critical illness.
EdeAges 18 years+ - NCT06453421Recruiting
Breathing and exercise rehab for long-term breathing machine patients
This study tests a special breathing and exercise program for people who have been on a breathing machine for a long time through a tracheostomy. The program is designed to help them get stronger and breathe better.
FlorenceAges 18 years+ - NCT07001696Recruiting
Predicting breathing support needs with chest X-ray and blood gas
This trial looks at whether combining a chest X-ray and a blood gas test can help doctors decide if a critically ill patient needs a breathing machine (mechanical ventilation). It aims to find a better way to make this important decision.
Zagazig, Al SharqiaAges 18 years+ - NCT07001943Recruiting
Blood flow in stomach and gut injury in ICU patients
This trial checks if changes in blood flow to the stomach and intestines can predict gut injury in critically ill patients who need feeding through a tube. It uses a safe ultrasound test at the bedside.
Beijing, Beijing MunicipalityAges 18–80 - NCT06950294RecruitingEarly Phase 1
Inhaled nitric oxide for pneumonia patients on a ventilator
This study tests an inhaled gas (iNO300) given through your breathing tube to improve oxygen levels in critically ill patients with pneumonia. You may qualify if you are on a ventilator and have been diagnosed with pneumonia within the last 3 days.
Boston, MassachusettsAges 18 years+ - NCT05993390Recruiting
Reversing muscle relaxants in ICU patients
This trial tests two medicines that help reverse the muscle-relaxing drugs given to patients on breathing tubes in the intensive care unit. The goal is to see which one works better and faster so patients can wake up sooner.
Seoul, Jongno-guAges 19–90 - NCT04502511Recruiting
Study of different patterns of critical illness in ICU patients
This study looks at how critical illness can vary from person to person in the intensive care unit (ICU). It mainly helps researchers understand these differences and may improve future care for ICU patients.
Groningen, Provincie GroningenAges 18 years+ - NCT07189091RecruitingPhase 4
Reducing IV fluids in ICU patients
This trial tests if lowering the amount of salt water (sodium chloride) given as maintenance fluids or 'fluid creep' can help critically ill adults in the ICU recover better. It compares two ways of managing daily fluids to see which is safer and more effective.
AntwerpAges 18 years+ - NCT06762184Recruiting
Pain scores in serious brain surgery patients after ICU care
This study looks back at patients who had brain surgery and were in the intensive care unit (ICU) for more than 24 hours. Researchers want to learn about their pain scores, which can help improve care for future patients.
Beijing, BeijingAges 18 years+ - NCT04404400RecruitingPhase 3
Hydrocortisone and fludrocortisone for critical illness hormone shortage
This Phase 3 trial tests whether giving hydrocortisone plus fludrocortisone to critically ill ICU patients with suspected “corticosteroid insufficiency” can improve outcomes without relying on steroids already being used. It may help patients whose bodies aren’t making enough stress hormones during severe illness.
GarchesAges 18 years+
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Common questions
- Are there clinical trials for critical illness?
- Yes. Clin2 currently lists 336 recruiting critical illness studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a critical illness trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a critical illness trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.