Clinical trials
Decompensated Chronic Heart Failure clinical trials
Below are recruiting decompensated chronic heart failure clinical trials, each written for real people, not researchers. We’re tracking 82 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07219511RecruitingPhase 1
Safety study of VS-041 for heart failure with preserved pumping strength
This trial tests an investigational drug called VS-041 to see if it's safe and helps people with a type of heart failure where the heart pumps well but doesn't relax properly (HFpEF). It may be an option if you are 50 or older and have stable heart failure symptoms.
Little Rock, ArkansasAges 50 years+ - NCT07037459RecruitingPhase 3
A study of a new drug for heart failure with obesity
This trial tests a medication called maridebart cafraglutide for people with heart failure (where the heart doesn't pump as well as it should) and obesity. The goal is to see if it can help improve symptoms and outcomes.
Birmingham, AlabamaAges 18–99 - NCT07682298Recruiting
Measuring leftover fluid in hospitalized heart failure patients
This study looks at how well we can measure leftover fluid in the body in people hospitalized for heart failure with fluid overload. It aims to help doctors better manage treatment and improve recovery.
AarhusAges 18 years+ - NCT07325942Recruiting
Low vs high volume high-intensity interval training for heart failure
This study compares two different types of high-intensity interval exercise programs (one shorter, one longer) in people with chronic heart failure. It aims to see which program improves heart health and daily function more.
Cairo, Giza GovernorateAges 18 years+ - NCT07350759Recruiting
Using a wearable to detect heart failure worsening
This study tests if a wearable device can spot early signs of heart failure getting worse. If you already use a heart monitor and have stable readings, you may help show how a non-invasive wearable could alert you sooner.
Tampa, FloridaAges 18 years+ - NCT07372040RecruitingPhase 2
Adding a Water Pill for Heart Failure in the Hospital
This trial tests if adding a diuretic (water pill) called acetazolamide to usual care can help you get rid of extra fluid faster while you are in the hospital for worsening heart failure.
TantaAges 18 years+ - NCT02898181Recruiting
Ear cartilage stimulation for sudden heart failure worsening
This trial tests whether a gentle stimulation near your ear (on the tragus, a small ear area) can help people whose heart failure has recently gotten worse while in the hospital. If it works, it may improve symptoms and recovery during this acute phase.
Oklahoma City, OklahomaAges 18–80 - NCT07400991Recruiting
Restrictive vs liberal fluids for hospitalized heart failure
This trial studies whether drinking less fluid (restrictive) vs. the usual amount (liberal) helps people hospitalized with heart failure. It aims to find out which approach leads to better recovery and fewer symptoms.
HerningAges 18 years+ - NCT07419360Recruiting
Draining fluid from lungs in heart failure
This study tests whether draining fluid from around the lungs can help people with heart failure who are in the hospital. It looks at how this procedure affects breathing and recovery.
Albany, New YorkAges 18 years+ - NCT07472660Recruiting
Web-based prevention program after heart failure hospitalization
This trial tests a web-based prevention program for people recently hospitalized with heart failure (with low pumping ability). The goal is to help you stay healthier and avoid another hospital stay.
BremenAges 18–80 - NCT07508891Recruiting
Studying heart failure types in hospitalized patients
This trial looks at different types of acute heart failure in people who are hospitalized. Doctors will study your symptoms and health to better understand heart failure patterns, which might help improve future treatments.
HamburgAges 18 years+ - NCT07617376RecruitingPhase 4
Flu shot before leaving hospital after heart problems
This study tests whether giving a flu vaccine to patients before they leave the hospital after a heart condition improves their health. The vaccine may help protect your heart and prevent serious flu complications while you recover.
WroclawAges 18 years+ - NCT07204834Enrolling by invitation
Physical activity program for heart failure
This study tests a home-based physical activity program for people with heart failure. The program is designed to be safe and easy to follow, using a smartphone app to guide you, and may help you feel stronger and more active.
GranadaAges 18 years+ - NCT07057323Enrolling by invitation
Neck vein procedure for heart failure with preserved pumping strength
This study tests a small device placed in a neck vein (coronary sinus) to see if it can improve symptoms in people with a type of heart failure where the heart pumps normally but doesn't fill properly. The goal is to make you feel better and reduce fluid buildup.
Rochester, MinnesotaAges 18 years+ - NCT04551560Recruiting
Stress study in adults with heart failure using a heart monitor
This study looks at how stress affects blood pressure patterns in people with heart failure, using an implanted CardioMEMS pressure monitor. It may help doctors understand whether stress changes heart failure symptoms and pressure readings over time.
Hartford, ConnecticutAges 18 years+ - NCT06653725RecruitingPhase 2
Ketone supplement study for hospitalized heart failure patients
This trial tests if a ketone supplement can help people hospitalized for acute heart failure. The supplement is given orally and aims to support the heart and energy levels during recovery.
AalborgAges 18 years+ - NCT06977477Recruiting
Managing fluid buildup in heart failure patients
This study tests a new way to manage fluid buildup in patients with a specific type of heart failure (HFpEF) who are in the hospital. It aims to improve how doctors remove excess fluid and help you feel better.
Magdeburg, Saxony-AnhaltAges 18 years+ - NCT07402239Recruiting
Heart failure therapy and monitoring device study
This trial tests a device that treats and monitors heart failure. It may help people with chronic heart failure and reduced heart function who still have symptoms despite standard treatments.
Fuzhou, FujianAges 18 years+ - NCT06217302RecruitingPhase 3
Sotagliflozin for kidney protection in type 1 diabetes
This study tests whether sotagliflozin (a pill that helps control blood sugar and protects the kidneys) can slow down kidney function decline in people with type 1 diabetes and diabetic kidney disease. You may qualify if you have had type 1 diabetes for at least 8 years, have moderate kidney damage, and are on standard treatments.
Stanford, CaliforniaAges 18–75 - NCT06726109Recruiting
FOCUS study on acute heart failure
This trial is studying patients admitted to the hospital for acute heart failure. It will collect information to better understand and treat people with low heart pumping strength (ejection fraction less than 40%) and fluid retention.
Genk, BelgiumAges Any age - NCT05960968Recruiting
Hospital heart failure registry for adults in Santiago
This is a registry study that collects information from adults hospitalized for heart failure in Santiago. It aims to better understand heart failure in real-world patients, including differences by sex, by tracking what happens during the hospital stay.
Santiago, Santiago MetropolitanAges 18 years+ - NCT06495892RecruitingPhase 4
PVP-guided fluid removal for heart failure patients
This study tests a new way to guide fluid removal (decongestive therapy) in people hospitalized for heart failure. It aims to help doctors safely reduce fluid buildup, no matter what type of heart failure you have.
AnkaraAges 18–99 - NCT07375433Recruiting
Heart failure and COPD study for patients aged 50 to 70
This trial looks at how heart failure with preserved pumping function affects people who also have COPD. It aims to understand the course of the disease and long-term outlook.
Kazan'Ages 50–70 - NCT06935370RecruitingPhase 3
Testing vicadrostat with empagliflozin for heart failure with weak pump
This trial tests a new drug called vicadrostat combined with another drug, empagliflozin, for people with heart failure and a weak heart pump. It aims to see if this combination helps improve symptoms and outcomes.
Montgomery, AlabamaAges 18 years+
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Common questions
- Are there clinical trials for decompensated chronic heart failure?
- Yes. Clin2 currently lists 82 recruiting decompensated chronic heart failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a decompensated chronic heart failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a decompensated chronic heart failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.