Clinical trials
End-stage Heart Failure clinical trials
Below are recruiting end-stage heart failure clinical trials, each written for real people, not researchers. We’re tracking 79 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06965504Recruiting
Heart failure medications with an Impella heart pump for cardiogenic shock
This study tests whether a special heart pump (Impella 5.5) can help patients with severe heart failure (cardiogenic shock) safely start and increase their heart failure medications. The goal is to see if this approach can help the heart recover and improve outcomes.
Tampa, FloridaAges 18–80 - NCT06927440Enrolling by invitation
Registry for children with severe heart failure in China
This study is creating a registry to learn more about children with advanced heart failure. It will help doctors understand who can benefit from treatments like medicine, devices, or transplants.
Shanghai, Shanghai MunicipalityAges Up to 18 years - NCT06902896RecruitingPhase 1/Phase 2
FAP iCDC therapy for advanced heart failure from dilated cardiomyopathy
This trial tests a new treatment called FAP iCDC for people with end-stage dilated cardiomyopathy, a type of heart muscle disease. It aims to see if this therapy is safe and helps improve heart function when standard medicines are no longer enough.
Hangzhou, ZhejiangAges 18–75 - NCT06909682Recruiting
AI monitoring with wearables for chronic heart failure
This trial tests an AI system that uses wearable devices and mini-invasive tools to monitor people with chronic heart failure. The goal is to detect changes early and help manage the condition at home.
SalernoAges 19 years+ - NCT06455878Recruiting
Mobile app for weight loss in heart failure patients
This trial tests a mobile app that helps you track your diet to manage your weight. It is designed for people with heart failure who are overweight and have recently been in the hospital for their condition.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06877169Recruiting
Staged heart and kidney transplant study
This study compares two ways of doing a combined heart and kidney transplant. It looks at doing the surgeries in separate stages instead of all at once, to see if that is safer or works better.
Los Angeles, CaliforniaAges 18 years+ - NCT06800716Recruiting
Impella temporary pump for end-stage heart failure
This study tests whether using a temporary heart pump called Impella 5.5 can help strengthen a very weak and enlarged heart (dilated cardiomyopathy) in people who are waiting for a heart transplant. If you qualify, the pump is placed to support your heart temporarily, and the research team will check how your heart responds.
New York, New YorkAges 18 years+ - NCT06783335Recruiting
Cordella sensor for chronic heart failure
This trial studies a small sensor placed in the lung artery to help manage chronic heart failure. It compares patients who get the sensor to those who receive standard care, to see if the sensor improves outcomes.
Naperville, IllinoisAges 18 years+ - NCT06299176Enrolling by invitationPhase 1
Whole-heart radiation therapy for advanced heart failure
This trial tests if a low dose of radiation to the whole heart can help people with very advanced heart failure. It is for people who have severe symptoms despite maximum medications and are not candidates for a heart pump or transplant.
Montreal, QuebecAges 65 years+ - NCT06205225Recruiting
Mobile health program for heart failure self-care
This study tests a mobile health program (phone app and coaching) to help people with heart failure better manage their condition at home. It aims to improve self-care and reduce hospital visits.
Chicago, IllinoisAges 18 years+ - NCT05647213RecruitingPhase 1
Skin biopsy study of stem-cell therapy for congenital heart disease
This early study takes a small skin sample to make a personalized type of heart stem cells in the future. It is testing whether this approach is safe and feasible for people with complex single-chamber congenital heart disease and advanced heart failure.
Rochester, MinnesotaAges 18–40 - NCT04768322Recruiting
LVAD versus standard heart failure medicines in advanced patients
This trial compares an LVAD device (a pump placed in the chest) plus medicines versus medicines alone for people with advanced, end-stage heart failure. It aims to see which approach works better to help patients live and stay out of the hospital.
BesançonAges 18 years+ - NCT04671771Recruiting
Testing a new graft for hemodialysis access in kidney failure
This study tests whether an “AV graft” implant works safely and well for people with end-stage kidney disease who need hemodialysis. It may help your dialysis access last and work better, compared with current expectations for AV grafts.
Phoenix, ArizonaAges 18–90 - NCT04641416Recruiting
Ultrasound test for people with HeartMate 3 blood pumps
This study checks whether a noninvasive ultrasound-based method can help diagnose what’s going on in people with a HeartMate 3 blood pump. It may help detect important pump-related changes while keeping the process safer for certain high-risk situations.
ViennaAges 18–75 - NCT07506499Recruiting
Cardiac Rehab for Hospitalized Heart Failure Patients
This study tests whether a cardiac rehabilitation program (a supervised exercise and education plan) helps people recovering in the hospital from severe heart failure. It is for those aged 45–65 whose heart pumps less than 40% of its normal amount.
Banī Suwayf, Beni-Suef GovernorateAges 45–65 - NCT07485816Enrolling by invitation
Heart-brain oxygen and thinking changes in heart failure
This study looks at how well your heart and brain work together to use oxygen, and how that relates to changes in thinking and memory for people with heart failure.
Kunming, YunnanAges 18–70 - NCT07402239Recruiting
Heart failure therapy and monitoring device study
This trial tests a device that treats and monitors heart failure. It may help people with chronic heart failure and reduced heart function who still have symptoms despite standard treatments.
Fuzhou, FujianAges 18 years+ - NCT07400991Recruiting
Restrictive vs liberal fluids for hospitalized heart failure
This trial studies whether drinking less fluid (restrictive) vs. the usual amount (liberal) helps people hospitalized with heart failure. It aims to find out which approach leads to better recovery and fewer symptoms.
HerningAges 18 years+ - NCT07099885Recruiting
Urine test to guide water pill treatment for heart failure
This study tests a simple urine test to help doctors choose the best dose of water pills (diuretics) for people hospitalized with heart failure and leg swelling. The goal is to relieve congestion faster and more safely.
Wroclaw, DolnosląskieAges 18 years+ - NCT02638142Recruiting
Testing IV diuretic treatment for sudden worsening heart failure
This trial studies how an IV (into-the-vein) “water pill” (furosemide/loop diuretic) works in people whose heart failure has suddenly gotten worse. It may help doctors find the best way to reduce fluid-related symptoms like breathing trouble and swelling.
Chioggia, VeneziaAges 18 years+ - NCT06364644Recruiting
Reducing heart failure risk in low-income adults with diabetes
This study looks at how low income and diabetes together raise the risk of heart failure. It offers a program to help you manage your health and reduce that risk.
Baltimore, MarylandAges 30–70 - NCT07372040RecruitingPhase 2
Adding a Water Pill for Heart Failure in the Hospital
This trial tests if adding a diuretic (water pill) called acetazolamide to usual care can help you get rid of extra fluid faster while you are in the hospital for worsening heart failure.
TantaAges 18 years+ - NCT05738525Recruiting
Compare two types of home dialysis for kidney outcomes and quality of life
This study compares two forms of home peritoneal dialysis—how well they work for kidney health and how they affect daily life. You may be considered if you have end-stage kidney disease and meet specific test and safety requirements.
Beijing, Beijing MunicipalityAges 18–75 - NCT07720401Recruiting
Exercise during dialysis for posture problems
This study tests if doing gentle exercise during dialysis can help improve posture problems like a rounded upper back or forward head tilt. It is a small, early-stage study to see if the exercises are safe and might help.
IsfahanAges 18–80
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Common questions
- Are there clinical trials for end-stage heart failure?
- Yes. Clin2 currently lists 79 recruiting end-stage heart failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a end-stage heart failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a end-stage heart failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.