Clinical trials
Heart Failure NYHA Class IV clinical trials
Below are recruiting heart failure nyha class iv clinical trials, each written for real people, not researchers. We’re tracking 131 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07420088Recruiting
Seasonal activity in heart failure with a heart device
This trial studies how physical activity changes with the seasons in people with heart failure who have a pacemaker or defibrillator. It aims to help doctors understand how to better support your activity levels throughout the year.
ÇorumAges 18 years+ - NCT05265520Recruiting
Pacing strategy study for certain heart failure patients
This trial tests a pacing approach designed to improve how the heart beats in some people with heart failure and a specific heart rhythm pattern on ECG. If you already need a device (CRT-D) based on your results, the study may help see whether this pacing correction improves outcomes.
Phoenix, ArizonaAges 18 years+ - NCT07761117RecruitingPhase 3
Heart failure treatment study for people with preserved pumping function
This study tests an investigational medication called elecoglipron to see if it can improve heart and blood vessel outcomes in people with heart failure with preserved or mildly reduced ejection fraction. If you join, you will receive either the study drug or a placebo, and your heart health will be monitored over time.
Fairhope, AlabamaAges 18 years+ - NCT06174103Recruiting
BiVACOR total artificial heart early feasibility study
This study tests a new total artificial heart called BiVACOR for people with severe heart failure that cannot be helped by standard pumps. It is designed to keep you alive while you wait for a heart transplant.
Phoenix, ArizonaAges 18–70 - NCT05508035RecruitingPhase 3
Testing sacubitril/valsartan vs ramipril for heart failure
This trial compares two blood-pressure and heart-failure medicines: sacubitril/valsartan versus ramipril, to see which improves heart pumping and heart structure over time. It’s aimed at people with ischemic (blocked-artery) heart failure with mid-range ejection fraction and ongoing symptoms.
Krakow, Lesser Poland VoivodeshipAges 18 years+ - NCT07067658Recruiting
Monitoring leg swelling in heart failure to reduce hospital stays
This trial tests a new home monitoring device for people with heart failure and leg swelling. The device helps track fluid changes early, so you may be able to avoid hospital stays.
Aylesbury, BuckinghamshireAges 18 years+ - NCT06704633RecruitingPhase 4
Heart failure drug study for rural Tanzanians
This trial tests a medicine called sacubitril-valsartan for people in rural Tanzania with heart failure and reduced pumping strength. It aims to see if switching to this drug can improve symptoms and outcomes.
Ifakara, MorogoroAges 18 years+ - NCT06105580Recruiting
Pacing methods for heart failure with wide QRS
This trial compares two ways to pace the heart in people with heart failure and a wide QRS (a sign the heart's electrical signals are slowed). The goal is to see which method better reduces the risks of death, heart failure hospitalization, or needing a heart transplant.
BarcelonaAges 18 years+ - NCT05583773RecruitingPhase 4
Herbal medicine for heart failure with lower pumping strength
This trial tests SHengXIaN-QuYu decoction (an herbal treatment) in people with symptomatic heart failure and reduced pumping function. It looks to see whether the herbal formula is safe and helpful for heart failure symptoms and heart function.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07100561Recruiting
Heart Failure Re-Admission Study
This trial will follow people with heart failure who are admitted to the hospital to see who returns within 30 and 90 days. It aims to understand how to reduce future hospital visits.
Kumasi, Ashanti RegionAges 18 years+ - NCT07281859Recruiting
Heart monitor alert study for new ICD patients
This study tests a heart failure alert system called HeartInsight in people who recently received an ICD or CRT-D device. The goal is to see if the alerts help doctors manage care better. You may qualify if you got a new (not replacement) device less than a year ago.
Mercogliano, AvellinoAges 18 years+ - NCT06249932RecruitingPhase 4
Empagliflozin for heart failure and end-stage kidney disease
This trial tests whether empagliflozin, a medication for heart failure, can help people who also have end-stage kidney disease and are on dialysis. It aims to see if the drug improves heart function in this group.
Hsinchu, TaiwanAges 20 years+ - NCT06249945RecruitingPhase 4
Empagliflozin for heart failure with preserved ejection fraction and dialysis
This trial tests whether a medicine called empagliflozin (used for diabetes and heart failure) can help people with both heart failure (with preserved pumping ability) and end-stage kidney disease who are on dialysis. The study looks at how the drug affects heart function and overall well-being.
HsinchuAges 20 years+ - NCT06702501Recruiting
Shunt device to treat heart failure with preserved ejection fraction
This trial tests a tiny tube (shunt) placed in the heart to relieve pressure and ease severe shortness of breath. It's for people with a type of heart failure where the heart pumps well but doesn't relax enough.
Rochester, MinnesotaAges 30 years+ - NCT06148935Recruiting
Study of vericiguat in Korean heart failure patients
This study looks at how well Verquvo (vericiguat) works in daily life for Korean adults with chronic heart failure and a weak heart pump. It’s for people whose heart failure has recently gotten worse and who are starting Verquvo for the first time.
Multiple LocationsAges 19 years+ - NCT05666518Recruiting
Study of vericiguat safety in Japanese chronic heart failure patients
This study checks how safe the medicine vericiguat is for Japanese people with chronic heart failure when used in everyday care. It compares patients who receive vericiguat with patients who continue standard treatments without vericiguat.
Multiple Locations, Many LocationsAges Any age - NCT07486791Recruiting
Baduanjin exercise for heart health after heart attack
This study tests whether a gentle exercise called 'Lying-Sitting-Standing' Baduanjin can improve heart and lung function and quality of life in people who have had a heart attack and also have heart failure.
Taiyuan, ShanxiAges Up to 85 years - NCT05491655Recruiting
Testing a new pacing approach in some heart failure patients
This study looks at whether a high-intensity “His bundle” heart pacing method can help people with heart failure who have a specific heart rhythm pattern on ECG. It likely aims to improve heart pumping and symptoms in people who are otherwise a good match for an ICD and meet other criteria.
Acquaviva delle Fonti, BariAges 18–90 - NCT06241651Recruiting
Comparing two types of pacemakers for heart failure patients
This trial tests if a new pacemaker method (CSP) works better than the standard method (BiVP) for people with heart failure who already have a right ventricular pacemaker and need an upgrade.
Nanjing, JiangsuAges 18–80 - NCT06620705Recruiting
Pacing options for AF with low heart function
This trial compares two types of pacing for people with permanent atrial fibrillation (AF) and a weak heart pump (ejection fraction less than 50%). It tests whether pacing the left bundle branch area works as well as or better than standard biventricular pacing to improve heart function.
Aarhus N, Aarhus NAges 18 years+ - NCT05972070Recruiting
Telemedicine home cardiac rehab after heart procedure
This trial studies whether cardiac rehabilitation done at home, with help from telemedicine, is safe and helps you stick with the program after a recent heart procedure. It may help you recover with more convenience while still improving heart-related fitness and adherence.
Brookfield, ConnecticutAges 18 years+ - NCT06735521Recruiting
Heart MRI stress test for Fontan circulation
This study uses a special heart MRI with a medicine that stresses the heart (like exercise) to look at blood flow in people who have had the Fontan surgery. The goal is to better understand how the heart works after this surgery.
StockholmAges 18 years+ - NCT05519046Recruiting
Test a heart pacing treatment for Chagas-related heart failure
This study looks at a heart treatment called cardiac contractility modulation in people with Chagas heart disease who have moderate symptoms and weak heart pumping. It aims to see whether this therapy improves heart function and related outcomes in the right patients.
São Paulo, São PauloAges 18–75 - NCT07407816Recruiting
Supira heart support device for high-risk artery stenting
This trial tests a new device (the Supira system) that helps support your heart's pumping function during and after a high-risk procedure to open blocked coronary arteries. It is for people with heart failure and complex blockages who may need extra circulatory support.
Tbilisi, K'alak'i T'bilisiAges 18–90
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Common questions
- Are there clinical trials for heart failure nyha class iv?
- Yes. Clin2 currently lists 131 recruiting heart failure nyha class iv studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a heart failure nyha class iv trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a heart failure nyha class iv trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.