Clinical trials
Heart Failure NYHA Class IV clinical trials
Below are recruiting heart failure nyha class iv clinical trials, each written for real people, not researchers. We’re tracking 139 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05491655Recruiting
Testing a new pacing approach in some heart failure patients
This study looks at whether a high-intensity “His bundle” heart pacing method can help people with heart failure who have a specific heart rhythm pattern on ECG. It likely aims to improve heart pumping and symptoms in people who are otherwise a good match for an ICD and meet other criteria.
Acquaviva delle Fonti, BariAges 18–90 - NCT07486791Recruiting
Baduanjin exercise for heart health after heart attack
This study tests whether a gentle exercise called 'Lying-Sitting-Standing' Baduanjin can improve heart and lung function and quality of life in people who have had a heart attack and also have heart failure.
Taiyuan, ShanxiAges Up to 85 years - NCT06241651Recruiting
Comparing two types of pacemakers for heart failure patients
This trial tests if a new pacemaker method (CSP) works better than the standard method (BiVP) for people with heart failure who already have a right ventricular pacemaker and need an upgrade.
Nanjing, JiangsuAges 18–80 - NCT06620705Recruiting
Pacing options for AF with low heart function
This trial compares two types of pacing for people with permanent atrial fibrillation (AF) and a weak heart pump (ejection fraction less than 50%). It tests whether pacing the left bundle branch area works as well as or better than standard biventricular pacing to improve heart function.
Aarhus N, Aarhus NAges 18 years+ - NCT05972070Recruiting
Telemedicine home cardiac rehab after heart procedure
This trial studies whether cardiac rehabilitation done at home, with help from telemedicine, is safe and helps you stick with the program after a recent heart procedure. It may help you recover with more convenience while still improving heart-related fitness and adherence.
Brookfield, ConnecticutAges 18 years+ - NCT06735521Recruiting
Heart MRI stress test for Fontan circulation
This study uses a special heart MRI with a medicine that stresses the heart (like exercise) to look at blood flow in people who have had the Fontan surgery. The goal is to better understand how the heart works after this surgery.
StockholmAges 18 years+ - NCT05519046Recruiting
Test a heart pacing treatment for Chagas-related heart failure
This study looks at a heart treatment called cardiac contractility modulation in people with Chagas heart disease who have moderate symptoms and weak heart pumping. It aims to see whether this therapy improves heart function and related outcomes in the right patients.
São Paulo, São PauloAges 18–75 - NCT07407816Recruiting
Supira heart support device for high-risk artery stenting
This trial tests a new device (the Supira system) that helps support your heart's pumping function during and after a high-risk procedure to open blocked coronary arteries. It is for people with heart failure and complex blockages who may need extra circulatory support.
Tbilisi, K'alak'i T'bilisiAges 18–90 - NCT06570473RecruitingPhase 2
RV failure treatment trial for pulmonary hypertension patients
This trial is testing two heart medications, empagliflozin and ranolazine, to see if they can improve right heart function in people with pulmonary hypertension and right ventricular failure. Participants will monitor their symptoms using a smartphone or tablet.
Calgary, AlbertaAges 18 years+ - NCT07444398RecruitingPhase 1
Vericiguat for worsening heart failure
This trial tests if adding vericiguat to standard heart failure medicines helps people hospitalized with worsening heart failure. It's for those with a weak heart pump and high NT-proBNP levels.
Rawalpindi, Punjab ProvinceAges 25–65 - NCT07420907Recruiting
Tracking heart health over time
This study uses a wearable patch to monitor heart-related signs in people with heart conditions. It aims to learn more about how these conditions progress, which could help improve future care.
Chicago, IllinoisAges 18 years+ - NCT07750873RecruitingPhase 2
Study of an investigational medicine for heart failure with reduced pumping function
This trial tests an investigational medicine called CRD-4730 (taken as a pill) to see if it can improve heart function and symptoms in people with heart failure and a reduced pumping ability. It may help you feel better and slow the progression of your condition.
Pasadena, CaliforniaAges 18–85 - NCT06312748RecruitingPhase 1
Improving blood vessels in veterans with heart failure
This test is looking at whether certain medications (like statins) can help improve blood vessel health in veterans who have heart failure with preserved pumping function. It may help reduce symptoms and keep you out of the hospital.
Salt Lake City, UtahAges 18 years+ - NCT06055504Recruiting
Personalized defibrillator plan for non-ischemic heart failure (SPANISH-1)
This trial is testing a personalized approach to deciding who gets an implantable defibrillator (ICD) for people with heart failure due to dilated cardiomyopathy (not from blocked arteries). It aims to see if MRI scans and other factors can better match the device to those who need it most.
Santiago de Compostela, A CoruñaAges 18 years+ - NCT06645535Enrolling by invitation
Gut Bacteria and Blood Substances in Stiff Heart Failure
This study looks at how bacteria in your gut and certain substances in your blood relate to a type of heart failure called HFpEF (where the heart is stiff and doesn't relax well). It may help doctors understand the condition better and find new ways to treat it.
Naning, JiangsuAges 18 years+ - NCT04913805RecruitingPhase 2
Study for HFpEF using heart pressure and energy signals
This Phase 2 study tests how matching heart “filling pressure” and heart muscle “energy use” may improve understanding or treatment of HFpEF, a type of heart failure with preserved pumping strength. You may be asked to have heart scans/tests and follow a study plan if your symptoms and test results fit.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05138575RecruitingPhase 2
Testing SGLT2 pill and potassium nitrate for heart failure with preserved EF
This trial studies whether two medicines—an SGLT2 inhibitor and potassium nitrate—can improve symptoms and heart function in people with heart failure with preserved ejection fraction (HFpEF). It focuses on people who still have signs of “stiff” or high filling pressure in the heart despite a normal-ish ejection fraction.
Philadelphia, PennsylvaniaAges 18 years+ - NCT04592445Recruiting
Nerve ablation for right-sided symptoms in HFpEF heart failure
This trial tests a procedure to “turn off” the right greater splanchnic nerve to improve symptoms in people with HFpEF (heart failure with preserved pumping function). If successful, it may reduce shortness of breath and fluid congestion in daily life.
Birmingham, AlabamaAges 40 years+ - NCT07207811RecruitingPhase 3
Study of coramitug for heart failure from ATTR amyloidosis
This study tests an investigational medicine called coramitug in people with heart failure caused by ATTR amyloidosis, a condition where abnormal protein builds up in the heart. The goal is to see if it can slow or improve heart function.
Phoenix, ArizonaAges 18 years+ - NCT06169540Recruiting
Saliva test for heart failure diagnosis
This study tests whether a simple saliva sample can detect certain molecules (lncRNAs) that might help diagnose heart failure. It looks at two types of heart failure: chronic stable heart failure and acute decompensated heart failure, and compares them to people without heart failure who are having a heart procedure.
Boston, MassachusettsAges 18 years+ - NCT07492979Recruiting
Pacemaker placement study for heart failure
This trial compares two types of pacemaker placement to improve heart function in people with heart failure. One method paces the heart's natural conduction system, while the other paces the lower chambers of the heart. The goal is to find which approach works better for heart resynchronization therapy.
AarhusAges 18–99 - NCT07664189Enrolling by invitation
Left bundle pacing plus CRT vs. LBBP alone
This trial tests a new pacing approach that combines a left bundle branch pacemaker with standard cardiac resynchronization therapy (CRT) for people with heart failure. It aims to improve the heart's pumping efficiency compared to using the left bundle branch pacemaker alone.
Medellín, AntioquiaAges 18 years+ - NCT06902896RecruitingPhase 1/Phase 2
FAP iCDC therapy for advanced heart failure from dilated cardiomyopathy
This trial tests a new treatment called FAP iCDC for people with end-stage dilated cardiomyopathy, a type of heart muscle disease. It aims to see if this therapy is safe and helps improve heart function when standard medicines are no longer enough.
Hangzhou, ZhejiangAges 18–75 - NCT04654988RecruitingPhase 4
Immunosuppression study for active myocarditis or inflammatory cardiomyopathy
This Phase 4 study tests whether weakening the immune system (immunosuppression) works better for people with active myocarditis or inflammatory cardiomyopathy. It includes extra heart tests—two heart muscle biopsies and two heart MRI scans—to confirm the diagnosis and guide treatment.
WarsawAges 18–65
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Common questions
- Are there clinical trials for heart failure nyha class iv?
- Yes. Clin2 currently lists 139 recruiting heart failure nyha class iv studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a heart failure nyha class iv trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a heart failure nyha class iv trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.