Clinical trials
Heart Failure With Reduced Ejection Fraction clinical trials
Below are recruiting heart failure with reduced ejection fraction clinical trials, each written for real people, not researchers. We’re tracking 182 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07054489Recruiting
Genetic guided beta blocker therapy for heart failure
This trial tests whether a genetic test can help doctors choose the best beta blocker for people with heart failure who have mildly reduced pumping function. It aims to improve treatment by matching the drug to your genetic profile.
Detroit, MichiganAges 18–89 - NCT05641662Recruiting
Video games that get you moving for heart failure inactivity
This study tests whether playing “exergames” (motion-based video games) can help people with heart failure who are mostly inactive spend less time sitting. It checks whether the games are safe and practical and whether they can improve activity over time.
PortoAges 18 years+ - NCT07210606RecruitingPhase 4
Sleep apnea treatment study for veterans with heart failure
This study looks at how well a medicine called trazodone might help treat central sleep apnea in veterans who also have heart failure. It aims to improve sleep and breathing, which may help you feel better.
Detroit, MichiganAges 18 years+ - NCT05712824Recruiting
Device to measure left-heart pressure in advanced heart failure
This trial tests a wirelessly implanted device that measures pressure in the left upper heart chamber (left atrial pressure) in people with advanced heart failure. By tracking that pressure, researchers hope to better understand disease status and guide care.
Tbilisi, GeorgiaAges 22–88 - NCT07025629RecruitingPhase 3
Dapagliflozin after ICU discharge for heart and kidney health
This study tests if the drug dapagliflozin (a medicine that helps protect the heart and kidneys) can improve recovery in patients who needed a breathing machine or blood pressure support in the ICU. If you qualify, you would take the drug after leaving the ICU to see if it lowers the risk of heart or kidney problems.
ParisAges 18 years+ - NCT06147336Recruiting
Testing the V-Lap system for heart failure monitoring
This trial tests a new device called V-Lap that is placed in the heart to monitor pressure. It may help doctors better manage heart failure and reduce hospital stays. Researchers want to see if it works well in people with mild to moderate heart failure.
Boston, MassachusettsAges 22–88 - NCT06902896RecruitingPhase 1/Phase 2
FAP iCDC therapy for advanced heart failure from dilated cardiomyopathy
This trial tests a new treatment called FAP iCDC for people with end-stage dilated cardiomyopathy, a type of heart muscle disease. It aims to see if this therapy is safe and helps improve heart function when standard medicines are no longer enough.
Hangzhou, ZhejiangAges 18–75 - NCT05876000Recruiting
Heart pump study for very severe heart failure
This trial tests a left ventricular assist system (a mechanical heart pump for the left side of the heart) in people with very severe heart failure. It may help people who are too sick or not improving despite best available medical treatment.
GrazAges 18–75 - NCT05672836RecruitingPhase 4
Enavogliflozin after TAVR for heart narrowing with mild heart weakness
This trial tests enavogliflozin (a diabetes medication that may help the heart) in people who have had a TAVR procedure for severe aortic stenosis. It looks at whether the medicine can improve outcomes for people with symptoms and mildly reduced or preserved pumping function.
Bucheon-siAges 19 years+ - NCT05230745Recruiting
Test device for heart failure safety and how well it works
This trial studies whether the ContraBand device can be safely placed in people with long-term, symptomatic heart failure and reduced heart pumping. It also looks at whether the approach is practical and tolerable, and gathers early safety information.
AalstAges 18–85 - NCT04323371Recruiting
Study testing for heart-shock to reduce future events
This trial studies how to identify different types of “cardiogenic shock,” a serious drop in heart blood flow. It aims to use detailed patient information to guide care and possibly lower the chance of dangerous outcomes.
MilanAges 18–74 - NCT03895541Recruiting
Heart ultrasound stiffness test for elderly diastolic heart failure
This trial tests a new heart ultrasound method to measure stiffness in the heart muscle, which could help doctors diagnose a type of heart failure where the heart is stiff but still squeezes normally. It is for elderly patients with heart failure, and the findings might lead to a simpler and safer way to identify this condition.
ParisAges 18–100 - NCT07583446RecruitingPhase 2/Phase 3
Istaroxime for acute heart failure with low blood pressure
This trial tests an investigational drug called istaroxime for people hospitalized with acute heart failure and low blood pressure (cardiogenic shock). The drug aims to improve heart function and stabilize blood pressure, potentially helping you feel better and recover.
YerevanAges 18–80 - NCT01174108RecruitingPhase 2
Stem cell transplant with donor T-cells for severe bone marrow failure
This Phase 2 study tests a specific type of donor stem cell transplant for severe bone marrow failure conditions, aiming to improve cure rates while reducing transplant risks. It includes people with diseases like severe aplastic anemia and certain bone marrow disorders, especially when standard transplant plans feel too risky.
Baltimore, MarylandAges 4–80
Hear when a new Heart Failure With Reduced Ejection Fraction trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for heart failure with reduced ejection fraction?
- Yes. Clin2 currently lists 182 recruiting heart failure with reduced ejection fraction studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a heart failure with reduced ejection fraction trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a heart failure with reduced ejection fraction trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Heart Failure With Mildly Reduced Ejection Fraction
- Chronic Heart Failure With Reduced Ejection Fraction
- Heart Failure With Preserved Ejection Fraction
- Heart Failure With Mid Range Ejection Fraction
- Heart Failure With Normal Ejection Fraction
- Acute Heart Failure
- Chronic Heart Failure
- Congestive Heart Failure
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.