Clinical trials
Heart Failure With Reduced Ejection Fraction clinical trials
Below are recruiting heart failure with reduced ejection fraction clinical trials, each written for real people, not researchers. We’re tracking 183 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05641662Recruiting
Video games that get you moving for heart failure inactivity
This study tests whether playing “exergames” (motion-based video games) can help people with heart failure who are mostly inactive spend less time sitting. It checks whether the games are safe and practical and whether they can improve activity over time.
PortoAges 18 years+ - NCT07492524Recruiting
Better care for older adults with AF and heart failure in rural China
This trial tests a new way to manage care for older patients with atrial fibrillation and heart failure living in rural areas. It uses village doctors and telemedicine to help monitor and treat these conditions together.
Yancheng, DongtaiAges 65–80 - NCT07076615RecruitingPhase 4
Dapagliflozin for acute heart failure
This trial tests if a medicine called dapagliflozin (Farxiga) helps people with acute heart failure. You may qualify if you are in the hospital or ER for heart failure and need IV water pills.
CairoAges 18 years+ - NCT06902896RecruitingPhase 1/Phase 2
FAP iCDC therapy for advanced heart failure from dilated cardiomyopathy
This trial tests a new treatment called FAP iCDC for people with end-stage dilated cardiomyopathy, a type of heart muscle disease. It aims to see if this therapy is safe and helps improve heart function when standard medicines are no longer enough.
Hangzhou, ZhejiangAges 18–75 - NCT04323371Recruiting
Study testing for heart-shock to reduce future events
This trial studies how to identify different types of “cardiogenic shock,” a serious drop in heart blood flow. It aims to use detailed patient information to guide care and possibly lower the chance of dangerous outcomes.
MilanAges 18–74 - NCT04591639Recruiting
DAPA test for diabetes and heart failure using body scans
This study tests how a medication called DAPA (an SGLT2 inhibitor) affects the body in people with heart failure (with or without type 2 diabetes), or in some people with type 2 diabetes only. It may help researchers understand who could benefit most and what changes happen in the heart, using specialized heart imaging.
Edinburgh, ScotlandAges 18 years+ - NCT05230745Recruiting
Test device for heart failure safety and how well it works
This trial studies whether the ContraBand device can be safely placed in people with long-term, symptomatic heart failure and reduced heart pumping. It also looks at whether the approach is practical and tolerable, and gathers early safety information.
AalstAges 18–85 - NCT05235685Recruiting
Testing muscle fatigue during exercise in COPD and heart failure
This study looks at how tired your muscles get during a controlled cycling exercise test in people who have COPD, and—if applicable—heart failure at the same time. It may help researchers understand exercise limits and how to better support you with these conditions.
Échirolles, Auvergne-Rhône-AlpesAges 18 years+ - NCT05712824Recruiting
Device to measure left-heart pressure in advanced heart failure
This trial tests a wirelessly implanted device that measures pressure in the left upper heart chamber (left atrial pressure) in people with advanced heart failure. By tracking that pressure, researchers hope to better understand disease status and guide care.
Tbilisi, GeorgiaAges 22–88 - NCT05876000Recruiting
Heart pump study for very severe heart failure
This trial tests a left ventricular assist system (a mechanical heart pump for the left side of the heart) in people with very severe heart failure. It may help people who are too sick or not improving despite best available medical treatment.
GrazAges 18–75 - NCT06147336Recruiting
Testing the V-Lap system for heart failure monitoring
This trial tests a new device called V-Lap that is placed in the heart to monitor pressure. It may help doctors better manage heart failure and reduce hospital stays. Researchers want to see if it works well in people with mild to moderate heart failure.
Boston, MassachusettsAges 22–88 - NCT07025629RecruitingPhase 3
Dapagliflozin after ICU discharge for heart and kidney health
This study tests if the drug dapagliflozin (a medicine that helps protect the heart and kidneys) can improve recovery in patients who needed a breathing machine or blood pressure support in the ICU. If you qualify, you would take the drug after leaving the ICU to see if it lowers the risk of heart or kidney problems.
ParisAges 18 years+ - NCT05672836RecruitingPhase 4
Enavogliflozin after TAVR for heart narrowing with mild heart weakness
This trial tests enavogliflozin (a diabetes medication that may help the heart) in people who have had a TAVR procedure for severe aortic stenosis. It looks at whether the medicine can improve outcomes for people with symptoms and mildly reduced or preserved pumping function.
Bucheon-siAges 19 years+ - NCT07449325Recruiting
Heart sinus reducer for chest pain from small vessel disease
This trial tests a device placed in a heart vein (the coronary sinus) to improve blood flow and reduce chest pain in people with coronary microvascular dysfunction (small blood vessel disease). It aims to help those who still have symptoms despite taking heart medications.
New Haven, ConnecticutAges 18 years+ - NCT01174108RecruitingPhase 2
Stem cell transplant with donor T-cells for severe bone marrow failure
This Phase 2 study tests a specific type of donor stem cell transplant for severe bone marrow failure conditions, aiming to improve cure rates while reducing transplant risks. It includes people with diseases like severe aplastic anemia and certain bone marrow disorders, especially when standard transplant plans feel too risky.
Baltimore, MarylandAges 4–80
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Common questions
- Are there clinical trials for heart failure with reduced ejection fraction?
- Yes. Clin2 currently lists 183 recruiting heart failure with reduced ejection fraction studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a heart failure with reduced ejection fraction trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a heart failure with reduced ejection fraction trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Heart Failure With Mildly Reduced Ejection Fraction
- Chronic Heart Failure With Reduced Ejection Fraction
- Heart Failure With Preserved Ejection Fraction
- Heart Failure With Mid Range Ejection Fraction
- Heart Failure With Normal Ejection Fraction
- Acute Heart Failure
- Chronic Heart Failure
- Congestive Heart Failure
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.