Clinical trials
Heart Failure With Reduced Ejection Fraction clinical trials
Below are recruiting heart failure with reduced ejection fraction clinical trials, each written for real people, not researchers. We’re tracking 182 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05255172Enrolling by invitation
Exercise program for heart failure with preserved or reduced pumping
This trial tests whether a structured exercise program can help people with heart failure. It focuses on people who are currently not very active, aiming to improve symptoms and heart/fitness measures safely.
LundAges 50–90 - NCT05230784Recruiting
Air purifier study for people with heart failure
This trial tests whether using air purifiers can help people with heart failure breathe better and feel better. It enrolls adults with recent heart failure and specific heart and lung conditions, while avoiding people with certain severe breathing problems or recent heart device treatment.
Thiruvananthapuram, KeralaAges 18 years+ - NCT05966415RecruitingPhase 2
Endocalyx for heart failure with fluid overload
This Phase 2 study tests Endocalyx to treat people with heart failure who currently show signs of fluid buildup (congestion). If you qualify, you may help researchers see whether this supplement can improve symptoms and heart-failure–related measurements.
Amsterdam, North HollandAges 18–110 - NCT06036615Recruiting
Exercise training for frailty and fall risk in heart failure
This trial tests whether a supervised exercise program can reduce frailty and fall risk in people with chronic heart failure, and what happens when training stops. It may help you feel stronger and more stable.
Thessaloniki, ThermiAges 18–100 - NCT07692256RecruitingPhase 2
Empagliflozin for heart failure in children
This trial tests if empagliflozin, a diabetes medicine that also helps the heart, can improve symptoms in children with heart failure. It may help kids with severe symptoms or high levels of a heart stress marker called BNP.
Cairo, Cairo GovernorateAges 1 month–18 years - NCT06809686Recruiting
ECG and patient experience study for heart failure
This study collects detailed ECG data and feedback from people with heart failure to better understand the condition and improve care. It involves noninvasive monitoring and a discussion of your symptoms and daily life.
London, LondonAges 45–80 - NCT07325942Recruiting
Low vs high volume high-intensity interval training for heart failure
This study compares two different types of high-intensity interval exercise programs (one shorter, one longer) in people with chronic heart failure. It aims to see which program improves heart health and daily function more.
Cairo, Giza GovernorateAges 18 years+ - NCT07490054RecruitingPhase 1
Fecal transplant for chronic heart failure
This trial tests whether transferring healthy gut bacteria (fecal microbiota transplant) can help people with chronic heart failure feel better and improve their heart function.
New York, New YorkAges 18 years+ - NCT07552142Recruiting
Heart Failure Check-In: Using Questionnaires to Spot Early Warning Signs
This study asks heart failure patients who recently were hospitalized to answer regular questionnaires about how they're feeling. Researchers want to see if these questions can detect when heart failure is getting worse before a patient needs emergency care.
Moscow, Non-US/Non-CanadianAges 18 years+ - NCT06560047Recruiting
Early catheter ablation for atrial fibrillation with heart failure
This trial tests whether early catheter ablation (a procedure to fix irregular heartbeats) helps people who have both heart failure and atrial fibrillation. It looks at how this treatment affects your heart function and quality of life.
AalborgAges 18–80 - NCT06573242Recruiting
Home heart rehab for heart failure and caregivers
This trial tests a home-based heart rehab program for people with heart failure and their caregivers. It aims to help you manage your condition with support at home, instead of traveling to a center.
Herlev, copenhagenAges 18 years+ - NCT06586008Recruiting
Heart failure ultrasound and recovery study
This trial uses a special ultrasound scoring system to see how well people with a certain type of heart failure (weak heart pumping) are doing. It looks at whether this score can predict how their recovery goes.
Semarang, Central of JavaAges 18–70 - NCT07047547Recruiting
Vericiguat study for kidney disease and heart failure patients
This trial tests how a medication called vericiguat works in people with both chronic kidney disease and heart failure. It aims to see if the drug helps manage these conditions together.
Guangzhou, GuangdongAges 18–80 - NCT07296081Recruiting
PET scan study for heart scarring in heart failure
This study uses a special PET scan to look for scarring (fibrosis) in the heart muscle of people with heart failure. It may help doctors better understand why some hearts get stiff or weak.
Coimbra, Coimbra DistrictAges 18 years+ - NCT06927440Enrolling by invitation
Registry for children with severe heart failure in China
This study is creating a registry to learn more about children with advanced heart failure. It will help doctors understand who can benefit from treatments like medicine, devices, or transplants.
Shanghai, Shanghai MunicipalityAges Up to 18 years - NCT05441696Enrolling by invitation
Check a noninvasive heart failure blood-flow measurement in hospital
This study tests a device that measures blood flow and pressure in a noninvasive way (using sensors on the body) for people admitted with worsening heart failure. It may help doctors monitor heart failure and potentially lower the chance of coming back to the hospital.
Palo Alto, CaliforniaAges 18 years+ - NCT05562167RecruitingPhase 2
Inorganic nitrate plus exercise for heart failure performance
This Phase 2 study tests whether taking inorganic nitrate can improve exercise ability and heart-function symptoms in people with heart failure with reduced pumping. It also checks whether the treatment is safe when combined with an exercise program.
St Louis, MissouriAges 19–79 - NCT07527715Recruiting
Heart MRI Study for Dilated Heart Muscle Disease
This research uses cardiac MRI scans and patient data to better predict outcomes in people with dilated cardiomyopathy—a condition where the heart's main pumping chamber becomes enlarged and weakened. Participating could help doctors improve how they care for similar patients in the future.
Jinan, ShandongAges 18 years+ - NCT06580392Recruiting
CCM device plus medications for heart failure with low pump strength
This study tests a heart device (CCM) plus standard medications to see if the combination helps people with a weak heart pump. It's for those whose heart function is low and who still have symptoms despite current treatment.
Rome, ItalyAges 18 years+ - NCT07321509RecruitingPhase 4
Digoxin after a recent heart failure hospitalization
This trial tests whether digoxin, a heart medication, can help people who were recently hospitalized for heart failure with a weak heart pump. It aims to see if it improves symptoms and daily activity.
Buenos Aires, Buenos Aires F.D.Ages 18–120 - NCT07650474Recruiting
Mobile app for heart failure management and quality of life
This study tests whether using a mobile phone app to monitor and manage chronic heart failure improves how you feel and function day-to-day. Researchers will check in with you regularly through your phone to track your symptoms and health.
Addis AbabaAges 18–65 - NCT07054489Recruiting
Genetic guided beta blocker therapy for heart failure
This trial tests whether a genetic test can help doctors choose the best beta blocker for people with heart failure who have mildly reduced pumping function. It aims to improve treatment by matching the drug to your genetic profile.
Detroit, MichiganAges 18–89 - NCT07492498Recruiting
Atrial fibrillation care program to prevent heart failure in rural China
This trial tests a new way of caring for older adults with atrial fibrillation (irregular heartbeat) in rural villages to help prevent heart failure. Trained village doctors will use telemedicine (remote healthcare) to manage your condition.
Yancheng, DongtaiAges 65–80 - NCT05641662Recruiting
Video games that get you moving for heart failure inactivity
This study tests whether playing “exergames” (motion-based video games) can help people with heart failure who are mostly inactive spend less time sitting. It checks whether the games are safe and practical and whether they can improve activity over time.
PortoAges 18 years+
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Common questions
- Are there clinical trials for heart failure with reduced ejection fraction?
- Yes. Clin2 currently lists 182 recruiting heart failure with reduced ejection fraction studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a heart failure with reduced ejection fraction trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a heart failure with reduced ejection fraction trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Heart Failure With Mildly Reduced Ejection Fraction
- Chronic Heart Failure With Reduced Ejection Fraction
- Heart Failure With Preserved Ejection Fraction
- Heart Failure With Mid Range Ejection Fraction
- Heart Failure With Normal Ejection Fraction
- Acute Heart Failure
- Chronic Heart Failure
- Congestive Heart Failure
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.