Clinical trials · California
Heart failure clinical trials in California
We’re tracking 83 recruiting heart failure studies with a site in California — including Phase 1, Phase 1/Phase 2, Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT07298993Enrolling by invitationPhase 4
Can older adults with heart failure safely stop beta-blockers?
This trial tests whether it is safe to gradually stop beta-blocker medication in older adults with heart failure with preserved ejection fraction (a type of heart failure where the heart pumps normally but is stiff). It aims to improve quality of life by reducing unnecessary medications.
Pleasanton, CaliforniaAges 60 years+ - NCT06999369Enrolling by invitation
Heart failure nutrition app study
This study tests a digital nutrition tool to help people with heart failure improve their health. It is for patients recently hospitalized or seeing their doctor regularly.
Walnut Creek, CaliforniaAges 18–89 - NCT06361524Enrolling by invitation
Gut bacteria study in chronic heart failure
This study looks at the bacteria in your gut (your 'gut microbiome') and how it relates to chronic heart failure. It may help doctors understand why some people with heart failure do better than others and could lead to better treatments in the future.
Stanford, CaliforniaAges 18–75 - NCT06065761Enrolling by invitation
Better risk assessment for heart failure in the ER
This trial looks at ways to better understand how serious heart failure is for people who come to the emergency room. It could help doctors decide on the best treatment more quickly.
Fresno, CaliforniaAges 18 years+ - NCT05610787Enrolling by invitation
Testing a device that helps move an EXCOR pediatric heart pump
This trial studies an “active driving” system that controls the EXCOR pediatric heart pump. It’s meant for children who need a heart pump as a bridge to heart transplantation, to help the pump work more safely and effectively.
Los Angeles, CaliforniaAges Up to 21 years - NCT07335510Recruiting
Baroreflex therapy for heart failure patients
This trial tests a device that stimulates a nerve in your neck to help your heart pump better. It is for people with heart failure and a weak heart pump who still have symptoms despite taking medications.
San Francisco, CaliforniaAges 18 years+ - NCT06425848Recruiting
Heart failure monitoring study
This study looks at how a small monitor inside the blood vessel to the lungs helps manage heart failure. It aims to improve care for people with advanced heart failure.
La Jolla, CaliforniaAges 18–100 - NCT06541509RecruitingPhase 1/Phase 2
Semaglutide for heart failure in overweight patients
This trial studies whether the drug semaglutide can help people with heart failure who are overweight. It aims to see if the drug improves heart function and symptoms.
Palo Alto, CaliforniaAges 20–80 - NCT06929806RecruitingPhase 3
Iron infusion for iron deficiency with heart failure
This study tests whether giving iron through a vein can help people with heart failure and low iron levels feel better. It compares iron treatment to no iron treatment.
Pasadena, CaliforniaAges 18 years+ - NCT05441696Enrolling by invitation
Check a noninvasive heart failure blood-flow measurement in hospital
This study tests a device that measures blood flow and pressure in a noninvasive way (using sensors on the body) for people admitted with worsening heart failure. It may help doctors monitor heart failure and potentially lower the chance of coming back to the hospital.
Palo Alto, CaliforniaAges 18 years+ - NCT04141605Enrolling by invitation
Heart transplant candidates matched for better heart preservation
This study creates a worldwide registry and information database to help improve how donor hearts are preserved for transplant. If you are a heart transplant candidate, your details may be recorded to see what matching and preservation approaches work best.
Stanford, CaliforniaAges Any age - NCT07775976Enrolling by invitation
Whole-heart checkup with a wearable heart monitor
This study looks at how well a wearable heart monitor and special software can check the health of your whole heart and assess your risk of future heart problems. It may help doctors create more personalized care plans.
Pasadena, CaliforniaAges 18 years+ - NCT07567001RecruitingPhase 3
Testing NNC0487-0111 for Heart Failure and Obesity
This study tests whether a new medication called NNC0487-0111 can help people with heart failure who also have obesity. Researchers will compare it to a placebo (inactive pill) to see if it improves heart function and overall health.
Alhambra, CaliforniaAges 18 years+ - NCT06024746RecruitingPhase 3
Finerenone plus SGLT2i for hospitalized heart failure
This trial tests whether adding two heart medicines together (finerenone and an SGLT2 inhibitor) helps people who are in the hospital for heart failure recover better. It may be an option for you if you are currently hospitalized and your heart stress markers are high.
El Centro, CaliforniaAges 18 years+ - NCT04196842Recruiting
Heart failure precision medicine study using heart tests and blood tests
This study looks at how “personalized” (precision) treatment planning for heart failure may work, using results from heart imaging (echocardiogram) or a blood test called B-type natriuretic peptide. You may join if you have heart failure and can follow frequent study check-ins.
Sacramento, CaliforniaAges 21 years+ - NCT06991257RecruitingPhase 2
Study of PF-07328948 for adults with heart failure
This trial tests a new medicine, PF-07328948, for adults with heart failure to see if it can improve symptoms and daily life. It is for people who have had heart failure for at least 3 months and can walk without too much difficulty.
Santa Maria, CaliforniaAges 18–79 - NCT06935370RecruitingPhase 3
Testing vicadrostat with empagliflozin for heart failure with weak pump
This trial tests a new drug called vicadrostat combined with another drug, empagliflozin, for people with heart failure and a weak heart pump. It aims to see if this combination helps improve symptoms and outcomes.
Beverly Hills, CaliforniaAges 18 years+ - NCT06307652RecruitingPhase 3
Testing a new heart failure and kidney treatment combo
This study tests a new combination of two medicines (balcinrenone and dapagliflozin) for people with heart failure and reduced kidney function. The goal is to see if this combination helps improve heart and kidney health better than current treatments.
Covina, CaliforniaAges 18–130 - NCT07217366Enrolling by invitation
Speech-to-text tool for heart failure patients
This study tests a speech-to-text tool to help people with heart failure report their symptoms and health information more easily. It aims to see if using voice instead of typing can improve data collection.
Palo Alto, CaliforniaAges 18 years+ - NCT06979362RecruitingPhase 2
Study of CDR132L for heart failure with preserved pumping function
This trial tests if CDR132L can improve heart structure and function in people with a type of heart failure where the heart pumps normally but is stiff and thickened. It may help if you have heart failure with preserved ejection fraction and a thickened heart muscle.
Covina, CaliforniaAges 40–84 - NCT05996328Recruiting
Meal delivery study for older veterans with heart failure
This study tests if providing ready-to-eat meals to older veterans recently hospitalized with heart failure can help them recover and avoid going back to the hospital. It aims to make it easier to follow a heart-healthy diet at home.
Long Beach, CaliforniaAges 60 years+ - NCT05265520Recruiting
Pacing strategy study for certain heart failure patients
This trial tests a pacing approach designed to improve how the heart beats in some people with heart failure and a specific heart rhythm pattern on ECG. If you already need a device (CRT-D) based on your results, the study may help see whether this pacing correction improves outcomes.
Los Angeles, CaliforniaAges 18 years+ - NCT06428097RecruitingPhase 1
Thyroid hormone before heart transplant
This study tests whether giving a thyroid hormone supplement called levothyroxine before a heart transplant can help with recovery. It is for people already listed for a heart transplant who do not have thyroid problems.
San Francisco, CaliforniaAges 18 years+ - NCT06183437RecruitingPhase 4
Can I stop heart meds after cancer therapy?
This trial tests whether it is safe to stop taking heart failure medications in people who developed heart weakness after cancer treatment but whose heart function has since recovered. It aims to see if stopping these drugs leads to any worsening of heart health.
Los Angeles, CaliforniaAges 18 years+
Heart failure trials by city in California
Where these studies are running in California
Institutions with a site for the recruiting heart failure studies listed above.
- Stanford University · 3 studies
- University of California, San Francisco · 3 studies
- Valley Clinical Trials · 3 studies
- Amicis Research Center · 2 studies
- Care Access · 2 studies
- FOMAT Medical Research · 2 studies
- Kaiser Permanente-San Francisco · 2 studies
- Scripps Health · 2 studies
What taking part in a heart failure study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Heart failure trials in other states
Common questions
- Are there heart failure clinical trials in California?
- Yes. We're currently tracking 83 recruiting heart failure studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a heart failure study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a heart failure trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New heart failure studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.