Clinical trials
High Grade Glioma (III or IV) clinical trials
Below are recruiting high grade glioma (iii or iv) clinical trials, each written for real people, not researchers. We’re tracking 1,283 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07391215RecruitingPhase 1/Phase 2
Paxalisib for newly diagnosed glioblastoma after standard treatment
This trial tests a drug called paxalisib in people with a newly diagnosed aggressive brain tumor (glioblastoma) who have just finished standard radiation and chemotherapy. The goal is to see if adding paxalisib can help prevent the tumor from coming back by targeting a specific pathway in the cancer cells.
SuttonAges 16 years+ - NCT07391670RecruitingPhase 1
Testing subcutaneous durvalumab for lung and liver cancer
This trial tests a new way to give the immunotherapy drug durvalumab as a shot under the skin (subcutaneous) instead of through an IV. It is for people with certain types of lung cancer or liver cancer that has not spread widely and who have not had immunotherapy before. The goal is to see if the subcutaneous injection is safe and works similarly to the IV form.
FitzroyAges 18 years+ - NCT07394062Recruiting
Comparing chemo-immunotherapy combinations for advanced lung cancer
This study compares two standard treatments for metastatic non-small cell lung cancer when the tumor has low levels of a protein called PD-L1. It looks at how well chemotherapy plus pembrolizumab works versus chemotherapy plus nivolumab and ipilimumab.
AnkaraAges 18 years+ - NCT07394387RecruitingPhase 2
HIFU with or without immunotherapy before chemo for triple-negative breast cancer
This trial tests whether adding focused ultrasound (HIFU) and an immunotherapy drug (PD-1 inhibitor) before standard chemotherapy can improve outcomes for women with stage II or III triple-negative breast cancer (TNBC). It aims to find a more effective way to shrink tumors before surgery.
Nanjing, JiangsuAges 18–70 - NCT01937949Recruiting
Fenestrated stent treatment for complex abdominal aortic aneurysms
This trial studies a custom-made stent graft placed from inside the blood vessel to treat complex aneurysms in the aorta. It may help prevent rupture and manage aneurysm risk, but it requires specific aneurysm anatomy and follow-up.
Rochester, MinnesotaAges 18 years+ - NCT01898039RecruitingPhase 1/Phase 2
Vaccine study for certain melanoma patients with specific blood markers
This trial tests a modified vaccine to help the immune system recognize melanoma. It is mainly for people with melanoma at higher risk or certain stages, and who have specific inherited tissue markers on blood testing.
JerusalemAges Any age - NCT01793168Recruiting
Rare disease registry and history study
This study keeps a registry (a structured list) of people with rare diseases and may also track how the condition changes over time. It can help researchers better understand rare illnesses and find gaps in care, which may improve future treatments.
Sioux Falls, South DakotaAges Any age - NCT01935778RecruitingPhase 3
Extra chemo after stomach cancer surgery: compare two drug plans
This Phase 3 trial tests which combination of chemotherapy works better after surgery for stage IIIB/IV stomach or stomach–esophagus junction adenocarcinoma. Participants get randomized to one of two chemotherapy plans to see which helps people live longer and/or prevents cancer from coming back.
SeoulAges 20–75 - NCT02115295RecruitingPhase 2
Venetoclax plus chemotherapy for AML, high-risk MDS, or blast CML
This trial tests a combination treatment (venetoclax plus several chemotherapy medicines) for people with AML, high-risk MDS, or CML that has progressed into a blast phase. It may help by killing leukemia-like blood cells and improving disease control.
Houston, TexasAges 18–65 - NCT02323399RecruitingPhase 4
IV medicine study for blood pressure effects during anesthesia
This trial studies how phenylephrine given through an IV affects blood pressure during procedures under general or spinal/epidural anesthesia. It may help doctors understand how to control blood pressure more safely during surgery.
Wilmington, DelawareAges 12–16 - NCT02622581Recruiting
Lung cancer testing and treatment outcomes research study platform
This study collects information from adults with different types and stages of lung cancer to connect molecular test results with treatment choices and outcomes. It may help improve how lung cancer is diagnosed and managed by building a better understanding of what works for different patients.
OldenburgAges 18 years+ - NCT03275194RecruitingPhase 2
HIPEC during interval surgery for advanced ovarian cancer
This trial looks at whether a heated chemotherapy treatment given in the abdomen during a planned second surgery (HIPEC) can improve outcomes for certain advanced ovarian cancers. It is for people who have already had initial chemotherapy and partially responded, with enough health to safely undergo surgery.
Mexico CityAges 18–70 - NCT07675499RecruitingPhase 2/Phase 3
Exercise and Nasal Insulin for Type 2 Diabetes
This study tests if adding nose spray insulin and exercise together improves blood sugar control and brain function in older adults with type 2 diabetes.
New Brunswick, New JerseyAges 55–80 - NCT06162221RecruitingPhase 1/Phase 2
Study of RAS inhibitors for advanced RAS-mutated lung cancer
This trial tests new drugs that target specific RAS mutations in advanced non-small cell lung cancer. It's for people whose cancer has a KRAS G12C, G12D, or other RAS mutation and who have already tried standard treatments.
Gilbert, ArizonaAges 18 years+ - NCT07527689Recruiting
Faster vs. Standard Radiation After Breast Cancer Surgery
This study compares two radiation schedules for breast cancer patients at high risk of cancer returning in lymph nodes. Both use modern radiation therapy, but one delivers treatment faster (ultra-hypofractionated) while the other uses a more moderate schedule. The goal is to see which approach works better with fewer side effects.
ShanghaiAges 18 years+ - NCT02266719Enrolling by invitation
Fenestrated branched stents for complex aortic aneurysms and safety
This trial studies a specialized endovascular (through-the-vessel) repair using fenestrated and branched stents to treat complex aortic aneurysms and related dissections. It aims to track clinical outcomes and how much radiation exposure is used during the procedure to improve safety.
Atlanta, GeorgiaAges 18 years+ - NCT07400549Recruiting
Exercise plan study for people with high blood pressure, blood sugar, cholesterol, or uric acid
This study tests a tool that helps doctors create personalized exercise plans for people with conditions like high blood pressure, diabetes, high cholesterol, or high uric acid (the "Four Highs"). It could help you stay active and manage your health better.
BeijingAges 18 years+ - NCT07413757Recruiting
Study on factors in choosing lung cancer treatment
This study looks at what doctors and patients consider when deciding on a first-line treatment for advanced lung cancer. It aims to understand how choices are made for people taking a type of targeted therapy.
ChengduAges 18 years+ - NCT07418125Recruiting
Study of tumor cell clusters in high-risk early breast cancer
This trial looks at whether clusters of tumor cells in the blood can give more information about high-risk early breast cancer. It is for people with certain types of breast cancer who are about to start treatment before surgery (neoadjuvant therapy).
LjubljanaAges 18 years+ - NCT07423650RecruitingPhase 4
Continuous Nefopam infusion after pancreas surgery
This trial tests if giving a steady dose of a painkiller called nefopam through an IV can help manage pain after a Whipple procedure (pancreatoduodenectomy). It aims to see if this approach reduces the need for other pain medications and improves recovery.
Cluj-Napoca, ClujAges 18–80 - NCT07428993RecruitingPhase 2
CAR T-Cell Therapy for High-Risk Osteosarcoma
This trial tests a new type of cell therapy called B7-H3 CAR T cells for children and young adults with high-risk osteosarcoma that hasn't spread or worsened after standard chemotherapy. The treatment uses your own immune cells that are modified to attack a protein (B7-H3) found on cancer cells.
Memphis, TennesseeAges Up to 21 years - NCT07429240RecruitingPhase 1/Phase 2
Gene editing trial for Duchenne muscular dystrophy (ages 2-7)
This trial tests a new gene editing treatment called PBGENE-DMD for boys with Duchenne muscular dystrophy (DMD) whose genetic mutation falls within a specific range of the dystrophin gene (exons 45-55). The goal is to see if it is safe and can help improve muscle function.
Little Rock, ArkansasAges 2–7 - NCT07438002Recruiting
Exercise for kidney disease patients on dialysis or in treatment
This trial studies whether high-intensity physical exercise helps people with chronic kidney disease, including those on dialysis. It aims to improve health and physical function.
Peschiera del Garda, VeronaAges 18 years+ - NCT07443254RecruitingPhase 1/Phase 2
IR-led deep sedation study for image-guided procedures
This study tests if a radiologist can safely give deep sedation medicine (ketamine) for certain procedures instead of general anesthesia. It might help you avoid general anesthesia while still being comfortable.
Charleston, West VirginiaAges 18 years+
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Common questions
- Are there clinical trials for high grade glioma (iii or iv)?
- Yes. Clin2 currently lists 1,283 recruiting high grade glioma (iii or iv) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a high grade glioma (iii or iv) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a high grade glioma (iii or iv) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.