Clinical trials · Massachusetts
High blood pressure clinical trials in Massachusetts
We’re tracking 45 recruiting high blood pressure studies with a site in Massachusetts — including Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in Massachusetts
- NCT04555161Recruiting
Test of an implanted device for pulmonary arterial hypertension
This trial studies an implanted system (the Aria CV Pulmonary Hypertension System) to treat pulmonary arterial hypertension, a serious lung-blood vessel and heart condition. It aims to see whether the device can improve outcomes for people who are still sick despite existing PH medicines.
Boston, MassachusettsAges 18 years+ - NCT03683186Enrolling by invitationPhase 3
Long-term study of ralinepag for pulmonary hypertension
This study follows people with pulmonary arterial hypertension (PAH) to see how safe and effective ralinepag is over the long term. It may help your care team understand what to expect from continued treatment and monitoring.
Boston, MassachusettsAges 18 years+ - NCT06948838Recruiting
Improving blood pressure control in safety-net clinics
This study tests if a program to help primary care teams better manage high blood pressure can lower patients' blood pressure. It aims to find ways to improve care for people who get their care at community health centers or similar safety-net clinics.
Boston, MassachusettsAges 18 years+ - NCT06059638Recruiting
Pacemaker pacing for blood pressure control
This study tests whether adjusting the timing of a pacemaker can help lower blood pressure in people who already have or need a pacemaker. It could be an option for those whose blood pressure is not well controlled with medication.
Boston, MassachusettsAges 18 years+ - NCT06835959Recruiting
Moms at Home: A story-based app to manage blood pressure in pregnancy
This study tests if using a storytelling app on your smartphone can help you better manage your blood pressure during pregnancy. You would share your blood pressure readings at home and use the app as part of your care.
Worcester, MassachusettsAges 18–50 - NCT07218029RecruitingPhase 3
Long-term study of sotatercept for PAH
This study is for people who have already taken part in a clinical trial of sotatercept for pulmonary arterial hypertension and done well enough to continue. It tests the long-term safety and effectiveness of staying on sotatercept, an investigational treatment that helps lower blood pressure in the lungs.
Boston, MassachusettsAges 18 years+ - NCT04278404Recruiting
Drug safety study for children already on certain medicines
This study measures how certain medicines move through the body and checks their safety in children. It may help doctors better understand dosing and side effects in kids who are already receiving these treatments, or in some kids who recently tested positive for COVID-19.
Boston, MassachusettsAges birth–20 years - NCT06891911Recruiting
Free healthy groceries to help lower blood pressure
This study gives people with high blood pressure free healthy groceries for 4 weeks to see if eating better can lower their blood pressure. It might help you get your blood pressure into a healthier range.
Boston, MassachusettsAges 18 years+ - NCT07318597RecruitingPhase 2
A study of an experimental drug for pulmonary arterial hypertension
This trial tests a new medication called REGN13335 for people with pulmonary arterial hypertension (PAH). It aims to see if the drug can improve symptoms and function compared to standard care alone.
Boston, MassachusettsAges 18 years+ - NCT05884190Recruiting
Help for early high blood pressure after childbirth
This study tests a “trauma-informed” approach to detect and manage high blood pressure soon after delivery. It may help you get faster support and safer treatment during the early postpartum period.
Worcester, MassachusettsAges 18 years+ - NCT06911632Recruiting
AI-assisted check for pulmonary hypertension in interstitial lung disease
This study uses an AI tool to help doctors decide if you should be tested for pulmonary hypertension (high blood pressure in the lungs), which can be a complication of interstitial lung disease. If the tool suggests you might have it, you may get an echocardiogram (an ultrasound of the heart) and a right heart catheterization (a test to measure pressure in the heart) to find out for sure.
Boston, MassachusettsAges 18 years+ - NCT05798923RecruitingPhase 2
LAM-001 for lung scarring with high blood pressure
This trial tests a new medication called LAM-001 for people with high blood pressure in the lungs caused by lung scarring. It aims to see if it can improve symptoms and help you feel better.
Boston, MassachusettsAges 18–80 - NCT05593055RecruitingPhase 4
Test a heart and blood-pressure therapy in people with hypertension
This study looks at how mineralocorticoid-related hormone signaling affects small heart blood vessels and how efficiently the heart works in people with high blood pressure. It may help doctors understand which treatments could improve heart function in hypertension.
Boston, MassachusettsAges 18–75 - NCT06554340Recruiting
Exercise study for multiple sclerosis with high blood pressure
This study tests if exercise can improve blood vessel health and daily function in people with multiple sclerosis (MS) who also have high blood pressure. It may help you move better and feel better.
Boston, MassachusettsAges 18 years+ - NCT06610448Recruiting
Wearable blood pressure monitoring study for Boston adults
This study tests a wearable device that tracks your blood pressure throughout the day while you go about your normal routine. If you live in the Boston area and are willing to wear the device, you may help improve how blood pressure is measured outside the doctor's office.
Boston, MassachusettsAges 18–100 - NCT07041281RecruitingPhase 2
Spironolactone to improve postpartum blood pressure after pregnancy hypertension
This study tests whether the medication spironolactone can help manage high blood pressure after delivery in people who had gestational hypertension or preeclampsia. It may help prevent long-term heart problems.
Boston, MassachusettsAges 18 years+ - NCT07312227Recruiting
Pregnancy at high altitude study
This study follows pregnant women living at high altitude in Bolivia to understand how pregnancy differs from those at sea level. It may help improve care for mothers and babies in high-altitude regions.
Boston, MassachusettsAges 18–45 - NCT07365332RecruitingPhase 3
IKT-001 for pulmonary arterial hypertension
This study tests a new medicine called IKT-001 for people with pulmonary arterial hypertension (PAH). It aims to see if IKT-001 helps improve exercise ability and other symptoms when added to current PAH therapies.
Boston, MassachusettsAges 18–75 - NCT02249923Recruiting
Children with pulmonary hypertension registry in Spanish or English
This registry study collects information from children and families affected by pulmonary hypertension to better understand the condition. It may help researchers track outcomes over time and improve future care.
Boston, MassachusettsAges 1 day–21 years - NCT07142356RecruitingPhase 2
Modified release RTN-001 for uncontrolled high blood pressure
This trial tests a new modified-release drug, RTN-001, to see if it can help people whose blood pressure remains high despite taking at least two standard blood pressure medicines. You will take either RTN-001 or a placebo, and researchers will monitor your blood pressure closely.
Boston, MassachusettsAges 18–70 - NCT06052072Enrolling by invitation
Heart failure trial testing nerve treatment for lung pressure
This trial tests a new treatment that uses a device to calm overactive nerves in the lung's blood vessels. It is for heart failure patients who also have high blood pressure in their lungs, to see if it can help them breathe easier and feel better.
Boston, MassachusettsAges 22–85 - NCT07064473RecruitingPhase 3
Testing vicadrostat plus empagliflozin for diabetes, high blood pressure, and heart disease
This study tests a new pill called vicadrostat taken with another medicine (empagliflozin) to see if it helps people with type 2 diabetes, high blood pressure, and heart disease. It may reduce the risk of heart problems, but you must not have had heart failure or use certain other heart medications.
Malden, MassachusettsAges 18 years+ - NCT07288398RecruitingPhase 3
Levosimendan for exercise limitation in PH-HFpEF
This trial tests if the drug levosimendan can help people with a specific type of pulmonary hypertension (PH-HFpEF) feel less tired and breathless during daily activities, and improve their exercise ability.
Boston, MassachusettsAges 18–85 - NCT06297291Recruiting
Long-term safety study for a kidney nerve treatment
This study tests a device that uses ultrasound to calm overactive kidney nerves, which may help lower blood pressure. It is for people with high blood pressure that is hard to control with medication.
Boston, MassachusettsAges 18 years+
High blood pressure trials by city in Massachusetts
Where these studies are running in Massachusetts
Institutions with a site for the recruiting high blood pressure studies listed above.
- Brigham and Women's Hospital · 8 studies
- Massachusetts General Hospital · 6 studies
- Tufts Medical Center · 4 studies
- Beth Israel Deaconess Medical Center · 3 studies
- Boston Children's Hospital · 2 studies
- ActivMed Practices and Research
- Boston Healthcare for the Homeless (BHCHP)
- Boston Medical Center
What taking part in a high blood pressure study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
High blood pressure trials in other states
Common questions
- Are there high blood pressure clinical trials in Massachusetts?
- Yes. We're currently tracking 45 recruiting high blood pressure studies with a site in Massachusetts, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a high blood pressure study in Massachusetts?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Massachusetts to take part?
- Not necessarily. These studies have a site in Massachusetts, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a high blood pressure trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New high blood pressure studies open in Massachusetts regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.