Clinical trials · Pennsylvania
High blood pressure clinical trials in Pennsylvania
We’re tracking 50 recruiting high blood pressure studies with a site in Pennsylvania — including Early Phase 1, Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in Pennsylvania
- NCT04071327Recruiting
Pulmonary hypertension registry for patient experiences
This trial is a registry that collects health information from people with pulmonary hypertension to better understand the disease and improve care. You may be asked to share details about your diagnosis and visits, especially soon after you start seeing a specialized PH care center.
Pittsburgh, PennsylvaniaAges birth+ - NCT06281665RecruitingPhase 4
Aspirin after preeclampsia: the TAP trial
This trial tests whether taking low-dose aspirin after giving birth can help people who had preeclampsia. It aims to see if aspirin can lower the risk of future heart problems.
Pittsburgh, PennsylvaniaAges 18–55 - NCT03683186Enrolling by invitationPhase 3
Long-term study of ralinepag for pulmonary hypertension
This study follows people with pulmonary arterial hypertension (PAH) to see how safe and effective ralinepag is over the long term. It may help your care team understand what to expect from continued treatment and monitoring.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07175038RecruitingPhase 2
Study of a new pill for pulmonary hypertension
This study tests a new pill, ROC-101, for people with pulmonary hypertension (high blood pressure in the lungs). It aims to see if the pill can improve symptoms and daily function.
Philadelphia, PennsylvaniaAges 18–80 - NCT07214376Recruiting
Nerve ablation for pulmonary hypertension from left heart disease
This trial tests a device that uses a catheter to deliver energy to nerves around the pulmonary arteries, aiming to reduce high blood pressure in the lungs caused by left heart failure. It is for people with ongoing heart failure symptoms despite optimal medications.
Mechanicsburg, PennsylvaniaAges 18–85 - NCT07599579Recruiting
Mobile app to manage high blood pressure after pregnancy complications
This study tests a smartphone app to help women who had high blood pressure during pregnancy manage their blood pressure now, 10–20 years later. The goal is to see if the app helps keep blood pressure under control and reduces heart disease risk.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06388421Recruiting
PH-ILD patient registry: tracking real-world outcomes
This study tracks people with both lung scarring and high blood pressure in the lungs (Group 3 PH-ILD) to better understand the disease and how treatments like Tyvaso work in real life. It may help you and your doctor make more informed decisions about your care.
Bethlehem, PennsylvaniaAges 18 years+ - NCT06468202RecruitingPhase 4
Aspirin dose study to prevent high blood pressure in pregnancy
This trial compares two doses of aspirin to see which is better at preventing conditions like preeclampsia (a serious form of high blood pressure during pregnancy). You may qualify if you are in early pregnancy and have certain risk factors.
Pittsburgh, PennsylvaniaAges 14–35 - NCT06059638Recruiting
Pacemaker pacing for blood pressure control
This study tests whether adjusting the timing of a pacemaker can help lower blood pressure in people who already have or need a pacemaker. It could be an option for those whose blood pressure is not well controlled with medication.
Doylestown, PennsylvaniaAges 18 years+ - NCT07218029RecruitingPhase 3
Long-term study of sotatercept for PAH
This study is for people who have already taken part in a clinical trial of sotatercept for pulmonary arterial hypertension and done well enough to continue. It tests the long-term safety and effectiveness of staying on sotatercept, an investigational treatment that helps lower blood pressure in the lungs.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT04278404Recruiting
Drug safety study for children already on certain medicines
This study measures how certain medicines move through the body and checks their safety in children. It may help doctors better understand dosing and side effects in kids who are already receiving these treatments, or in some kids who recently tested positive for COVID-19.
Hershey, PennsylvaniaAges birth–20 years - NCT07181109RecruitingPhase 3
Study of zilebesiran for high-risk hypertension patients
This trial tests a new medicine called zilebesiran for people with high blood pressure that isn't well controlled. It may be an option if you have heart or blood vessel disease, or are at high risk for it.
Camp Hill, PennsylvaniaAges 18 years+ - NCT07132788Recruiting
How PAH affects muscle mass
This study looks at how pulmonary arterial hypertension (PAH) impacts lean muscle mass. It may help researchers understand changes in your body and find new ways to support your health.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07179380RecruitingPhase 3
A study of an inhaled drug for lung disease with high blood pressure
This trial tests an inhaled medicine (TPIP) for people with both lung scarring (interstitial lung disease) and high blood pressure in the lungs (pulmonary hypertension). It aims to see if the drug helps improve exercise ability and symptoms.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06343298RecruitingPhase 2
Testing MANP for hard-to-control high blood pressure
This trial tests a new drug called MANP for people whose blood pressure stays high despite taking three or more different types of blood pressure medications. The goal is to see if MANP is safe and effective in lowering blood pressure.
Philadelphia, PennsylvaniaAges 18–80 - NCT06911632Recruiting
AI-assisted check for pulmonary hypertension in interstitial lung disease
This study uses an AI tool to help doctors decide if you should be tested for pulmonary hypertension (high blood pressure in the lungs), which can be a complication of interstitial lung disease. If the tool suggests you might have it, you may get an echocardiogram (an ultrasound of the heart) and a right heart catheterization (a test to measure pressure in the heart) to find out for sure.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06843577Recruiting
Handgrip therapy for high blood pressure
This trial tests if a simple handgrip exercise device can help lower blood pressure in people with elevated blood pressure or hypertension. You will use the device at home and have regular check-ups to see how well it works.
Pittsburgh, PennsylvaniaAges 22 years+ - NCT04720456RecruitingPhase 2
Ultrasound test study for high pressure in liver veins in kids
This Phase 2 trial looks at a special ultrasound approach to better understand and measure portal hypertension—high pressure in the liver’s vein system—in children with long-term (chronic) liver disease. The results may help doctors track this condition more accurately and safely.
Philadelphia, PennsylvaniaAges 6–21 - NCT05442671Recruiting
Exercise coaching program for children with pulmonary hypertension
This trial tests whether a structured exercise program, done with remote support, is safe and helpful for children with pulmonary hypertension. It aims to improve how well kids function day-to-day while they stay on their usual PH medications.
Philadelphia, PennsylvaniaAges 8–18 - NCT05470205RecruitingPhase 3
Noninvasive blood-pressure measurement to estimate liver portal pressure
This Phase 3 study tests a noninvasive ultrasound-based method to estimate portal hypertension, which is high blood pressure in the liver’s blood vessels. It aims to help doctors measure how severe the liver circulation problem is without needing invasive pressure testing.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05546931Recruiting
Mobile health program to help control high blood pressure
This study tests a phone-based (mobile) health program to help people in rural areas better control high blood pressure. It may help you track your readings and follow a plan that supports safer blood pressure over time.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT05587712RecruitingPhase 2
Sotatercept trial for children with pulmonary arterial hypertension
This Phase 2 trial tests sotatercept, a medicine that targets the blood-vessel changes in pulmonary arterial hypertension (PAH), in children. It may help improve how well the heart and lungs work by changing the underlying disease process.
Philadelphia, PennsylvaniaAges 1–17 - NCT06482853RecruitingEarly Phase 1
Heart effects of a natural protein in obesity and high blood pressure
This study tests whether a natural protein called angiotensin-(1-7) can improve heart health in people with obesity and high blood pressure. It may help researchers find new ways to treat these conditions together.
Hershey, PennsylvaniaAges 18–65 - NCT06559891Recruiting
Ultrasound treatment for high blood pressure
This trial tests an ultrasound device that targets nerves around the kidney to lower blood pressure. It may help people whose blood pressure is not well controlled with medication.
Lancaster, PennsylvaniaAges 22–75
High blood pressure trials by city in Pennsylvania
Where these studies are running in Pennsylvania
Institutions with a site for the recruiting high blood pressure studies listed above.
- University of Pennsylvania · 7 studies
- Thomas Jefferson University Hospital · 4 studies
- Children's Hospital of Philadelphia · 3 studies
- Temple University Hospital · 3 studies
- University of Pittsburgh Medical Center · 3 studies
- Allegheny General Hospital · 2 studies
- Magee-Womens Hospital of UPMC · 2 studies
- Penn Medicine Lancaster General Health · 2 studies
What taking part in a high blood pressure study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
High blood pressure trials in other states
Common questions
- Are there high blood pressure clinical trials in Pennsylvania?
- Yes. We're currently tracking 50 recruiting high blood pressure studies with a site in Pennsylvania, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a high blood pressure study in Pennsylvania?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Pennsylvania to take part?
- Not necessarily. These studies have a site in Pennsylvania, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a high blood pressure trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New high blood pressure studies open in Pennsylvania regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.