Clinical trials
Locally Advanced clinical trials
Below are recruiting locally advanced clinical trials, each written for real people, not researchers. We’re tracking 971 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07137416RecruitingPhase 1
Combination drug study for HER2-positive breast and other cancers
This study tests a new combination of two anti-cancer drugs (CX-5461 and T-DXd) for people with HER2-positive breast cancer or other solid tumors. It aims to see if the combination is safe and how well it works.
Boston, MassachusettsAges 18 years+ - NCT07448142RecruitingPhase 2
Low-dose radiation with immunotherapy and chemo for advanced rectal cancer
This trial tests a combination of low-dose radiation, an immunotherapy drug called pucotenlimab, and chemotherapy for locally advanced rectal cancer that has not spread. The goal is to see if adding radiation helps shrink the tumor more effectively before surgery.
Guangzhou, GuanggongAges 18–75 - NCT03671252RecruitingPhase 3
Chemotherapy before surgery for rectal cancer vs chemo with radiation
This Phase 3 trial compares two treatment plans given before rectal surgery. It tests whether stronger chemotherapy alone works better than chemotherapy pills plus long-term radiation to improve outcomes for locally advanced rectal cancer.
Guangzhou, GuangdongAges 18–75 - NCT03961373RecruitingPhase 3
Standard vs longer lymph node surgery after chemo for stomach cancer
This study compares two surgical approaches to remove lymph nodes after you’ve already had chemotherapy for stomach cancer. It aims to see whether removing lymph nodes in a more extended way improves outcomes without causing unacceptable side effects.
SienaAges 18–80 - NCT03825861RecruitingPhase 2
Before-surgery chemotherapy for locally advanced stomach cancer
This Phase 2 study tests chemotherapy given before surgery (called FOLFIRINOX) for people with locally advanced stomach cancer. The goal is to shrink the tumor and improve outcomes after the surgery plan is completed.
São PauloAges 18–75 - NCT04733820RecruitingPhase 3
Extra chemo after surgery for advanced cervical cancer
This Phase 3 trial tests whether adding chemotherapy after surgery helps people with locally advanced cervical cancer, especially when prior treatment didn’t fully match standard guidelines. It looks at whether this “adjuvant” chemotherapy improves outcomes after neoadjuvant chemotherapy and an extensive hysterectomy.
Wuhan, HubeiAges 18–70 - NCT05148767RecruitingPhase 4
UGT1A1-guided irinotecan for locally advanced rectal cancer
This trial studies whether adjusting irinotecan treatment based on a person’s UGT1A1 gene test can improve outcomes for locally advanced rectal cancer. It focuses on people who are about to start (or continue) chemoradiation and do not have cancer spread to distant organs.
Hangzhou, ZhejiangAges 18–75 - NCT04974346RecruitingPhase 3
Radiation to prevent spread in cervical cancer lymph nodes
This Phase 3 trial tests whether adding a preventive radiation treatment to lymph node areas near the abdomen helps stop cervical cancer from spreading. It aims to improve outcomes for people with certain cervical cancer stages and lymph node results on PET-CT.
Hangzhou, ZhejiangAges 18–75 - NCT05201430RecruitingPhase 3
FOLFOXIRI vs CapeOX before surgery for locally advanced rectal cancer
This trial compares two chemotherapy plans given before rectal cancer surgery to see which helps more people and works better for disease control. If you have locally advanced rectal cancer and have not had treatment yet, this study may be an option.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT03617133RecruitingPhase 2
MRI-guided radiation plus chemo for cervical cancer
This trial tests a more precise way to deliver radiation for locally advanced cervical cancer using MRI guidance during treatment, along with chemotherapy. It may help shrink tumors more effectively while aiming to reduce side effects by targeting the right areas.
ViennaAges 18–99 - NCT02102477Recruiting
Surgery or radiation for prostate cancer in the pelvis
This trial compares surgery versus radiation for men with locally advanced prostate cancer that has not spread to distant sites. It aims to see which treatment works better and is easier to manage for people like you.
AalborgAges 18–75 - NCT02354274Recruiting
New radiation approach for locally advanced lung cancer
This study tests a new way of giving radiation for people with locally advanced non-small cell lung cancer (NSCLC), along with a chemotherapy medicine (navelbine). It may help by improving how well the treatment controls the cancer in the chest while watching for side effects.
AalborgAges 18 years+ - NCT05378919RecruitingPhase 2
Testing new pre-surgery treatment for locally advanced rectal cancer
This Phase 2 trial compares a pre-surgery (neoadjuvant) treatment plan versus the standard plan for people with stage II–III rectal cancer. The goal is to see which approach works better and is safe before surgery.
KaunasAges 18 years+ - NCT04807673RecruitingPhase 3
Pembrolizumab before surgery versus chemoradiation for esophageal cancer
This Phase 3 study compares two treatment plans before surgery for locally advanced esophageal squamous cell carcinoma. It tests whether adding pembrolizumab (an immune therapy) to chemotherapy improves outcomes compared with standard chemoradiation.
Tianjin, Tianjin MunicipalityAges 18–75 - NCT04973306RecruitingPhase 2/Phase 3
Chemo-immunotherapy before surgery versus chemo-radiation
This trial compares adding immunotherapy to standard chemo-radiation before surgery for locally advanced, operable esophageal squamous cell cancer. It aims to improve how well the tumor responds and whether patients do better after surgery.
ShanghaiAges 18–75 - NCT04138212RecruitingPhase 3
Chemo alone vs chemo with radiation before esophagus surgery
This study compares chemotherapy alone versus chemotherapy plus radiation given before surgery for locally advanced esophagus squamous cell cancer. The goal is to see which treatment helps more people have a successful operation and better cancer control.
Zhengzhou, HenanAges 18–70 - NCT04926584Recruiting
Immunotherapy for advanced or limited-spread lung cancer
This trial tests whether starting immunotherapy can help people with newly diagnosed advanced or limited-spread non-small cell lung cancer that cannot be fully cured with standard local treatments. It may offer a new treatment approach when surgery or definitive chemoradiation isn’t a good option.
Esslingen am NeckarAges 18 years+ - NCT05339568Recruiting
Smartphone support program for people with advanced lung cancer
This trial tests a “whole process follow-up” care plan, using a smartphone, to support people with non-small cell lung cancer from diagnosis through treatment and follow-up. It may help you manage care steps more smoothly if you’re not a candidate for curative (radical) treatment or don’t want surgery.
Jinan, ShandongAges 18 years+ - NCT05563012RecruitingPhase 2
Short radiation plus chemo and PD-1 immunotherapy for stomach cancer
This Phase 2 trial tests whether giving a short course of radiation before surgery, along with chemotherapy and a PD-1 immunotherapy drug, can improve treatment outcomes for locally advanced stomach cancer. It may help shrink the tumor before surgery and strengthen the immune system’s attack on cancer.
Wuhan, HubeiAges 18–75 - NCT05628922RecruitingPhase 2
Blood EBV DNA–guided therapy for advanced nasopharyngeal cancer
This trial tests a treatment approach for people with locally advanced nasopharyngeal cancer using their blood EBV DNA level (a cancer-related virus marker). It may help doctors choose and adjust therapy based on how much of this marker is in your blood after standard treatment.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT03836196Recruiting
Improve treatment for advanced prostate cancer with careful planning
This study looks at how to best plan and deliver treatment for men with advanced local prostate cancer. It may help find the most effective approach while keeping side effects manageable.
Vancouver, British ColumbiaAges 18 years+ - NCT03466424Recruiting
Short radiation then chemotherapy for locally advanced rectal cancer
This trial tests a short course of radiation given before chemotherapy for people with locally advanced rectal cancer (cancer that has grown into nearby tissue and/or nearby lymph nodes but can still be removed). It may help shrink the tumor and make treatment more effective while assessing how well this approach works.
Fuzhou, FujianAges 18–70 - NCT05136326RecruitingPhase 2
Pre-surgery chemo-radiation for rectal cancer without MGMT
This trial studies whether adding two chemotherapy medicines (capecitabine and temozolomide) to standard pre-surgery chemo-radiation can work better for people with locally advanced rectal cancer that has a specific tumor marker pattern (MGMT “silenced”) and is mismatch-repair proficient (MSS). It aims to shrink the tumor before surgery and improve cancer control.
MilanAges 18 years+ - NCT05772208RecruitingPhase 3
New treatment plan for nasopharyngeal cancer after EBV DNA stays detectable
This Phase 3 trial tests a stronger treatment approach for people with locally advanced nasopharyngeal cancer whose EBV “DNA” (a cancer-related virus signal in blood) does not go away after one cycle of chemotherapy. It may help improve outcomes by changing treatment based on how the cancer responds early.
Shanghai, Shanghai MunicipalityAges 18–70
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Common questions
- Are there clinical trials for locally advanced?
- Yes. Clin2 currently lists 971 recruiting locally advanced studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a locally advanced trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a locally advanced trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.