Clinical trials
Lumbar Degenerative Disease clinical trials
Below are recruiting lumbar degenerative disease clinical trials, each written for real people, not researchers. We’re tracking 56 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06650046Recruiting
Topping-off technique for lower back arthritis
This trial tests a 'topping-off' surgical technique for people with arthritis and disc problems in the lower back. If you have tried 3 months of non-surgical treatments without success, this surgery may be an option to relieve pain and improve function.
Jinan, ShandongAges 18–85 - NCT07396077Recruiting
Pre-op health boost for elderly spine surgery patients
This trial tests if a 6-week prehabilitation program (exercise and nutrition) before spine surgery helps elderly patients recover better. It is for people 75 or older with long-term lower back problems who need spinal fusion surgery.
Beijing, Beijing MunicipalityAges 75 years+ - NCT07587775Enrolling by invitationPhase 2
Osteoporosis Medication Effects on Spine Bone Quality
This study tests how a bone-strengthening medication called Abaloparatide affects the quality of bones in your lower spine. Researchers will use imaging scans to see if the medication helps improve bone strength in people with osteoporosis who also have spine wear-and-tear.
Buffalo, New YorkAges 50 years+ - NCT05981222Enrolling by invitation
Osteo Match vs. PEEK cages for spinal fusion in osteoporosis
This study compares two types of cages used in spinal fusion surgery for people with osteoporosis. It aims to see if one type leads to better bone healing and stability.
Beijing, Beijing MunicipalityAges 50 years+ - NCT07001969Enrolling by invitation
Percutaneous facet spine fixation for instability
This study tests a minimally invasive procedure to fix unstable vertebrae in the neck or lower back using a small incision. It may help people with spinal instability causing nerve symptoms or pressure on the spinal cord.
Cairo, ShoroukAges Any age - NCT06029764Recruiting
Extended fusion for spinal disc vacuum signs
This trial tests a surgery that fuses one extra spinal disc to treat a 'vacuum sign' (air pockets in the disc) that hasn't caused symptoms yet. It aims to prevent future problems in people with lumbar disc disease who need fusion surgery.
Beijing, Beijing MunicipalityAges 18–60 - NCT06709391Recruiting
Spinal fusion vs. no surgery for chronic low back pain
This trial tests whether a spinal fusion surgery is better than staying with non-surgical treatments for people with long-term, severe low back pain from worn-out discs in the lower spine. It aims to find out which approach offers better pain relief and quality of life.
GothenburgAges 25–65 - NCT07489001Recruiting
Comparing opioid-free to standard anesthesia for back surgery
This study compares two types of anesthesia for lower back surgery: one that uses opioids and one that does not. The goal is to see which approach controls pain better with fewer side effects.
Istanbul, MaltepeAges 18–75 - NCT06011551Recruiting
Gel injection for painful lumbar discs
This trial tests a gel (HYDRAFIL-D) injected into painful discs in your lower back to see if it relieves pain. It's for people whose back pain hasn't improved with other treatments.
Birmingham, AlabamaAges 22–85 - NCT04679844Recruiting
Test bone putty for back fusion versus bone graft alternatives
This study compares a ready-to-use bone putty to standard bone graft materials (with or without your own bone) during back fusion surgery for unstable lower back problems. It looks at whether the putty works as well or better to help the bones fuse and heal.
Irvine, CaliforniaAges 18 years+ - NCT06686017Enrolling by invitation
New bone graft for lower back fusion surgery
This trial studies a new bone graft material called Virtuos for use in lower back spinal fusion surgery. It may help patients needing a one or two-level lumbar fusion by providing a safe and effective option for bone healing.
South Bend, IndianaAges 18 years+ - NCT04641039Recruiting
Study of scar differences after lumbar disc replacement
This study compares how postoperative scars look and behave after certain lumbar disc replacement surgery. It may help doctors choose approaches that reduce excessive scar-related problems after surgery.
Valencia, ValenciaAges 18–50 - NCT07552519Recruiting
Patient Outcomes in Spinal Disease Treatment
This study tracks how patients feel and function after receiving treatment for spinal disease (which may include procedures like spinal cord stimulation). Researchers want to understand what matters most to patients during their recovery.
Hasselt, LimburgAges 18 years+ - NCT04982965RecruitingEarly Phase 1
Study brain changes behind cannabis pain relief
This early study looks at how the brain may respond to cannabis to reduce long-lasting lower back pain. You may be asked to follow strict rules about cannabis, opioids, and safety checks (including MRI) to help researchers understand the brain mechanisms.
La Jolla, CaliforniaAges 21–65 - NCT05997121Recruiting
Testing a new spinal implant for degenerative disc disease
This trial studies a new spinal implant system (Hexanium TLIF) for people with degenerative disc disease. It aims to see if the implant is safe and works well to help with back pain and stability.
BrugesAges 18 years+ - NCT05366140Recruiting
Implanet Jazz spine fusion for adults needing thoracolumbar stabilization
This trial looks at using the Implanet Jazz system during spine fusion surgery for adults who need stabilization in the middle-to-lower back. It may help patients by improving how well the fused spine heals and stays in place.
Lexington, KentuckyAges 18–100 - NCT06394089Recruiting
Spine surgery study for stenosis with mild slippage
This study tests a minimally invasive spine surgery (unilateral biportal endoscopy) to see if it works well for people with lumbar spinal stenosis who also have a mild vertebra slippage (spondylolisthesis). The goal is to improve leg symptoms like pain or numbness when walking.
Beijing, Beijing MunicipalityAges 50–80 - NCT05508360Recruiting
Testing an artificial spacer implant for one-level low back pain
This study tests whether inserting a small artificial implant into a single painful disc can reduce long-term low back pain and disability. It’s for people who tried non-surgical treatments for at least 6 months but still have significant symptoms from degenerative disc disease.
Medellín, AntioquiaAges 22 years+ - NCT06355791Recruiting
Study of the Minuteman device for spine fusion
This study looks at how well the Minuteman device works for people with chronic low back pain and leg symptoms caused by aging spine conditions. It tests if the device helps patients move better after surgery.
Newnan, GeorgiaAges 18 years+ - NCT04407338Recruiting
B-DYN device versus standard fusion for lumbar stenosis
This trial compares a specific spinal fusion approach (B-DYN) with the standard fusion surgery for people with lumbar spinal stenosis. It aims to improve function after surgery and check whether the newer approach is well tolerated.
BordeauxAges 40 years+ - NCT07217964Enrolling by invitation
Study of natural protein for spinal fusion surgery
This trial is testing a natural protein material used during spinal fusion surgery to treat lower back pain caused by worn-out discs. It may help patients who haven't gotten better with other treatments and need surgery on up to four levels of the lower spine.
New York, New YorkAges 18 years+ - NCT03553186RecruitingPhase 3
Tranexamic acid to reduce bleeding in spine surgery
This Phase 3 trial tests whether tranexamic acid can reduce bleeding during major spine fusion surgery for adults with scoliosis or spine degeneration. It may help lessen blood loss and the need for transfusions, while monitoring safety.
New York, New YorkAges 18–80 - NCT07059065Recruiting
New bone graft for spinal fusion surgery
This trial tests a new bone graft material called FIBERGRAFT Aeridyan for people needing spinal fusion to stabilize their lower back. It aims to see if it helps bones heal together safely and effectively.
Sacramento, CaliforniaAges 18 years+ - NCT05332249Recruiting
Registry for Degenerative Spine Disease in the Neck and Low Back
This study is a registry (a way to collect health information) for people with wear-and-tear (“degenerative”) problems in the neck and/or low back. It may help doctors better understand these conditions and improve future care plans.
Seoul, KoreaAges 18–100
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Common questions
- Are there clinical trials for lumbar degenerative disease?
- Yes. Clin2 currently lists 56 recruiting lumbar degenerative disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lumbar degenerative disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lumbar degenerative disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.