Clinical trials
Major Depression Disorder clinical trials
Below are recruiting major depression disorder clinical trials, each written for real people, not researchers. We’re tracking 505 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06821646Enrolling by invitation
Brain responses in depression and autism with TMS and EEG
This study uses brain stimulation (TMS) and brain wave recording (EEG) to understand how the brain works in people with autism, depression, or both. It may help find better ways to treat these conditions.
TaipeiAges 20–50 - NCT07294924Recruiting
Predicting depression treatment response with brain imaging
This study uses a special brain-imaging headband to see if it can predict how well people with depression respond to a treatment called accelerated rTMS (a type of brain stimulation). It compares results with people who do not have depression.
Los Angeles, CaliforniaAges 18–75 - NCT06050070Recruiting
Using Real-Time Brain Imaging to Help Depression
This study tests whether real-time brain imaging (fMRI) can help people with depression learn to change their brain activity. You will receive feedback on your brain signals while thinking positive or neutral thoughts.
Ann Arbor, MichiganAges 18–55 - NCT06590025RecruitingPhase 3
Can a cognitive training program help depression?
This study tests a computer-based program called INCREM that helps improve thinking and memory skills in people with depression. If you have depression and notice trouble with concentration or daily tasks, this program may help you get back on track.
Barcelona, CataloniaAges 18 years+ - NCT07216404RecruitingPhase 2
Psilocybin therapy for depression in lung cancer patients
This trial tests whether a psychedelic-assisted therapy can help treat major depression in people with non-small cell lung cancer. If you have moderate to severe depression and are receiving cancer treatment, you may be able to join.
Columbus, OhioAges 18 years+ - NCT06725277Recruiting
Observing ketamine and Spravato for depression
This study follows people who are already taking or about to start IV ketamine or Spravato® for hard-to-treat depression. Researchers want to learn more about how these treatments work in real life.
Milford, ConnecticutAges Any age - NCT06788249RecruitingEarly Phase 1
Ketamine for treatment-resistant depression brain study
This trial tests whether a single dose of ketamine can quickly improve depression by studying brain chemical changes using MRI. It's for people with treatment-resistant depression who haven't used ketamine before.
Philadelphia, PennsylvaniaAges 25–65 - NCT07473648Recruiting
A trial of ECT and magnetic seizure therapy for mood disorders
This study compares two types of brain stimulation treatments—electroconvulsive therapy (ECT) and magnetic seizure therapy (MST)—to see which works better for people with certain mental health conditions. It may be an option if you have a mood disorder or vision problems that could be helped by these treatments.
Hefei, AnhuiAges 12–80 - NCT04923685Recruiting
Study looks at blood markers linked to childhood trauma and suicide risk
This study checks whether tiny genetic signals in blood (microRNAs) are linked to childhood maltreatment and thoughts or risk of suicide, especially in people with major depression. It may help researchers understand biological clues that could someday guide better care.
Birmingham, AlabamaAges 18–60 - NCT06605105Enrolling by invitationPhase 3
Long-term extension trial of CYB003 for depression
This long-term study is for people who already completed an earlier trial of the experimental drug CYB003 for major depression and who stayed on their regular antidepressant. It looks at the safety and effects of taking CYB003 again over many months.
Phoenix, ArizonaAges 18–85 - NCT05004987RecruitingPhase 4
Study brain and blood changes in older adults with depression
This study looks at how a brain protein linked to Alzheimer’s disease changes over time in older adults who have major depression but no major memory problems. It involves brain scans, blood and urine tests, and a spinal fluid sample to better understand the connection between depression and brain aging.
New York, New YorkAges 60 years+ - NCT05327699RecruitingEarly Phase 1
Ketamine study for depression with reduced pleasure
This early-phase study tests whether ketamine can help people with major depression who have trouble feeling pleasure. It also studies how the brain may change in response to stress, to better understand who might respond to treatment.
Atlanta, GeorgiaAges 18–65 - NCT05366270Recruiting
Testing how mild heat affects depression symptoms and brain signals
This study tests whether controlled whole-body heat can change immune-related brain and body signals in people with major depressive disorder. It may help researchers understand why heat affects mood and who might benefit, while closely monitoring safety.
Boston, MassachusettsAges 18–65 - NCT05437705Recruiting
Brain scan and stimulation study for low mood
This study uses brain imaging (MRI) and a brain-stimulation method (TMS) to understand and possibly change brain patterns linked with low mood. You may be eligible if you have moderate to severe depression symptoms and can safely complete the scans and stimulation sessions.
Philadelphia, PennsylvaniaAges 18–65 - NCT05585047Recruiting
Looking for brain and blood markers in major depression
This study looks at treatment response markers (signs in the body) in people with major depressive disorder (MDD). It may help researchers understand who is more likely to benefit from antidepressant treatment.
Changsha, HunanAges 18–60 - NCT05613972Recruiting
Therapy program for suicide risk and past trauma
This trial tests an integrated therapy approach for people who are currently having significant thoughts about suicide and also have a history of childhood trauma. It may help by combining support for trauma experiences with strategies to reduce suicide risk.
Toronto, OntarioAges 18 years+ - NCT05630469Recruiting
Predicting who will benefit from electroconvulsive therapy
This study looks for ways to predict how well electroconvulsive therapy (ECT) will work for severe depression. It may help doctors choose the best treatment approach and timing for future patients.
ViennaAges 18–65 - NCT05645575Recruiting
Inpatient TMS for treatment-resistant depression
This study tests an in-hospital brain stimulation treatment (TMS) for people with moderate to severe depression who did not improve after multiple antidepressant treatments. It may help your mood by targeting brain circuits involved in depression, and you would follow an intensive accelerated schedule.
Los Angeles, CaliforniaAges 18–65 - NCT05922878RecruitingPhase 2
ALTO-300 study for moderate to severe depression
This trial tests ALTO-300 as an add-on treatment for people with moderate to severe major depressive disorder (MDD). It aims to see whether ALTO-300 helps improve depression symptoms when you’re already on a stable antidepressant.
Phoenix, ArizonaAges 18–70 - NCT05996900Recruiting
Brain stimulation study for adults with epilepsy
This study uses advanced brain monitoring and noninvasive magnetic stimulation to understand how repetitive brain stimulation works in people with epilepsy who are already scheduled for hospital monitoring. It may help develop better treatments for seizures.
Stanford, CaliforniaAges 18–65 - NCT06183359Recruiting
Self-Identification Program for Depression
This study tests a self-identification program for people aged 18 to 70 who are currently in a major depressive episode. It aims to explore whether a simple self-monitoring tool can help you better manage your depression.
MontpellierAges 18–70 - NCT06236880RecruitingPhase 2
Testing GM-2505 for Moderate to Severe Depression
This trial tests a new oral medication, GM-2505, for people with moderate to severe major depressive disorder (MDD). The goal is to see if it is safe and well-tolerated, either as a stand-alone treatment or alongside a stable SSRI/SNRI antidepressant.
ManchesterAges 18–65 - NCT06385405Recruiting
Brain stimulation for depression using EEG guidance
This trial uses a brain scan technique (EEG) to guide a treatment called repetitive transcranial magnetic stimulation (rTMS) for people with major depressive disorder. It aims to see if personalizing the treatment based on brain activity can help improve depression symptoms.
Shanghai, Shanghai MunicipalityAges 16–65 - NCT06546917Recruiting
Cognitive training trial for mild depression with brain scans
This trial tests a computer-based cognitive training program (bWell-D) to see if it can improve thinking skills like memory and focus in people with mild depression. You will also have an MRI brain scan to see how the training affects your brain.
Vancouver, British ColumbiaAges 19–55
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Common questions
- Are there clinical trials for major depression disorder?
- Yes. Clin2 currently lists 505 recruiting major depression disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a major depression disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a major depression disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.