Clinical trials
Metastases clinical trials
Below are recruiting metastases clinical trials, each written for real people, not researchers. We’re tracking 450 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05534321RecruitingPhase 1/Phase 2
Preventive radiation for high-risk spinal bone metastases
This trial tests whether preventive (before serious problems happen) radiation to the spine can help people with high-risk, mostly symptom-free bone metastases. It may reduce the chance of pain escalation or dangerous complications from cancer in the spine.
Miami, FloridaAges 18 years+ - NCT05522660RecruitingPhase 3
Immunotherapy or targeted therapy with focused brain radiation
This Phase 3 study tests whether immunotherapy or targeted medicine, with or without a one-time focused brain radiation procedure, can control brain metastases from melanoma or non-small cell lung cancer. It mainly enrolls people who have no (or minimal) brain symptoms and are newly diagnosed in the brain (except for certain recent brain surgery).
NaplesAges 18 years+ - NCT05464992Recruiting
PET/MRI scan study using a special brain MRI technique
This trial studies whether a special type of MRI during a PET/MRI scan (called CEST) can help doctors better evaluate brain tumors and tumor return after treatment. It may improve how well scans show where disease is before surgery or when tumors come back.
StrasbourgAges 18 years+ - NCT05428358Recruiting
MRI helps choose which pancreatic cancer patients can have surgery
This trial studies whether adding an MRI scan improves the selection of people with pancreatic cancer who may benefit from surgery. It focuses on patients without liver spread and with tumors that are borderline or likely removable.
AalborgAges 18–99 - NCT05452005RecruitingPhase 1
PET scan with a new tracer for lung cancer brain metastases
This Phase 1 study tests whether a specialized PET scan tracer can “light up” metastatic non-small cell lung cancer in the brain. If you join, you’ll get brain MRI and PET/CT scans and you’ll continue with your planned cancer treatments and follow-up imaging.
Sacramento, CaliforniaAges 18 years+ - NCT05354570RecruitingPhase 2
Radiation for thymic cancer that has spread to lung lining
This Phase 2 study tests a precise type of chest radiation that targets cancer in the lung lining (pleura) while trying to protect healthy lungs and organs. It may help people with thymic cancer that has spread to the pleura, including cases that return after prior treatment.
Basking Ridge, New JerseyAges 18–79 - NCT05317026Recruiting
Test adding cement injection to SBRT for spine pain
This study tests whether adding a vertebroplasty procedure (a cement injection to stabilize a spine bone) to standard SBRT radiation can reduce pain from spinal metastases. It may help people with painful, possibly unstable spine lesions by improving early pain relief.
Montreal, QuebecAges 18 years+ - NCT05285358RecruitingPhase 1
Aerosol chemo plus standard drugs for bile duct and gallbladder cancer
This trial tests a new way to give the drug paclitaxel directly into your belly as a mist, along with two standard chemo drugs given through your veins, for bile duct or gallbladder cancer that has spread to the lining of the belly. The goal is to see if this approach can better control the cancer in the belly.
Duarte, CaliforniaAges 18 years+ - NCT05235165RecruitingPhase 3
Surgery choice for lung spread of osteosarcoma
This Phase 3 trial compares two ways to remove lung metastases (open surgery vs keyhole surgery) in people with osteosarcoma. It aims to see which approach works better and is safer for patients with a limited number of lung spots that can be removed.
Birmingham, AlabamaAges Up to 50 years - NCT05248581Recruiting
Living donor liver transplant for unresectable colon cancer spread
This trial looks at using a living donor liver transplant for people whose colon or rectal cancer has spread to the liver in a way that can’t be removed with standard surgery. It may help if you might otherwise have limited options because your liver surgery would be too risky.
Rochester, New YorkAges 18 years+ - NCT05184816RecruitingPhase 1
Deferoxamine for leptomeningeal cancer spread in the brain lining
This Phase 1 study tests deferoxamine, a medicine given directly into spinal fluid, for leptomeningeal metastasis (cancer spreading to the brain and spinal cord lining). It’s meant to see whether the treatment can be safely given and whether it may help control this difficult-to-treat cancer location.
Basking Ridge, New JerseyAges 18 years+ - NCT05139277Recruiting
Using a imaging system during brain tumor surgery
This study tests the CONVIVO system to help surgeons see certain brain tumors during surgery. It may help make operations safer and more effective by improving how tumors are identified.
Lebanon, New HampshireAges 18 years+ - NCT05027711RecruitingPhase 2
MRI-guided precise radiation for liver metastases
This Phase 2 trial tests an MRI-guided, highly targeted radiation treatment (SBRT) for tumors that have spread to the liver. It may help shrink 1–3 liver metastases while using imaging to better guide treatment.
HeidelbergAges 18 years+ - NCT05045950RecruitingPhase 2
Whole brain radiation that aims to protect thinking skills
This Phase 2 trial tests a modified form of whole brain radiation to see if it can better protect thinking and memory in adults with brain metastases. You may join even if you’ve had other cancer treatments before, as long as your situation fits the study rules.
Milwaukee, WisconsinAges 18 years+ - NCT05026983RecruitingPhase 2
Targeted drugs for melanoma spread to the brain
This Phase 2 trial tests two targeted medicines (binimetinib and encorafenib) for melanoma that has spread to the brain. It focuses on people whose tumor has a specific BRAF V600 mutation and who have brain metastases that are progressing or need treatment.
Houston, TexasAges 18 years+ - NCT04987086Recruiting
68Ga PSMA PET-CT for kidney cancer spread
This study checks whether a special PET-CT scan using 68Ga PSMA can better find where renal cell carcinoma has spread. It may help doctors plan the right next steps by confirming suspected metastases on CT.
Lanzhou, GansuAges 18–90 - NCT04796818Recruiting
MRI scan to track response in colorectal liver metastases
This study uses a special MRI scan to see how colorectal cancer in the liver responds to planned chemotherapy before and after surgery. It may help doctors better measure treatment success and plan care.
Houston, TexasAges 18 years+ - NCT04693377Recruiting
Freezing tumor treatment plus targeted radiation for painful bone spread
This study tests whether combining a “freezing” procedure (cryoablation) with focused external radiation (SBRT) can reduce pain from bone metastases. It’s for people with certain cancers that have spread to bone and are having significant pain in a specific bone spot.
Houston, TexasAges 18 years+ - NCT04622423Recruiting
Advanced therapies for colon or pancreas liver metastases
This study tests advanced treatments for cancer that has spread to the liver, either from colon cancer or pancreatic cancer. It may help by targeting liver tumors using treatment plans and, for some participants, liver tissue samples.
Milan, MilanAges 18 years+ - NCT04299646RecruitingPhase 2
Stereotactic radiation for limited spread in kidney cancer
This trial tests whether targeted, high-precision radiation (stereotactic radiotherapy) can control a small number of growing kidney cancer metastases while you continue systemic treatment. It may help people who have “oligoprogressive” disease, where only 1–3 spots are getting worse.
AlbiAges 18 years+ - NCT04491929Recruiting
Radiation treatment for colon cancer in the liver using tiny beads
This trial studies a targeted liver radiation procedure that uses tiny radioactive beads to treat colon cancer spread mostly in the liver. It may help people whose liver tumors cannot be removed or treated with other common local treatments, but it has several safety and “screening” checks.
Aarhus N, DanmarkAges 18 years+ - NCT04511013RecruitingPhase 2
Trial for BRAF-mutant melanoma spread to the brain
This Phase 2 study tests whether a 3-drug plan (encorafenib + binimetinib + nivolumab) works better than ipilimumab + nivolumab for melanoma that has spread to the brain. If you qualify, you’ll get either treatment and have frequent brain scans to track how well it controls the tumors.
Birmingham, AlabamaAges 18 years+ - NCT04560036Recruiting
FAZA PET/MR scan for stomach and esophagus cancer
This study uses a special PET/MR scan (FAZA with imaging) to better understand stomach and esophagus cancer. You may be able to join if you have eligible cancer and can safely complete the scan.
Toronto, OntarioAges 18 years+ - NCT04343157RecruitingPhase 2
Image-guided radiation for brain tumors that protects thinking
This trial tests a special type of radiation therapy for brain tumors that aims to protect your memory and thinking skills. It may be an option if you have certain brain tumors or a small number of brain metastases.
San Diego, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for metastases?
- Yes. Clin2 currently lists 450 recruiting metastases studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a metastases trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a metastases trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.