Clinical trials
Mitral Valve Regurgitation clinical trials
Below are recruiting mitral valve regurgitation clinical trials, each written for real people, not researchers. We’re tracking 113 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05496998Recruiting
Heart valve replacement using a catheter for leaking mitral valve
This trial studies a catheter-based procedure to replace the mitral valve in people with severe (or specific moderate) mitral valve leakage that causes symptoms. It may help by reducing leaking and related symptoms when standard surgery or less invasive fixes aren’t suitable for you.
AarhusAges 18 years+ - NCT05090540Enrolling by invitation
Less Invasive vs Usual Surgery for Mitral Valve Leaks
This trial compares a less invasive catheter procedure to the standard surgical operation to treat “secondary” leaking of the mitral valve. It may help people with significant valve leak decide which approach works better for reducing symptoms and heart strain.
Saint-DenisAges 18–90 - NCT05061004Recruiting
Cephea valve study for severe mitral valve disease
This study tests a new device called the Cephea valve, which is placed through a small tube (catheter) to treat severe leaking or narrowing of the mitral valve. It may be an option for people who are not good candidates for open-heart surgery.
Phoenix, ArizonaAges 18 years+ - NCT04688190Recruiting
Registry study for choosing a mitral valve treatment
This study collects and compares real-world results to help doctors choose the best treatment for mitral valve “leakiness.” If you have clinically significant mitral insufficiency and have already had a specific heart procedure screening, your echocardiogram results may be used to understand outcomes over at least a month.
Tucson, ArizonaAges 18 years+ - NCT04734756Enrolling by invitation
Dragonfly device study for leaking mitral valve in high-risk patients
This trial tests the safety and effectiveness of a heart procedure that repairs a leaking mitral valve through thin tubes, using the Dragonfly system. It’s for people who have significant mitral valve leak symptoms but are considered high risk for open-heart surgery.
Hangzhou, ZhejiangAges 18 years+ - NCT04408430Recruiting
Valve replacement for severe mitral valve disease in high-risk adults
This trial tests a less-invasive way to treat severe mitral valve problems using a transcatheter valve. It may help people who are too high-risk for standard open-heart mitral surgery by improving symptoms and heart function.
Gilbert, ArizonaAges 18 years+ - NCT03958773Enrolling by invitation
Transcatheter treatment for severe leaking mitral valve
This study tests a new catheter-based system to treat severe mitral valve leaking when open-heart surgery is considered high risk. It may help improve blood flow and symptoms by repairing the valve without open surgery, using ultrasound guidance and follow-up visits to track safety and results.
KaunasAges 18 years+ - NCT03389542Recruiting
Early mitral valve repair versus watchful waiting
This trial compares doing mitral valve repair early versus closely monitoring without surgery in people who have severe leakage but no symptoms. It aims to see whether early repair helps prevent future heart problems.
AmiensAges 18–75 - NCT03242642Recruiting
Testing a new catheter procedure to replace a leaking mitral valve
This trial studies whether a new catheter-based system can replace a badly leaking mitral valve in people who have symptoms. It may help if you can’t safely get current approved valve treatments or standard surgery.
Birmingham, AlabamaAges 18 years+ - NCT03142152Recruiting
Mitral valve implant for heart failure with leaky mitral valve
This trial tests whether a device called the Carillon Mitral Contour System can help people with heart failure caused by a mild-to-moderate leaky mitral valve. You’d be compared against a control group, and the goal is to improve heart failure symptoms and outcomes.
Gilbert, ArizonaAges 18 years+ - NCT02245763Recruiting
Mitral valve procedure registry for patients who can take blood thinners
This is a study that collects medical information about people having a mitral valve procedure, to better understand outcomes. It may help because it improves how doctors choose and manage care for mitral valve problems.
Washington D.C., District of ColumbiaAges 1 year+ - NCT05469165RecruitingPhase 2
Testing serotonin blockers after a first heart attack
This Phase 2 trial tests whether blocking serotonin receptors can help after a first heart attack that has caused a specific type of leaking mitral valve problem. It aims to see if the treatment improves heart function and heart-valve measurements while keeping patients safe.
QuébecAges 18–80 - NCT06738537Recruiting
Choosing treatment for mitral valve prolapse
This study looks at how to involve you in decisions about treating mitral valve prolapse, a condition where a heart valve doesn't close tightly. It aims to find the best way to help you and your doctor choose the right treatment.
Los Angeles, CaliforniaAges 21 years+ - NCT06600191Recruiting
New mitral valve study for leak repair
This trial tests a new device called the Capstan system to fix a leaky mitral valve (mitral regurgitation) without open-heart surgery. It may help people whose valve leak is moderate to severe and still have symptoms despite medicines.
MelbourneAges 18 years+ - NCT05628779Enrolling by invitation
Clip procedure to repair a leaking tricuspid valve
This trial studies a minimally invasive “edge-to-edge” clip procedure to reduce severe leakage of the tricuspid valve. It’s for people who still feel unwell despite standard treatments and may be too high-risk for open-heart surgery.
AmsterdamAges 18 years+ - NCT07055919Recruiting
Assist system for mitral valve clip procedure
This study is testing a new assist system to help doctors perform a minimally invasive procedure (MitraClip) that clips the leaky mitral valve without open-heart surgery. It is for people with severe mitral regurgitation who cannot safely have surgery or choose not to.
Xiamen, FujianAges 18 years+ - NCT07517588Recruiting
Mitral Valve Repair Using Polares System for Heart Failure
This trial tests a minimally invasive procedure to repair a leaky mitral valve (the valve between the upper and lower chambers of your heart) in people with heart failure who haven't improved with medication alone. The procedure uses a catheter-based system inserted through the groin to replace part of the valve, potentially reducing symptoms and improving heart function.
Atlanta, GeorgiaAges 21 years+ - NCT07414225Recruiting
MitraClip procedure for atrial functional mitral regurgitation
This trial tests a minimally invasive procedure to repair a leaky mitral valve in people with a specific type of heart failure. The goal is to see if the procedure, called transcatheter edge-to-edge repair (TEER), is safe and effective in reducing symptoms and improving heart function.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06797687Recruiting
Studying the mitral valve with different scans before surgery
This study looks at how well CT scans and 3D echo (ultrasound) measure the mitral valve ring before surgery for severe mitral valve leakage. It may help doctors better plan valve repair.
RomaAges 18 years+ - NCT06684171Recruiting
Comparing two ways to guide mitral valve clip repair
This trial tests whether using only ultrasound (echo) to guide a mitral valve clip repair is as good as using ultrasound plus X-ray. The study may help patients with a leaky mitral valve who are not good candidates for open heart surgery.
Shenzhen, GuangdongAges Any age - NCT07741383Recruiting
Combined procedure for severe mitral regurgitation and atrial fibrillation
This study tests whether combining a valve repair procedure with a heart rhythm reset procedure is safe and effective for people with severe mitral regurgitation and atrial fibrillation. It may help improve heart function and reduce symptoms.
Hangzhou, ZhejiangAges 18 years+ - NCT04919980Recruiting
Testing a new mitral valve repair device for high-surgery-risk patients
This study looks at a new way to treat a leaky mitral heart valve using the INNOVALVE system. It’s meant for people who have symptoms from mitral regurgitation but are considered high risk for open-heart surgery, to see if the approach can help safely.
Los Angeles, CaliforniaAges 18 years+ - NCT04343313Recruiting
Transcatheter repair for leaky mitral valve in high-risk adults
This pilot study tests a newer catheter-based way to reduce leakage of the mitral valve in people who feel sick from mitral regurgitation but are considered too high-risk for standard surgery. If you fit the valve and heart anatomy needs, the study may help improve symptoms and valve function without open-heart surgery.
New York, New YorkAges 21–95 - NCT07539298RecruitingPhase 2/Phase 3
Valsartan for Heart-Related Mitral Valve Leaking
This study tests whether a blood pressure medication called valsartan can reduce leaking in the mitral valve (a valve in your heart) caused by an enlarged left chamber. The goal is to see if this medication can improve heart function and reduce symptoms without needing surgery.
Québec, QuebecAges 18–85
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Common questions
- Are there clinical trials for mitral valve regurgitation?
- Yes. Clin2 currently lists 113 recruiting mitral valve regurgitation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mitral valve regurgitation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mitral valve regurgitation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.