Clinical trials
Parkinson’s disease clinical trials
A movement disorder caused by the loss of dopamine-producing brain cells. We’re tracking 723 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06778135Recruiting
Brain cell study in Parkinson's DBS surgery
This trial studies how brain cells in a specific area (the prefrontal cortex) affect thinking and planning in people with Parkinson's disease who are getting deep brain stimulation (DBS) surgery. The goal is to learn more about brain function to improve future treatments.
Aurora, ColoradoAges 45–85 - NCT06683365RecruitingPhase 1
Nerve graft trial for Parkinson's or MSA
This trial tests whether grafting a piece of your own leg nerve into a specific part of the brain can improve symptoms of Parkinson's disease or multiple system atrophy (MSA). It aims to help people whose movement problems are moderate but not too severe.
Lexington, KentuckyAges 40–75 - NCT06617884Recruiting
Home balance training for movement disorders
This study tests a home-based walking and balance training program for people with cerebellar ataxia or Parkinson's disease. The training is done at home, so you don't need to travel. The goal is to see if this simple exercise program can improve your walking and balance.
Düsseldorf, North Rhine-WestphaliaAges 18–75 - NCT06671626Enrolling by invitation
Brain recordings during DBS surgery for Parkinson's
This study records brain activity during deep brain stimulation (DBS) surgery for Parkinson's disease to better understand how the brain controls actions. It might help improve future treatments.
Dallas, TexasAges 18 years+ - NCT06570824Recruiting
Can repetitive TMS help with levodopa-induced dyskinesia?
This study tests whether a non-invasive brain stimulation technique called repetitive TMS can reduce the involuntary movements (dyskinesia) that some people with Parkinson's disease experience as a side effect of their levodopa medication. If you have Parkinson's and bothersome dyskinesia when your medication is working, this trial may be an option.
HvidovreAges 18–80 - NCT06553625Recruiting
RF ablation study for pain or CNS conditions
This study observes how well a Boston Scientific radiofrequency (RF) system works for treating pain or central nervous system (CNS) conditions. It helps researchers understand real-world benefits for patients scheduled for this procedure.
CologneAges Any age - NCT06498349Recruiting
DBS for Parkinson's impulse control problems
This trial tests whether deep brain stimulation (DBS) of the subthalamic nucleus can help control impulse control problems (like gambling, overeating, or shopping) in people with Parkinson's disease. It is for patients whose medication-related impulse symptoms are moderate to severe and who are good candidates for DBS surgery.
CologneAges 18–70 - NCT06489483Recruiting
Parkinson's and action regulation study in Dallas
This study looks at how people with Parkinson's disease regulate their actions. It will test your behavior during 'on' periods (when medication is working well) to understand decision-making and movement control.
Dallas, TexasAges 18–80 - NCT06289582RecruitingEarly Phase 1
Brain imaging study for Parkinson's disease
This study uses a special PET scan to look at inflammation in the brain of people with Parkinson's disease or those at risk for it. The goal is to better understand the disease and possibly find new ways to track its progression.
Birmingham, AlabamaAges 18–99 - NCT05943652Recruiting
Study of how functional overlay affects movement disorders
This study looks at movement disorders that are functional (not caused by damage to the nervous system) or non-functional, and how a “functional overlay” may change symptoms. It is observational, meaning it does not test a new treatment, but it may help researchers better understand these differences and improve care.
Graz, StyriaAges 18–18 - NCT06169852Recruiting
Brain signal study during DBS surgery for Parkinson's
This study looks at brain signals during awake deep brain stimulation (DBS) surgery for Parkinson's disease. The goal is to learn how these signals can help guide the placement of electrodes to improve treatment.
Birmingham, AlabamaAges 18–89 - NCT02897063RecruitingPhase 1
Test medicines for low blood pressure in nerve-related disorders
This early (Phase 1) study tests whether midodrine and droxidopa can improve blood-flow pooling in the belly in people with nerve problems that affect blood pressure when standing. It’s looking at safety and how the body responds, which may help reduce dizziness or fainting for some participants.
Nashville, TennesseeAges 40–80 - NCT06013956RecruitingPhase 4
Personalized deep brain stimulation for Parkinson's
This study tests a personalized way to adjust deep brain stimulation (DBS) therapy in real time for people with Parkinson's disease. It aims to improve how DBS works by tailoring it to each person's needs.
Cleveland, OhioAges 18–80 - NCT05198076Recruiting
TMS follow-up study for balance changes in Parkinson’s
This study looks at how “high-frequency TMS” (a brain stimulation treatment) may change balance in people with Parkinson’s disease over a 6-month follow-up. You may be considered if you have mild to moderate Parkinson’s, have not had TMS before, and are medically stable.
Giza, Ad Doqi, Giza District, Giza GovernorateAges 55–70 - NCT05967390Enrolling by invitation
Personalized brain-mapping test using a scalp-to-brain scan
This trial looks at whether a personalized brain “map” using imaging and scalp measurements can be measured and evaluated in people who can safely attend the testing. It may help researchers better understand how brain structure relates to performance, using scan-based measurements and related procedures.
Hong KongAges 60–95 - NCT05919160Enrolling by invitation
New tiny electrode to record brain activity during DBS
This study tests a high-density microelectrode that captures detailed brain recordings while surgeons place a deep brain stimulator for Parkinson’s disease. It may help doctors better locate the exact brain area to target during surgery.
Los Angeles, CaliforniaAges 18 years+ - NCT05893186RecruitingEarly Phase 1
Testing DBS settings for walking and balance in Parkinson’s
This early-phase study looks at whether adjusting deep brain stimulation (DBS) can improve posture, walking, and balance in people with Parkinson’s disease. If you already have DBS in place, the trial uses computer-based planning to try different DBS directions and settings to see what helps you most.
Minneapolis, MinnesotaAges 18–89 - NCT05822388Recruiting
Deep brain stimulation and memory changes in Parkinson’s
This study looks at whether deep brain stimulation (a surgical treatment for Parkinson’s disease) affects thinking and memory over time. It compares Parkinson’s participants to people without Parkinson’s to better understand what changes happen with treatment.
Charleston, South CarolinaAges 18 years+ - NCT05819008Recruiting
Online brain testing for people with neurological conditions
This trial studies how well a remote, online memory and thinking assessment works for people with neurological disorders or injuries. You may be invited if you can do the computer-based testing and speak Swedish.
UmeåAges 18 years+ - NCT05826457Enrolling by invitation
Study for early RBD as a possible Parkinson’s risk
This study looks at people with REM sleep behavior disorder (RBD), confirmed by a sleep test, who may be in the early “prodromal” stage before Parkinson’s or related diseases. It also enrolls healthy controls to compare results from brain and body testing to better understand who is at risk.
Los Angeles, CaliforniaAges 18 years+ - NCT04116996Recruiting
Brain stimulation for severe insomnia in Parkinson’s
This trial tests whether stimulating a specific brain area (the globus pallidus) can improve severe insomnia in people who also have Parkinson’s symptoms. You might be considered if your insomnia is very difficult to control and you meet the study’s brain, sleep, and travel requirements.
Jacksonville, FloridaAges 40–80 - NCT05317390Recruiting
Tests an AI tool to diagnose isolated dystonia
This trial checks whether an AI (software) called DystoniaNet can accurately identify isolated dystonia using information from your evaluation, and compares its results to standard diagnosis. If you have focal, segmental, or generalized dystonia, this study may help improve faster and more accurate diagnosis in the future.
Boston, MassachusettsAges Any age - NCT05763732Recruiting
Testing how brain stimulation affects walking in Parkinson’s
This trial looks at how turning on and using a specific Parkinson’s brain stimulator affects your walking. It may help doctors understand what changes in gait (walking) can happen with this device and settings.
Baltimore, MarylandAges 18–89 - NCT05721911Recruiting
Study using brain-cell tests to better understand Parkinson’s risk
This study collects blood and related samples to create a “biobank” and uses lab tests to study genetic risk in Parkinson’s disease and idiopathic REM sleep behavior disorder (RBD). It may help researchers understand why symptoms develop and improve future prevention or treatment approaches.
Milan, ItalyAges 18 years+
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Common questions
- Are there clinical trials for parkinson’s disease?
- Yes. Clin2 currently lists 723 recruiting parkinson’s disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a parkinson’s disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a parkinson’s disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.