Clinical trials
Placebo - Control clinical trials
Below are recruiting placebo - control clinical trials, each written for real people, not researchers. We’re tracking 3,902 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05782244RecruitingPhase 2
Sildenafil trial for long-term brain blood-flow problems after TBI
This Phase 2 study tests whether sildenafil (a medication better known for erectile function) can improve long-term symptoms and brain blood-flow issues after a past traumatic brain injury (TBI). It may help by improving blood vessel function in the brain and possibly reducing persistent post-concussion symptoms.
Philadelphia, PennsylvaniaAges 18–70 - NCT05787327RecruitingPhase 2
Chinese Herbal Medicine for COVID-19
This trial tests a combination of two traditional Chinese herbal formulas (Yinqiaosan and Maxingganshitang) to see if they can help people with mild to moderate COVID-19 recover faster. It's for adults who have had symptoms for no more than 3 days and have been diagnosed with a specific Chinese medicine pattern.
Hong KongAges 18–65 - NCT05794165Enrolling by invitationPhase 2
Antithrombin to prevent blood clots after serious trauma
This Phase 2 trial studies whether giving antithrombin can better prevent harmful blood clots (venous thromboembolism) after serious injuries. The goal is to reduce clot risk while you’re in the trauma ICU or step-down unit.
Aurora, ColoradoAges 18 years+ - NCT05785065RecruitingPhase 2
Mycophenolate for early lung scarring in systemic sclerosis
This Phase 2 study tests whether mycophenolate mofetil (MMF) can slow or improve early, mild lung scarring in people with systemic sclerosis. It’s meant for systemic sclerosis patients who have lung involvement on a CT scan but still have good breathing test results.
Montreal, QuebecAges 18 years+ - NCT05782829Recruiting
L-tyrosine to reduce stress during outpatient hernia surgery
This trial studies whether an L-tyrosine supplement before surgery can reduce stress or anxiety around the time of anesthesia and recovery. It is for adults having outpatient surgery for an inguinal hernia under general anesthesia.
MonacoAges 18–75 - NCT05805683Recruiting
Calcitonin for nerve pain after spinal cord injury
This study tests whether calcitonin can prevent or lessen nerve pain after a spinal cord injury. It may help reduce how often neuropathic (nerve-type) pain happens and how severe it becomes.
Tanta, Gharbia GovernorateAges 18 years+ - NCT05778591RecruitingPhase 2
Low-dose buprenorphine to improve social drive in schizophrenia
This study tests whether low-dose buprenorphine can improve social motivation in people with schizophrenia. It compares social motivation changes while keeping participants stable on treatment and avoiding certain medicines and substances.
Los Angeles, CaliforniaAges 18–60 - NCT05798819RecruitingPhase 3
PD-L1 cervical cancer trial with chemotherapy and possible bevacizumab
This Phase 3 study tests GLS-010 added to standard platinum chemotherapy, with or without bevacizumab, as a first treatment for cervical cancer that has persisted, come back, or spread. If you have PD-L1–positive tumors, the goal is to improve how long people can control the cancer compared with standard chemotherapy alone.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT05778188RecruitingPhase 2
RLS-0071 for newborns with moderate or severe HIE
This trial studies whether RLS-0071 is safe and can help some newborns with moderate or severe hypoxic-ischemic encephalopathy (HIE), a brain injury caused by low oxygen around birth. Babies in the study also receive standard whole-body cooling (therapeutic hypothermia), and the researchers will watch for side effects and early signs of benefit.
Little Rock, ArkansasAges Up to 10 hours - NCT05773586RecruitingPhase 1
Study of a new medicine for anemia, first tested for safety
This Phase 1 trial tests how safe APG-5918 is, how the body processes it, and looks for early signs it may help people with certain types of anemia. It may include healthy volunteers and people with anemia, but the study is very selective to protect participants.
Guangzhou, GuangdongAges 18 years+ - NCT05762107RecruitingPhase 2
Drug ZT-01 to reduce low blood sugar at night
This Phase 2 study tests ZT-01 to help prevent night-time low blood sugar (hypoglycemia) in people with type 1 diabetes. It may help if you’ve had low blood sugar during sleep or are at high risk based on recent glucose monitoring.
Birmingham, AlabamaAges 18–75 - NCT05754801RecruitingPhase 2
Yunzhi essence for quality of life in advanced cancer
This Phase 2 trial tests whether Yunzhi essence (a traditional Chinese medicine) can improve quality of life for people with advanced cancer. It also requires certain screening results about life expectancy, thinking/alertness, and symptom pattern.
Hong KongAges 21–89 - NCT05761860RecruitingEarly Phase 1
Oxytocin to lower opioid misuse risk and pain in older adults
This early-phase study tests whether oxytocin (a hormone-like medication) can reduce how “appealing” opioids feel and also reduce pain. It’s aimed at older adults who have used opioids before but are not currently dealing with chronic pain most days.
Gainesville, FloridaAges 45–85 - NCT05771675RecruitingEarly Phase 1
Simvastatin trial for symptom relief in pancreatitis
This early-phase study tests whether simvastatin can improve patient-reported symptoms in people with recurrent acute or chronic pancreatitis. It’s meant to see if the medicine is tolerable and helps with how you feel day to day.
Los Angeles, CaliforniaAges 18–75 - NCT05764733RecruitingPhase 4
How bone exercise, alendronate, and diet affect bone strength
This trial studies whether doing a structured bone-focused exercise program, taking alendronate (a medication that slows bone loss), and making a calorie-reducing diet can improve bone strength in people with low bone density. It also compares different combinations to see what helps most and is safest for you.
Aurora, ColoradoAges 60 years+ - NCT05759468RecruitingPhase 2
Add NAD to help protect kidneys in diabetes
This Phase 2 study tests whether adding NAD can improve kidney health in people with diabetes-related kidney disease. It is designed for people with certain urine lab results showing kidney stress, while keeping blood sugar and safety limits within range.
Boston, MassachusettsAges 30 years+ - NCT05758246RecruitingPhase 2
Fisetin to slow worsening of sepsis in older hospital patients
This Phase 2 trial tests whether a drug called fisetin can slow the progression of sepsis once you are admitted to the hospital. It may help patients recover more quickly or avoid worsening, but eligibility depends on how severe the illness is and what other treatments you need.
Gainesville, FloridaAges 65 years+ - NCT05764057RecruitingPhase 3
Dapagliflozin to help the heart heal after a heart attack
This trial tests whether dapagliflozin (a diabetes medicine also used for heart protection) can reduce harmful heart “remodeling” after an acute heart attack. It may help your heart function and structure recover over the following 6 months.
ParisAges 18 years+ - NCT05754073RecruitingPhase 2
Oxytocin to improve bone health in children with autism
This Phase 2 study tests whether oxytocin can help improve bone health in children and teens with autism spectrum disorder. It also checks safety by monitoring symptoms and doing blood tests and imaging.
Boston, MassachusettsAges 6–18 - NCT05753059RecruitingPhase 1
Study why some water pills stop working in heart failure
This Phase 1 study looks at why “water pills” (diuretics) like bumetanide may not remove fluid as expected in people with heart failure. The results may help clinicians improve treatment strategies for fluid control in the future.
New Haven, ConnecticutAges 18 years+ - NCT05746143RecruitingPhase 4
Zolpidem during recovery after lower-back fusion surgery
This trial studies whether taking zolpidem around the time of recovery from lower-back (lumbar) fusion surgery affects outcomes. It may help doctors understand how sleep medicine can (or can’t) support recovery in certain people.
Los Angeles, CaliforniaAges 18–75 - NCT04844528RecruitingPhase 2
Nicotinamide for CLL patients with recent skin cancer history
This Phase 2 trial tests whether nicotinamide (a form of vitamin B3) can help people with chronic lymphocytic leukemia (CLL) who have had non-melanoma skin cancers in the past 5 years. The study looks at how well new skin cancers can be prevented or reduced.
Salt Lake City, UtahAges 18 years+ - NCT05719441RecruitingPhase 2
Testing HIV antibodies plus early HIV treatment for possible remission
This trial tests whether giving two powerful HIV-fighting antibodies (called broadly neutralizing monoclonal antibodies) along with starting standard HIV medications soon after infection can help control the virus without needing daily pills. If successful, it might allow people to take a 'treatment pause' while keeping their immune system healthy.
Birmingham, AlabamaAges 18–70 - NCT05714085RecruitingPhase 2/Phase 3
Vericiguat study for children with heart failure
This trial tests whether vericiguat helps children with chronic heart failure caused by weaker left heart pumping. It also checks safety and how the medicine behaves in the body (dose and processing).
Los Angeles, CaliforniaAges 4 weeks–17 years
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Common questions
- Are there clinical trials for placebo - control?
- Yes. Clin2 currently lists 3,902 recruiting placebo - control studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a placebo - control trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a placebo - control trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.