Clinical trials
Preserved Ejection Fraction clinical trials
Below are recruiting preserved ejection fraction clinical trials, each written for real people, not researchers. We’re tracking 125 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06956560Recruiting
Heart Scar Imaging Study for Heart Attack and Failure Patients
This study uses a special imaging agent to see a protein called PDGFRß in the heart, which may help detect scarring (fibrosis) after a heart attack or in heart failure. It aims to improve how we understand and treat heart muscle damage.
UppsalaAges 40–70 - NCT06930495Enrolling by invitation
Weight loss and heart failure with normal pumping strength
This study tests whether weight loss treatments can improve muscle and blood vessel function in people with a specific type of heart failure (HFpEF) who also have obesity. It may help if you have heart failure with a normal ejection fraction and a high BMI.
Dallas, TexasAges 18 years+ - NCT06905405Recruiting
Imaging for early heart failure with stiff heart muscle (HFpEF)
This study uses advanced imaging to find early signs of a type of heart failure where the heart pumps well but doesn't relax properly (HFpEF). It may help if you have shortness of breath and a slightly enlarged heart chamber but don't yet have a clear heart failure diagnosis.
Sheffield, South YorkshireAges 18 years+ - NCT06793371RecruitingPhase 2
Study of CK-4021586 for heart failure with preserved ejection fraction
This trial tests an investigational drug called CK-4021586 for people with heart failure with preserved ejection fraction (HFpEF). It aims to see if the drug is safe and well-tolerated. You may qualify if you are 40 to 85, have heart failure symptoms, and have a heart that pumps well but shows signs of strain.
Fairhope, AlabamaAges 40–85 - NCT06702501Recruiting
Shunt device to treat heart failure with preserved ejection fraction
This trial tests a tiny tube (shunt) placed in the heart to relieve pressure and ease severe shortness of breath. It's for people with a type of heart failure where the heart pumps well but doesn't relax enough.
Rochester, MinnesotaAges 30 years+ - NCT06762964RecruitingPhase 2
Dapagliflozin for Failing Fontan Circulation
This study tests whether a medication called dapagliflozin (a pill for heart failure) can help people with a Fontan circulation who feel short of breath. It aims to improve symptoms and quality of life.
Rochester, MinnesotaAges 18 years+ - NCT06741436Recruiting
Exercise testing after preeclampsia
This study looks at how the heart and blood vessels work after a pregnancy complicated by preeclampsia. It uses exercise testing to see if there are lasting effects, which may help improve long-term heart health monitoring and care.
Nashville, TennesseeAges 18 years+ - NCT06309550Recruiting
Testing for heart failure with preserved ejection fraction
This trial uses special tests to see if you have a type of heart failure where the heart pumps well but doesn't relax properly (HFpEF). It's for people who feel short of breath but haven't been diagnosed with this condition yet.
MilanAges Any age - NCT06678841Recruiting
Pacing therapy for heart failure with preserved pumping ability
This study tests a new pacing approach for people with a specific type of heart failure (HFpEF) to see if it can improve symptoms and quality of life. It involves a pacemaker-like device that adjusts heart rate based on your needs.
Phoenix, ArizonaAges 40 years+ - NCT06645535Enrolling by invitation
Gut Bacteria and Blood Substances in Stiff Heart Failure
This study looks at how bacteria in your gut and certain substances in your blood relate to a type of heart failure called HFpEF (where the heart is stiff and doesn't relax well). It may help doctors understand the condition better and find new ways to treat it.
Naning, JiangsuAges 18 years+ - NCT06650995Recruiting
Ablation and Exercise for Heart Failure with Normal Pumping
This study tests whether a combination of catheter ablation (a procedure to correct irregular heartbeats) and a structured exercise program can improve symptoms and quality of life in people with diastolic heart failure and a recent onset of persistent atrial fibrillation.
MunichAges 18–99 - NCT04822649Recruiting
Assessing exercise capacity in people with heart microvascular problems
This study looks at how well you can exercise and how your body composition relates to tiny blood-vessel problems in the heart. It may help doctors better understand symptoms and function in people who don’t have major blockages in the large heart arteries.
SeoulAges 20–80 - NCT06409585Recruiting
Heart muscle disease imaging study for scarring
This study uses advanced imaging (PET/MR or PET/CT) to look at scarring (fibrosis) in the heart muscle. It is for people with various heart muscle diseases, including heart failure with preserved pumping, thickened heart muscle, high blood pressure-related heart damage, heart inflammation, and others.
Edinburgh, ScotlandAges 30–90 - NCT06312748RecruitingPhase 1
Improving blood vessels in veterans with heart failure
This test is looking at whether certain medications (like statins) can help improve blood vessel health in veterans who have heart failure with preserved pumping function. It may help reduce symptoms and keep you out of the hospital.
Salt Lake City, UtahAges 18 years+ - NCT06081543Recruiting
Ketogenic vs. Mixed Diet for Heart Failure
This study compares a ketogenic (low-carb, high-fat) diet to a standard mixed diet in people with heart failure. It aims to see if the ketogenic diet can improve heart function and symptoms.
Columbus, OhioAges 18–80 - NCT06015776Recruiting
Heart cell signals after menopause
This trial studies how heart cells communicate after menopause. Researchers are looking at a chemical signal called purinergic signaling during heart surgery.
Boston, MassachusettsAges 30–88 - NCT05873634Recruiting
Using health records and testing to study heart failure types
This study combines electronic health record data and detailed heart testing to better understand different heart failure types and what treatments may work best for each. It mainly enrolls people with known heart failure, and also some people without heart failure for comparison.
Sacramento, CaliforniaAges 30 years+ - NCT05838287RecruitingPhase 4
Pioglitazone for heart failure with preserved pumping in type 2 diabetes
This trial tests whether pioglitazone (a diabetes medicine) helps people who have type 2 diabetes and a specific type of heart failure where the heart pumps normally. It may improve heart failure symptoms and function in carefully selected patients.
San Antonio, TexasAges 30–70 - NCT05723679Recruiting
Breathing-targeted program to improve function in HFpEF
This trial studies a breathing-focused treatment to help people with HFpEF (a type of heart failure) feel and function better. It may help improve daily activity by addressing breathing limits that commonly come with this condition.
Dallas, TexasAges 55–90 - NCT05585125RecruitingPhase 4
Testing an informed approach for older adults with HFpEF
This study looks at an “informed” approach to help manage HFpEF (a type of heart failure) in people age 65 and older. It checks whether a structured plan and monitoring are practical and safe for you over time.
New York, New YorkAges 65 years+ - NCT05279742Enrolling by invitationPhase 1/Phase 2
Study drug to boost a hormone system in HFpEF
This early-phase trial tests a treatment that aims to improve the “natriuretic peptide” hormone system in people with HFpEF (heart failure with preserved pumping strength). It may help reduce symptoms and improve heart and fluid pressure behavior, especially in certain related conditions like kidney disease.
Rochester, MinnesotaAges 18 years+ - NCT05138575RecruitingPhase 2
Testing SGLT2 pill and potassium nitrate for heart failure with preserved EF
This trial studies whether two medicines—an SGLT2 inhibitor and potassium nitrate—can improve symptoms and heart function in people with heart failure with preserved ejection fraction (HFpEF). It focuses on people who still have signs of “stiff” or high filling pressure in the heart despite a normal-ish ejection fraction.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05057806RecruitingEarly Phase 1
Testing how ketones may affect heart benefits in type 2 diabetes
This early study looks at people with type 2 diabetes and certain types of heart failure to see whether changes in “ketones” relate to heart benefits. It may help researchers understand who could benefit most from treatment-related metabolism changes.
San Antonio, TexasAges 18–80 - NCT04913805RecruitingPhase 2
Study for HFpEF using heart pressure and energy signals
This Phase 2 study tests how matching heart “filling pressure” and heart muscle “energy use” may improve understanding or treatment of HFpEF, a type of heart failure with preserved pumping strength. You may be asked to have heart scans/tests and follow a study plan if your symptoms and test results fit.
Philadelphia, PennsylvaniaAges 18 years+
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Common questions
- Are there clinical trials for preserved ejection fraction?
- Yes. Clin2 currently lists 125 recruiting preserved ejection fraction studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a preserved ejection fraction trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a preserved ejection fraction trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Heart Failure With Preserved Ejection Fraction
- Heart Failure With Reduced Ejection Fraction
- Heart Failure With Mildly Reduced Ejection Fraction
- Heart Failure With Mid Range Ejection Fraction
- Heart Failure With Normal Ejection Fraction
- Chronic Heart Failure With Reduced Ejection Fraction
- Preserved Ratio Impaired Spirometry (PRISM)
- Preserved Ratio Impaired Spirometry
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.