Clinical trials
Rectal Cancer, Radiotherapy clinical trials
Below are recruiting rectal cancer, radiotherapy clinical trials, each written for real people, not researchers. We’re tracking 209 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03961776Recruiting
MRI to monitor treatment response in rectal cancer
This trial tests whether an MRI scan done during chemoradiation can help doctors track how rectal cancer treatment is working. It may improve how they measure response early so treatment planning can be better tailored.
Los Angeles, CaliforniaAges 18 years+ - NCT07802002Recruiting
Dietary supplement to prevent bowel injury during radiation for rectal cancer
This trial tests whether a special dietary supplement can help protect the rectum from radiation damage during chemoradiation for locally advanced rectal cancer. If it works, it may reduce painful bowel symptoms like frequent stools and cramping.
Guangzhou, GuangdongAges 18–75 - NCT07786493Recruiting
3D-printed internal radiation for rectal cancer
This study tests a new way to deliver internal radiation therapy (brachytherapy) to rectal cancer using a 3D-printed guide. It may help people who cannot have or do not want surgery, with the goal of preserving the rectum.
Tianjin, Tianjin MunicipalityAges 18–80 - NCT07292298RecruitingPhase 2
Rectal cancer brachytherapy after treatment to avoid surgery
This trial tests a special type of internal radiation (brachytherapy) for people with low-lying rectal cancer that did not fully go away after standard chemoradiation and chemotherapy. The goal is to shrink the remaining tumor enough to avoid major surgery like removing the rectum or colostomy.
Aurora, ColoradoAges 18–100 - NCT03064646Recruiting
Preserving tissue in near-complete rectal cancer response
This trial studies whether it’s safe to preserve the rectum (instead of removing it right away) for people with locally advanced rectal cancer who respond very well after pre-treatment radiation and/or chemotherapy. It may help some patients avoid major surgery, but eligibility depends on response seen on exam, scope, and MRI, and on having no spread to distant organs.
Elche, AlicanteAges 18 years+ - NCT07866313RecruitingPhase 2/Phase 3
Chemotherapy, radiation, and immunotherapy before surgery for low rectal cancer
This trial tests a new combination of chemotherapy, radiation, and immunotherapy given before surgery for low rectal cancer. It aims to see if this approach can shrink tumors and improve outcomes for patients with a specific type of cancer that is microsatellite stable (MSS).
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06653452Recruiting
PET/MRI for rectal cancer treatment response
This study uses a special scan called PET/MRI to see how well treatment works for locally advanced rectal cancer before surgery. It may help doctors choose the best treatment plan for you.
Beijing, Beijing MunicipalityAges 18–75 - NCT07527026RecruitingPhase 2
Camrelizumab and chemotherapy with radiation for advanced rectal cancer
This trial tests a combination of an immunotherapy drug (camrelizumab) with chemotherapy and radiation to shrink advanced rectal cancer before surgery. The goal is to help more patients have successful surgery with complete tumor removal.
Beijing, Beijing MunicipalityAges 18–75 - NCT07393048Recruiting
Personalized ctDNA test to predict rectal cancer treatment response
This trial uses a personalized blood test (ctDNA-MRD) to see how well neoadjuvant therapy works for rectal cancer. If you have stage II or III rectal cancer that can be surgically removed, this study might help guide your treatment.
Beijing, Beijing MunicipalityAges 18–75 - NCT06894797Recruiting
Chemo and radiation before and after surgery for rectal cancer
This study tests a sequence of chemotherapy and radiation before and after surgery for rectal cancer. It compares giving more chemo between the end of radiation and surgery (consolidation) versus giving some chemo before radiation starts (induction). The goal is to see which order works better.
BeijingAges 18–75 - NCT06940388RecruitingPhase 2
Immunotherapy plus standard treatment for rectal cancer
This trial is testing whether adding the immunotherapy drug tislelizumab to standard total neoadjuvant treatment (chemotherapy and radiation before surgery) can improve outcomes for people with locally advanced rectal cancer. The goal is to see if the combination helps shrink the tumor more than standard treatment alone.
MainzAges 18 years+ - NCT06864013RecruitingPhase 2
Short course radiation with chemo and immunotherapy for rectal cancer
This trial tests a combination of short course radiation therapy, chemotherapy, and two immunotherapy drugs for people with a specific type of rectal cancer that is locally advanced but can still be removed by surgery. It may offer a more effective treatment option for those with mismatch repair proficient (pMMR) or microsatellite stable (MSS) tumors.
Hangzhou, ZhejiangAges 18–75 - NCT05412082RecruitingPhase 1
Smart chemo and radiation plan for locally advanced rectal cancer
This Phase 1 study tests a “smart” total treatment plan using chemotherapy (chemo) and radiation before surgery for people with locally advanced rectal cancer. The goal is to see if this approach is safe and can work well while helping plan treatment based on your situation.
Miami, FloridaAges 18 years+ - NCT06455124RecruitingPhase 2
Short radiation and chemo-immunotherapy for early rectal cancer after local surgery
This trial tests a combination of short-course radiation, chemotherapy (CapeOx), and an immunotherapy drug (PD-1 inhibitor) for people with early-stage rectal cancer who have had a local excision but are at high risk of the cancer coming back. The goal is to avoid more extensive surgery while still effectively treating the cancer.
ShanghaiAges 18–75 - NCT02649647Recruiting
Surgery plan for rectal cancer after chemo-radiation
This trial looks at a specific type of rectal surgery after you’ve already finished chemo-radiation, aiming to remove the tumor while trying to preserve the anal sphincter (muscle control). It’s meant for people whose cancer can be safely operated on and who don’t have spread to distant organs.
Guangzhou, GuangdongAges 18–75 - NCT07454720RecruitingPhase 2/Phase 3
Study of Adebrelimab with SHR-8068 and chemoradiation before surgery for rectal cancer
This trial tests whether adding two immunotherapy drugs (adebrelimab and SHR-8068) to standard chemoradiation before surgery can improve outcomes for adults with locally advanced rectal cancer that can be surgically removed.
Wuhan, HubeiAges 18–75 - NCT07337811Recruiting
Selective removal of rectal cancer after radiation and chemotherapy
This trial tests how well a precise surgery removes the remaining rectal cancer after you have had radiation and chemotherapy. It is for people whose tumor has shrunk a lot but is still there, and the tumor is very low in the rectum.
Guangzhou, GuanggongAges 18–75 - NCT07297004RecruitingPhase 2
Targeted radiation for recurrent rectal cancer
This trial tests targeted radiation (SBRT) for people whose rectal cancer has come back in the pelvis and cannot be surgically removed. The goal is to see if this focused radiation can control the tumor with fewer side effects.
Guangzhou, GuangdongAges 18–75 - NCT07245745Recruiting
Comparing two types of radiotherapy for prostate cancer
This trial compares adaptive radiotherapy (which adjusts to changes in your body) with conventional radiotherapy for prostate cancer. It aims to see which approach leads to better patient-reported outcomes.
BrusselsAges 18 years+ - NCT07448142RecruitingPhase 2
Low-dose radiation with immunotherapy and chemo for advanced rectal cancer
This trial tests a combination of low-dose radiation, an immunotherapy drug called pucotenlimab, and chemotherapy for locally advanced rectal cancer that has not spread. The goal is to see if adding radiation helps shrink the tumor more effectively before surgery.
Guangzhou, GuanggongAges 18–75 - NCT07514754Recruiting
Immunonutrition support during cancer treatment
This study tests whether special nutritional support (called immunonutrition) helps patients with head and neck, lung, or rectal cancer who are receiving chemotherapy, radiation, or immunotherapy. The goal is to see if it improves how well treatment works and how you feel during and after cancer care.
Candiolo, Torino (TO)Ages 18 years+ - NCT07721181Recruiting
STEP-UP: Higher radiation for recurrent rectal cancer
This trial tests giving a higher dose of radiation to people whose rectal cancer has come back in the pelvis after surgery and cannot be removed. It aims to see if more radiation can help control the tumor when surgery is not an option.
Maastricht, LimburgAges 18 years+ - NCT07646639RecruitingPhase 2
Radiation, chemotherapy, and immunotherapy for advanced rectal cancer
This study tests a combination of radiation therapy, chemotherapy drugs (capecitabine and oxaliplatin), and two types of immunotherapy (a PD-1 blocker and IL-2) for locally advanced rectal cancer. The goal is to see if this combination helps shrink tumors and improve outcomes before surgery.
Nanjing, JiangsuAges 18–70 - NCT06837831Recruiting
Mepilex Lite Dressing for radiation skin damage on anal area
This trial tests a special wound dressing (Mepilex Lite) to treat skin burns from radiation therapy in patients with rectal cancer. It may help heal the skin around the anal canal more comfortably.
Jinan, ShandongAges 18 years+
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Common questions
- Are there clinical trials for rectal cancer, radiotherapy?
- Yes. Clin2 currently lists 209 recruiting rectal cancer, radiotherapy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a rectal cancer, radiotherapy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a rectal cancer, radiotherapy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.