Clinical trials
Rectal Cancer, Radiotherapy clinical trials
Below are recruiting rectal cancer, radiotherapy clinical trials, each written for real people, not researchers. We’re tracking 209 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06204094RecruitingPhase 2
Preserving the anus with chemo, immunotherapy, and radiation for rectal cancer
This trial tests a treatment plan that combines chemotherapy, immunotherapy, and radiation before surgery for patients with middle or low rectal cancer. The goal is to shrink the tumor enough to avoid removing the anus, preserving bowel function.
Jinhua, ZhejiangAges 18–75 - NCT06162650RecruitingPhase 2
Pre-surgery chemo-radiation therapy for rectal cancer
This trial tests a combination of chemotherapy and radiation therapy before surgery for people with mid or low rectal cancer that hasn't spread. The goal is to see if this approach works better than current treatments.
TainanAges 20 years+ - NCT06123156RecruitingPhase 3
Early erectile rehabilitation after rectal cancer treatment
This trial tests if sildenafil (Viagra) given soon after surgery and radiation for rectal cancer can help preserve erectile function. It is for men with normal erectile function before treatment who have a regular partner.
AmiensAges 18–70 - NCT06051695RecruitingPhase 1/Phase 2
CAR T cell therapy for mesothelin-positive solid tumors
This trial tests a new type of immune cell therapy (CAR T-cells) designed to target cancer cells that have a protein called mesothelin but have lost a marker that lets them hide from the immune system. It's for people with advanced solid tumors who have already tried standard treatments.
Gilbert, ArizonaAges 18 years+ - NCT06052332Recruiting
Comparing two pre-surgery treatments for older adults with rectal cancer
This study compares two approaches to treating rectal cancer in people age 70 and older who have not yet had surgery. One approach gives chemotherapy and radiation before surgery, and the other adds more chemotherapy after radiation. The goal is to find which plan works better with fewer side effects.
Antwerp, AntwerpenAges 70 years+ - NCT05943210Recruiting
Molecular testing of rectal cancer after short-course radiation
This study looks at molecular (tumor biology) features of rectal cancer in people receiving standard short-course radiation. Your tissue and/or samples may be used to better understand the cancer and how it responds to treatment.
Chicago, IllinoisAges 18–90 - NCT05868226RecruitingPhase 1/Phase 2
Personalized cancer treatment study for advanced solid tumors
This study tests different treatments tailored to your cancer's biology. It aims to find which therapy might work best for you, potentially improving outcomes. You'd receive one of the study drugs, with close monitoring and support.
Birmingham, AlabamaAges 18 years+ - NCT05338866Enrolling by invitation
Chemo plus targeted high-dose radiation for low rectal cancer
This trial tests whether combining chemotherapy with high-dose radiation guided by MRI (a special scan) can better treat low rectal cancer. It may help shrink the tumor and improve local control while targeting the tumor more precisely.
Guangzhou, GuangdongAges 18–80 - NCT05024097RecruitingPhase 2
New medicines with chemotherapy after short radiation for rectal cancer
This trial tests two new immune-related medicines (an anti–PD-1 drug and an adenosine blocker) added to standard chemotherapy after a short course of radiation for rectal cancer. It aims to improve cancer control while checking safety.
New York, New YorkAges 18–90 - NCT04095299RecruitingPhase 3
Standard vs high-dose radiotherapy for rectal cancer
This Phase 3 trial compares standard-dose and higher-dose radiotherapy given along with chemotherapy in people with rectal cancer. The goal is to see whether a higher dose can improve rectal cancer outcomes while keeping the rectum functioning and avoiding too much harm.
AalborgAges 18 years+ - NCT04703101RecruitingPhase 1
Short radiation plus chemo for stage II–III rectal cancer
This trial tests a short course of radiation therapy combined with chemotherapy for people with stage II or III rectal cancer. It’s designed to see whether this approach is safe and effective before or around cancer surgery.
Los Angeles, CaliforniaAges 18 years+ - NCT04643041Recruiting
Watch-and-wait after PD-1 for certain rectal cancer
This study looks at whether people with a very strong response to a PD-1 antibody can safely delay or avoid more standard rectal cancer treatment (a “watch-and-wait” approach). It may help some people avoid surgery, radiation, or ongoing treatment while still closely monitoring the cancer.
Guangzhou, GuangdongAges 18–80 - NCT04215731RecruitingPhase 3
Chemo plus targeted drug before surgery for high-risk rectal cancer
This trial tests giving chemotherapy (mFOLFOXIRI) plus bevacizumab before surgery for rectal cancer that has higher-risk features. It aims to shrink or control the cancer early to improve outcomes after treatment.
Guangzhou, GuangdongAges 18–70 - NCT04098471Recruiting
Comparing two rectal cancer surgeries for T2 tumors
This trial compares two different surgery approaches for early-stage rectal cancer (T2N0M0) that is close to the anus. It tests whether a less invasive local removal followed by radiation works as well as more extensive surgery (total mesorectal excision).
Nanjing, JiangsuAges 18–75 - NCT03853733Recruiting
Shorter radiation plan for non-surgery rectal cancer
This trial looks at a shorter radiation schedule for people with advanced rectal (or nearby sigmoid) cancer who cannot have surgery. The goal is to control the cancer while keeping treatment simpler, especially for those who cannot safely undergo an operation.
Terrassa, CataloniaAges 18 years+ - NCT03573791Recruiting
Testing markers to predict chemo-radiation response in rectal cancer
This trial studies lab “biomarkers” (measurable cancer features) to predict whether rectal cancer will resist chemo-radiation before surgery. The goal is to help doctors better choose treatments and avoid ineffective therapy.
Wuhan, HubeiAges 18–75 - NCT03516708RecruitingPhase 1/Phase 2
Epacadostat with pre-op radiation for locally advanced rectal cancer
This trial studies whether adding epacadostat (a cancer drug) to standard pre-operative chemoradiation can improve outcomes for people with locally advanced rectal cancer. It’s designed to see if the added treatment is safe and potentially more effective before surgery.
Orange, CaliforniaAges 18 years+ - NCT03051464RecruitingPhase 2/Phase 3
Testing two ways to boost radiation to prevent rectal surgery
This study looks at whether two different added “boosts” of radiation can work as well for rectal cancer patients, aiming to avoid or reduce the need for rectal cancer surgery. You would receive a specific combination of radiation (including brachytherapy) and chemotherapy, and your tumor’s location and size will determine if you can take part.
Dallas, TexasAges 18–80 - NCT05228431RecruitingPhase 2
Tested treatment plan for locally advanced rectal cancer
This Phase 2 study looks at a modified “sandwich” treatment sequence for people with locally advanced rectal cancer—aiming to control the cancer before and after surgery. It may help you if you’re eligible and can follow the study’s treatment and safety requirements.
Guangzhou, GuangdongAges 18–75 - NCT07622771RecruitingPhase 2
Radiation, chemotherapy, and immunotherapy for advanced rectal cancer
This trial tests a combination of radiation therapy, a chemotherapy drug called NALIRIFOX, and an immunotherapy drug called adebrelimab for rectal cancer that has grown into nearby tissue or lymph nodes. The goal is to see if this combination helps shrink the tumor before surgery and improves outcomes.
Guangzhou, GuangdongAges 18–75 - NCT07616297Recruiting
Higher Radiation Dose to Avoid Surgery in Rectal Cancer
This study tests whether giving a higher dose of radiation to rectal cancer tumors can help patients avoid surgery altogether. The goal is to shrink the tumor enough that surgery is no longer needed, preserving normal bowel function.
Rotterdam, South HollandAges 18 years+ - NCT06840665RecruitingPhase 2
Radiation plus immunotherapy and chemo for rectal cancer
This trial combines a special type of radiation (MRI-guided adaptive radiotherapy) with an immunotherapy drug (PD-1 antibody) and chemotherapy (CAPOX) for locally advanced rectal cancer. The goal is to see if this combination can improve treatment outcomes.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT04525989Recruiting
Short-course proton vs photon radiation before rectal surgery
This study compares two types of pre-surgery radiation—protons versus standard photons—in people with high-risk rectal cancer. The goal is to shrink and control the tumor while safely getting you ready for surgery, and to see which approach works better.
Stockholm, SolnaAges 18 years+ - NCT03190941RecruitingPhase 1/Phase 2
T-cell therapy for HLA-A11:01 and KRAS G12V tumors
This trial tests a custom immune-cell treatment made from your blood that targets the KRAS G12V change in certain cancers. It is for people with advanced cancer who have already tried standard treatments, and it may help your immune system recognize and attack tumor cells.
Bethesda, MarylandAges 18–72
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Common questions
- Are there clinical trials for rectal cancer, radiotherapy?
- Yes. Clin2 currently lists 209 recruiting rectal cancer, radiotherapy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a rectal cancer, radiotherapy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a rectal cancer, radiotherapy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.