Respiratory clinical trials

Closed-loop breathing control vs standard care for kids in ICU

This study compares a computerized “closed-loop” system that helps match breathing support to a child’s needs versus usual (standard) breathing control. It’s for critically ill children on a breathing machine, aiming to improve synchronization between the child and the ventilator.

Breath and heart tests to study lung disease stiffness

This study uses breath analysis and heart/electrical heart testing to look at how stiff the arteries are in people with long-term lung conditions. It may help researchers better understand lung disease effects on the cardiovascular system.

Measuring diaphragm breathing signals during ICU ventilation

This study measures electrical activity of the diaphragm and how your breathing system works while you are on a breathing machine in the ICU. It may help doctors better understand breathing during recovery after major lung events.

Improving breathing support during flexible bronchoscopy

This trial studies how to give oxygen and breathing support during a flexible bronchoscopy (a camera test through the airways). It may help make the procedure safer and more comfortable by refining the way oxygen is managed during the test.

Test a breathing-device method to reduce breathing effort

This trial checks whether a special “through-flow” system can safely reduce how hard your body has to breathe when you are on a breathing machine. It is mainly a feasibility study, meaning the focus is on whether the approach can be done safely and effectively.

Testing blood-clot guidance for ICU patients with severe lung failure

This Phase 2 trial tests whether using a blood test that shows clotting strength and “clot breakdown time” can help guide treatment for people in the ICU with acute respiratory failure from infection. If you qualify, the team will use these blood results to decide on clot-related therapy and compare outcomes to standard care.

Study how autoantibodies affect virus levels in severe lung infections

This study measures blood immune “autoantibodies” that may affect how much virus is in the body during severe respiratory infections. It may help doctors understand which patients are more likely to have higher virus levels and could guide future treatment choices.

Vaginal seeding to change a baby’s early gut microbes

This early-phase study looks at whether swabbing a mother’s vagina during a planned C-section (“vaginal seeding”) can help shape a newborn’s early respiratory and gut microbes. The goal is to see if this approach is safe and may influence early-life breathing health.

Respiratory Health Registry measuring lung function in different groups

This registry study collects information and measures lung function to better understand respiratory health across people with cystic fibrosis, other lung diseases, and healthy volunteers. Your results may help researchers track lung health and improve future research and care.

Breathing training to reduce anxiety symptoms

This study tests whether specific respiratory (breathing) training can reduce anxiety symptoms and fear responses. It may help people who have several kinds of anxiety or trauma-related anxiety, especially if they are not on anxiety medicines or only stable on them.

Tested treatment with tiny lung particles for moderate to severe ARDS

This Phase 3 trial studies an “extracellular vesicle” treatment in people with moderate to severe ARDS, a serious lung breathing problem. The goal is to see whether the treatment can improve outcomes compared with standard care.

Testing a lung opening breathing pattern in early ARDS

This study looks at a specific breathing event (“avalanche phenomenon”) when the lungs are opened in people with early, moderate-to-severe ARDS. The goal is to understand what’s happening in the lungs and whether it can guide better care.

Lung MRI registry to track breathing health

This study builds a lung imaging registry using MRI pictures to learn how breathing health looks and changes. It may help researchers understand lung problems and how well different people can complete breathing-related MRI scans.

Breathing muscle testing in children with breathing muscle weakness

This study looks at how hard it is for children to breathe and how their breathing muscles work, using specific breathing-related tests. It may help doctors better understand breathing problems and choose care more effectively.

Antibiotics for certain viral lung infections in hospitalized adults

This trial studies whether giving antibiotics affects recovery in adults hospitalized with moderately severe infections caused by specific viruses (influenza, parainfluenza, RSV, or hMPV). It may help show when antibiotics are helpful or unnecessary for viral airway illness.

After a chemical, biological, or nuclear disaster exposure

This trial studies how patients are medically managed after being exposed to a chemical, biological, radiological, or nuclear (CBRNE) attack. It may help improve care for people who are treated after these rare disasters, using real medical information recorded by hospital staff.

Prone positioning for very sick babies with lung distress

This trial tests whether turning very sick, ventilated infants onto their stomach (prone positioning) can improve breathing when they have severe lung distress from likely pneumonia or bronchiolitis. It may help your baby get better oxygen levels and recover faster, while doctors closely monitor safety.

PET scan study of brain inflammation after COVID

This early-phase study uses a special PET scan to look for signs of brain inflammation in people with ongoing (long-term) nervous system symptoms after COVID-19. It may help researchers understand what is driving symptoms and whether this imaging approach can detect inflammation.

Testing music to improve breathing and brain oxygen in preemies

This study looks at whether planned music sessions can help preterm babies breathe more steadily and improve oxygen reaching the brain. It may help staff learn how to use music therapy safely for newborns in the NICU.

Exercise and breathing study for young adults with vocal cord issues

This study looks at how the vocal cords move during exercise in young adults who have trouble breathing while active. It may help researchers understand why this happens and how to better diagnose and treat it.

Collecting respiratory virus samples for a research library

This study collects samples from people who have or might have a cold/respiratory virus, then stores them for future research. It may help researchers better understand respiratory germs and develop better treatments.

Pain block comparison for recovery after liver surgery

This study compares two types of pain-relieving nerve blocks used during liver surgery to see which one helps you breathe better and recover more comfortably after the operation.

Vascular ARDS Recruitment After Inhaled Nitric Oxide

Comparing two blood pressure medicines for newborns with lung hypertension

This trial compares two medicines (dopamine and norepinephrine) to see which works better for raising blood pressure in newborns who have both low blood pressure and high blood pressure in the lungs. Both medicines are given through a vein to help stabilize your baby's blood pressure.