Clinical trials
Rotator Cuff clinical trials
Below are recruiting rotator cuff clinical trials, each written for real people, not researchers. We’re tracking 156 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06414005RecruitingPhase 2/Phase 3
TPX-115 injection for partial-thickness rotator cuff tear
This trial tests an injection called TPX-115 for people with a partial-thickness rotator cuff tear (a shoulder tendon injury that doesn't go all the way through). It may help reduce pain and improve movement if you've had shoulder problems for more than 3 months despite other treatments.
Seongnam-si, Gyeonggi-doAges 19 years+ - NCT06766630RecruitingPhase 2/Phase 3
Silk mesh for rotator cuff tear repair
This trial tests a new silk-based surgical mesh to help repair large rotator cuff tears. It's for people who have not gotten better with other treatments and need surgery.
Hangzhou, ZhejiangAges 50–75 - NCT06971497Recruiting
ActivBraid implant for rotator cuff repair study
This study tests a special implant (ActivBraid) to help repair a torn rotator cuff. If you have a moderate-sized tear and haven't had prior shoulder surgery, you may be able to join.
Cleveland, OhioAges 18–75 - NCT07415967Recruiting
Dual-task exercise for rotator cuff shoulder pain
This study tests an exercise program that combines shoulder movements with mental tasks (like counting or naming things) to improve pain and function. It is for people with ongoing shoulder pain from common rotator cuff problems.
IstanbulAges 18–65 - NCT04057833Enrolling by invitationPhase 1
Cell treatment added to rotator cuff repair surgery
This Phase 1 study tests whether an added cell therapy (E-CEL UVEC cells) can improve healing after arthroscopic (keyhole) rotator cuff repair. It may help people with a specific type of tendon tear who have not improved with standard treatments.
New York, New YorkAges 45–70 - NCT07232511Recruiting
Cuff-assisted exercise for shoulder pain
This study tests whether using a blood pressure cuff during gentle shoulder exercises can help reduce pain and improve movement. It is for people with ongoing shoulder pain related to the rotator cuff (the muscles and tendons that help lift and rotate your arm).
Valencia, ValenciaAges 18–65 - NCT05981833Recruiting
Donated skin graft for large rotator cuff tears
This study tests whether adding a donated skin graft during rotator cuff repair helps heal large tears better than repair alone. It may be an option for people with a first-time, large rotator cuff tear who have moderate to severe fatty changes in the muscle.
Scottsdale, ArizonaAges 30–75 - NCT07228936Recruiting
Pectoralis minor tightness and rotator cuff tears
This trial looks at whether tightness in a small chest muscle (pectoralis minor) is linked to rotator cuff tears. If you have a partial rotator cuff tear or a healthy shoulder, you might be able to join to help answer this question.
Ankara, CankayaAges 18–55 - NCT04831164Recruiting
Study of shoulder rotator cuff tears and genetics
This study looks at how genes and risk factors relate to rotator cuff tears by comparing people with and without these tears. It may help researchers understand why tears happen and who is most at risk.
Iowa City, IowaAges 40–85 - NCT05896475Recruiting
Looking for who may develop shoulder pain from silent tears
This study looks at risk factors that predict when an “asymptomatic” (painless) rotator cuff tear might start causing symptoms. You may benefit by getting careful assessment and monitoring of your shoulder health over time.
Ghent, Oost-VlaanderenAges 55–100 - NCT07628244Recruiting
Anesthesia methods for rotator cuff shoulder surgery
This trial compares two different anesthesia maintenance approaches during arthroscopic (keyhole) rotator cuff repair surgery to see which one provides better visibility for the surgeon. You would receive general anesthesia combined with a nerve block in your shoulder.
Nice, Alpes-MaritimesAges 18 years+ - NCT07632729Enrolling by invitation
Knowledge of Results Training for Shoulder Pain
This study tests whether giving you immediate feedback during shoulder exercises helps reduce rotator cuff-related shoulder pain. The rotator cuff is a group of muscles and tendons in your shoulder; this trial focuses on people with impingement, bursitis, tendon inflammation, or small tears.
Ankara, SıhhıyeAges 18–35 - NCT05327972RecruitingPhase 2
Botox injections for painful degenerative rotator cuff disease
This Phase 2 study tests whether botulinum toxin (Botox) injections can reduce pain from long-lasting degenerative rotator cuff problems. You may be eligible if you have shoulder pain for over a month and ultrasound evidence of specific tendon irritation.
Paris, ParisAges 41 years+ - NCT07578168Enrolling by invitation
Kinesio Tape for Rotator Cuff Shoulder Pain
This study tests whether kinesiology tape (a special stretchy tape applied to the skin) can reduce pain and improve function in people with rotator cuff syndrome, a common shoulder condition. You'll be randomly assigned to receive the tape or a control treatment and tracked over several weeks.
Kırşehir, MerkezAges 18–65 - NCT05266339Enrolling by invitation
Testing mirror training after rotator cuff repair
This trial looks at whether mirror-based arm exercises (“cross-education”) help recovery after arthroscopic rotator cuff surgery. It may help improve shoulder movement and function by training the other arm to support rehab.
Istanbul, BakırkoyAges 35–65 - NCT01193647Enrolling by invitation
Study genetics that may raise rotator cuff injury risk
This study looks at genetic (inherited) factors that may make some people more likely to develop rotator cuff tears. You may be able to join if you’ve had a shoulder MRI for pain or you’re a close family member of someone with a documented tear.
Salt Lake City, UtahAges 18 years+ - NCT06723730Recruiting
Mobilization and core strength for rotator cuff pain
This trial tests if adding a specific type of shoulder movement therapy and upper body core exercises can reduce pain and improve function in people with rotator cuff-related shoulder pain. It may help you if you have had shoulder pain for more than 6 weeks and it started after an injury.
Rawalpindi, Punjab ProvinceAges 18–65 - NCT07448584Recruiting
Study of shoulder repair with Lok™ suture anchors
This trial tests how well Lok™ suture anchors work for repairing certain shoulder problems like rotator cuff tears, shoulder instability, or partial tears. It is for people whose MRI confirms the injury and who haven't had prior shoulder surgery on that side.
Valence, Auvergne-Rhône-AlpesAges 18 years+ - NCT05300607Recruiting
Arabic rotator cuff shoulder questionnaire for tendon tears
This study tests an Arabic version of a shoulder questionnaire for people with rotator cuff problems. It may help doctors better understand symptoms and track how well treatment works using a tool written in your language.
CairoAges 18–60 - NCT04571918Recruiting
Arthroscopic repair using a biodegradable spacer for severe shoulder tears
This study looks at an arthroscopic procedure (a minimally invasive surgery) that includes cleaning the tear and placing a biodegradable spacer to treat painful, severe rotator cuff tears. It may help reduce pain and improve shoulder function in people who have tried non-surgical treatments but still have symptoms.
ArendalAges 60–85 - NCT05925881Recruiting
Surgery for large shoulder tears: two repair methods compared
This trial compares two surgical approaches to fix a very large, irreparable rotator cuff tear. It may help people understand which technique leads to better shoulder function and recovery.
Halifax, Nova ScotiaAges 18 years+ - NCT06960343Recruiting
Shoulder repair with fat tissue for better healing
This trial tests whether adding a small amount of your own fat tissue to standard shoulder surgery helps the torn tendons heal better and last longer. It is for people with a full-thickness tear of the supraspinatus and infraspinatus tendons that needs arthroscopic repair.
Milan, ItalyAges 18 years+ - NCT04975581RecruitingPhase 4
Repairing a rotator cuff tear with a dermal patch
This trial studies whether repairing a rotator cuff tear using a patch made from human donor skin improves healing and shoulder function. It is for people with certain types of degenerative tears that can be fully repaired by surgery.
LeicesterAges 50–75 - NCT06553716Recruiting
Shoulder injection for frozen shoulder: a trial
This trial tests whether an ultrasound-guided injection of fluid and a steroid (triamcinolone acetonide) into the stiff shoulder joint can help improve range of motion and reduce pain in people with frozen shoulder (adhesive capsulitis).
Yinchuan, NingxiaAges 18–75
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Common questions
- Are there clinical trials for rotator cuff?
- Yes. Clin2 currently lists 156 recruiting rotator cuff studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a rotator cuff trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a rotator cuff trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.