Thyroid Cancer clinical trials

Trophoblast Cell-Surface Antigen 2 (Trop-2) Targeted PET/CT in Recurrent and Metastatic Thyroid Cancer

Family study of non-medullary thyroid cancer and genetics

This study looks at families affected by non-medullary thyroid cancer to understand patterns and possible genetic risk. You may be able to join even if you personally do not have the cancer, as long as you have the right family history and can complete a questionnaire.

Artificial tears to prevent tear duct blockage during RAI therapy

This study tests if using artificial tears (eye drops that keep your eyes moist) can prevent tear duct blockage in people receiving high-dose radioactive iodine for thyroid cancer. If you qualify, you will use artificial tears during your treatment to see if they help keep your tear ducts open.

Lutetium-177 LNC1004 for advanced thyroid cancer that no longer responds to standard treatments

This trial tests a radioactive drug called 177Lu-LNC1004 for people with a type of thyroid cancer that is no longer responding to standard treatments. The drug targets a protein called FAP found on tumor cells, which may help shrink tumors and slow disease progression.

MRI scan tests new markers for head and neck cancers

This trial tests special MRI scans to find warning signs of cancer that has returned or spread in the head and neck area. It may help doctors see these changes more clearly, which could improve treatment planning.

Using 68Ga-FAPI PET/CT scan for thyroid cancer lymph nodes

This study uses a special type of PET/CT scan (68Ga-FAPI) to see how well it finds cancer spread in lymph nodes before thyroid cancer surgery. It may help doctors plan your treatment more accurately.

Imaging removed tissue during cancer surgery

This study tests a high-resolution PET-CT scanner that takes pictures of tissue removed during surgery to help doctors see if all the cancer has been removed. You might qualify if you are having surgery for a range of cancers including breast, prostate, thyroid, skin, gastrointestinal, or brain tumors.

Better predicting easy thyroid removal through mouth or under chin

This study compares two approaches for thyroid removal surgery—one through the mouth and one under the chin—to find which is easier to perform. It is for people with thyroid nodules or early thyroid cancer that hasn't spread.

Video to help patients decide on thyroid surgery

This trial tests whether an educational video helps people feel more confident and satisfied when giving consent for thyroid surgery. It is for adults having their first thyroid surgery, such as a partial or full removal of the thyroid gland.

Active surveillance for Bethesda IV thyroid nodules

This study is testing whether it is safe to simply monitor (watch closely) a small thyroid nodule that has a certain biopsy result (Bethesda IV) instead of removing it right away. You would not receive a treatment, but would have regular checkups and ultrasounds to see if the nodule changes.

Registry for advanced thyroid cancer treatments

This study collects real-world information from patients with advanced thyroid cancer to better understand how standard treatments and specialized procedures work. Your participation will help improve care for others with this type of cancer.

Thermal ablation for small, low-risk thyroid cancer

This trial is studying a treatment called thermal ablation (using heat to destroy cancer cells) for people with small, low-risk papillary thyroid cancer. It aims to see how well it works and to predict outcomes.

Pharmaceutical management in targeted radionuclide therapy study

This study is for adults who are getting targeted radionuclide therapy and have a pharmacist involved in managing their medicines. It looks at how the medication is handled to improve treatment safety and effectiveness.

Study of tunlametinib for NRAS-mutant advanced thyroid cancer

This trial tests a targeted drug (tunlametinib) for advanced thyroid cancer that has a specific genetic change called NRAS mutation. It may help people whose cancer is not responding to standard treatments like radioactive iodine.

Thyroid hormone therapy after lobectomy for low-risk thyroid cancer

This trial is testing whether thyroid hormone replacement after surgery is safe for people with low-risk papillary thyroid cancer. It may help maintain normal hormone levels after part of the thyroid is removed.

Testing an iodine-like PET/CT scan for thyroid cancer

This study checks how well a new PET/CT scan (18F-TFB) can find thyroid cancer after a standard iodine whole-body scan. It may help doctors see where the cancer is using an added imaging test, which could improve planning for care.

Study medicine for BRAF-mutated advanced solid tumors

This Phase 1 trial studies how PF-07799544 works and what dose is safest in people with advanced cancer that has a specific genetic change called BRAF V600. You may receive it alone or with another treatment, depending on the tumor group, to see if it can treat the cancer.

Testing a new drug for advanced cancers with BRAF changes

This Phase 1 trial studies PF-07799933, a new medicine, in people whose advanced solid tumors have specific BRAF genetic changes. It may help if your cancer has continued to grow after standard treatments, and there may be specific options depending on your cancer type and past therapies.

Test drug APL-101 for lung or other tumors with MET changes

This Phase 2 study tests APL-101 to shrink advanced cancers that have certain MET-related changes, including specific MET mutations, MET gene amplification, or MET fusions. It may help people whose tumors have run out of standard treatment options.

New treatment for thyroid cancer that spread to neck lymph nodes

This study tests a minimally invasive treatment called irreversible electroporation for thyroid cancer that has come back or spread to lymph nodes in the neck. It may be an option for people who can't have another surgery or for whom radioactive iodine therapy hasn't worked.

Surgery for Thyroid Cancer With or Without Special Light to Protect Calcium Glands

This study tests whether using a special light (called autofluorescence) during thyroid cancer surgery helps lower the risk of a common side effect—hypoparathyroidism, which can cause low calcium levels. You may be able to join if you are scheduled for a complete thyroid removal and have normal calcium before surgery.

Wellness Coaching for Thyroid Cancer Survivors

This study tests whether personalized health coaching helps thyroid cancer survivors stick to their treatment plans and build healthier habits. You'll work with a coach to improve your overall wellness after thyroid cancer treatment.

Thyroid cancer after childhood radiation therapy

This study looks at thyroid cancer in people who had radiation therapy as children, comparing them to people who did not have radiation. The goal is to see how often thyroid cancer develops after childhood radiation.

Study of thinking and quality of life after thyroid surgery

This study looks at how thyroid surgery affects thinking (cognition) and day-to-day quality of life. It may help patients and doctors understand what to expect and how to support people after surgery.