Clinical trials
Treatment Failure clinical trials
Below are recruiting treatment failure clinical trials, each written for real people, not researchers. We’re tracking 139 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07734987Recruiting
Root tip surgery accuracy with a 3D-printed guide
This trial tests whether using a custom 3D-printed guide helps make root-end surgery more accurate and improves healing. It may be right for you if you have an infected or damaged root tip that needs surgery.
Ho Chi Minh CityAges 16 years+ - NCT05068531Recruiting
Detecting early treatment failure in stage IV colon cancer
This study looks for early signs that treatment is not working in people with stage IV colon or rectal cancer that has spread only to the liver. It may help doctors adjust care sooner by using regular blood, stool, and tissue samples around liver procedures.
Montreal, QuebecAges 18 years+ - NCT05520398Recruiting
Brain-targeting study of why OCD treatments may fail
This study looks at brain signals to understand why OCD treatments may not work for some people. If you have OCD and are about to start OCD therapy, you may be invited to take part.
LondonAges 18–55 - NCT06195189RecruitingPhase 1/Phase 2
Sunvozertinib Plus Chemo for EGFR Lung Cancer After TKI Failure
This trial tests a new pill (sunvozertinib) combined with chemotherapy for people with a specific EGFR mutation type of lung cancer whose previous targeted pill stopped working. It aims to see if the combination can shrink tumors or slow the cancer's growth.
Chengdu, SichuanAges 18–80 - NCT06405464Recruiting
Long-acting HIV shots vs daily pills in the Swiss HIV Cohort
This study looks at how well the long-acting injectable HIV treatment (cabotegravir plus rilpivirine) works in real life, compared to daily pills. It follows people in the Swiss HIV Cohort Study to understand who benefits most and why.
ZurichAges 18 years+ - NCT06663007RecruitingPhase 1/Phase 2
RC48 alone or with envafolimab for advanced prostate cancer with CDK12 changes
This trial tests a drug called RC48, alone or with envafolimab, for men with a specific type of advanced prostate cancer that has not responded to standard treatments. It aims to see if this combination can shrink tumors or slow disease progression.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT06717243Recruiting
Study on gene markers in lung cancer for treatment resistance
This study looks at genetic markers in two types of lung cancer (small cell and large cell neuroendocrine) to understand why some tumors stop responding to a standard treatment that combines chemotherapy with immunotherapy. If you have one of these cancers and are about to start this treatment, you may be able to join.
New York, New YorkAges 18–85 - NCT06916481Recruiting
Pneumonia subtypes based on lung bacteria
This study looks at the germs in your lungs to understand why some people's pneumonia doesn't get better with standard antibiotics. If you are hospitalized with pneumonia and have just started treatment, you may be asked to provide a sputum sample so researchers can study your lung microbiome.
ClichyAges 18 years+ - NCT05248919Enrolling by invitation
Study treatment for hepatitis C that did not work before
This trial looks at hepatitis C treatment for people whose last antiviral medicines did not fully clear the virus. It may help by testing a study drug approach for people in Pakistan who still have active hepatitis C infection.
Karachi, SindhAges 18–100 - NCT05540834RecruitingPhase 2
Testing blood-clot guidance for ICU patients with severe lung failure
This Phase 2 trial tests whether using a blood test that shows clotting strength and “clot breakdown time” can help guide treatment for people in the ICU with acute respiratory failure from infection. If you qualify, the team will use these blood results to decide on clot-related therapy and compare outcomes to standard care.
Liverpool, New South WalesAges 18–75 - NCT06785506Recruiting
Personalized heart failure treatment using multiple biomarkers
This trial tests if using a combination of biomarkers can help personalize treatment for people with a specific type of heart failure called HFpEF (or heart failure with preserved ejection fraction). It aims to find better treatments based on your individual test results.
Alkmaar, North HollandAges 18 years+ - NCT06452966Recruiting
Traditional Chinese medicine for organ failure in ICU
This trial is studying whether adding traditional Chinese medicine (TCM) to standard care can help patients in the surgical ICU recover from organ failure. It looks at how TCM might support your body's organs during critical illness.
TaichungAges 20 years+ - NCT06397833Recruiting
Monitoring heart pressure after heart failure hospitalization
This study is testing a new wearable device (Acorai ICPM) that measures pressure inside your heart. The goal is to see if it can help predict how well you will do after being discharged from the hospital for heart failure.
Uxbridge, MiddlesexAges 18 years+ - NCT07269717RecruitingPhase 2
Testing HRS-1893 for heart failure with preserved ejection fraction
This trial tests a new drug called HRS-1893 for people with heart failure with preserved ejection fraction (HFpEF). It aims to see if the drug can improve symptoms and quality of life.
Shanghai, Shanghai MunicipalityAges 40 years+ - NCT07486791Recruiting
Baduanjin exercise for heart health after heart attack
This study tests whether a gentle exercise called 'Lying-Sitting-Standing' Baduanjin can improve heart and lung function and quality of life in people who have had a heart attack and also have heart failure.
Taiyuan, ShanxiAges Up to 85 years - NCT05373758Recruiting
Help for people whose HIV treatment is not working
This trial tests different ways to manage “virologic failure,” meaning HIV viral load stays high while taking TLD (a common HIV medicine combination). It may help people better control the virus and improve treatment results, especially in parts of sub-Saharan Africa.
DurbanAges 15 years+ - NCT02161783Recruiting
Second transplant for blood stem cell graft failure
This trial studies treatment after a first stem cell transplant fails to produce lasting blood recovery. It may help people who need a second transplant because their counts never fully recovered or then dropped again.
Minneapolis, MinnesotaAges Any age - NCT06128980RecruitingPhase 2/Phase 3
Stopping heart meds after recovery from fast heartbeat damage
This trial tests if patients whose heart function returned to normal after treating a fast heartbeat can safely stop their heart failure medications. It aims to see if treatment can be withdrawn without the heart problems coming back.
CopenhagenAges 18 years+ - NCT06441032Enrolling by invitation
Metal crown survival study
This study looks back at patient records to see how long single-tooth crowns and partial crowns made of precious metal or non-precious metal last. It aims to find out which type of metal may hold up better over time.
Göttingen, Lower SaxonyAges Any age - NCT06562062Recruiting
New surgery for flexible flat foot
This study tests a modified surgical technique to fix a painful, flexible flat foot in adults who haven't improved with nonsurgical care. It may help by repairing a key ligament on the outside of the knee to support the arch.
Asyut, AssiuuAges 16–65 - NCT05152472RecruitingPhase 2
Imatinib plus atezolizumab versus imatinib alone for advanced GIST
This Phase 2 trial tests whether adding atezolizumab (an immune medicine) to imatinib works better than imatinib by itself in people with advanced gastrointestinal stromal tumors (GIST) that can’t be fully removed and have progressed after standard treatments. It may help by improving how well tumors respond and how long disease stays under control.
Lyon, RhôneAges 18 years+ - NCT01790152Recruiting
Dexrazoxane study to monitor heart damage in cancer survivors
This study tests dexrazoxane (DRZ) to see how it affects blood and heart-related “biomarkers,” or measurable signs of heart damage, after cancer treatment. It mainly targets survivors who may be at risk for cardiomyopathy (heart muscle weakness) or related heart failure.
Birmingham, AlabamaAges Any age - NCT06968533Enrolling by invitation
AI ECG for detecting low heart pumping in older adults
This trial uses an AI tool to analyze your ECG (heart tracing) to detect low pumping function. It may help find hidden heart issues early, especially if you haven't had a recent heart ultrasound.
TaipeiAges 60–85 - NCT07496372RecruitingPhase 3
Stem cell injection for advanced heart failure
This trial tests a treatment made from stem cells that are turned into heart muscle cells and injected directly into the heart. It is for people with advanced heart failure who are already on the best available medicines and who are scheduled to have bypass surgery.
Tianjin, Tianjin MunicipalityAges 18–75
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Common questions
- Are there clinical trials for treatment failure?
- Yes. Clin2 currently lists 139 recruiting treatment failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a treatment failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a treatment failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.