Clinical trials
Treatment Failure clinical trials
Below are recruiting treatment failure clinical trials, each written for real people, not researchers. We’re tracking 139 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05489575Recruiting
CPAP machine for high blood pressure when lying down at night
This study tests whether using a CPAP breathing machine at night can lower high blood pressure that happens while you sleep. It targets people with nervous-system problems that affect blood pressure changes when standing.
Nashville, TennesseeAges 40–80 - NCT07692256RecruitingPhase 2
Empagliflozin for heart failure in children
This trial tests if empagliflozin, a diabetes medicine that also helps the heart, can improve symptoms in children with heart failure. It may help kids with severe symptoms or high levels of a heart stress marker called BNP.
Cairo, Cairo GovernorateAges 1 month–18 years - NCT06781502Recruiting
Liver Disease and Transplant Study
This study is creating a database of people with severe liver problems or who have had a liver transplant. The goal is to learn more about these conditions and improve care.
Bologna, BolognaAges 18 years+ - NCT07265349RecruitingPhase 1/Phase 2
Stem cells plus bypass surgery for chronic heart failure
This trial tests whether injecting stem cells from umbilical cord tissue into the heart muscle during bypass surgery can improve heart function in people with chronic heart failure. It is for patients who are already scheduled for bypass surgery and have a weakened heart pump (LVEF between 21% and 40%).
Shanghai, Shanghai MunicipalityAges 18–80 - NCT07306286RecruitingPhase 2
Cryoablation plus immunotherapy for advanced pancreatic cancer
This trial tests combining cryoablation (freezing tumors) with a dual-antibody drug (PD-1/CTLA-4) for people whose locally advanced pancreatic cancer has stopped responding to first-line chemotherapy (AG regimen). The goal is to see if this combination can help control the cancer.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07306273RecruitingPhase 2
Testing IRE and an immunotherapy drug for advanced pancreatic cancer
This trial tests a new combination: a special electric field treatment (IRE) plus a dual-function antibody (PD-1/CTLA-4) for people with locally advanced pancreatic cancer that didn't respond to standard chemotherapy. The goal is to see if this approach can help shrink or control the cancer.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06310031Recruiting
Testing BrioVAD heart pump for severe heart failure
This trial tests a new left-ventricular assist device (LVAD) called BrioVAD for people with advanced heart failure who are not getting enough benefit from medicines. If you qualify, the device is implanted to help your heart pump blood.
Birmingham, AlabamaAges 18–100 - NCT05283512Recruiting
IV versus drink fluids to protect kidneys after CT scan
This study compares giving fluids through a vein versus drinking fluids to lower the risk of sudden kidney injury after a CT scan with contrast dye. It focuses on adults with very poor kidney function who are scheduled for an elective CT scan.
Odense C, FynAges 18 years+ - NCT05508256RecruitingPhase 4
Ablation for atrial fibrillation in heart failure with preserved function
This trial tests whether a catheter procedure that treats atrial fibrillation works better than standard care for people with heart failure with preserved ejection fraction. It aims to improve heart rhythm symptoms and overall outcomes compared with conventional treatment.
BerlinAges 18 years+ - NCT06454396Recruiting
Treating blocked dialysis fistulas from inside the blood vessel
This trial tests a new way to reopen blocked or narrowed fistulas (the blood vessels used for dialysis) in people on hemodialysis. The goal is to see how well it works and if it saves money compared to other treatments.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT06493292Recruiting
Treating a blocked dialysis fistula with balloon therapy
This trial tests a balloon treatment for blocked blood vessels in the arm used for dialysis. It aims to improve blood flow so dialysis can work better.
Zhengzhou, HenanAges 18–75 - NCT07099144Recruiting
Inhaled nitric oxide for newborns with breathing failure and high blood pressure in the lungs
This trial tests whether inhaled nitric oxide gas can help full-term newborns who have severe breathing problems and high blood pressure in their lungs. It aims to improve oxygen levels and reduce the need for more intensive support.
Guangzhou, GuangdongAges Up to 1 week - NCT05397392Recruiting
Diagnosis and treatment plan for heart–kidney problems
This study looks at the best way to diagnose and treat different types of heart-and-kidney problems that happen together. It may help you (or your caregiver) get the right classification and treatment approach based on how your heart and kidneys are affected.
NanjingAges 18 years+ - NCT07188805RecruitingPhase 3
Finerenone for children with heart failure
This study tests a new medicine called finerenone (a pill) to see if it helps children with heart failure who have a weak pumping heart. It compares finerenone to a placebo (a pill with no medicine) while both groups continue their usual heart treatments.
Aurora, ColoradoAges 6 months–17 years - NCT07219459RecruitingPhase 2
New drug combo for liver cancer after PD-1/PD-L1 treatment fails
This study tests three drugs (visugromab, nivolumab, lenvatinib) compared to a placebo plus lenvatinib for people with liver cancer (HCC) that cannot be removed or has spread, and who have already been treated with a PD-1/PD-L1 inhibitor without success. The goal is to see if the combination can help shrink tumors or slow the cancer.
Los Angeles, CaliforniaAges 18–100 - NCT06516562Recruiting
Heart failure study in Vietnam: following patients' health over time
This study follows people with heart failure in Vietnam to understand their health and treatment over time. It does not test a new drug—just collects information to improve care.
Ho Chi Minh CityAges 18 years+ - NCT05895136RecruitingPhase 2
Albumin plus blood thinner for severe cirrhosis after hospital recovery
This Phase 2 trial tests whether giving albumin together with enoxaparin (a blood thinner) can improve outcomes for people hospitalized with decompensated cirrhosis who are at high risk. It may help your recovery after certain serious liver-related complications and reduce the chance of poor outcomes.
ClichyAges 18–80 - NCT06033950RecruitingPhase 3
A study of finerenone for heart failure patients who can't take standard MRA drugs
This study tests whether finerenone, a new type of drug, can help people with heart failure who cannot take standard steroid-based MRAs (a kind of heart medication) because of side effects or other reasons. It aims to see if it improves symptoms and is safe for you.
Fairhope, AlabamaAges 18 years+ - NCT07056998Enrolling by invitation
AI detects root canal quality, then retreats if needed
This trial tests whether artificial intelligence can spot problems in root canal treatments seen on special X-rays (CBCT) compared to regular X-rays. If the AI finds an issue, a retreatment is done.
Cairo, Cairo GovernorateAges 18–50 - NCT07397819RecruitingPhase 1/Phase 2
Liposomal Irinotecan for Malignant Ascites
This trial tests a drug called liposomal irinotecan, given alone or with other medications, to treat fluid buildup in the belly caused by digestive system cancers. It's for people who have already tried standard treatments without success.
Guangzhou, GuangdongAges 18 years+ - NCT04504188Recruiting
Adjusting beta-blocker dose for women using a wearable defibrillator
This trial checks whether doctors can use a lower or adjusted dose of beta-blocker medicine in women who are wearing a wearable defibrillator (WCD). It aims to find an approach that’s safe and works while you’re using the device for about 3 months to protect your heart.
Cincinnati, OhioAges 18 years+ - NCT06065124Recruiting
Study on weight loss surgery for heart failure with irregular heartbeat
This trial tests if weight loss surgery can help people with heart failure and atrial fibrillation (an irregular heartbeat) improve their heart condition. You may join if you are between 45 and 70, have a BMI of 32 to 40, and have mild to moderate heart failure with preserved pumping function.
Arnhem, GelderlandAges 45–70 - NCT06218199RecruitingPhase 4
Diuretics vs. blood pressure meds for HeartLogic alerts
This trial compares two treatments—diuretics (water pills) and a blood pressure medication called sacubitril/valsartan—to see which works better when your heart device sends an alert. It's for people with a Boston Scientific heart device that has HeartLogic alerting turned on.
Huntsville, AlabamaAges 19 years+ - NCT07149688Recruiting
Heart disease health program for older adults in Qujiang
This study follows older adults in Qujiang District who have chronic heart or blood vessel conditions. It aims to improve care through village-based management and help researchers better understand how to support long-term heart health.
Beijing, Beijing MunicipalityAges 60 years+
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Common questions
- Are there clinical trials for treatment failure?
- Yes. Clin2 currently lists 139 recruiting treatment failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a treatment failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a treatment failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.