Clinical trials
Treatment Failure clinical trials
Below are recruiting treatment failure clinical trials, each written for real people, not researchers. We’re tracking 140 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03312556Recruiting
CPAP for high blood pressure when lying down
This trial looks at whether using CPAP (a breathing device) can help control high blood pressure that happens when you lie down, in people with autonomic failure. It’s designed for safety and effectiveness and may improve symptoms and blood pressure control.
Nashville, TennesseeAges 18–85 - NCT05689645RecruitingPhase 2
Drug trial for liver injury or liver failure
This Phase 2 trial tests an injection medicine (F573) to see if it can improve people with liver injury, drug-related liver damage, or liver failure. You may be screened with blood tests, liver stiffness measurements, and possibly symptom checks.
Beijing, Beijing MunicipalityAges 18–60 - NCT07281040Recruiting
Online discussion about heart failure treatment experiences
This study brings together people who have recently been in the hospital for heart failure and their caregivers to talk in small online groups about their experiences. The goal is to help doctors learn what matters most to patients and to plan better research on heart failure treatments.
Hull, YorkshireAges 18 years+ - NCT05613010Recruiting
Tech tools to help young transplant patients take meds correctly
This study tests technology (like text reminders and an electronic pill box) to help adolescents and young adults who received a kidney or liver transplant take their medicines every day. It may help protect the transplant by improving medication adherence.
Baltimore, MarylandAges 13–25 - NCT05486000Recruiting
Testing a device to help chronic left heart failure
This trial studies a small implant (an “atrial shunt” device) to improve symptoms and heart function in people with chronic left heart failure that stays active despite standard medicines. It focuses on whether the implant is safe and can help you feel better and possibly breathe easier.
Nantong, JiangsuAges 18 years+ - NCT06042621Enrolling by invitation
Improving communication in the ICU for patients, families, and staff
This study looks at how doctors, nurses, and other healthcare team members talk with patients and their families in the intensive care unit (ICU). It aims to improve understanding and support for everyone involved.
Chicago, IllinoisAges 18 years+ - NCT06613113Recruiting
Fruquintinib, adebrelimab, and radiation for advanced colorectal cancer
This trial tests a combination of two drugs (fruquintinib and adebrelimab) plus low or high dose radiation for people with advanced colorectal cancer that has not responded to standard treatments. The goal is to see if this combination can shrink tumors or slow the disease.
Ningbo, ZhejiangAges 18 years+ - NCT06470646Recruiting
Endovascular treatment for dialysis graft problems
This trial studies a procedure to open up blocked or narrowed areas in the plastic tube (graft) used for dialysis. It aims to see if the procedure works well and if it is cost-effective for patients who have trouble completing dialysis because of graft issues.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT05044403Recruiting
Hemoperfusion for severe sepsis causing multiple organ failure
This study tests whether a blood-filter treatment called hemoperfusion can help critically ill people with sepsis that is not responding to standard shock treatment and is affecting multiple organs. It aims to improve recovery when infections are controlled and inflammation markers are very high.
Castellon, CastellónAges 18–80 - NCT06052475Recruiting
Pacemaker upgrade study for heart failure
This trial is for people with a standard pacemaker that stimulates the right ventricle most of the time. It tests whether a newer type of pacemaker (CRT) can improve heart function and symptoms. If you have a weakened heart (LVEF between 35-50%) and your heart failure has gotten worse, this study may be a good fit.
CambridgeAges 18 years+ - NCT06426173Recruiting
Strength training for people waiting for a heart transplant
This study tests whether resistance training (strength exercises) can help people waiting for a heart transplant. It is for patients who have been on the transplant list for less than a month and are stable enough to exercise safely.
São Paulo, São PauloAges 18–70 - NCT07385417Recruiting
Early AF treatment for heart failure with preserved pumping function
This study tests using a new electrical pulse treatment for atrial fibrillation (AF) early on, in people who also have a type of heart failure where the heart pumps normally but is stiff. The goal is to see if this treatment helps manage both conditions better.
Frankfurt am MainAges 18–80 - NCT07397650RecruitingPhase 4
Early finerenone for heart failure in hospital
This trial tests if starting finerenone early helps patients hospitalized with heart failure who have symptoms like shortness of breath or swelling. It aims to see if the drug is safe and effective when given soon after admission.
Handa, Aichi-kenAges 18 years+ - NCT06651970RecruitingPhase 4
Acalabrutinib for chronic lymphocytic leukemia with heart problems
This trial tests a targeted therapy called acalabrutinib (a pill) against other standard treatments for chronic lymphocytic leukemia (CLL) in people who also have heart conditions. The goal is to see if acalabrutinib is a safer or more effective option for this group.
Charlotte, North CarolinaAges 18–130 - NCT06652087Recruiting
Testing rifaximin for heart failure with preserved pumping
This trial tests whether the antibiotic rifaximin (taken by mouth) can improve heart function in people with a type of heart failure where the heart pumps well but is still weak (HFpEF). Rifaximin might help by changing the bacteria in your gut.
MoscowAges 18–80 - NCT07192952RecruitingPhase 3
Long-term safety of finerenone in children and young adults with heart failure
This study tests the long-term safety of the drug finerenone when taken alongside standard heart failure treatments in children and young adults with weakened heart pumping function (left ventricular systolic dysfunction). It includes both children already in a related study and new infants under 6 months old.
Aurora, ColoradoAges Up to 18 years - NCT05759806Recruiting
Testing a device to treat fluid overload in heart failure
This trial studies a device (the Nephronyx System) used in the hospital to treat worsening heart failure with fluid buildup, especially when diuretics (water pills) aren’t working well. It aims to check the device’s safety and whether it performs as expected to help patients get better.
HaifaAges 18 years+ - NCT05026749RecruitingPhase 3
Azithromycin for severe RSV breathing failure in young children
This trial tests whether azithromycin (an antibiotic) can improve outcomes for babies and young children in the ICU who have RSV causing serious breathing problems. It mainly looks at children who start strong breathing support soon after RSV symptoms begin.
Birmingham, AlabamaAges 3 days–2 years - NCT06841328Recruiting
Stem cell therapy for fertility in ovaries and testes
This study tests a regenerative stem cell therapy to improve fertility in men with testicular failure or low sperm count and women with early ovarian failure. It is for people who have already tried standard treatments without success.
Dubai, DubaiAges 20–50 - NCT07506499Recruiting
Cardiac Rehab for Hospitalized Heart Failure Patients
This study tests whether a cardiac rehabilitation program (a supervised exercise and education plan) helps people recovering in the hospital from severe heart failure. It is for those aged 45–65 whose heart pumps less than 40% of its normal amount.
Banī Suwayf, Beni-Suef GovernorateAges 45–65 - NCT05484908Recruiting
Tested treatment for hepatitis B-related liver cancer after immunotherapy
This trial studies whether the ALSS treatment is safe and effective for people with hepatitis B-related hepatocellular carcinoma who recently received immune checkpoint inhibitors. It may help improve outcomes for certain liver-related complications after immunotherapy, based on how their liver tests look.
Guangzhou, GuangdongAges 18–65 - NCT07079605Recruiting
Sepsis and heart inflammation study
This trial looks at how sepsis (a severe response to infection) affects the heart, specifically whether it causes inflammation of the heart muscle (myocarditis). It may help understand and improve care for people with sepsis.
Jimma, OromiyaAges 18 years+ - NCT05440617Recruiting
Biobank for people having testicle-protecting cancer treatment
This study collects and stores biological samples from people who are planning to undergo OTC, a treatment used to help protect fertility during cancer therapy that can harm reproductive cells. It may help future research by providing researchers with tissue/blood samples linked to this treatment.
Bethesda, MarylandAges 4–35 - NCT05828719Recruiting
Compare heart stent treatment vs medicines for weak heart function
This study looks at whether opening blocked heart arteries with a stent (a PCI procedure) works better than staying on heart medicines for people with weakened pumping function and certain types of heart failure. It may help patients by testing which approach best improves outcomes over time.
SeoulAges 19 years+
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Common questions
- Are there clinical trials for treatment failure?
- Yes. Clin2 currently lists 140 recruiting treatment failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a treatment failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a treatment failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.