Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,834 recruiting studies in this area right now.
By phase
- Not applicable3,970
- Phase 2222
- Phase 4195
- Phase 1191
- Phase 3150
- Phase 1/Phase 273
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis183
- Rheumatoid Arthritis141
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee73
- Rheumatoid Arthritis (RA)64
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Chronic Pain38
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Musculoskeletal Pain36
- Pain34
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California208
- New York95
- Florida80
- Arizona76
- Massachusetts76
- Maryland73
- Texas64
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,834 total
- NCT06228573Recruiting
Brain stimulation and yoga for knee pain
This study combines a gentle brain stimulation technique (tDCS) with yoga to see if it helps reduce knee pain and improve movement in people with knee osteoarthritis.
Hamilton, OntarioAges 45 years+ - NCT07628218Recruiting
Video versus in-person exercise training for heel pain
This trial compares two ways to learn exercises for plantar fasciitis (heel pain caused by tissue strain): watching instructional videos on your own versus attending sessions with a doctor or trainer. The goal is to see which method helps reduce pain and improve walking more effectively.
BalıkesirAges 18–70 - NCT06807424RecruitingPhase 3
Study of icotrokinra for active psoriatic arthritis
This trial tests a new medication called icotrokinra for people with active psoriatic arthritis (PsA). It aims to see how well the drug works and if it is safe, including for those who have tried other treatments.
Glendale, ArizonaAges 18 years+ - NCT06245135RecruitingTeam says not enrolling
Home Exercise Program for People With Mobility Issues
This study tests a home exercise program (TIME at Home) to see if it helps improve balance and walking for people with mobility problems. You'll exercise at home with coaching via video calls, and a caregiver will join for the first session.
Edmonton, AlbertaAges 18 years+ - NCT06058169RecruitingTeam says not enrolling
Home vibration therapy for arthritis knee pain
This study tests if doing whole-body vibration exercises at home can help reduce knee pain from arthritis. You stand on a gently vibrating platform for short periods over several weeks.
Augusta, GeorgiaAges 40–75 - NCT05634369RecruitingTeam says not enrollingPhase 1/Phase 2
NK cell and chemotherapy trial for relapsed soft tissue sarcoma
This early-phase trial studies a type of immune cell treatment (NK cells) made from donor cells, given with chemotherapy drugs gemcitabine and docetaxel. It’s for children and young adults whose bone or soft tissue sarcoma has come back or hasn’t responded to prior treatment.
South Birmingham, AlabamaAges 2–40 - NCT05183152RecruitingTeam says not enrolling
Non-invasive brain signal control for assistive devices
This study tests an assistive device that you control using signals from the brain and muscles without surgery. It may help people with movement problems communicate or operate devices using gentle, non-invasive sensing.
Austin, TexasAges 18–80 - NCT07308834RecruitingPhase 1/Phase 2
Knee injection study for moderate to severe osteoarthritis pain
This study tests a new knee injection called CX-011 to see if it can reduce pain and improve function in people with knee osteoarthritis. It may be a good option if you have tried other treatments without enough relief.
Los Angeles, CaliforniaAges 40–75 - NCT07790328Recruiting
Long-term safety of the IntraSPINE implant for low back pain
This study checks how safe and effective the IntraSPINE implant is over time for people with low back pain from degenerative discs. The implant is placed in your spine to support it, and this trial helps see if it continues working well for years.
SaranAges 18 years+ - NCT07789288Recruiting
Hard collar use after cervical spine fusion
This study compares recovery outcomes with and without a hard cervical collar after posterior cervical fusion surgery. You may qualify if you have degenerative disk disease and are scheduled for this type of spine surgery.
Washington D.C., District of ColumbiaAges 18 years+ - NCT07541625Recruiting
Digital scanning for custom tooth attachments
This research tests whether advanced scanning technology improves the fit of custom attachments placed inside root-canal-treated teeth to support dentures. If you have some remaining teeth that need support and are considering a denture, this trial may help you get a better-fitting solution.
Giza, الجيزةAges 18–65 - NCT07404865RecruitingPhase 3
Telitacicept for active primary Sjögren's disease
This study tests an investigational drug called telitacicept for people with active primary Sjögren's disease. The goal is to see if it can reduce symptoms like joint pain, fatigue, and swelling better than a placebo.
Chandler, ArizonaAges 18–75 - NCT06569615Recruiting
Comparing shock wave, laser, and cold therapy for sacroiliitis pain
This trial compares three different treatments (shock wave therapy, laser therapy, and cold therapy) for people with sacroiliitis, a condition that causes pain in the lower back, buttocks, or hips. The goal is to see which treatment works best for reducing pain and improving movement.
Najran, Najran RegionAges 20–50 - NCT07104279Recruiting
Zimmer Biomet hip implant follow-up study
This study is for people who need a hip replacement for the first time. It is testing a specific hip implant system called the Z1 Hip System and will follow patients to see how well it works over time.
Charlotte, North CarolinaAges 18 years+ - NCT06782230Recruiting
A biobank for rare disease samples and data
This study creates a collection of biological samples and health information from people with rare diseases and their family members. It aims to build a shared resource that can help future research on rare conditions.
San Donato Milanese, MilanAges Any age - NCT05898074Recruiting
Testing a new gel during endoscopic skull base surgery
This trial looks at a new RADA16 hydrogel to see if it can help during an endoscopic surgery through the nose for a skull base tumor or a cerebrospinal fluid (CSF) leak. You might be a candidate if you are already planned for this specific type of nasal surgery and meet key safety requirements.
Indianapolis, IndianaAges 18 years+ - NCT05517434RecruitingPhase 2/Phase 3
Autologous bone and fat injections versus saline for knee OA
This trial compares different knee injections made from your own bone marrow and/or fat, plus platelet-rich plasma (a blood-derived healing factor), against saline (placebo) to treat painful knee osteoarthritis. It aims to see whether these “autologous” injections reduce knee pain and improve function.
Toronto, OntarioAges 30 years+ - NCT07154719RecruitingPhase 4
Testing a weight loss drug's effect on muscle and bone
This study tests a medication called tirzepatide (a type of GLP-1 drug) to see how it affects muscle and bone health during weight loss. It is for people with obesity who are not menopausal and do not have diabetes or bone disease.
Baton Rouge, LouisianaAges 18–50 - NCT07788404Recruiting
Study of rifampin levels in patients with bone or joint staph infections
This study looks at how the antibiotic rifampin behaves in the body when used to treat staph infections in bones or joints. It may help doctors better dose the drug for future patients.
Paris, ParisAges 18 years+ - NCT07212920Recruiting
Video physiotherapy for recent knee injuries
This study tests whether a video-based physiotherapy assessment works as well as an in-person exam for people with recent knee injuries. If you have a knee injury that started 1 to 12 weeks ago and haven't been treated yet, you may be able to participate from home using your phone or computer.
AlingsåsAges 18 years+ - NCT07017634RecruitingPhase 3
Novosis Putty for spine fusion in lumbar disc disease
This trial tests a new bone graft putty (Novosis Putty) used during a specific type of spine fusion surgery (TLIF) to treat a worn-out disc causing low back and leg pain. The goal is to see if it works as well as or better than current options.
Little Rock, ArkansasAges 21–80 - NCT07279688RecruitingPhase 3
Baricitinib plus steroids for polymyalgia rheumatica
This trial tests if adding baricitinib (a pill that calms inflammation) to standard steroids works better than steroids alone for people with polymyalgia rheumatica. It aims to improve symptoms and reduce steroid side effects.
Aix-en-ProvenceAges 50 years+ - NCT07188285Enrolling by invitation
Immune system study for active autoimmune diseases
This study uses a blood test called mass spectrometry to look at the immune system in people with active autoimmune diseases. It aims to find patterns that could help doctors better understand and treat these conditions.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07662239Recruiting
Exercise program for young sarcoma survivors
This study tests a personalized exercise service for teenagers and young adults who have had sarcoma. It aims to help you get active and stay healthy after treatment.
Boston, MassachusettsAges 15–39
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,834 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,906 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.