Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,611 recruiting studies in this area right now.
By phase
- Not applicable3,768
- Phase 2217
- Phase 4200
- Phase 1182
- Phase 3139
- Phase 1/Phase 271
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis172
- Rheumatoid Arthritis132
- Fibromyalgia105
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee64
- Shoulder Pain48
- Hip Osteoarthritis43
- Psoriatic Arthritis40
- Degenerative Disc Disease39
- Chronic Pain38
- Total Knee Arthroplasty38
- Duchenne Muscular Dystrophy37
- Systemic Lupus Erythematosus37
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital25
- Hacettepe University23
- Tanta University22
Where studies are running
- California207
- New York87
- Florida82
- Maryland76
- Arizona72
- Massachusetts71
- Texas67
- Alabama59
- Illinois51
- Pennsylvania48
Recruiting studies4,611 total
- NCT07878975Recruiting
Heart rate variability tracking for rheumatoid arthritis
This study uses a smart ring to track your heart rate variability (a measure of heart health) while you sleep, to see if it relates to rheumatoid arthritis activity. You would wear the ring at night and complete short weekly check-ins for about three months.
Orlando, FloridaAges 18 years+ - NCT07878286Recruiting
How body awareness relates to fibromyalgia symptoms
This study looks at how well women with fibromyalgia notice internal body signals (like heartbeat or breathing) and whether that affects their pain and other symptoms. It may help doctors understand fibromyalgia better and improve future treatments.
IstanbulAges 18–65 - NCT07627750Recruiting
Low-dose muscle relaxant for spine surgery monitoring
This study tests whether a low dose of a muscle relaxant called rocuronium is safe and effective during spine surgery when doctors are monitoring the nerves. This may help patients who need spine surgery with nerve monitoring.
Hanoi, HanoiAges 18 years+ - NCT07878273Recruiting
Tibial nerve size in chronic plantar fasciitis
This study compares the size of a nerve in the foot (the tibial nerve) between people with chronic plantar fasciitis and healthy individuals. It aims to understand if nerve changes are linked to this condition, which might help improve future treatments.
IstanbulAges 18–65 - NCT07219771RecruitingPhase 3
Knee injection for osteoarthritis pain
This study tests a single injection of PTP-001 (MOTYS™) into the knee to see if it reduces osteoarthritis pain. It is for people whose knee pain is their main pain problem and who haven't found relief from standard pain medicines.
Birmingham, AlabamaAges 40–80 - NCT07602595Recruiting
Early-life health risks and chronic pain in teens and young adults
This study looks at how early health problems might affect pain that lasts a long time. If you had a muscle or joint surgery, or a rheumatic disease, before age 18, you might help us understand why some people get ongoing pain.
Cincinnati, OhioAges 14–26 - NCT07878247Recruiting
Splint therapy for jaw pain and muscle spasms
This trial tests a dental splint (a custom mouthpiece) to see if it helps with jaw pain, muscle spasms, and chewing difficulties caused by temporomandibular disorders (TMD) or bruxism (teeth grinding).
CairoAges 18–60 - NCT05147675RecruitingPhase 1
Testing cord stem cell treatment for osteoarthritis safety
This early study (Phase 1) checks whether an infused stem cell product made from donated umbilical cord tissue is safe in people with osteoarthritis. It’s mainly looking for side effects and whether the treatment can be given safely.
Naples, FloridaAges Any age - NCT07855341RecruitingPhase 4
Nerve block study for hip replacement pain relief
This study tests two different amounts of a numbing medicine injected around the hip nerves before hip replacement surgery, to see if adding a steroid helps reduce pain after surgery. It aims to improve pain control and recovery.
Cairo, Cairo GovernorateAges 50–70 - NCT07786415Recruiting
Posture and physical function in college students with upper cross syndrome
This study looks at how posture affects everyday function in people with a common muscle imbalance called upper cross syndrome. It may help you understand your condition better, but you must be a college student in a specific age range and have this posture issue.
CairoAges 20–29 - NCT07104279Recruiting
Zimmer Biomet hip implant follow-up study
This study is for people who need a hip replacement for the first time. It is testing a specific hip implant system called the Z1 Hip System and will follow patients to see how well it works over time.
Platte City, MissouriAges 18 years+ - NCT00029965Recruiting
Natural history of inherited metabolic storage disorders
This study follows people with certain inherited metabolic conditions (like GM1 or GM2 gangliosidosis, sialidosis, or galactosialidosis) to learn more about how these diseases progress over time. Participating may help researchers understand the conditions better, which could improve future care.
Bethesda, MarylandAges 1 day–100 years - NCT04128670Recruiting
Kinesio tape test for sore muscles after exercise
This study checks whether Kinesio tape changes how sore your muscles feel after workouts. You may help researchers learn if the tape reduces “delayed onset muscle soreness” after upper-body activity.
Indianapolis, IndianaAges 18–30 - NCT04041583Recruiting
Cervical spine fusion using spacers to support healing and function
This study looks at how well a specific neck surgery (posterior cervical fusion using added spacers) works for people with long-standing, non-traumatic neck wear-and-tear problems. It will track outcomes using symptoms and imaging to see if the surgery improves function and healing.
Columbus, OhioAges 18 years+ - NCT07111065RecruitingPhase 2
Fatty Acid Supplement for Dermatomyositis
This study tests whether taking a fatty acid supplement (omega-3) for 6 months can help reduce disease activity in people with dermatomyositis. Participants will also receive dietary coaching and have regular check-ups at the NIH to monitor their progress.
Bethesda, MarylandAges 18–60 - NCT07700225Recruiting
Long-term study of myotonic dystrophy type 1
This study is a long-term follow-up for people with myotonic dystrophy type 1. It aims to find better ways to measure how the disease progresses, which could help develop future treatments.
Richmond, VirginiaAges 18–70 - NCT07877766Enrolling by invitation
Microbiome study for patients having neck fusion surgery
This study looks at the bacteria in your body before and after neck surgery to see if they affect recovery. It may help improve care for future patients.
New York, New YorkAges 18–80 - NCT07393503Enrolling by invitationPhase 4
Pain relief for new muscle and joint injuries
This trial compares two common treatments for new muscle or joint pain: an over-the-counter pain reliever (Tylenol and ibuprofen) versus an oral steroid (a stronger anti-inflammatory medication). The goal is to see which option works better for short-term pain and recovery.
Buffalo, New YorkAges 18 years+ - NCT07620392RecruitingPhase 2
Long-Term Safety Study of Afimkibart for Rheumatoid Arthritis
This is a follow-up study for people who already completed a previous trial testing afimkibart (an experimental drug) for rheumatoid arthritis. It checks whether the drug continues to work safely and effectively over a longer period.
Tamarac, FloridaAges 18 years+ - NCT07137598RecruitingPhase 2
A study of RO7790121 for moderate to severe rheumatoid arthritis
This study tests a new drug, RO7790121, for people with rheumatoid arthritis (RA) who have not gotten better with or could not tolerate common treatments like TNF inhibitors or JAK inhibitors. It aims to see if the drug is safe and can help reduce joint pain and swelling.
Avondale, ArizonaAges 18 years+ - NCT07875296Recruiting
Enzyme levels in knee arthritis
This study looks at certain enzymes in the blood of women with knee osteoarthritis. It may help doctors understand how arthritis works and could lead to better treatments.
AfyonkarahisarAges 40–70 - NCT03810573Recruiting
Bone graft for spinal fusion surgery
This trial tests a new bone graft material to help bones in the lower spine fuse together after surgery. It may be an option for people with degenerative disc disease or a mild spinal slip.
Clayton, VictoriaAges 17–70 - NCT05780450Recruiting
Brain stimulation for long covid headaches and pain
This trial tests a safe, non-invasive brain stimulation technique (transcranial direct current stimulation, or tDCS) to see if it can reduce persistent headaches and chronic pain in people with long covid. If you have ongoing pain after a confirmed covid infection, this could offer a new way to find relief.
Paiporta, ValenciaAges 16 years+ - NCT07869030Recruiting
Melatonin for dental implants in lower jaw
This study tests whether applying melatonin around new dental implants in the lower back teeth helps them heal and stay secure. It may improve the success of implants placed right after tooth extraction.
CairoAges 20–50
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,611 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,492 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.