Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,843 recruiting studies in this area right now.
By phase
- Not applicable3,974
- Phase 2225
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis140
- Fibromyalgia102
- Osteoporosis86
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University111
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad33
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida82
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois55
- Pennsylvania50
Recruiting studies4,843 total
- NCT07220603RecruitingPhase 2
Long-term safety study for people with myotonic dystrophy type 1
This is a follow-up study for people with myotonic dystrophy type 1 who already received the study drug PGN-EDODM1 in an earlier trial. It lets you continue treatment and helps researchers learn more about long-term safety and effects.
Calgary, AlbertaAges Any age - NCT07220824Recruiting
Study of guselkumab for psoriatic arthritis in real-world care
This study is testing how well guselkumab works for people with psoriatic arthritis who are starting it in everyday medical practice. Researchers want to see if the drug helps reduce joint swelling and tenderness, and if it can improve enthesitis (pain where tendons attach to bone).
BariAges 18 years+ - NCT07222696Recruiting
Health coaching for rheumatoid arthritis to improve mental wellbeing
This study tests if working with a health coach (a trained peer) can help people with rheumatoid arthritis feel better emotionally, especially if they are dealing with depression or anxiety. You would meet with a coach remotely using your phone or computer.
New York, New YorkAges 18 years+ - NCT07224958Recruiting
Knee brace for inner knee arthritis: a study
This study tests whether wearing a special knee brace for at least 4 hours a day can help reduce pain and improve function in people with arthritis in the inner part of the knee. It compares wearing a brace to not wearing one, so you could help find out if braces are a good option for managing knee pain.
Chicago, IllinoisAges 40–85 - NCT07226973Recruiting
Gait after hip replacement: comparing surgical approaches
This study compares how well people walk after three different types of hip replacement surgery for arthritis. It aims to see if one approach leads to a better walking pattern.
Metairie, LouisianaAges 18 years+ - NCT07227441Recruiting
Chronic Infections and Inflammation in ME/CFS
This study looks at how chronic infections and inflammation affect people with ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome) compared to healthy people. Researchers want to understand what causes symptoms and find better ways to help.
San Francisco, CaliforniaAges 18 years+ - NCT07228897Recruiting
Walking study for women with fibromyalgia
This study compares walking on a treadmill to walking outdoors to see which helps more with fibromyalgia symptoms. If you're a woman between 25 and 55 who hasn't been active lately, this may be a good fit.
Ankara, YenimahalleAges 25–55 - NCT07229079Recruiting
Body awareness therapy for flat feet
This study tests whether basic body awareness therapy can help people with flexible flat feet (when the foot arch flattens under weight but returns when not standing). If you have flat feet without other foot problems, you may qualify.
Mardin, Mardi̇nAges 18–45 - NCT07229144RecruitingPhase 1
Study of OM336 for people with active autoimmune diseases
This trial tests a new treatment called OM336 for people with active autoimmune diseases that have not improved after at least two other treatments. The goal is to see if OM336 can help control the disease.
Hamilton, Waikato RegionAges 18–75 - NCT07230171Recruiting
Short-term S-ketamine for fibromyalgia pain relief
This trial tests if low-dose S-ketamine, given as a short intravenous infusion, can safely improve fibromyalgia pain and other symptoms for people who haven't gotten enough relief from non-drug treatments. S-ketamine is a fast-acting medicine that blocks pain signals and may help reset how the brain processes pain.
BeijingAges 18 years+ - NCT07230197Recruiting
Pregabalin and dexmedetomidine for fibromyalgia pain
This trial tests whether combining two medications, pregabalin and dexmedetomidine, works better than standard treatments for fibromyalgia pain. It may help people with moderate to severe fibromyalgia who haven't found relief from non-drug therapies.
BeijingAges 18 years+ - NCT07230327Recruiting
Whole body MRI for inflammatory back disease
This trial uses a whole body MRI scan to find inflammation in the spine and joints in people with a type of arthritis called axial spondyloarthritis (axSpA). It aims to see if the scan can detect disease activity and track changes over time, helping doctors choose the right treatment.
Nanjing, JiangsuAges 18 years+ - NCT07230353RecruitingPhase 1
Plamotamab for moderate to severe rheumatoid arthritis
This trial tests a new treatment called plamotamab for people with moderate to severe rheumatoid arthritis (RA) who have not had enough relief from current treatments. The goal is to see if it is safe and to help control RA symptoms.
TbilisiAges 18 years+ - NCT07230470Recruiting
Walking rehabilitation after stroke: Exoskeleton vs treadmill
This study compares two robotic devices (the LoKomat exoskeleton and the C-Mill treadmill) to see which one helps people walk better after a stroke. If you are recovering from a stroke and able to understand instructions, you may be able to join.
SalamancaAges 18–65 - NCT07231471Recruiting
Platelet-rich plasma for muscle and joint pain
This study tests whether an injection of your own platelet-rich plasma (PRP) can help heal muscle, tendon, or joint problems that haven't gotten better with other treatments like physical therapy or medications.
Salt Lake City, UtahAges 18 years+ - NCT07231822Recruiting
Virtual reality for postmenopausal osteoporosis patients
This study tests if virtual reality exercises can help improve balance and strength in postmenopausal women with osteoporosis. It may offer a safe and engaging way to support bone and muscle health.
Center, Kirşehi̇rAges 40–65 - NCT07233798Recruiting
Dural pulsation in lumbar spinal stenosis
This study looks at a natural movement called dural pulsation (pulsing of the spinal sac) in people with lumbar spinal stenosis. It might help doctors understand the condition better and could lead to better treatments for your back or leg pain.
Pendik, IstanbulAges 18–85 - NCT07234747Recruiting
Core stability: exergaming vs. standard exercises for kids with JIA
This study compares two types of core-strengthening exercises for children with juvenile idiopathic arthritis (JIA). One group does standard core-stability exercises, and the other plays active video games (exergaming) that work the same muscles. The goal is to see which approach works better and is more fun for kids.
Istanbul, BuyukcekmeceAges 8–12 - NCT07234773RecruitingPhase 1
Study of a new injectable drug for rheumatoid arthritis
This early-stage study tests a new injectable medicine (KT501) for people with moderate to severe rheumatoid arthritis who have not responded well enough to other treatments and have specific antibodies in their blood. It aims to see how safe and well-tolerated the drug is.
BayswaterAges 18–75 - NCT07235982Recruiting
Shoulder block plus steroid vs. steroid alone for frozen shoulder pain
This trial compares two treatments for frozen shoulder (adhesive capsulitis): a steroid injection alone versus a steroid injection plus a nerve block. The goal is to find which approach provides better pain relief for people who have not improved after two weeks of conservative care.
ZagazigAges 41–65 - NCT07236229Recruiting
VR Therapy for Early Frozen Shoulder
This study tests if using a virtual reality (VR) headset during physical therapy helps people with early-stage frozen shoulder recover better than standard therapy alone.
Küçükçekmece, IstanbulAges 18–65 - NCT07236658Recruiting
Using AI to detect arm problems after breast cancer surgery
This trial uses artificial intelligence (a computer program) to help predict arm and shoulder problems that can happen after breast cancer surgery. It aims to find these issues early so they can be treated better.
AnkaraAges 18 years+ - NCT07236762RecruitingPhase 1
YTS109 cell therapy for severe autoimmune diseases
This trial tests a new cell therapy called YTS109 for people with severe autoimmune diseases like lupus, Sjögren's syndrome, systemic sclerosis, inflammatory myopathy, vasculitis, and antiphospholipid syndrome. It's for those whose disease hasn't improved with standard treatments.
BengbuAges 18–65 - NCT07236801RecruitingPhase 1
Cell therapy for hard-to-treat autoimmune diseases
This trial tests a new cell therapy called YTS109 for people with several autoimmune diseases that have not improved with standard medications. It aims to see if this treatment can help control the disease when other treatments have failed.
Xuzhou, JiangsuAges 18–65
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,843 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,987 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.