Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,607 recruiting studies in this area right now.
By phase
- Not applicable4,687
- Phase 21,190
- Phase 1566
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer480
- Pancreatic Cancer289
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer147
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Ovarian Cancer90
- Pancreas Cancer90
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis76
Leading sponsors
- Fudan University100
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)50
- National Taiwan University Hospital45
Where studies are running
- California443
- Arizona189
- Texas140
- Alabama129
- Florida127
- Massachusetts120
- New York120
- Maryland88
- Ohio80
- Illinois69
Recruiting studies7,607 total
- NCT05392387Recruiting
Treatment and outcomes study for long-term hepatitis B
This trial looks at people with long-term hepatitis B infection and studies how treatment may affect health over time. It may help you understand whether your care improves outcomes for chronic hepatitis B.
Changsha, HunanAges 18–79 - NCT04622540Recruiting
Study for living donor liver transplant patients
This study looks at living donor liver transplant care and follows patients for about 3 years to see how they do over time. If you had (or are scheduled for) a living donor liver transplant and can be followed long-term, this trial may be able to collect your outcomes.
SeoulAges 19–79 - NCT04306458Recruiting
Testing robot-assisted vs standard surgery for resectable esophageal cancer
This trial compares a robot-assisted approach to a standard minimally invasive approach for surgery in people with certain types of esophageal or gastroesophageal junction cancer that can be removed. It aims to see which surgery method works better and is safer for these patients.
MainzAges 18–90 - NCT04578301Recruiting
Predicting who develops serious liver worsening after surgery
This study looks at your liver health before and after surgery to predict the risk of “acute-on-chronic liver failure,” which means a sudden worsening of liver function on top of an existing liver condition. If you qualify, your doctors may use study data to better identify who needs closer monitoring after surgery.
BonnAges 18 years+ - NCT05378919RecruitingPhase 2
Testing new pre-surgery treatment for locally advanced rectal cancer
This Phase 2 trial compares a pre-surgery (neoadjuvant) treatment plan versus the standard plan for people with stage II–III rectal cancer. The goal is to see which approach works better and is safe before surgery.
KaunasAges 18 years+ - NCT05396560Recruiting
Stool blood test to decide if follow-up colonoscopy is needed
This trial tests whether a stool blood test can help decide who truly needs a follow-up colonoscopy after prior colon polyps. It may reduce unnecessary colonoscopies while still catching concerning changes early.
Calgary, AlbertaAges 18–74 - NCT05399745Recruiting
Study of biliary atresia in children with heart disease
This trial is studying children who have biliary atresia, a serious liver problem, including some who also have tetralogy of Fallot (a congenital heart condition). It also includes healthy children for comparison, and may help researchers understand the illness and treatments better.
CopenhagenAges birth–18 years - NCT04807673RecruitingPhase 3
Pembrolizumab before surgery versus chemoradiation for esophageal cancer
This Phase 3 study compares two treatment plans before surgery for locally advanced esophageal squamous cell carcinoma. It tests whether adding pembrolizumab (an immune therapy) to chemotherapy improves outcomes compared with standard chemoradiation.
Tianjin, Tianjin MunicipalityAges 18–75 - NCT04499833Recruiting
Test an AI score to guide liver transplant decisions
This study looks at a prediction tool that estimates outcomes for people with liver cancer and cirrhosis, to help decide whether a liver transplant is a good option. It may help doctors choose the right timing and patients who could benefit most from transplantation.
LisbonAges 18–70 - NCT05426135Recruiting
AI tool to assess cancer risk and guide care
This study tests an artificial intelligence (AI) system that uses your health information and medical images to better judge cancer risk and support diagnosis and treatment decisions. It may help doctors make more consistent assessments by combining clinical records, imaging, and other lab-style data.
Wuhan, HubeiAges 18–75 - NCT05188313RecruitingPhase 3
HER2 medicines before surgery for resectable esophageal cancer
This trial tests two targeted medicines, trastuzumab and pertuzumab (HER2-blocking drugs), given before surgery for HER2-positive esophageal or stomach-esophagus junction cancer. The goal is to shrink the tumor and improve how well surgery works and outcomes after treatment.
AmsterdamAges 18 years+ - NCT04973306RecruitingPhase 2/Phase 3
Chemo-immunotherapy before surgery versus chemo-radiation
This trial compares adding immunotherapy to standard chemo-radiation before surgery for locally advanced, operable esophageal squamous cell cancer. It aims to improve how well the tumor responds and whether patients do better after surgery.
ShanghaiAges 18–75 - NCT05392413Recruiting
Predicting who benefits from PD-1 antibody for esophageal cancer
This study uses an “immune indicator model” to help predict how well a PD-1 antibody (a cancer-fighting immune drug) works when combined with chemotherapy for stage IV esophageal squamous cell cancer. If you qualify, you receive the treatment and the researchers also look for immune-related signs that may explain who benefits most.
GuangzhouAges 18–75 - NCT04945304Recruiting
9-Step magnetic revisional weight-loss surgery
This trial studies a specific 9-step approach using magnetic technology for people having revisional bariatric (weight-loss) surgery. It may help improve how safely and effectively surgery is done for people who qualify.
Maracaibo, ZuliaAges 18–65 - NCT05248763Recruiting
Cancer Moonshot program for specific cancer types
This study is for people with certain cancers: lung, breast, gastric (stomach), pancreatic, or ovarian. It aims to test a Moonshot-style approach to improve cancer care for these groups.
TaipeiAges 20 years+ - NCT05466565Recruiting
Peginterferon antiviral treatment after liver cancer surgery
This trial studies an antiviral medicine given after surgery for liver cancer to help prevent the cancer from coming back. It focuses on people who are hepatitis B–positive (HBsAg positive) and have complete remission on follow-up checks.
Changsha, HunanAges 18–65 - NCT05472922Recruiting
Small stomach bypass surgery for weight loss
This trial compares a “mini” gastric bypass procedure to help with weight loss in adults who qualify for bariatric (weight-loss) surgery. It’s testing whether the approach works well and is safe for people who meet the study requirements.
AlmeloAges 18 years+ - NCT05300269RecruitingPhase 2
Test drug SHR-1701 with chemo and radiation for rectal cancer
This trial studies whether adding SHR-1701 to standard chemotherapy and long-course radiation can improve treatment for locally advanced rectal cancer that can be removed by surgery. It’s mainly for people who have not had prior rectal cancer treatment and who fit several health and cancer-spread requirements.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT04767945Recruiting
Cirrhosis patient hospital registry
This study keeps a record of people who have liver cirrhosis and were admitted to the hospital after a worsening event. It may help doctors better understand what leads to hospital stays and improve future care.
Banská BystricaAges 19 years+ - NCT05015283Recruiting
Gastric bypass type surgery to help type 2 diabetes go into remission
This study compares two kinds of weight-loss surgeries to see which helps people with type 2 diabetes reach diabetes remission more safely. It may help if your diabetes is not well controlled and your care team recommends one of these operations.
Beijing, Beijing MunicipalityAges 18–65 - NCT05434026Recruiting
Colorectal cancer database study for people having surgery
This study enrolls people with colon cancer found on biopsy and who are able to have surgery. It mainly builds a medical database to help researchers understand care and outcomes, and it depends on you consenting to participate.
BeijingAges Any age - NCT04138212RecruitingPhase 3
Chemo alone vs chemo with radiation before esophagus surgery
This study compares chemotherapy alone versus chemotherapy plus radiation given before surgery for locally advanced esophagus squamous cell cancer. The goal is to see which treatment helps more people have a successful operation and better cancer control.
Zhengzhou, HenanAges 18–70 - NCT02931513Recruiting
Blood marker test in newly diagnosed PBC patients
This study looks at how a specific blood marker (sCD163) changes in people newly diagnosed with primary biliary cholangitis (PBC). It’s mainly meant to see whether this marker could help predict treatment response, especially before starting UDCA.
Aarhus C, Central JutlandAges 18 years+ - NCT05501587Recruiting
Respiratory Health Registry measuring lung function in different groups
This registry study collects information and measures lung function to better understand respiratory health across people with cystic fibrosis, other lung diseases, and healthy volunteers. Your results may help researchers track lung health and improve future research and care.
Vancouver, British ColumbiaAges birth–99 years
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,607 recruiting gastroenterology studies from the U.S. registry right now, out of 11,926 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.