Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,599 recruiting studies in this area right now.
By phase
- Not applicable4,683
- Phase 21,187
- Phase 1568
- Phase 3457
- Phase 1/Phase 2366
- Phase 4228
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona189
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,599 total
- NCT07432295RecruitingPhase 2
Givastomig plus nivolumab and chemo for advanced stomach cancer
This trial tests a new drug, givastomig, combined with standard immunotherapy (nivolumab) and chemotherapy for people with advanced stomach, gastroesophageal junction, or esophageal cancer. It is for people whose tumors have certain markers (CLDN18.2 and PD-L1) and who have not had treatment for advanced disease.
Goodyear, ArizonaAges 18 years+ - NCT07433946Recruiting
Liquid nutrition to prevent weight loss in IBD
This study tests whether adding a special liquid nutrition drink (partial enteral nutrition) to your regular diet can help prevent weight loss and muscle loss in people with Crohn's disease or ulcerative colitis who are at risk of malnutrition.
Rozzano, MilanoAges 18–65 - NCT07427680RecruitingPhase 1/Phase 2
Study of TGM-312-SC01 for MASH patients
This trial tests a new drug called TGM-312-SC01 to see if it can help people with MASH (a type of fatty liver disease that causes inflammation and damage). It is for adults aged 18 to 70 who are otherwise healthy or have MASH.
LondonAges 18–70 - NCT07427901Recruiting
Quality of life in colorectal cancer survivors
This study looks at how colorectal cancer and its treatment affect your daily life and well-being. It aims to help doctors better support patients like you during and after treatment.
LjubljanaAges 18 years+ - NCT07427017RecruitingPhase 2
Selenium for Ulcerative Colitis Patients on Biologics
This trial tests whether taking selenium supplements can help people with moderate to severe ulcerative colitis that is being treated with advanced therapies (biologics). The goal is to see if selenium can improve symptoms and reduce inflammation.
Chicago, IllinoisAges 18–85 - NCT07428356Recruiting
Sound waves for liver tumors
This study tests a new, noninvasive treatment called histotripsy that uses sound waves to destroy small liver tumors. It is for people whose liver cancer hasn't spread much and who haven't had success with or can't have surgery or other standard treatments.
SingaporeAges 21–99 - NCT07429864Recruiting
Bulevirtide for hepatitis D: bile acids and gut bacteria
This study looks at how Bulevirtide, a treatment for hepatitis D, affects bile acids and gut bacteria. It may help patients with chronic HDV and stable liver disease who are already on HBV therapy.
RomaAges 18 years+ - NCT07430579Recruiting
Adebrelimab with chemo for esophageal cancer
This trial tests adding adebrelimab (an immunotherapy drug) to standard chemotherapy for people with a type of esophageal cancer called squamous cell carcinoma. The goal is to see if this combination helps shrink tumors before surgery.
JinanAges 18–80 - NCT07430540Recruiting
A simpler colon cancer screening pathway
This study tests if a more straightforward screening process can work better for people referred with possible colon cancer symptoms. It looks at how a positive stool test (FIT) leads to a diagnosis.
EdinburghAges 18 years+ - NCT07433283RecruitingPhase 1/Phase 2
Iron nanoparticle injection for advanced solid tumors
This trial tests a new treatment for advanced solid tumors that uses tiny iron particles guided by carbon nanoparticles, injected directly into the tumor. It may be an option if standard treatments have stopped working or aren't available, and you have a tumor that can be safely injected.
Beijing, Beijing MunicipalityAges 18–80 - NCT07426003Recruiting
Healthy volunteer nutrition study with a special drink
This study looks at how healthy adults digest a special nutritional drink. Researchers want to understand normal digestion to help improve care for people with feeding tubes.
Philadelphia, PennsylvaniaAges 18–70 - NCT07428226Recruiting
Bile acid tests in pregnancy with liver issues
This study looks at bile acid levels in pregnant women who have intrahepatic cholestasis of pregnancy (ICP), a liver condition that causes itching and can affect the baby. It also includes two control groups: healthy pregnant women and healthy non-pregnant women for comparison.
Jena, ThuringiaAges 18–45 - NCT07434687Recruiting
Comparing two keyhole surgeries for belly button hernia
This trial tests two minimally invasive surgical methods for fixing a hernia near the belly button. It aims to find which approach works better and has fewer complications.
Lahore, Punjab ProvinceAges 18–65 - NCT07433985Recruiting
California mobile app study for men after jail release
This study tests a mobile app to help men recently released from jail or prison who use drugs or have sex with men stay healthy and avoid HIV. It's for people who don't have HIV and live in certain California counties.
Oakland, CaliforniaAges 18–59 - NCT07434843RecruitingPhase 2
Pemigatinib for a rare type of GIST
This trial tests a drug called pemigatinib for people with a specific type of GIST (SDH-deficient GIST) that has spread or cannot be removed with surgery. The goal is to see if the drug can help stop the cancer from growing.
Boston, MassachusettsAges 18 years+ - NCT07427992Recruiting
Study of zolbetuximab for stomach cancer with claudin 18.2
This trial is looking at a drug called zolbetuximab, given with chemotherapy, for people with a certain type of stomach or gastroesophageal junction cancer that has spread and has high levels of a protein called claudin 18.2. The goal is to see how well it works in real-world settings.
MilanAges 18–100 - NCT07432347Recruiting
Decoding liver cancer immune evasion with advanced testing
This trial studies liver cancer tissue to understand how the tumor hides from the immune system. The goal is to use this knowledge to improve future treatments.
Milan, LombardyAges 18 years+ - NCT07434739Recruiting
Pain relief after minimally invasive esophagectomy: catheter vs. epidural
This study compares two ways to manage pain after minimally invasive esophagectomy: a paravertebral catheter (a small tube near the spine) versus epidural analgesia (a tube in the back). The goal is to see which method provides better pain relief with fewer side effects.
LilleAges 18 years+ - NCT07431983Recruiting
IBUS vs colonoscopy and enterography for UC and CD
This study compares a newer, possibly greener imaging method (IBUS) with standard colonoscopy and enterography for people with ulcerative colitis (UC) or Crohn's disease (CD). The goal is to see if IBUS is as helpful and produces less waste or carbon emissions.
Hyderabad, TelanganaAges 18–80 - NCT07429760Enrolling by invitation
Bowel prep with or without antibiotics for left-sided colon surgery
This study compares two ways to prepare for left-sided colorectal cancer surgery: cleaning the bowel with liquid alone, or cleaning the bowel plus taking oral antibiotics beforehand. The goal is to see if adding antibiotics reduces infections after surgery.
Lahore, Punjab ProvinceAges 18–60 - NCT07427927Enrolling by invitation
Hemorrhoid surgery patient groups study
This study looks at people who have had surgery for hemorrhoids to find common patterns or groups among them. It may help improve care by better understanding different types of hemorrhoid disease.
San Donato Milanese, MilanAges 18 years+ - NCT07426835Recruiting
Comparing two hernia prevention methods in robotic esophageal cancer surgery
This trial compares two ways of closing the diaphragm during robotic esophageal cancer surgery to see if one reduces the chance of a hernia later. If you're having a robotic esophagectomy for cure, you may be able to join.
Dublin, BeaumontAges 18 years+ - NCT07431606RecruitingPhase 2
Duloxetine for Inflammatory Bowel Disease
This study tests whether duloxetine, a medication used for pain and mood, can help people with inflammatory bowel disease (IBD) who are also dealing with high stress, disability, or gut-related anxiety.
Philadelphia, PennsylvaniaAges 24 years+ - NCT07428629Recruiting
Insomnia treatment trial for people with ulcerative colitis
This trial tests whether a sleep-focused therapy can help people with active ulcerative colitis who also have trouble sleeping. It aims to improve both sleep and UC symptoms.
Lebanon, New HampshireAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,599 recruiting gastroenterology studies from the U.S. registry right now, out of 11,991 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.