Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,599 recruiting studies in this area right now.
By phase
- Not applicable4,683
- Phase 21,187
- Phase 1568
- Phase 3457
- Phase 1/Phase 2366
- Phase 4228
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona189
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,599 total
- NCT07430202RecruitingPhase 1
Vaccine plus drug combination for advanced fibrolamellar carcinoma
This study tests a new vaccine (a shot that may help your immune system attack cancer cells) combined with a glutamine-blocking drug (DRP-104) and two immunotherapy drugs (nivolumab and ipilimumab) for advanced fibrolamellar carcinoma. It aims to see if this combination can shrink tumors or slow their growth.
Baltimore, MarylandAges 12 years+ - NCT07434596Recruiting
Newborns with suspected intestinal blockage
This study looks at newborns who had signs of a possible intestinal blockage on a prenatal ultrasound. It aims to understand how before-birth findings relate to outcomes after delivery.
Florence, FlorenceAges birth–4 weeks - NCT07430579Recruiting
Adebrelimab with chemo for esophageal cancer
This trial tests adding adebrelimab (an immunotherapy drug) to standard chemotherapy for people with a type of esophageal cancer called squamous cell carcinoma. The goal is to see if this combination helps shrink tumors before surgery.
JinanAges 18–80 - NCT07429760Enrolling by invitation
Bowel prep with or without antibiotics for left-sided colon surgery
This study compares two ways to prepare for left-sided colorectal cancer surgery: cleaning the bowel with liquid alone, or cleaning the bowel plus taking oral antibiotics beforehand. The goal is to see if adding antibiotics reduces infections after surgery.
Lahore, Punjab ProvinceAges 18–60 - NCT07426835Recruiting
Comparing two hernia prevention methods in robotic esophageal cancer surgery
This trial compares two ways of closing the diaphragm during robotic esophageal cancer surgery to see if one reduces the chance of a hernia later. If you're having a robotic esophagectomy for cure, you may be able to join.
Dublin, BeaumontAges 18 years+ - NCT07428629Recruiting
Insomnia treatment trial for people with ulcerative colitis
This trial tests whether a sleep-focused therapy can help people with active ulcerative colitis who also have trouble sleeping. It aims to improve both sleep and UC symptoms.
Lebanon, New HampshireAges 18 years+ - NCT07427992Recruiting
Study of zolbetuximab for stomach cancer with claudin 18.2
This trial is looking at a drug called zolbetuximab, given with chemotherapy, for people with a certain type of stomach or gastroesophageal junction cancer that has spread and has high levels of a protein called claudin 18.2. The goal is to see how well it works in real-world settings.
MilanAges 18–100 - NCT07433426RecruitingPhase 2
Shigella infection treatment study for young children
This study tests how well a recommended treatment works for children aged 6 months to 5 years who have diarrhea caused by Shigella bacteria. It aims to find the best way to help children recover faster.
ChāndpurAges 6 months–4.9 years - NCT06295328RecruitingPhase 1/Phase 2
Terbinafine for chronic hepatitis B: safety and effect
This study tests whether a fungus-fighting drug, terbinafine, can help treat chronic hepatitis B. It is for people with stable disease who are not on other antivirals or are only on tenofovir.
Amsterdam, North HollandAges 18–60 - NCT06782412RecruitingPhase 2/Phase 3
New imaging test for different cancers using FAPI-PET
This trial is testing a new imaging method called FAPI-PET to see if it can help find and understand tumors better than standard scans. It is for people with newly diagnosed stomach/esophageal cancer, pancreatic cancer, or those with unclear symptoms or scan results.
EdegemAges 18 years+ - NCT05596630Recruiting
Stereotactic radiation for small liver cancer recurrence safety
This trial tests a precise type of radiation to treat small liver cancer that has come back after prior treatment. It aims to help with safety and long-term outcomes while protecting nearby organs and healthy liver.
Hangzhou, ZhejiangAges 18–80 - NCT06814600Recruiting
Fatty liver study in inflammatory bowel disease patients
This study checks how often people with Crohn's or ulcerative colitis also have fatty liver disease. It uses a painless scan to measure liver stiffness and fat. If you have IBD, you may join to help researchers learn about the link between these conditions.
BrusselsAges 18 years+ - NCT06813508Recruiting
Liver cancer and transplant study for MASLD patients
This study looks at factors that predict liver cancer and the need for a liver transplant in people with a liver condition called MASLD (metabolic dysfunction-associated steatotic liver disease). The goal is to better understand the disease and improve care.
Bologna, BolognaAges 18 years+ - NCT02972372Recruiting
Compare chemoradiation with surgery for esophageal cancer
This study compares two treatment approaches for certain locally advanced esophageal cancers: chemoradiation (chemo plus radiation) versus esophagus surgery. It may help find which option works better to control the cancer and improve outcomes.
Anyang, HenanAges 18–75 - NCT06139042Recruiting
Early detection of liver, bile duct, and pancreas cancers
This study aims to find new ways to detect liver, bile duct, and pancreatic cancers early using a blood test. It may help doctors diagnose these cancers sooner, when they are easier to treat.
Hangzhou, ZhejiangAges 40–75 - NCT04475952Recruiting
Diagnosing upper digestive problems earlier during routine care
This study aims to learn how to detect problems in the upper digestive tract earlier. People may be asked to help with diagnosis while they are already undergoing routine tests or treatment, which could improve future care.
LondonAges 18–90 - NCT06256393Recruiting
Studying inflammatory bowel disease in Nantes
This study collects information and samples from people with active inflammatory bowel disease who need surgery or an endoscopy. It aims to better understand these conditions and improve future treatments.
NantesAges 18 years+ - NCT06542796Recruiting
Classifying treatment effects for advanced liver cancer
This study looks at how well different treatments work for people with advanced liver cancer. It may help doctors better understand which treatments are most effective for patients like you.
Hangzhou, ZhejiangAges 18–75 - NCT06814457Recruiting
Nursing care bundle for swallowing after breathing tube removal in children
This trial tests a special nursing care plan to help children who had a breathing tube eat and drink safely after it's removed. It aims to reduce swallowing problems in the intensive care unit.
Kafr ash Shaykh, Kafr Ash Shaykh, Kafr el-Sheikh, Egypt,Ages 6–18 - NCT07421596Recruiting
Dietary supplement study for gut and digestive health
This trial tests whether a dietary supplement system can improve gut and digestive health over 8 weeks. You may be eligible if you have digestive symptoms like bloating, stomach pain, or diarrhea.
San Francisco, CaliforniaAges 18–80 - NCT07422870Recruiting
Registry for granulomatous mastitis
This study is creating a registry (a database) for people with a rare inflammatory breast condition called granulomatous mastitis. It aims to learn more about the disease and how it affects people, without testing any new treatments.
Düsseldorf, North Rhine-WestphaliaAges 18 years+ - NCT07424677RecruitingPhase 3
Saroglitazar for PBC with incomplete UDCA response
This trial tests a new oral medication, saroglitazar magnesium, for people with Primary Biliary Cholangitis (PBC) who have not improved enough on standard therapy (UDCA) or cannot tolerate it. The goal is to see if it can help control liver enzymes and improve outcomes.
Lakewood Rch, FloridaAges 18–80 - NCT07419841RecruitingPhase 1
A study of CTX-10726 for certain advanced cancers
This trial tests a new drug called CTX-10726 in people with advanced kidney, liver, stomach, or uterine cancer that has not responded to standard treatments. The goal is to see if the drug is safe and tolerable.
Phoenix, ArizonaAges 18 years+ - NCT07423000RecruitingPhase 1
Testing PVT401 in healthy volunteers
This study tests a new investigational drug called PVT401 in healthy people. It is a first-in-human study to see how the drug is handled by the body and to check for any side effects.
Melbourne, VictoriaAges 18–65
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,599 recruiting gastroenterology studies from the U.S. registry right now, out of 11,991 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.