Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,599 recruiting studies in this area right now.
By phase
- Not applicable4,683
- Phase 21,187
- Phase 1568
- Phase 3457
- Phase 1/Phase 2366
- Phase 4228
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona189
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,599 total
- NCT07423000RecruitingPhase 1
Testing PVT401 in healthy volunteers
This study tests a new investigational drug called PVT401 in healthy people. It is a first-in-human study to see how the drug is handled by the body and to check for any side effects.
Melbourne, VictoriaAges 18–65 - NCT07416552RecruitingPhase 1
Study of CEA-PRIT 2.0 for advanced colorectal cancer
This trial tests an experimental drug called CEA-PRIT 2.0 in people whose colorectal cancer has spread and is no longer responding to standard treatments. The goal is to see if it can help shrink tumors or slow the cancer's growth.
Chicago, IllinoisAges 18 years+ - NCT07424677RecruitingPhase 3
Saroglitazar for PBC with incomplete UDCA response
This trial tests a new oral medication, saroglitazar magnesium, for people with Primary Biliary Cholangitis (PBC) who have not improved enough on standard therapy (UDCA) or cannot tolerate it. The goal is to see if it can help control liver enzymes and improve outcomes.
Lakewood Rch, FloridaAges 18–80 - NCT06816615Recruiting
Treating gallstones and bile duct problems through the skin
This trial tests a new way to diagnose and treat gallstones or bile duct narrowing without surgery, using a needle through the skin (percutaneous treatment). It is for people whose condition could not be fixed with an endoscope.
Bologna, BOAges 18 years+ - NCT07420309Recruiting
Colonoscopy training with or without AI assistance for residents
This trial tests whether using artificial intelligence (AI) during colonoscopy training helps endoscopy trainees find polyps better. It involves adult patients getting a colonoscopy for screening, diagnosis, or follow-up.
LarissaAges Any age - NCT07418112RecruitingPhase 4
Laser vs other device for hard bile or pancreas stones
This study compares two types of lithotripsy (stone-breaking) devices, holmium laser and electrohydraulic lithotripsy, for treating difficult stones in the bile or pancreatic ducts. If you have a bile or pancreas stone that is large, stuck, or could not be removed with standard procedures, this trial may help determine which method works best.
Chicago, IllinoisAges 19–85 - NCT07424391Recruiting
Predicting polyp types during colonoscopy
This trial uses a digital tool to help doctors predict polyp types during a colonoscopy, avoiding unnecessary removal and speeding up results.
Charenton-le-Pont, Val de MarneAges 18 years+ - NCT07425054RecruitingPhase 2
Chemoradiation with or without immunotherapy for anal cancer
This trial tests whether adding an immunotherapy drug (retifanlimab) to standard chemoradiation improves outcomes for people with locally advanced anal cancer. The treatment is adjusted based on HPV DNA levels in your blood.
Cleveland, OhioAges 18 years+ - NCT07419490Recruiting
Moving ovaries and uterus to preserve fertility during pelvic radiation
This trial moves the ovaries and uterus higher in the belly before pelvic radiation to protect them, so patients may still be able to have children later. It is for women aged 18-40 with pelvic cancers that require radiation.
Tampa, FloridaAges 1.5 years–3.3 years - NCT07422974Recruiting
Surgery results after pre-treatment for colorectal cancer
This study looks at how well patients recover from colorectal cancer surgery, comparing those who had chemotherapy or radiation before surgery to those who did not. The goal is to understand if pre-treatment affects surgical outcomes.
OsijekAges 18 years+ - NCT07417800Recruiting
Predicting liver cancer treatment after surgery
This study uses digital scans of your tumor tissue and CT/MRI images to build a computer model that helps predict whether you might need extra treatment (adjuvant therapy) after liver cancer surgery. The goal is to use your own tissue and scan data to personalize follow-up care.
Hangzhou, ZhejiangAges 18 years+ - NCT07424963Recruiting
Comparing two ways to measure liver pressure
This study compares a newer, less invasive method using an endoscope (EUS-PPG) with a standard catheter method (HVPG) to measure liver pressure in people with advanced liver disease. The goal is to see if the newer method is equally accurate and safer.
Prague, BohemiaAges 18–75 - NCT07420231Recruiting
Prebiotic and Postbiotic for Digestive Comfort
This trial tests whether taking a prebiotic and a postbiotic together can help reduce intestinal discomfort such as bloating, gas, or stomach pain. If you have ongoing mild to moderate digestive symptoms, this study may offer a new approach to feeling better.
Louvain-la-Neuve, Brabant WallonAges 18–75 - NCT07417358Recruiting
Single-stapled method for colorectal reconnection
This study compares a single-stapled method for reconnecting the colon after left-sided colorectal surgery. It aims to see if this technique works as well or better than the usual approach.
GothenburgAges 18 years+ - NCT07416760Recruiting
Gut bacteria study after intestinal surgery
This study looks at how gut bacteria change after surgery to reconnect the intestines (anastomosis). It may help doctors understand complications and improve recovery.
MadridAges 18 years+ - NCT07417267Enrolling by invitation
Clean Air Study for Lung Health in CF or PCD
This study tests whether using air cleaners in your home can improve lung health for people with cystic fibrosis (CF) or primary ciliary dyskinesia (PCD). It takes place in Cyprus and requires you to stay at home most days.
Nicosia, AglantziaAges 6 years+ - NCT07418008Recruiting
Thinking and memory study for people with liver cirrhosis
This study is creating a new test to measure thinking and memory problems in people with liver cirrhosis. It may help doctors find these problems earlier.
Ambāla, HaryanaAges 18–75 - NCT07419724Recruiting
Portal hypertension biobank study
This study collects medical data and images from people with portal hypertension who have enlarged veins in the esophagus or stomach. It aims to build a database for future research.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07424898Enrolling by invitation
Lactose Intolerance and Gut Health Study
This study looks at how lactose intolerance is linked to gut health. It is for adults with ongoing digestive issues like bloating, pain, or diarrhea, to see if their gut lining may be more sensitive.
IstanbulAges 18–70 - NCT07422792Recruiting
Amino acids for gut failure patients on IV nutrition
This trial tests how well a special amino acid solution given through a vein helps people with chronic intestinal failure who rely on home IV nutrition. It aims to see if it can improve your body's ability to build and repair tissue.
LjubljanaAges 18 years+ - NCT07425483RecruitingPhase 1
CAR-NK cell therapy for advanced pancreatic cancer
This trial tests a new treatment using immune cells (CAR-NK cells) to fight pancreatic cancer that has spread or come back. It may be an option if standard treatments have stopped working, were not tolerated, or were refused.
ShanghaiAges 18–75 - NCT07424586RecruitingEarly Phase 1
Better recovery for older adults with ostomy surgery
This study tests a program to help adults aged 65 and older recover well after ostomy surgery (a surgery that creates an opening on the belly for waste to leave the body). It also involves their healthcare providers.
Boston, MassachusettsAges 18 years+ - NCT07425249Recruiting
Chewing gum after stomach or bowel surgery
This trial tests if chewing gum after open stomach or bowel surgery can help your intestines start moving again sooner. It is for people undergoing open gastrointestinal surgery who do not have certain health conditions or take specific medicines.
Peshawar, KPKAges 17–85 - NCT07417488RecruitingPhase 1
Vaccine therapy for advanced colorectal and small bowel cancer
This trial tests a vaccine therapy for people with advanced colorectal or small bowel cancer that has spread or can't be removed. The vaccine targets a protein found on cancer cells to help your immune system fight the cancer.
Philadelphia, PennsylvaniaAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,599 recruiting gastroenterology studies from the U.S. registry right now, out of 11,991 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.