Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,879 recruiting studies in this area right now.
By phase
- Not applicable4,911
- Phase 21,185
- Phase 1581
- Phase 3465
- Phase 1/Phase 2391
- Phase 4235
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer491
- Gastric Cancer296
- Pancreatic Cancer289
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer97
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona177
- Texas149
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland85
- Ohio79
- Pennsylvania72
Recruiting studies7,879 total
- NCT04250259RecruitingPhase 2
SAMe treatment study for alcoholic cirrhosis
This Phase 2 study tests whether SAMe can help people with alcoholic cirrhosis (scarred liver) who are in early to mid stages. It may also include healthy volunteers to compare safety and blood/body measurements.
Los Angeles, CaliforniaAges 18–70 - NCT04255693Recruiting
Real-life reflux study of diet and behavior changes
This study looks at how following specific diet and behavior changes affects symptoms of acid reflux (heartburn/regurgitation) in everyday life. It may help you understand what lifestyle steps improve reflux and how symptoms change over time.
MoscowAges 18–80 - NCT04259580Recruiting
Patient registry for ERCP procedures and related studies
This trial is a registry that collects information about adults who are having an ERCP procedure at the study site. It may help researchers better understand outcomes and improve care by tracking real-world results and possibly running smaller future studies.
Calgary, AlbertaAges 18 years+ - NCT04268121RecruitingPhase 2
Neoadjuvant chemotherapy before surgery for certain digestive neuroendocrine cancers
This study looks at whether chemotherapy given before surgery improves how long patients live without the cancer coming back. It’s aimed at people with localized, poorly differentiated digestive neuroendocrine carcinoma with a higher growth rate marker.
AmiensAges 18 years+ - NCT04273061RecruitingPhase 2
Atezolizumab for tumors that look sensitive on DNA/RNA testing
This Phase 2 study tests atezolizumab, an immunotherapy drug, in people with advanced, incurable solid tumors whose tumor DNA/RNA suggests they may respond. The goal is to see if the treatment works better for patients selected by these lab results.
Vancouver, British ColumbiaAges 18 years+ - NCT04275557Recruiting
Using scan and blood data to judge pancreatic cyst risk
This study looks at how medical images and lab samples can predict which pancreatic cysts or tumors are more likely to be dangerous. If you are being evaluated for a pancreatic problem and haven’t started pancreas treatment, your scans and samples may help researchers improve risk prediction.
Lakewood Rch, FloridaAges 18 years+ - NCT04278222RecruitingPhase 2
Anlotinib plus immunotherapy for advanced stomach cancer
This Phase 2 study tests whether combining two medicines—anlotinib and toripalimab—can work well as first treatment for advanced (stage IV) stomach cancer. It’s meant for people who have an adequate overall health status and certain blood/organ function levels.
ShanghaiAges 18 years+ - NCT04278287RecruitingPhase 1/Phase 2
Chemoradiation study for unresectable esophageal cancer
This Phase 1/2 trial tests a treatment plan using chemotherapy plus radiation for esophageal squamous cell cancer that cannot be removed with surgery. It may help shrink or control the cancer and guide safer dosing, but it’s only for people with specific tumor stage, health status, and blood test results.
Anyang, HenanAges 18–75 - NCT04280822RecruitingPhase 3
Immunotherapy plus chemo versus chemo alone before surgery
This Phase 3 trial tests whether adding immunotherapy to chemotherapy before surgery works better than chemotherapy alone for resectable esophageal cancer. The goal is to improve outcomes after tumor shrinkage before the operation.
Zhengzhou, HenanAges 18–75 - NCT04280510Recruiting
Study of immune-related gut illnesses in adults
This study looks at adults with immune-related stomach and intestine problems to better understand what may cause them. If you qualify, you can share information and consent to help researchers learn how these conditions work.
CréteilAges 18 years+ - NCT04282044RecruitingPhase 1
CRX100 drug trial for advanced cancers with or without pembrolizumab
This Phase 1 trial tests CRX100 (a new cancer medicine) alone and with pembrolizumab (an immune checkpoint drug) in people with advanced solid tumors. It’s mainly designed to check safety and side effects, and to see whether tumors respond, potentially helping people whose cancer has come back or stopped responding to standard treatment.
Scottsdale, ArizonaAges 18 years+ - NCT04288999RecruitingPhase 3
Surgery plus chemo versus chemo-radiation then surgery for recurrent rectal cancer
This study compares two treatment plans for locally recurrent rectal cancer: (1) surgery plus chemo, or (2) chemo plus radiation first, then surgery, followed by chemo. It aims to see which approach works better in controlling the cancer and helping patients recover.
ChibaAges 20–80 - NCT04290806Recruiting
SAPHIR registry for advanced stomach and esophagus cancer
This registry collects information from people with stage IV (metastatic) stomach or esophagus cancers who are about to start their first medicines to control the disease. It may help researchers understand which treatments are used and how patients do over time.
Multiple LocationsAges 18 years+ - NCT04291755Recruiting
Stool bank for people receiving cancer immunotherapy
This study is building a “stool bank,” meaning they collect and store stool samples from people who are getting cancer immunotherapy. Researchers plan to analyze these samples to better understand cancer and treatment—your participation may help future research.
Fountain Valley, CaliforniaAges 18 years+ - NCT04291651Recruiting
Pancreatic Cyst Registry for Adults With Pancreatic Cysts
This registry study collects information from adults who have a pancreatic cyst (a fluid-filled sac in the pancreas). It may help doctors understand these cysts and how they change over time, which can improve future care.
San Francisco, CaliforniaAges 18 years+ - NCT04294043RecruitingPhase 1
Gallium IV study for adults with cystic fibrosis and NTM lung infection
This Phase 1 study tests whether an IV medicine called gallium can treat hard-to-treat lung infections (NTM) in adults with cystic fibrosis. It is mainly for people who have not been treated yet for NTM or who have NTM that has not cleared despite antibiotics.
Birmingham, AlabamaAges 18 years+ - NCT04305769RecruitingPhase 2
Alanyl-glutamine to help treat C. difficile diarrhea
This study tests whether the supplement alanyl-glutamine, given along with standard treatment, can improve outcomes for adults being treated for C. difficile infection (a cause of diarrhea). It may help the body recover better after antibiotics that usually treat C. difficile.
Charlottesville, VirginiaAges 18–105 - NCT04307901Recruiting
Test a capsule that checks the colon when colonoscopy isn’t finished
This trial tests whether a swallowable camera capsule can safely check the colon and find possible tumor-related issues when a standard colonoscopy can’t be completed. It may help people who can’t or don’t want another colonoscopy right away.
SvendborgAges 18 years+ - NCT04310787Recruiting
Tracking outcomes in adults with hepatitis B liver failure
This study looks at long-term survival in people ages 18–65 who are hospitalized with hepatitis B–related acute-on-chronic liver failure. It may help doctors better predict prognosis and improve care for people with this serious condition.
Guangzhou, GuangdongAges 18–65 - NCT04312633Recruiting
Testing a new throat biopsy mapping method for Barrett’s disease
This study follows people for 5 years to see how well a new biopsy-mapping test (WATS3D) works during routine upper endoscopy. It may help doctors find Barrett’s esophagus changes earlier and better guide follow-up after treatment.
Bethpage, New YorkAges 18 years+ - NCT04314375RecruitingPhase 4
Budesonide tablets for children with mild to moderate ulcerative colitis
This trial studies whether budesonide extended-release tablets are safe and effective for improving symptoms in children ages 5–17 with active, mild to moderate ulcerative colitis. It also measures how the medicine moves through the body.
Garden Grove, CaliforniaAges 5–17 - NCT04320199Recruiting
Fermented beetle powder for alcohol-related liver problems
This trial tests whether a fermented powder made from a specific beetle can improve or protect the liver after alcohol-related liver injury. It’s looking for people with certain liver blood test levels, and it excludes several conditions and recent herbal or liver-affecting treatments.
Pusan, Ami-dongAges 19 years+ - NCT04328948RecruitingPhase 3
Preventive radiation for early esophagus cancer after chemoradiation
This Phase 3 trial tests whether giving preventive (prophylactic) radiation reduces cancer coming back in people with early esophagus cancer after standard chemoradiation. It may help by lowering the chance that microscopic cancer spreads to nearby areas.
TokyoAges 20 years+ - NCT04329494RecruitingPhase 1
Study of targeted drug delivery into the abdomen using PIPAC
This Phase 1 trial tests PIPAC, a way to deliver anti-cancer medicine directly into the abdomen using a minimally invasive procedure. It is for people with peritoneal spread from certain cancers to see whether this approach is safe and potentially helpful.
Duarte, CaliforniaAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,879 recruiting gastroenterology studies from the U.S. registry right now, out of 12,372 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.