Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,599 recruiting studies in this area right now.
By phase
- Not applicable4,683
- Phase 21,187
- Phase 1568
- Phase 3457
- Phase 1/Phase 2366
- Phase 4228
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona189
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,599 total
- NCT07418112RecruitingPhase 4
Laser vs other device for hard bile or pancreas stones
This study compares two types of lithotripsy (stone-breaking) devices, holmium laser and electrohydraulic lithotripsy, for treating difficult stones in the bile or pancreatic ducts. If you have a bile or pancreas stone that is large, stuck, or could not be removed with standard procedures, this trial may help determine which method works best.
Chicago, IllinoisAges 19–85 - NCT07420231Recruiting
Prebiotic and Postbiotic for Digestive Comfort
This trial tests whether taking a prebiotic and a postbiotic together can help reduce intestinal discomfort such as bloating, gas, or stomach pain. If you have ongoing mild to moderate digestive symptoms, this study may offer a new approach to feeling better.
Louvain-la-Neuve, Brabant WallonAges 18–75 - NCT07420309Recruiting
Colonoscopy training with or without AI assistance for residents
This trial tests whether using artificial intelligence (AI) during colonoscopy training helps endoscopy trainees find polyps better. It involves adult patients getting a colonoscopy for screening, diagnosis, or follow-up.
LarissaAges Any age - NCT07425483RecruitingPhase 1
CAR-NK cell therapy for advanced pancreatic cancer
This trial tests a new treatment using immune cells (CAR-NK cells) to fight pancreatic cancer that has spread or come back. It may be an option if standard treatments have stopped working, were not tolerated, or were refused.
ShanghaiAges 18–75 - NCT05984511Recruiting
Combined treatment for liver cancer with portal vein tumor thrombus
This trial tests whether adding immunotherapy (atezolizumab/bevacizumab) and a type of internal radiation (I-125 seeds) to standard chemoembolization (TACE) can help people with liver cancer that has spread into the main liver blood vessel (portal vein). It aims to control the tumor and improve outcomes.
Guangzhou, GuangzhouAges 18–75 - NCT05520788Recruiting
Genetic test-guided treatment for advanced bile and liver cancers
This study looks at using a genetic test (next-generation sequencing) to find cancer gene changes in stage IV hepatobiliary cancer. If there is a matching approved medicine, the study follows how well the “right drug for the right mutation” helps patients receiving palliative care.
Wuhan, HubeiAges 18 years+ - NCT05920863RecruitingPhase 2
Lenvatinib, immunotherapy, plus liver artery treatment before surgery
This Phase 2 trial tests whether giving lenvatinib and immunotherapy along with TACE (a liver artery treatment) before surgery can lower the risk of hepatocellular carcinoma coming back after surgery. It targets people with certain higher-risk early-stage liver tumors (CNLC IB/IIA).
Hangzhou, ZhejiangAges 18–75 - NCT05737953Recruiting
Testing a lab test to identify pancreatic cyst tumor type
This study builds a “molecular marker” lab model using pancreatic cyst fluid taken during planned pancreatic surgery. It aims to help tell which pancreatic cystic tumors are which, based on fluid analysis.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06594783RecruitingPhase 4
Preventing varices bleeding with carvedilol and banding
This trial tests whether adding endoscopic banding helps prevent bleeding from enlarged varices in people with cirrhosis who still have high-risk varices despite taking carvedilol.
TaipeiAges 18–90 - NCT04103567Recruiting
Testing stool and bacteria clues for poor rectal cancer response
This study looks at stool samples to see whether gut bacteria or other microbes help explain why some rectal cancers respond less well to treatment given before surgery. If you have mid or lower rectal cancer and are planning pre-surgery treatment, your information and stool sample may help researchers improve how treatment is chosen.
Montpellier, HéraultAges 18 years+ - NCT06819215RecruitingPhase 1/Phase 2
VB15010 for advanced solid tumors with HRR gene mutation
This trial tests an oral medication (VB15010) in people with advanced solid tumors that have a specific DNA repair gene mutation (called HRR mutation). The goal is to see if the drug can stop or slow down cancer growth.
Jinan, ShandongAges 18–75 - NCT03449264Recruiting
Database study for people with certain new cancers
This study builds a clinical and biological database for people newly diagnosed with certain cancers. It may help doctors better understand cancer patterns and improve future care, and it involves agreeing to extra blood samples.
MontpellierAges 18 years+ - NCT03976999Recruiting
Database study for ovarian, fallopian tube, and peritoneal cancers
This is a study that collects information and samples from people diagnosed with epithelial ovarian cancer, fallopian tube cancer, or primary peritoneal cancer. It helps doctors better understand these cancers by building a clinical and biological database, which may improve care planning in the future.
MontpellierAges 18 years+ - NCT03976960Recruiting
Database study for colon cancer surgery patients
This study collects clinical and lab information from people who have surgery for colon cancer (or certain precancer growths) and related spread to organs. It may help researchers better understand colon cancer and improve future care, but it is not a new medication trial.
Montpellier, HéraultAges 18 years+ - NCT03713879RecruitingPhase 3
Indomethacin vs pancreatic stent to prevent post-ERCP pancreatitis
This study compares indomethacin (an anti-inflammatory medicine) against using a temporary pancreatic stent to prevent pancreatitis after an ERCP procedure. It may help you lower the chance of painful inflammation of the pancreas after ERCP.
Xi'an, ShaanxiAges 18–99 - NCT03978078Recruiting
Database study for metastatic GI cancer care
This study collects clinical and lab information to better understand metastatic cancers of the digestive system and how patients respond to treatment. It may help improve future care, but it is mainly focused on collecting data rather than testing a new drug.
Montpellier, HéraultAges 18 years+ - NCT04136132Recruiting
Pancreatic cancer patient database for research
This study collects medical and lab information from adults with pancreatic cancer to help researchers understand care and outcomes. You may be asked for follow-up visits and basic data, and it may be used to improve future treatments.
Montpellier, OccAges 18 years+ - NCT05792267Recruiting
AI system for pancreas scans during endoscopic ultrasound
This trial tests a new computer (deep-learning) system to help analyze pictures from an endoscopic ultrasound scan of the pancreas. It may improve how the scan is done or interpreted, depending on study results.
Changsha, HunanAges 18–80 - NCT05802264RecruitingPhase 1
Inhaled amphotericin B for healthy volunteers and cystic fibrosis
This early-phase study tests how different doses of an inhaled medicine (amphotericin B) work and are tolerated. It includes healthy adults and people with cystic fibrosis (CF) to see if the dose schedule is safe and potentially beneficial.
Canberra, Australian Capital TerritoryAges 16 years+ - NCT05974904Recruiting
Study links a liver-related cell marker to fatty liver damage
This study looks at existing health survey data to see whether a specific immune-cell marker (called HsCAR) is related to fatty liver disease and liver scarring. It may help researchers better understand which people are at higher risk for worsening liver damage.
Chongqing, Chongqing MunicipalityAges 18–90 - NCT06636513Recruiting
Testing SMT04 for irritable bowel syndrome
This trial tests a new treatment called SMT04 for people with irritable bowel syndrome (IBS), specifically the diarrhea or mixed types. It may help reduce symptoms like abdominal pain and changes in bowel habits.
Singapore, SingaporeAges 21–55 - NCT06144762Recruiting
Precision imaging for early detection and treatment monitoring in pancreatic cancer
This trial uses advanced imaging to detect pancreatic cancer early and track how well treatment is working. It may help if you have pancreatic cancer that can be surgically removed, either right away or after chemotherapy.
MontpellierAges 18 years+ - NCT06318949Recruiting
Albumin changes as early signs of chronic liver disease
This study is looking at whether changes in a protein called albumin can help find liver disease earlier. It is for people who have some liver scarring but no serious complications.
AngersAges 18 years+ - NCT06055387Recruiting
Frailty care for older stomach cancer patients after surgery
This study tests a frailty assessment and intervention program for people aged 65+ with stage II or III stomach cancer who will have surgery and chemotherapy afterward. It aims to improve recovery and quality of life.
Taoyuan, TaiwanAges 65 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,599 recruiting gastroenterology studies from the U.S. registry right now, out of 11,991 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.