Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,890 recruiting studies in this area right now.
By phase
- Not applicable4,918
- Phase 21,185
- Phase 1582
- Phase 3465
- Phase 1/Phase 2393
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer491
- Gastric Cancer296
- Pancreatic Cancer290
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer97
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona177
- Texas149
- Florida133
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,890 total
- NCT06461208RecruitingPhase 3
Fecal transplant for people with cirrhosis
This trial tests whether transplanting healthy gut bacteria (from donor stool) can improve outcomes in people with cirrhosis. If you have mild to moderate cirrhosis, you may be able to join.
BasildonAges 18 years+ - NCT06461910RecruitingPhase 2
Immunotherapy, thymalfasin, and chemo before surgery for stomach cancer
This trial is testing a combination of three medicines—an immunotherapy (anti-PD-1), an immune booster (thymalfasin), and a chemotherapy regimen (SOX)—given before surgery to shrink stage III stomach or gastroesophageal junction cancer and improve outcomes.
Nanjing, JiangsuAges 18–75 - NCT06462183RecruitingPhase 1
Study of RGT-61159 for Advanced ACC or CRC
This trial tests a new drug called RGT-61159 for adults with adenoid cystic carcinoma or colorectal cancer that has returned or stopped responding to treatment. The goal is to see if the drug is safe and effective in shrinking tumors.
Boston, MassachusettsAges 18 years+ - NCT06462963Recruiting
Single vs multiple radiation doses for cancer spread
This trial compares a single, strong dose of radiation to multiple smaller doses for treating cancer that has spread to a few spots. It aims to see which approach causes fewer side effects.
AalstAges Any age - NCT06463522RecruitingPhase 1/Phase 2
Immune cell therapy for liver cancer
This trial tests using your own immune cells (tumor-infiltrating lymphocytes) to fight advanced liver cancer. It may help if you have Barcelona Clinic Liver Cancer (BCLC) stage B or C and your liver function is still fairly good.
BeijingAges 18–70 - NCT06463834RecruitingPhase 2
Sintilimab plus chemo before surgery for esophageal cancer
This study tests a combination of an immunotherapy drug (sintilimab) with chemotherapy given before surgery for a type of esophageal cancer called squamous cell carcinoma. The goal is to see if this treatment shrinks the tumor and improves outcomes.
Fuzhou, FujianAges 18–75 - NCT06463912Recruiting
Hepatitis C screening for people who inject drugs in Armenia
This study is testing a screening program for hepatitis C among people who inject drugs in Armenia, Colombia. It aims to find and help those who may have the virus but don't know it.
Armenia, Quindío DepartmentAges 18–100 - NCT06464952Recruiting
Prebiotics for PTSD and cirrhosis
This trial tests if a prebiotic supplement can improve gut health and PTSD symptoms in people with cirrhosis and PTSD. It aims to see if changing the gut microbiome can help both conditions.
Richmond, VirginiaAges 18 years+ - NCT06464978Recruiting
Reinforcement patches during stomach cancer surgery
This study tests whether adding a special reinforcement patch to the surgical stapler during stomach cancer surgery helps reduce complications. It compares this to the standard stapler method.
Nanchong, SichuanAges 18–85 - NCT06466291Recruiting
Spanish Wilson Disease Registry
This study is a registry that collects information about people with Wilson disease. By joining, you can help researchers learn more about the condition and improve care for others.
BarcelonaAges 18 years+ - NCT06466902Recruiting
Using photos to check lymph node removal in stomach cancer surgery
This study tests if taking photos during minimally invasive stomach cancer surgery can help doctors check that all the right lymph nodes were removed. If you're having a laparoscopic or robotic gastrectomy for stomach cancer, this study might be for you.
Cremona, CRAges 18 years+ - NCT06467799RecruitingPhase 2
New drug combo before and after surgery for high-risk liver cancer
This trial tests giving a liver-directed chemotherapy (HAIC) plus an immunotherapy (PD-1) before surgery, followed by more immunotherapy after surgery, for people with a specific type of liver cancer that has a high chance of coming back. The goal is to see if this approach can reduce the risk of recurrence.
Guangzhou, GuangdongAges 18–75 - NCT06468280RecruitingPhase 2
Immunotherapy and chemo with surgery for limited-spread stomach cancer
This trial tests a combination of an immunotherapy drug (PD-1 antibody) plus chemotherapy or targeted therapy, followed by surgery, for people with stomach cancer that has spread to a limited number of other sites. The goal is to see if this approach can help shrink the cancer enough to make surgery more effective.
Shanghai, Shanghai CityAges 18–79 - NCT06468709RecruitingPhase 4
Preventing recurrence of high-risk type 1 AIP
This trial studies a treatment to prevent recurrence in people with type 1 autoimmune pancreatitis (AIP) who are at high risk. It looks at how well the treatment works and whether it can keep the disease from coming back.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06468774Recruiting
Test for gut ischemia in chronic belly artery disease
This study tests a blood marker for chronic mesenteric ischemia (poor blood flow to the gut). If it works, it could help doctors diagnose the condition faster and more easily.
Oslo, OsloAges 18 years+ - NCT06469424Recruiting
Safety of Tofacitinib in Ulcerative Colitis
This study follows people with moderately to severely active ulcerative colitis who are taking the medication tofacitinib (Xeljanz). It aims to track any safety concerns in a real-world setting, using information already collected in a European registry (UR-CARE).
BonheidenAges 18 years+ - NCT06472063Recruiting
Surgery first vs chemo then surgery for advanced stomach cancer
This trial compares two approaches for stomach cancer that has spread a bit but can still be removed with surgery. One group has surgery first, the other gets chemotherapy before surgery. The goal is to see which sequence leads to better long-term outcomes.
Orbassano, PiedmontAges 18 years+ - NCT06472388RecruitingPhase 2
Testing two doses of everolimus for neuroendocrine tumors
This trial compares two daily doses (5 mg vs 10 mg) of everolimus, a targeted therapy, to see which works better and is safer for people with advanced neuroendocrine tumors (NETs). You may qualify if your cancer has grown despite previous treatment and you are in relatively good health.
São Paulo, São PauloAges 16 years+ - NCT06473454Recruiting
Physiotherapy for irritable bowel syndrome
This study is testing whether a special physiotherapy program focused on posture and movement can help ease symptoms of Irritable Bowel Syndrome. It is for people who want a non-drug treatment option and are willing to participate in exercise sessions.
IstanbulAges 18–65 - NCT06474468RecruitingPhase 1/Phase 2
Study of a new drug combo for advanced esophageal cancer
This trial tests a combination of two investigational drugs for people with advanced or metastatic esophageal squamous cell carcinoma. The goal is to see if the combination can shrink tumors or slow cancer growth.
Jinan, ShandongAges 18–70 - NCT06475118Recruiting
Blood tests and scans to measure muscle loss in liver cancer
This study looks at whether measuring certain proteins in your blood (myokines) can help detect muscle loss (sarcopenia) in people with liver cancer, and compares these blood tests to special CT scans. If you're newly diagnosed with liver cancer and have a CT scan already, you may be able to join.
ReimsAges 18 years+ - NCT06475170Recruiting
Double-tract reconstruction after stomach cancer surgery
This trial tests a new surgical method called 'λ+α' double-tract reconstruction after laparoscopic removal of the upper part of the stomach for early-stage stomach cancer. It aims to see if this procedure improves recovery and quality of life for patients.
YangzhouAges 18–75 - NCT06475326RecruitingPhase 2
Adebrelimab plus chemo for locally advanced pancreas cancer
This trial tests a new immunotherapy drug (adebrelimab) combined with a standard chemotherapy cocktail (NALIRIFOX) for people with locally advanced pancreatic cancer that cannot be removed by surgery. The goal is to see if this combination shrinks or controls the cancer better than chemo alone.
ShanghaiAges 18–75 - NCT06475352RecruitingPhase 2
Tailoring chemo dose for GI cancer patients low in a liver enzyme
This trial tests whether adjusting the dose of chemotherapy drugs (5-FU or capecitabine plus oxaliplatin) based on a liver enzyme test can improve safety and effectiveness for people with gastrointestinal cancer who are starting this type of chemo for the first time.
AmiensAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,890 recruiting gastroenterology studies from the U.S. registry right now, out of 12,399 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.