Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,874 recruiting studies in this area right now.
By phase
- Not applicable4,909
- Phase 21,178
- Phase 1584
- Phase 3466
- Phase 1/Phase 2389
- Phase 4235
- Phase 2/Phase 3113
Top conditions
- Colorectal Cancer495
- Gastric Cancer297
- Pancreatic Cancer294
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer174
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer113
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)103
- Liver Cancer99
- Lung Cancer98
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University89
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California465
- Arizona175
- Texas146
- Florida134
- Massachusetts128
- New York123
- Alabama121
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,874 total
- NCT05484206RecruitingPhase 1
Study how liver impairment affects two investigational medicines
This Phase 1 study tests how two investigational medicines move through the body and how safe they are in people with different levels of liver impairment, compared with healthy volunteers. It may help doctors understand dosing and safety for people with liver problems.
Rialto, CaliforniaAges 18–70 - NCT05449119Recruiting
Study links gut health, diet, and thinking and movement in seniors
This study looks at how differences in gut bacteria and nutrition may relate to changes in thinking and movement in people over 75 who have a reduced appetite (“small eaters”). It may help doctors better understand what could be contributing to these problems and how nutrition might play a role.
DijonAges 75 years+ - NCT05424159Recruiting
Carbon ion radiation for locally advanced pancreatic cancer
This trial tests a type of radiation that uses carbon ions to treat pancreatic cancer that can’t be removed with surgery but has not spread to distant organs. It may help shrink or control the tumor while limiting radiation side effects to nearby organs.
ShanghaiAges 18–80 - NCT05418244RecruitingPhase 2/Phase 3
Inhaled isopropyl alcohol for nausea and vomiting relief
This trial tests whether breathing in a small amount of isopropyl alcohol through the nose can reduce nausea or vomiting. It may help people who still have bothersome nausea even with usual care, by using a non-oral approach to start feeling better.
Buffalo, New YorkAges 7–17 - NCT05355909Recruiting
High-intensity pre-surgery training before major belly surgery
This trial tests whether a structured, high-activity fitness program before elective abdominal surgery can help you prepare and recover better. It’s meant for people considered at moderate to high surgical risk who can safely do pre-op exercise.
Innsbruck, TyrolAges 18–99 - NCT05327478Recruiting
Compare treatments for controlled donation after circulatory death
This trial compares different care approaches for adult donors in a specific type of controlled donation after the heart stops. It aims to find which approach best supports organ/tissue use after donation.
Rotterdam, South HollandAges 50–75 - NCT05303714RecruitingPhase 3
PIPAC plus chemo for limited peritoneal stomach cancer
This trial tests a treatment called PIPAC (medicine delivered into the abdomen through a small scope) along with “multimodal” therapy, including chemotherapy, for stomach cancer that has spread only in the lining of the abdomen in limited amounts. It may help control the cancer and prevent progression after surgery.
VeronaAges 18–75 - NCT05255978Recruiting
Follow-up study for hepatitis B with fatty liver
This observational study looks at people with chronic hepatitis B who also have fatty liver (non-alcoholic fatty liver disease). It follows how their liver health changes over time and may help doctors understand outcomes and risk factors.
Wuhan, HubeiAges 18 years+ - NCT05099432Recruiting
CARMA technique after removing up to two colon polyps
This study tests a specific approach (the CARMA technique) for colon polyp treatment after doctors remove polyps during colonoscopy. It may help reduce future problems at the polyp site, but only certain polyp types and follow-up plans qualify.
Woolloongabba, QueenslandAges 16 years+ - NCT05090267Recruiting
Gut-brain treatments for alcohol use and memory changes
This study tests whether gut-brain–targeted treatments (including probiotics and stimulation of a nerve) can improve thinking and inflammation-related health in people who use alcohol. You may be able to join if you have memory/thinking problems and meet specific medical limits, including HIV immune system levels.
Coral Gables, FloridaAges 35–70 - NCT05020158Recruiting
Family Talk support after a serious illness in the family
This trial tests a “Family Talk” support program for families dealing with a child’s life-threatening or life-limiting illness. It aims to help families talk and cope together during the early period after diagnosis or relapse.
StockholmAges 6 years+ - NCT04713670RecruitingPhase 4
Tested medicines to cure new H. pylori infection
This trial compares different stomach-medicine combinations to eliminate a new (first-time) H. pylori infection. It may help find the most effective treatment approach for people who have never tried eradication therapy before.
TaipeiAges 20 years+ - NCT04615013RecruitingPhase 1
NBTXR3 with chemoradiation for esophageal cancer treatment
This early-phase study tests adding NBTXR3 (a special treatment given into the tumor) to standard chemotherapy and radiation for esophageal cancer. The goal is to see if it can improve cancer control and to learn about safety and dosing.
Houston, TexasAges 18 years+ - NCT04541095Recruiting
Milk formula for very preterm babies: more vs less beta-palmitate
This study tests an infant milk formula that has a higher or lower amount of beta-palmitate in babies born very early. The goal is to see if the formula supports healthy growth in preterm infants who are stable and can feed through the stomach.
AnconaAges 6 months–7 months - NCT04418258Recruiting
Test a new scope suction catheter during endoscopy
This study tests a special aspiration (suction) catheter used during an upper GI endoscopy to see how well it works during routine care. It may help doctors improve how they clear fluid or residue during the procedure.
Los Angeles, CaliforniaAges 18–85 - NCT04373473RecruitingPhase 2
Oral stool treatment to prevent ulcerative colitis flare-ups
This study tests whether taking freeze-dried (lyophilized) donor stool material by mouth can help prevent ulcerative colitis from coming back or causing intestinal inflammation. Participants are in remission and stay on their usual treatment while receiving the study product.
Houston, TexasAges 18 years+ - NCT04332848RecruitingPhase 4
Testing-guided treatment for stubborn stomach H. pylori
This trial studies whether using lab testing to guide antibiotic choice works better than using a standard (empirical) treatment plan for stubborn H. pylori infection. You might benefit if past treatments have not cleared the infection after multiple attempts.
TaipeiAges 20–90 - NCT04219137Recruiting
MOCHA study of blood and biopsy features in stomach tumors
This study looks at the “molecular” features (biologic characteristics) of gastroesophageal cancer from tissue samples. It may help doctors better understand which cancers are best matched to treatment plans and future therapies.
Toronto, OntarioAges 18 years+ - NCT04055571Recruiting
Review of pancreatic disease treatments since 2005
This study looks back at people diagnosed with pancreatic disease and how their treatment outcomes turned out. It may help doctors improve care for both non-cancerous and cancerous pancreatic problems.
Richardson, TexasAges 18 years+ - NCT03905746Recruiting
Study tests microRNA markers in worsened liver cirrhosis
This study looks at microRNA (tiny molecules in blood) to better understand what’s happening during sudden worsening of cirrhosis. It may help doctors recognize and monitor decompensated cirrhosis more accurately.
LyonAges 18 years+ - NCT03732131Recruiting
Study of stool bacteria transplant to help people with infections
This study looks at fecal microbiota transplantation (FMT), which is a stool bacteria transplant, to help adults whose symptoms persist or return, often from C. difficile infection. If you’re already planning or receiving FMT for certain conditions, this trial may add information on how it helps and who benefits.
LahtiAges 18–120 - NCT03363061Recruiting
People taking blood thinners having colonoscopy
This study looks at patients who are already taking blood-thinning medicines and are scheduled for a planned colonoscopy. It may help improve how colonoscopies are done safely for people on these medicines.
Hong KongAges 18 years+ - NCT03064646Recruiting
Preserving tissue in near-complete rectal cancer response
This trial studies whether it’s safe to preserve the rectum (instead of removing it right away) for people with locally advanced rectal cancer who respond very well after pre-treatment radiation and/or chemotherapy. It may help some patients avoid major surgery, but eligibility depends on response seen on exam, scope, and MRI, and on having no spread to distant organs.
Elche, AlicanteAges 18 years+ - NCT02781870Recruiting
3D laparoscopic groin hernia repair with special mesh fix
This study looks at a laparoscopic (keyhole) operation to repair a groin (inguinal) hernia using a 3D “visible” mesh, with or without an added fixation method. If you have a first-time hernia on one side and are planning a laparoscopic repair, this trial may be an option to discuss with your surgical team.
GhentAges 18–80
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,874 recruiting gastroenterology studies from the U.S. registry right now, out of 12,294 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.