Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,607 recruiting studies in this area right now.
By phase
- Not applicable4,687
- Phase 21,190
- Phase 1566
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer480
- Pancreatic Cancer289
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer147
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Ovarian Cancer90
- Pancreas Cancer90
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis76
Leading sponsors
- Fudan University100
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)50
- National Taiwan University Hospital45
Where studies are running
- California443
- Arizona189
- Texas140
- Alabama129
- Florida127
- Massachusetts120
- New York120
- Maryland88
- Ohio80
- Illinois69
Recruiting studies7,607 total
- NCT06044506RecruitingPhase 1
Natural killer cell therapy for liver cancer
This study tests an experimental therapy using your own natural killer cells to fight liver cancer. It may be an option if you have a specific stage of liver cancer and are generally in good health.
Jakarta Pusat, Jakarta Special Capital RegionAges 20–60 - NCT05994859Recruiting
SIRT for potentially removable liver cancer
This trial tests a targeted radiation treatment (SIRT) for people with liver cancer that is still confined to one side of the liver and has not been treated before. The goal is to see if SIRT can shrink the tumor enough to make surgical removal possible.
Guangzhou, GuangdongAges 18–75 - NCT06036862Recruiting
Treating rectal narrowing with a tube through the anus
This trial tests a procedure using a thin, flexible tube with a camera to fix a narrowing (stenosis) where the colon is reconnected after rectal cancer surgery. It may help people who have trouble with bowel movements due to this narrowing.
Guangzhou, GuangdongAges 18–70 - NCT06039800Recruiting
Hernia surgery outcomes at Shouldice Hospital
This study asks patients who had hernia surgery at Shouldice Hospital about their recovery and results. It helps doctors understand how well the surgery works.
Thornhill, OntarioAges 16 years+ - NCT05450029RecruitingPhase 2
Adding immunotherapy to chemo-radiation for rectal cancer
This Phase 2 trial studies whether adding sintilimab (an immunotherapy drug) to standard chemo-radiation before surgery can improve outcomes for people with locally advanced rectal cancer. It’s aimed at tumors with certain immune “signature” scores and specific cancer stage features.
Guangzhou, GuangdongAges 18–75 - NCT06043999Recruiting
Chemotherapy vs. surgery for high-risk rectal cancer after local removal
This trial compares standard chemotherapy to more extensive surgery (total mesorectal excision) for patients whose initial local surgery showed high-risk features like poor differentiation, lymphovascular invasion, or larger tumor size. It aims to find the best treatment to prevent cancer from coming back.
Guangzhou, GuangdongAges 18–75 - NCT06042998Recruiting
Robot vs. laparoscopic surgery for stomach cancer after chemo
This trial compares robotic and laparoscopic surgery for stomach cancer patients who have already received chemotherapy or targeted therapy. It aims to see which approach leads to better outcomes after neoadjuvant (pre-surgery) treatment.
Qingdao, ShandongAges 18–75 - NCT06043466RecruitingPhase 1
CAR-T cell therapy for CEA-positive advanced solid tumors
This trial tests a new cell therapy called CAR-T that targets cancer cells with a protein called CEA. It is for people with certain advanced cancers that have not responded to standard treatments.
Hangzhou, ZhejiangAges 18 years+ - NCT05438836Recruiting
Adaptive radiation planning for anal cancer treatment
This trial tests an online, adaptive way to plan and adjust radiation during treatment for people with biopsy-proven anal cancer. The goal is to better target the cancer while keeping side effects as low as possible.
HerlevAges 18 years+ - NCT04616495Recruiting
Liver transplant for colorectal cancer that can’t be removed
This trial studies liver transplantation for people with colorectal cancer that has spread to the liver but cannot be surgically removed. It aims to see if transplant can improve outcomes when the cancer is limited to the liver.
ValenciaAges 18–65 - NCT06055010Recruiting
Improving pancreatic cancer care with computer science
This study uses data from patients with pancreatic conditions and healthy people to improve care through computer analysis. It may help researchers develop better tools for diagnosis and treatment.
UtrechtAges Any age - NCT06035250Recruiting
AI predicts stomach cancer response to chemo before surgery
This study tests whether an AI tool can predict how well stomach cancer responds to chemotherapy before surgery. It uses CT scans and biopsy images taken before treatment starts to see if the AI can help guide future care.
BeijingAges 18 years+ - NCT06056336RecruitingPhase 2
Perioperative tislelizumab plus chemo for esophageal cancer
This trial tests whether giving tislelizumab (an immunotherapy) along with chemotherapy before and after surgery can help people with a type of esophageal cancer called squamous cell carcinoma. The goal is to see if this combination improves outcomes for patients whose cancer is in the chest and can be removed with surgery.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06051045Recruiting
Bulevirtide for chronic hepatitis B and D
This study tests a drug called bulevirtide for people with chronic hepatitis B and D co-infection. It aims to see if the drug is safe and effective, and to study biomarkers that may help predict how well it works.
StockholmAges 18 years+ - NCT05528900Recruiting
Study of children with acute food-triggered gut reactions
This study follows children (from birth to age 17) who have been diagnosed with acute food protein–induced enterocolitis syndrome (FPIES). Doctors want to better understand this condition after a suspected reaction to food, using either symptom-based diagnosis or a supervised food challenge when needed.
AngersAges Up to 17 years - NCT06060769Recruiting
MRI risk assessment for liver cancer in chronic liver disease
This study uses special MRI scans to better predict liver cancer risk in people with chronic liver disease. It may help doctors identify high-risk patients earlier and improve monitoring.
Zhuhai, GuangdongAges 18 years+ - NCT06061042Recruiting
Time-restricted eating for metabolic health
This study tests whether eating only during a specific time window each day can improve metabolic health in people with obesity and insulin resistance. If you have a high BMI and early signs of diabetes, this trial might help you understand a simple dietary change.
Amsterdam, North HollandAges 50–75 - NCT05061576Recruiting
At-home exercise program for people with liver scarring
This study tests an at-home, guided physical exercise plan for people with liver cirrhosis. It may help improve strength and day-to-day functioning while monitoring safety.
StockholmAges 18 years+ - NCT06065891Recruiting
Lymph node removal in pancreatic cancer surgery
This trial studies whether removing extra lymph nodes during surgery for pancreatic cancer can help find if the cancer has spread. It is for patients whose tumor is considered removable or borderline removable.
OdenseAges 18 years+ - NCT05686785Recruiting
Test how reliable a liver scan is in chronic hepatitis
This study checks whether a “liver stiffness” scan (called transient elastography) gives consistent, dependable results in adults with long-term viral hepatitis. It may help improve how doctors monitor liver changes over time.
Helsingborg, Skåne CountyAges 18 years+ - NCT06041945Recruiting
AI study for cheaper colon cancer screening
This study uses artificial intelligence to help doctors predict if colon polyps are harmless during a colonoscopy. This could reduce the need for lab tests and save costs.
Rozzano, MilanoAges 40 years+ - NCT05697991Recruiting
Study of fatty liver in adults with type 2 diabetes
This study looks at people with type 2 diabetes who also have fatty liver. The goal is to learn more about this condition in a Saudi group and test approaches that could improve care.
Riyadh, Select A State Or ProvinceAges 18–60 - NCT06070740RecruitingPhase 2
Durvalumab Plus Chemo for Advanced Gastrointestinal NEC
This trial tests a combination of durvalumab (an immunotherapy drug) plus a chemotherapy called XELOX as the first treatment for advanced gastrointestinal neuroendocrine carcinoma (NEC). It aims to see if the combination works better than chemo alone.
Beijing, Beijing MunicipalityAges 18–75 - NCT03964753RecruitingPhase 2
Chemo before surgery for middle-lower esophageal cancer
This trial tests a chemotherapy combination (nab-paclitaxel plus cisplatin) given before surgery for locally advanced, operable esophageal squamous cell cancer. It aims to shrink the tumor and improve outcomes by treating cancer earlier while it’s still in one region.
Shijiazhuang, HebeiAges 18–75
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,607 recruiting gastroenterology studies from the U.S. registry right now, out of 11,926 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.