Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,890 recruiting studies in this area right now.
By phase
- Not applicable4,918
- Phase 21,185
- Phase 1582
- Phase 3465
- Phase 1/Phase 2393
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer491
- Gastric Cancer296
- Pancreatic Cancer290
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer97
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona177
- Texas149
- Florida133
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,890 total
- NCT06663059RecruitingPhase 2
Adebrelimab before surgery for esophageal cancer: 2 vs 4 cycles
This trial tests a drug called Adebrelimab (an immunotherapy) given before surgery to treat esophageal squamous cell cancer. It compares 2 cycles of treatment with 4 cycles to see which works better. The goal is to shrink the tumor and make surgery more effective.
Xi'an, ShannxiAges 18–75 - NCT06663839RecruitingPhase 1
Study of NILK-2301 for advanced colorectal cancer
This trial tests a new drug called NILK-2301 for people with colorectal cancer that has spread or cannot be removed. It is for those who have already tried at least one other treatment and have relatively small tumors.
BarcelonaAges 18 years+ - NCT06664996RecruitingPhase 2
Immunotherapy plus radiation before surgery for liver cancer with portal vein tumor clot
This trial tests combining an immunotherapy drug (sintilimab) with focused radiation (SBRT) before surgery for liver cancer that has spread into a branch of the portal vein. The goal is to see if this combination can shrink the tumor and make surgery more successful.
Chengdu, SichuanAges 18 years+ - NCT06665867Recruiting
Video Follow-Up for Kids With Stomach Pain
This trial tests whether video consultations (video calls) are a good option for follow-up appointments in children with functional abdominal pain disorders. It aims to make check-ups easier for families.
AmsterdamAges 4–17 - NCT06665971RecruitingPhase 4
Dupilumab for esophagus muscle function in EoE
This trial tests if dupilumab, a weekly injection, can improve the muscle function of the esophagus in people with eosinophilic esophagitis (EoE) who haven't gotten better with acid-reducing medications. Researchers want to see if it helps with swallowing and reduces inflammation.
La Jolla, CaliforniaAges 22 years+ - NCT06666192Recruiting
OSU Community Cancer Screening Program
This program aims to make cancer screening easier for people in certain neighborhoods near Ohio State University clinics. It works with clinics, healthcare providers, and patients to improve access to preventive care.
Columbus, OhioAges Any age - NCT06668454Recruiting
Chemoimmunotherapy before surgery for limited spread esophageal cancer
This trial tests a treatment plan that combines chemotherapy with immunotherapy, followed by surgery, for people whose esophageal or stomach cancer has spread to a few areas (oligometastatic). The goal is to see if this approach can shrink the cancer and improve outcomes.
Toronto, OntarioAges 18–80 - NCT06668727RecruitingPhase 1
Testing a new antibody for hepatitis B safety
This trial tests an experimental antibody treatment for people with chronic hepatitis B who have been on antiviral medication for at least 6 months. It aims to see if the antibody is safe and can help control the virus.
Aarhus NAges 18–70 - NCT06669377Recruiting
Combination therapy for liver cancer with main portal vein tumor clot
This trial tests a combination of treatments for liver cancer that has spread to the main portal vein. It uses a special stent, radiation seeds, and targeted therapies to shrink the tumor and improve blood flow. This may help patients who haven't had certain prior treatments.
Nanjing, JiangsuAges 18 years+ - NCT06670495Recruiting
HPV types and anal cancer in China
This study looks at how different types of HPV are linked to anal cancer in China. By testing your tumor sample, the researchers hope to better understand what causes anal cancer, which could help guide prevention and treatment.
ShanghaiAges Any age - NCT06670521RecruitingPhase 2
Steroids for swallowing problems after breathing tube removal
This trial tests a steroid medication (corticosteroids) to reduce swelling in the voice box after a breathing tube is taken out. It may help improve swallowing and reduce the risk of food or drink going into the lungs.
Aurora, ColoradoAges 18 years+ - NCT06670638Recruiting
New test for crohn's disease in people with a permanent ileostomy
This study aims to develop a new way to measure inflammation and symptoms in people with Crohn's disease who have a permanent ileostomy. Participants will undergo a routine ileoscopy and answer questions to help create better tools for future clinical trials.
Rochester, MinnesotaAges 18 years+ - NCT06671093RecruitingPhase 1
Study of Tune-401 for chronic hepatitis B
This study tests a new medicine, Tune-401, for adults with chronic hepatitis B who are already on a daily antiviral pill. The goal is to see if it is safe and can reduce the virus in your body.
Hong KongAges 18–75 - NCT06671886Recruiting
NAFLD care pathway for veterans
This trial tests a new care pathway for non-alcoholic fatty liver disease (NAFLD) in veterans. It aims to improve how patients are diagnosed and treated through their primary care team.
Houston, TexasAges 18 years+ - NCT06672913Recruiting
Skin-to-skin care study for premature babies
This study looks at how holding your baby skin-to-skin affects their health and development, for babies born at 32 weeks or earlier.
AnkaraAges 1 day+ - NCT06673329RecruitingPhase 1
Brodalumab for immune-related side effects from cancer treatment
This trial tests if brodalumab, an antibody that blocks a specific immune pathway (IL-17), can help control side effects caused by immunotherapy cancer treatment. It is for people with advanced solid organ cancers who have immune-related side effects that are suspected to involve IL-17.
New York, New YorkAges 18 years+ - NCT06675201RecruitingPhase 2
Personalized vaccine for advanced esophageal cancer after treatment
This trial tests a personalized vaccine made from your tumor's unique markers (neoantigens) to help prevent your advanced esophageal cancer from coming back. It's for people who have already completed strong treatment and are currently cancer-free, but have a high risk of recurrence.
Chengdu, Please SelectAges 18–80 - NCT06674356Recruiting
Chin tuck exercise for swallowing after stroke
This trial tests a simple neck exercise (chin tuck against resistance) to help people who have trouble swallowing after a recent stroke. The goal is to see if this exercise improves swallowing safety and strength.
TaipeiAges 18–100 - NCT06675240Recruiting
Meditative neurofeedback for depression
This trial tests whether a technique that combines meditation with real-time brain activity feedback can help treat depression. It may help if you have moderate depression and are not currently struggling with substance abuse, psychosis, bipolar disorder, or suicidal behavior.
La Jolla, CaliforniaAges 18 years+ - NCT06675825Recruiting
New cap for expanding narrow esophagus in kids
This trial tests a new cap that helps doctors widen a narrowed part of the esophagus (the tube that carries food from the mouth to the stomach) in children. The cap is used during a scope procedure to make the dilation safer and easier.
RomeAges birth–18 years - NCT06676449RecruitingPhase 3
A study on radiation-sparing treatment for advanced esophageal cancer
This trial tests a new approach for advanced esophageal cancer that combines targeted radiation, immunotherapy, and chemotherapy. It aims to see if skipping radiation to certain lymph nodes can improve outcomes while reducing side effects.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06676813Recruiting
Fasting every other day for fatty liver disease
This study tests whether fasting every other day (alternate day fasting) can help reverse fatty liver disease (NASH/MASH) when added to standard medical care. It is for people with fatty liver and some liver scarring, who are not on weight loss medications and do not have diabetes that is poorly controlled.
DelhiAges 18–65 - NCT06678100Recruiting
Swallowing study for adults with Alzheimer's
This study looks at swallowing problems in people with Alzheimer's disease compared to healthy older adults. If you have Alzheimer's, you'll have a swallowing test and your caregiver will answer questions about your daily life.
Nashville, TennesseeAges 60 years+ - NCT06678919Recruiting
A registry for metastatic colorectal cancer beyond second line
This study tracks people with metastatic colorectal cancer who have already tried at least two standard treatments. It aims to collect real-world data on how well newer treatments work in later lines of therapy.
LinzAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,890 recruiting gastroenterology studies from the U.S. registry right now, out of 12,399 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.