Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,896 recruiting studies in this area right now.
By phase
- Not applicable4,922
- Phase 21,186
- Phase 1581
- Phase 3466
- Phase 1/Phase 2394
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer492
- Gastric Cancer297
- Pancreatic Cancer292
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer147
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer98
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic74
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California462
- Arizona177
- Texas149
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,896 total
- NCT07012798RecruitingPhase 2
Sequential therapy for advanced liver cancer that may become removable
This trial tests a sequence of chemotherapy (FOLFOX), immunotherapy (durvalumab), targeted therapy (bevacizumab), and focused radiation to shrink liver tumors that are not removable now, with the goal of making them operable later.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT07012772RecruitingPhase 2
Testing a new airway device for sedated ERCP
This trial tests a new breathing device (called a combo endoscopy oropharyngeal airway) to help keep your airway open during a sedated ERCP procedure. It may improve safety and comfort for people having this exam.
Hangzhou, ZhejiangAges 18 years+ - NCT07012928Recruiting
Study of immune responses in eosinophilic esophagitis patients
This study looks at how the immune system and the esophageal barrier function in people with eosinophilic esophagitis (EoE) compared to those without. It involves taking biopsies during an upper endoscopy to understand the disease better. The results may help improve treatments for EoE.
Amsterdam, North HollandAges 18–75 - NCT07013578Recruiting
Mental health support trial for IBD patients
This trial tests a mental health program for people with inflammatory bowel disease (IBD) who have mild to moderate anxiety or depression. It aims to see if the program can improve their emotional well-being.
North York, OntarioAges 18–75 - NCT07014150RecruitingPhase 2
Neoadjuvant combo therapy for liver cancer before surgery
This trial tests a combination of two immunotherapy drugs (iparomlimab and tuvonralimab) plus lenvatinib (a targeted therapy) given before surgery for hepatocellular carcinoma (a type of liver cancer). The goal is to see if this treatment can shrink tumors and reduce the chance of cancer coming back after surgery.
Beijing, Beijing MunicipalityAges 18–75 - NCT07015580Recruiting
Mouth bacteria in pancreatitis types
This study looks at the bacteria in your mouth to see if they are different in chronic pancreatitis and autoimmune pancreatitis. It might help doctors understand these diseases better.
Shanghai, Shanghai, ChinaAges 18 years+ - NCT07016724RecruitingPhase 2
Study of radiation and chemo with cadonilizumab for esophageal cancer
This trial tests combining radiation, chemotherapy, and the drug cadonilizumab before surgery for locally advanced esophageal squamous cell cancer. It aims to shrink the tumor and improve treatment outcomes.
Zhengzhou, HenanAges 18–75 - NCT07017283Recruiting
Comparing two sedation methods for older adults having ERCP
This study compares two ways of keeping you comfortable and safe during an ERCP procedure: deeper sedation with a breathing tube versus deep sedation without a breathing tube. It aims to find which method causes fewer side effects in older adults.
Hangzhou, ZhijiangAges 60 years+ - NCT07018518RecruitingPhase 1
Pin and immunotherapy combo for advanced liver cancer
This trial tests a new treatment combining a drug called PIN with an immunotherapy (anti-PD1) for people with advanced liver cancer (HCC) that has stopped responding to standard treatments. The goal is to see if this combination can shrink tumors or control the disease.
Beijing, Biotherapeutic Department of Chinsese PLA Gereral HospitalAges 18–75 - NCT07018661RecruitingPhase 2/Phase 3
Testing a PET/CT scan for advanced stomach cancer
This trial tests whether a special PET/CT scan (using a drug called [18F]F-FAPI) and a laparoscopy (a small camera through the belly) can better show the spread of advanced stomach or esophagus cancer before surgery. The goal is to help doctors decide the best treatment plan.
AlmeloAges 18 years+ - NCT07018869RecruitingPhase 3
A website to improve follow-up care for colorectal cancer survivors
This study tests if an educational website, viewed with a supporter, can improve follow-up care for people who had surgery for stage II or III colorectal cancer. It aims to help patients and their supporters find helpful information together.
Anchorage, AlaskaAges 18 years+ - NCT07019844Recruiting
PSMA PET scan for liver cancer staging
This trial tests if a special PET scan (PSMA PET) can better stage liver cancer that has not been treated yet and is at a moderate to advanced stage (BCLC B or C). It may help guide treatment decisions.
West Los Angeles, CaliforniaAges 18 years+ - NCT07020221RecruitingPhase 1/Phase 2
Study of VS-7375 for KRAS G12D solid tumors
This trial tests a new oral drug called VS-7375 for people with advanced solid tumors that have a specific KRAS G12D mutation. The goal is to see if it can shrink tumors or slow their growth.
Los Angeles, CaliforniaAges 18 years+ - NCT07021586Recruiting
Tongue pressure in adults with chronic neck pain
This study looks at how tongue pressure might be related to chronic neck pain in people aged 50 to 65. If you have ongoing neck pain, it could help researchers understand how your muscles work.
TaipeiAges 50–65 - NCT07021742Recruiting
BioHealx device study for anal fistula treatment
This study tests a device called BioHealx for closing anal fistulas that have not healed after previous treatment. It aims to see how well the device works in real-world use.
Fort Myers, FloridaAges 18–75 - NCT07024199RecruitingPhase 4
Pain relief for children with acute pancreatitis
This trial compares three common pain relievers (paracetamol, ibuprofen, and metamizole) to see which works best for children with acute pancreatitis. It aims to help your child feel better faster with fewer side effects.
WarsawAges 3–18 - NCT07024225Recruiting
A look back at colon and rectal cancers
This study reviews medical records of people with colon or rectal cancer to better understand the disease. It helps researchers learn more without any new treatments or procedures.
Sohag, Sohag GovernmentAges 18–80 - NCT07024849Recruiting
Nutrition program for esophageal cancer survivors
This study tests a personalized nutrition program designed to improve quality of life for people who have had or will have surgery for esophageal cancer. It aims to help you eat better and feel better during recovery.
Seoul, SeoulAges 18 years+ - NCT07025174RecruitingPhase 2
Sequential anti-angiogenic therapy after immunotherapy for advanced bile duct cancer
This trial tests whether giving a drug that blocks blood vessel growth (anti-angiogenic therapy) after immunotherapy can help people with advanced bile duct, gallbladder, or cholangiocarcinoma that cannot be removed by surgery. The goal is to see if this sequence improves outcomes for patients who have not had prior treatment for advanced disease.
Hangzhou, ZhejiangAges 18–75 - NCT07026240Recruiting
Post-operative monitoring study for gastric cancer
This study monitors people after surgery for gastric cancer. It checks how patients recover and helps doctors learn more about the condition. You can join if you have stomach discomfort and are receiving care at the gastric surgery clinic of this center.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07026513Recruiting
Aminaphtone and lidocaine spray for hemorrhoids
This trial tests a medication called aminaphtone taken by mouth, combined with a lidocaine spray, to treat painful internal hemorrhoids. It may help reduce symptoms without surgery.
TrevisoAges 18–85 - NCT07028112Recruiting
Iron and liver health after stem cell transplant
This study looks at how too much iron in the body (from past transfusions) affects the liver in people who had a stem cell transplant at least 10 years ago. It will help doctors understand who needs special monitoring for liver problems.
ParisAges 18 years+ - NCT07028580Recruiting
High-Protein Plant Diet for Liver Cirrhosis
This study tests whether a special diet high in plant-based protein (with some animal protein) can help people with severe liver cirrhosis who are waiting for a kidney transplant. The diet aims to improve nutrition and health without overloading the liver.
Athens, AtticaAges 18–80 - NCT07029152Recruiting
Anal cancer screening for gay and bisexual men on PrEP
This study is screening gay and bisexual men for anal cancer by taking a swab sample. It aims to find early signs of cancer so it can be treated early.
BrugesAges 35 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,896 recruiting gastroenterology studies from the U.S. registry right now, out of 12,425 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.