Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,903 recruiting studies in this area right now.
By phase
- Not applicable4,926
- Phase 21,187
- Phase 1582
- Phase 3466
- Phase 1/Phase 2395
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer493
- Gastric Cancer297
- Pancreatic Cancer292
- Hepatocellular Carcinoma284
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer147
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer101
- Lung Cancer98
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University91
- Mayo Clinic74
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California462
- Arizona177
- Texas149
- Florida135
- Massachusetts127
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,903 total
- NCT07035886Recruiting
Fruzaqla for metastatic colorectal cancer in South Korea
This study monitors the safety and effectiveness of Fruzaqla (a targeted therapy taken as a pill) in adults with advanced colorectal cancer that has spread to other parts of the body. It is being done in South Korea to gather real-world information about how well the treatment works and how patients respond.
SeoulAges 18 years+ - NCT07035925Recruiting
Testing a hydrogel for treating anal fistulas
This trial tests a hydrogel made from natural materials to help heal a specific type of anal fistula. It may be an option if you have a single high transsphincteric fistula with a seton in place for at least four weeks.
Lebanon, New HampshireAges 18 years+ - NCT07035990RecruitingPhase 1
Testing combinations of three study drugs in healthy volunteers
This trial tests how safe and tolerable three different study drugs (SION-451, SION-2222, and SION-109) are when taken together in healthy adults. The goal is to find a good dose combination for future studies in people with cystic fibrosis.
Brisbane, QueenslandAges 18–55 - NCT07036848Recruiting
Surgery for type IVa bile duct cyst
This study tests how well and safely a surgery works for treating a certain type of bile duct cyst (Todani type IVa). It aims to improve outcomes for people who need this operation for the first time.
Beijing, Beijing MunicipalityAges Up to 80 years - NCT07036874Recruiting
Predicting outcomes in liver cancer with non-invasive tests
This study uses non-invasive tests, like scans or blood tests, to predict how well people with liver cancer (hepatocellular carcinoma, or HCC) will do after curative treatment. It may help doctors better understand your condition without needing invasive procedures.
Hong KongAges 18 years+ - NCT07038629RecruitingPhase 2
Chemo, radiation, and immunotherapy for older adults with esophageal cancer
This trial tests combining chemoradiation with the immunotherapy drug iparomlimab for adults aged 70 and older with advanced esophageal cancer. The goal is to see if adding immunotherapy after standard chemoradiation improves outcomes.
Tianjin, Tianjin MunicipalityAges 70–90 - NCT07039162RecruitingPhase 2
Tislelizumab with chemo and radiation before surgery for advanced esophageal cancer
This trial tests a combination of an immunotherapy drug (tislelizumab) with chemotherapy and radiation, followed by surgery, for people with advanced esophageal cancer that cannot be removed right away. It aims to see if this approach can help shrink the tumor enough to allow surgery.
Kaohsiung CityAges 20 years+ - NCT07039526RecruitingPhase 2
Cytalux for finding cancer during surgery
This trial tests a dye called Cytalux that helps surgeons see cancer during surgery. You get the dye before surgery, and it makes cancer cells glow under a special light. This could help doctors remove more cancer.
Dallas, TexasAges 18 years+ - NCT07039747RecruitingPhase 2
Can a dietary supplement help people with irritable bowel syndrome?
This trial is testing if a dietary supplement can reduce symptoms of irritable bowel syndrome (IBS). You might qualify if you have been diagnosed with IBS, have moderate to severe symptoms, and are between 18 and 75 years old.
Rouen, FranceAges 18–75 - NCT07039773Recruiting
Gluten challenge in celiac disease: finding the best gluten type
This trial compares different forms of gluten to see which one causes the strongest immune reaction in people with celiac disease. It may help doctors choose the best way to test gluten sensitivity in the future.
Oslo, OsloAges 18–80 - NCT07042685RecruitingPhase 2
5-FU and Fruquintinib for advanced colorectal cancer
This trial tests a combination of two drugs (5-FU and fruquintinib) in people with advanced colorectal cancer that cannot be removed by surgery or has spread. It is for those who have not had chemotherapy before.
Houston, TexasAges 18 years+ - NCT07042919RecruitingPhase 1/Phase 2
Zanzalintinib for advanced liver cancer after prior treatment
This trial tests a new drug called zanzalintinib for people with advanced liver cancer (HCC) that can't be treated with surgery. You may join if your cancer has gotten worse after at least one prior treatment, or you couldn't tolerate that treatment.
Chicago, IllinoisAges 18 years+ - NCT07043270RecruitingPhase 2
Alternating chemo regimens for borderline resectable pancreatic cancer
This trial compares two chemotherapy regimens — GnP (gemcitabine and nab-paclitaxel) and mFOLFIRINOX — given in alternating cycles for people with borderline resectable pancreatic cancer. The goal is to see if this alternating approach can shrink the tumor enough to allow surgery.
Lebanon, New HampshireAges 18 years+ - NCT07043387Recruiting
Simplified radioembolization for liver cancer and bile duct cancer
This trial tests a streamlined way to deliver radioactive beads (radioembolization) directly to liver tumors in people with metastatic liver cancer or bile duct cancer. It aims to make treatment simpler and safer while still effectively targeting tumors.
Goyang-siAges 19 years+ - NCT07043491Recruiting
Comparing scopes and X-rays after esophagus surgery
This trial compares two ways doctors check the surgical connection (anastomosis) after removing a cancerous part of the esophagus. It looks at whether a flexible tube with a camera (endoscopy) or a special X-ray (esophagram) is better for routine follow-up.
Guangzhou, GuangdongAges 18 years+ - NCT07044362Recruiting
Histotripsy plus chemo vs. chemo alone for advanced liver-only colorectal cancer
This trial tests whether adding histotripsy—a non-invasive ultrasound treatment that destroys liver tumors—to standard chemotherapy improves outcomes for people with advanced colorectal cancer that has spread to the liver. It may be an option if your cancer is mainly in the liver and you are starting or have recently had chemotherapy.
Cleveland, OhioAges 18 years+ - NCT07045571Recruiting
DNA blood test for pancreatic cancer prognosis and treatment
This study tests whether a blood test that looks at DNA changes (ctDNA methylation) can help predict how pancreatic cancer will behave and guide treatment decisions. It includes people with suspected pancreatic cancer who are planning surgery or a biopsy.
Shanghai, Shanghai MunicipalityAges Any age - NCT07046468Recruiting
Smart pill to check gut health in colon inflammation and cancer
This trial tests a smart pill that measures gut health in people with colon inflammation (ulcerative colitis) or colon cancer. It aims to see if the pill can help doctors better understand how the gut is working during treatment or before surgery.
Nijmegen, GelderlandAges 18 years+ - NCT07046585Recruiting
Blood test for colon cancer screening
This trial tests a new blood test to screen for colorectal cancer in people at average risk. You would give a blood sample before your scheduled colonoscopy, and the results will be compared to the colonoscopy findings.
Austin, TexasAges 40 years+ - NCT07047339RecruitingPhase 2/Phase 3
Probiotic 6600 for colitis patients
This trial tests whether adding Probiotic 6600 to your usual treatment can help manage colitis, including ulcerative colitis or Crohn's disease. It aims to see if the probiotic improves symptoms and is safe to use.
ShanghaiAges 18–75 - NCT07047482Recruiting
p16 marker study in colorectal cancer
This study looks at a marker called p16 in colorectal cancer tissue. It aims to find out if p16 is linked to how the disease behaves, which could help guide treatment decisions.
Sohag, RecruitingAges Any age - NCT07047560RecruitingPhase 2
A new chemo combo for advanced colorectal cancer
This trial tests a different way of giving a chemotherapy drug called irinotecan, along with two other drugs (5-FU and bevacizumab), for people whose cancer got worse after first-line treatment. It aims to see if this combination can help control the cancer.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT07047586RecruitingPhase 2
Lenvatinib plus Tislelizumab vs Lenvatinib alone for liver cancer
This trial tests whether combining two targeted drugs (lenvatinib and tislelizumab) works better than lenvatinib alone for people with advanced liver cancer whose disease worsened after prior treatment with an immunotherapy and a blood vessel growth blocker (bevacizumab).
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07049055RecruitingPhase 1/Phase 2
EDV nanocell therapy with chemo for advanced pancreatic cancer
This trial tests a new targeted therapy (EDV nanocells) combined with two standard chemotherapy drugs for people with metastatic pancreatic cancer. It is for patients whose cancer has progressed after first-line FOLFIRINOX or NALIRIFOX treatment.
El Segundo, CaliforniaAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,903 recruiting gastroenterology studies from the U.S. registry right now, out of 12,451 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.