Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,916 recruiting studies in this area right now.
By phase
- Not applicable4,936
- Phase 21,188
- Phase 1583
- Phase 3465
- Phase 1/Phase 2396
- Phase 4237
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer493
- Gastric Cancer298
- Pancreatic Cancer292
- Hepatocellular Carcinoma284
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer148
- Crohn Disease144
- Ulcerative Colitis140
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)107
- Liver Cancer101
- Lung Cancer99
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma89
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University91
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona174
- Texas148
- Florida135
- Massachusetts127
- Alabama123
- New York123
- Maryland87
- Ohio80
- Pennsylvania72
Recruiting studies7,916 total
- NCT07523529RecruitingPhase 1/Phase 2
CAR-T Cell Therapy for Advanced Solid Tumors
This trial tests a new type of immune cell therapy (CAR-T cells) designed to target two markers on cancer cells at once. The goal is to help patients with advanced solid tumors where standard treatments have stopped working or aren't an option.
Shenzhen, GuangdongAges 18–75 - NCT07523919Recruiting
How fitness and breathing affect colorectal cancer recovery
This study looks at how your physical fitness and lung function may affect how well you do after colorectal cancer treatment. Researchers will test your strength, movement, and breathing to understand what helps people recover better long-term.
Merkez, Gümüşhane ProvinceAges 18–80 - NCT07524244Recruiting
Ketogenic and carnivore diets for IBD and rheumatoid arthritis
This study tests whether special diets (ketogenic or carnivore/meat-based) can help reduce inflammation and symptoms in people with inflammatory bowel disease or rheumatoid arthritis. You'll follow dietary guidelines for 3 weeks, then continue in the study while researchers track how you respond.
Charlottesville, VirginiaAges 18–64 - NCT07524439Recruiting
Beta-glucan cream for incontinence-related skin irritation
This study tests whether a special cream containing beta-glucan (a natural ingredient) can soothe and protect skin damaged by urine or stool leakage. You'd apply the cream during a hospital stay of at least one week to see if it helps healing.
Edmonton, AlbertaAges 18 years+ - NCT07525765Recruiting
AI tool to help decide if you need surgery again after stomach cancer operation
This study uses artificial intelligence to help doctors decide whether patients who bleed after stomach cancer surgery need another operation. Researchers will review medical records and test an AI system to improve decision-making for this serious complication.
Hangzhou, ZhejiangAges 18–90 - NCT07528209RecruitingPhase 3
Chemotherapy with or without immunotherapy for advanced rectal cancer
This study tests whether adding an immunotherapy drug (pucotenlimab) to standard chemotherapy (CAPOX) before surgery helps treat locally advanced rectal cancer better. The goal is to shrink tumors and improve survival while preserving bowel function when possible.
Guangzhou, GuangdongAges 18–75 - NCT07529301Recruiting
Lung Function Tests Before Surgery to Predict Recovery
This study measures your lung function and physical fitness before surgery to see if these tests can predict how quickly you'll recover. The researchers want to understand which patients might have an easier or harder recovery after their operation.
MalatyaAges 18–80 - NCT07529626Recruiting
Stress and Pancreatic Cancer Disease Outcomes Study
This research study examines how chronic psychological stress (long-term worry, anxiety, or emotional burden) affects the course of pancreatic cancer and related pancreatic diseases. Understanding this connection may help doctors provide better support and treatment plans for patients.
Changsha, HunanAges 18 years+ - NCT07530094RecruitingPhase 2
Radiation and chemotherapy with immunotherapy for advanced esophageal cancer
This trial tests a combination of radiation, chemotherapy (cisplatin and paclitaxel), and an immunotherapy drug called camrelizumab for patients with advanced esophageal squamous cell carcinoma that cannot be surgically removed. The goal is to see if adding immunotherapy improves outcomes compared to standard treatment alone.
Nanjing, JiangsuAges 18–75 - NCT07530354Recruiting
Understanding Body Changes After Bile Duct Surgery in Children
This study follows children who have had bile duct (biliary tract) surgery to understand how their bodies change and adapt afterward. Researchers compare them with healthy children to learn what is normal and help improve care.
Wuhan, HubeiAges Up to 16 years - NCT07530445RecruitingPhase 2
Immunotherapy plus chemotherapy for advanced biliary tract cancer
This study tests a combination of two immunotherapy drugs (iparomlimab and tuvonralimab) plus chemotherapy and a targeted drug (lenvatinib) for biliary tract cancer that has spread or cannot be surgically removed. The goal is to slow cancer growth in patients whose cancer has progressed after one prior treatment.
GuangzhouAges 18–70 - NCT07531342Recruiting
Brain Stimulation and Diet for Severe Crohn's Disease
This study tests whether repetitive transcranial magnetic stimulation (a non-invasive brain treatment) combined with an anti-inflammatory diet can help people with severe, treatment-resistant Crohn's disease feel better. The brain stimulation uses magnetic pulses on the scalp to reduce inflammation and improve symptoms.
Giza, Giza GovernorateAges 40–60 - NCT07532213Recruiting
Real-world outcomes of guselkumab for ulcerative colitis or Crohn's disease
This study tracks how well guselkumab (a biologic medication that blocks IL-23, a protein that drives inflammation) works for moderate-to-severe ulcerative colitis or Crohn's disease in everyday clinical practice. Researchers want to understand long-term benefits and safety in real patients.
BernAges 18 years+ - NCT07533864Recruiting
Swallowing Support After Neck Surgery
This trial tests an approach to help patients who develop swallowing difficulties after front-of-neck spine surgery. Researchers will track swallowing problems and test whether a specific care method reduces symptoms.
Hamilton, OntarioAges 18 years+ - NCT07534800Recruiting
Bougie Cap device for treating swallowing problems from benign esophageal strictures
This study tests a device called Bougie Cap that helps open up benign (non-cancerous) narrowings in the esophagus (food pipe) to relieve swallowing difficulties. If you have a confirmed benign stricture causing trouble swallowing and haven't had endoscopic treatment yet, this study may be right for you.
LyonAges 18 years+ - NCT07534852Recruiting
Nutrition and exercise support for colon cancer surgery patients
This study tests whether nutrition support and exercise help patients with early-stage colon cancer recover better after surgery. Researchers will provide dietary guidance and a supervised exercise program tailored to your needs.
Málaga, MalagaAges 18–75 - NCT07535021Recruiting
Mandala Art Therapy to Help With Cancer Surgery Recovery
This study tests whether creating mandala art (decorative circular patterns) helps colorectal cancer patients cope better after surgery. Researchers want to see if art therapy reduces stress, builds emotional strength, and improves your ability to handle the surgery and recovery.
SivasAges 18–74 - NCT07536113Recruiting
Blood Test to Guide Second Colorectal Cancer Treatment
This study looks at whether a simple blood test can help doctors decide if you should receive a specific type of cancer drug again. The blood test looks for cancer DNA to predict if the drug will work for your advanced colorectal cancer.
Milan, ItaliaAges 18 years+ - NCT07536191Recruiting
Gallbladder Drainage Methods for Acute Cholecystitis
This trial compares two ways to drain an inflamed gallbladder in patients who cannot safely have surgery: one approach goes through the stomach wall using ultrasound guidance, and the other goes through a bile duct opening. The goal is to find which method works better and causes fewer problems.
AichiAges 18 years+ - NCT07536841Recruiting
Testing New Criteria for Autoimmune Pancreas Inflammation
This study validates a new diagnostic tool (Odesa Criteria 2026) to help doctors accurately identify autoimmune pancreatitis—a rare condition where the body attacks the pancreas. If you're being evaluated for possible pancreas inflammation, this trial may help confirm whether you have this specific type.
OdesaAges 18 years+ - NCT07537361RecruitingPhase 2
Leucine-Restricted Diet With Chemotherapy for Gastric Cancer
This trial tests whether a special diet low in leucine (an amino acid) combined with chemotherapy and immunotherapy drugs can help treat locally advanced gastric cancer before surgery. The goal is to see if this combination is safe and more effective than standard treatment alone.
Jinan, ShandongAges 18–70 - NCT07537634RecruitingPhase 4
New stomach acid medicine versus standard treatment for H. pylori infection
This trial compares two different antibiotic combinations to treat H. pylori, a common stomach bacteria that causes indigestion and ulcers. One uses a newer acid-blocking medicine (vonoprazan) and the other uses a standard one (esomeprazole), both paired with antibiotics.
DhakaAges 18 years+ - NCT07537998RecruitingPhase 2/Phase 3
Intestinal Fluid Recycling to Reduce Bowel Problems After Rectal Cancer Surgery
This trial tests a surgical technique that recycles intestinal fluids during rectal cancer surgery to help prevent bowel dysfunction and frequent bowel movements after surgery. If you've had mid-to-low rectal cancer removed and created a temporary opening (stoma), this study may help improve your quality of life.
Guangzhou, GuangdongAges 18–75 - NCT07538882Recruiting
AI-Assisted Staging and Treatment Planning for Liver Cancer
This trial uses artificial intelligence to help doctors better stage (classify the severity of) and plan treatment for hepatocellular carcinoma, a type of primary liver cancer. Researchers will collect your clinical information and imaging to see if AI can improve decision-making about your care.
Beijing, ChangpingAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,916 recruiting gastroenterology studies from the U.S. registry right now, out of 12,516 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.