Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,916 recruiting studies in this area right now.
By phase
- Not applicable4,936
- Phase 21,188
- Phase 1583
- Phase 3465
- Phase 1/Phase 2396
- Phase 4237
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer493
- Gastric Cancer298
- Pancreatic Cancer292
- Hepatocellular Carcinoma284
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer148
- Crohn Disease144
- Ulcerative Colitis140
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)107
- Liver Cancer101
- Lung Cancer99
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma89
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University91
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona174
- Texas148
- Florida135
- Massachusetts127
- Alabama123
- New York123
- Maryland87
- Ohio80
- Pennsylvania72
Recruiting studies7,916 total
- NCT07578441Enrolling by invitation
VitaSmart HOPE System liver transplant registry
This study follows people who receive a liver transplant using a special machine called the VitaSmart HOPE System, which keeps the donated liver healthy before transplant. The study tracks how well these livers work after transplant.
Cleveland, OhioAges Any age - NCT07576049Enrolling by invitation
Colorectal Cancer Treatment Experience Study
This research study looks at how colorectal cancer patients are treated and their outcomes at a major medical center in Rome. It helps doctors understand what approaches work best for patients like you.
RomaAges Any age - NCT07567716Enrolling by invitation
Study of How Advanced Esophageal Cancer Spreads After Surgery
This research examines tissue samples from patients who had surgery to remove advanced esophageal cancer in the neck or chest area. The study aims to understand how the cancer invaded surrounding tissues, which may help doctors better treat similar patients in the future.
ShanghaiAges Any age - NCT07564947Enrolling by invitation
Reishi Mushroom for Fatty Liver Disease
This study tests whether Ganoderma lucidum (reishi mushroom) can improve liver health and reduce inflammation in people with fatty liver disease. Researchers will measure how it affects your liver function and antioxidant levels.
Peshawar, Khyber PakhtunkhwaAges 35–49 - NCT07564609Enrolling by invitation
Infliximab injection therapy outcomes in inflammatory bowel disease
This study tracks how patients with Crohn's disease or ulcerative colitis respond to infliximab (a biologic medication) given as injections under the skin after an initial IV dose. Researchers want to understand which patients benefit most and for how long.
AmiensAges 18 years+ - NCT07550582Enrolling by invitationPhase 2
Surgery for small tumors at the food pipe opening
This trial tests a new surgical approach combining laparoscopic (minimally invasive) surgery with endoscopy (a camera procedure) to remove small tumors located where the esophagus meets the stomach. The goal is to safely remove these tumors while preserving normal function.
Beijing, Beijing MunicipalityAges 18–80 - NCT07546942Enrolling by invitationPhase 1/Phase 2
Autism Treatment Using Stem Cells, Gut Microbiome, and Diet
This study tests whether a combination of stem cell therapy, gut microbiome restoration (using specially prepared stool), and dietary changes can improve autism symptoms, communication, social behavior, and digestive issues. Researchers believe gut health and immune system problems may contribute to autism, and this trial explores whether treating these areas helps.
Hamilton, MontanaAges 10–90 - NCT07542951Enrolling by invitationPhase 4
TAF vs TDF antiviral treatment during pregnancy for hepatitis B
This study compares two antiviral medications (TAF and TDF) in pregnant women with hepatitis B to see which is safer and more effective during pregnancy and for the baby's health.
Guangzhou, GuangdongAges 20–40 - NCT07542262Enrolling by invitationPhase 2
Low-dose immunotherapy for advanced colorectal and stomach cancer
This study tests a lower dose of immunotherapy in patients with colorectal or stomach cancer that has spread or cannot be removed by surgery. The cancer must have a specific genetic feature (MSI/dMMR). The goal is to see if this approach works well with fewer side effects.
MoscowAges 18 years+ - NCT07537205Enrolling by invitation
Nurse-led preparation program for liver cancer surgery
This study tests whether a personalized preparation program led by nurses before liver cancer surgery helps patients recover better and have fewer complications. The program is designed specifically for people scheduled to have part of their liver removed.
Shanghai, XuhuiAges 18–84 - NCT07533825Enrolling by invitation
Minimally Invasive Surgery Staging for Advanced Stomach Cancer
This trial tests whether a minimally invasive camera-guided surgical procedure (laparoscopy) can better detect hidden cancer spread in patients with advanced stomach cancer. The goal is to help doctors plan the best treatment and improve outcomes.
Tianjin, Tianjin MunicipalityAges 18–75 - NCT07522385Enrolling by invitation
Endoscopic ultrasound treatment for gallstones while keeping gallbladder
This study tests a minimally invasive procedure that uses ultrasound guidance to create a small opening between your gallbladder and stomach or small intestine, allowing gallstones to pass without removing your gallbladder. It may help if you have symptoms from gallstones but want to preserve your gallbladder.
Wuhan, HubeiAges 18–80 - NCT07503847Enrolling by invitation
Colorectal Cancer Screening for Ages 40-49 with Family History
This trial helps people aged 40-49 who have a parent, sibling, or child with colorectal cancer decide on the best way to get screened. It aims to find the most effective screening method for those at higher risk.
TaipeiAges 40–49 - NCT07493967Enrolling by invitation
Stomach balloon for fatty liver disease study
This study looks at how a stomach balloon affects symptoms and quality of life in people with obesity and fatty liver disease. It will track your health over time to see if the balloon helps.
Dallas, TexasAges 18 years+ - NCT07490834Enrolling by invitation
Long-term nutrition after necrotizing enterocolitis in preemies
This study looks at how necrotizing enterocolitis (a serious gut infection) affects the long-term nutrition of premature babies. If your baby was born early and had this condition, participating could help doctors understand its lasting effects.
Nancy, LorraineAges Any age - NCT07488312Enrolling by invitationPhase 1
Leucine-restricted diet for gastric cancer patients
This trial tests if a diet low in leucine (an amino acid) can help treat gastric cancer before surgery. It aims to see if it's safe and effective for patients who are preparing for tumor removal.
Jinan, ShandongAges 18–70 - NCT07475052Enrolling by invitation
Heart rate monitoring to predict biologic therapy response in IBD
This study tests whether a wearable heart rate monitor can help predict how well biologic medications work for people with Crohn's disease or ulcerative colitis. If you are starting infliximab or vedolizumab for the first time, you may be eligible.
Xi'an, ShaanxiAges 18–75 - NCT07471490Enrolling by invitation
Stool test study for inflammatory bowel disease vs. irritable bowel syndrome
This study collects stool samples and health information to help develop a new test that may tell the difference between inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). If you have not been diagnosed with a chronic gut disorder, you may be able to join.
Minneapolis, MinnesotaAges 2 years+ - NCT07470658Enrolling by invitation
Surveillance after positive FIT and normal colonoscopy
This trial studies the best way to follow up with people who had a positive FIT stool test (high blood level) but a normal colonoscopy. It aims to find the right schedule for future screening to catch any problems early.
TaipeiAges 45–74 - NCT07458555Enrolling by invitation
Anesthetic impact on FLIP measurements
This trial looks at how different anesthetics affect FLIP measurements during endoscopy or POEM for esophageal problems. FLIP helps doctors check how well the esophagus opens and closes.
Dallas, TexasAges 18–75 - NCT07448753Enrolling by invitation
Testing for genetic causes of chronic intestinal blockage
This trial checks if a genetic test can find causes of a rare condition where the intestines don't move normally, causing blockages. It may help people with poor esophagus muscle function.
MilanAges 18 years+ - NCT07445204Enrolling by invitation
Electrical stimulation for swallowing after stroke
This trial tests whether a gentle electrical stimulation technique on neck muscles can help improve swallowing in people who recently had a stroke. It may be a good option if you are still having trouble swallowing after your stroke.
IstanbulAges 18 years+ - NCT07444099Enrolling by invitation
Early treatment after surgery for stomach cancer patients
This trial tests an early treatment plan after stomach cancer surgery. It is for people who completed chemotherapy before surgery without serious side effects and had a short hospital stay.
Jinan, ShandongAges 18–80 - NCT07442682Enrolling by invitation
Studying cystic fibrosis in adults at a Belgian center
This trial gathers information about adults with cystic fibrosis at the Erasme Hospital in Belgium. Your participation helps doctors better understand the condition and how it affects quality of life.
BrusselsAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,916 recruiting gastroenterology studies from the U.S. registry right now, out of 12,516 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.