Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,916 recruiting studies in this area right now.
By phase
- Not applicable4,936
- Phase 21,188
- Phase 1583
- Phase 3465
- Phase 1/Phase 2396
- Phase 4237
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer493
- Gastric Cancer298
- Pancreatic Cancer292
- Hepatocellular Carcinoma284
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer148
- Crohn Disease144
- Ulcerative Colitis140
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)107
- Liver Cancer101
- Lung Cancer99
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma89
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University91
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona174
- Texas148
- Florida135
- Massachusetts127
- Alabama123
- New York123
- Maryland87
- Ohio80
- Pennsylvania72
Recruiting studies7,916 total
- NCT07662356Recruiting
NAFLD study in Chinese patients having obesity surgery
This study follows Chinese patients who are having obesity surgery to understand how nonalcoholic fatty liver disease (NAFLD) changes over time and to find markers that might predict its course. It could help doctors better treat liver problems in people with obesity.
Hong Kong, New TerritoriesAges 18 years+ - NCT07662642Recruiting
Timing of lung inflation during robotic prostate surgery
This trial compares two different timings of a lung inflation maneuver during robotic prostate surgery to see which approach helps patients breathe better after surgery.
AnkaraAges 18 years+ - NCT07667101Recruiting
Hepatitis C team care for people in supportive housing
This study tests a team-based approach — a pharmacist, doctor, and patient navigator working together — to help people living in permanent supportive housing get hepatitis C care. If you have hepatitis C and live in DESC housing, the study will check how well this team helps you through treatment over 2 years.
Seattle, WashingtonAges 18 years+ - NCT07668453RecruitingPhase 2
Adebrelimab plus chemo for advanced bile duct cancer
This study tests adding the immunotherapy adebrelimab to standard chemotherapy (gemcitabine and nab-paclitaxel) as a first treatment for advanced biliary tract cancer that can't be removed by surgery. The goal is to see if this combination helps shrink tumors and improve outcomes.
Nanjing, JiangsuAges 18–75 - NCT07669220RecruitingPhase 2
Short radiation, immunotherapy, and chemo for advanced rectal cancer
This trial compares a new treatment approach—short-course radiation followed by an immunotherapy drug (PD-1 inhibitor) and chemotherapy (FOLFOX)—to the standard long-course chemoradiation for people with a specific type of advanced rectal cancer that is pMMR/MSS. The goal is to see if the shorter treatment works as well or better.
GuangzhouAges 18–75 - NCT07669298Recruiting
Monitoring vs chemoradiation for early rectal cancer
This study compares two approaches after early-stage rectal cancer is removed: either careful monitoring or a follow-up treatment with chemotherapy and radiation. The goal is to see which strategy works better to keep the cancer from returning.
LimogesAges 18 years+ - NCT07669454RecruitingPhase 3
Nuvastatic® for metastatic colorectal cancer
This trial tests a new capsule (Nuvastatic®) added to standard chemotherapy for people with metastatic colorectal cancer. The goal is to see if it helps shrink tumors and improve well-being.
Visakhapatnam, Andhra PradeshAges 18–65 - NCT07670273RecruitingPhase 2
Drug combo for advanced HER2 bile duct cancer
This trial tests a combination of three drugs (trastuzumab rezetecan, adebrelimab, and lenvatinib) as a first treatment for people with advanced HER2-positive or HER2-low bile duct or gallbladder cancer. The goal is to see if this combination helps shrink or control the cancer.
BeijingAges 18–75 - NCT07670286Recruiting
Spotting early warning signs of pancreatic cancer wasting
This study checks if advanced computer analysis of your tumor and body can predict severe weight loss and muscle wasting (cachexia) from pancreatic cancer. If you join, you may help doctors find earlier warning signs to improve treatment.
BeijingAges 18 years+ - NCT07670975Recruiting
Energy use in children with new IBD diagnosis
This study measures how many calories children with newly diagnosed inflammatory bowel disease (Crohn's or ulcerative colitis) burn at rest. It helps doctors understand and manage their energy needs.
Alessandria, PiedmontAges 6–17 - NCT07670988Recruiting
Kidney health in kids with inflammatory bowel disease
This study checks if children with inflammatory bowel disease (IBD) are more likely to have kidney problems. Researchers will look at medical records to compare kidney health in kids with IBD and those without.
Alessandria, PiedmontAges 2–17 - NCT07671339RecruitingPhase 1
Vaccine for pancreatic cancer with KRAS mutations
This trial tests a cancer vaccine (ELI-002 7P) for people with pancreatic cancer that hasn't spread to other parts of the body. It may be given alone or with another drug (tislelizumab) that helps the immune system fight cancer. The goal is to see if these treatments can help keep the cancer from coming back after surgery or chemotherapy.
Basking Ridge, New JerseyAges 18 years+ - NCT07671625Recruiting
Prehabilitation program for esophageal or gastric cancer
This trial tests a comprehensive program that includes exercise, nutrition, and psychological support before and after surgery for patients with locally advanced esophageal or gastric cancer. It aims to improve recovery and outcomes.
BrnoAges 18 years+ - NCT07672145Recruiting
Gallbladder removal: belly button vs. upper belly cut
This trial compares two ways to remove the gallbladder during laparoscopic surgery: through the belly button or through a cut just below the breastbone. It aims to find which method causes less pain and recovers faster.
Lahore, Punjab ProvinceAges 18–60 - NCT07668934Enrolling by invitationPhase 4
TAF for early and middle pregnancy with chronic hepatitis B
This trial tests a hepatitis B medicine called TAF in pregnant women who need antiviral treatment. It helps protect both mom and baby from complications of the virus.
Guangzhou, GuangdongAges 20–40 - NCT07662902Enrolling by invitation
Gut Barrier Study in Ulcerative Colitis Remission
This study looks at gut barrier function in people with ulcerative colitis who are in remission. It uses a non-invasive liver test to check for subtle changes in the body.
ZagrebAges 18–70 - NCT07642401Enrolling by invitation
Building models to understand esophageal cancer
This research study uses medical records and imaging from patients with various esophageal conditions—from inflammation to cancer—to develop better diagnostic and prediction tools. Researchers want to understand what changes in the esophagus lead to cancer and how to catch it earlier.
Anyang, HenanAges 18–90 - NCT07634614Enrolling by invitation
Speech therapy for reflux-related bloating and belching
This trial tests whether speech and language therapy can help reduce bloating, belching, and other air-related symptoms in people with acid reflux (GERD). Researchers will measure how much the therapy improves these symptoms before and after treatment.
Schlieren, Canton of ZurichAges 18 years+ - NCT07631442Enrolling by invitation
Digital Health Monitoring for Primary Biliary Cholangitis
This study uses a smartphone app or digital platform to track how you're feeling day-to-day if you have primary biliary cholangitis (PBC), a liver condition where your immune system damages bile ducts. Researchers want to see if this digital monitoring helps them better understand and manage PBC symptoms.
Redwood City, CaliforniaAges 18 years+ - NCT07621757Enrolling by invitation
Genetic Risk Testing for Colorectal Cancer Screening
This study looks at how genetic risk information can help decide who needs colorectal cancer screening and when. Researchers want to see if testing for genetic risk factors improves screening decisions for people who haven't had a colonoscopy before.
Evanston, IllinoisAges 45–75 - NCT07617038Enrolling by invitation
MRI Scan to Predict Liver Cancer Treatment Response
This trial uses a special type of MRI scan to see if doctors can predict how well a liver cancer treatment (called TACE) will work for you. The scan may help doctors understand your treatment response better.
Montreal, QuebecAges 18–70 - NCT07613827Enrolling by invitation
AI screening for fatty liver disease using CT scans
This study uses artificial intelligence to help doctors identify fatty liver disease from CT scans you may already be having. If eligible, you'll have some blood tests and possibly an ultrasound or MRI to confirm liver health, helping catch liver disease early.
Shenyang, LiaoningAges 18 years+ - NCT07603232Enrolling by invitation
Long-Term Health Outcomes in Children With Hirschsprung's Disease or Anorectal Malformations
This study follows children who were born with Hirschsprung's disease (a condition affecting the nerves in the colon) or anorectal malformations (differences in how the rectum or anus formed) to understand how they do over time. Researchers will track health outcomes and quality of life to help improve care for future children with these conditions.
Montreal, QuebecAges Up to 18 years - NCT07583342Enrolling by invitationPhase 4
RELiZORB for feeding problems in severe pancreatitis
This study tests whether a medication called RELiZORB can help adults with moderate to severe acute pancreatitis (sudden, severe pancreas inflammation) tolerate nutrition delivered through a feeding tube. If your body is struggling to accept enough nutrition during acute pancreatitis, this trial may help you receive adequate nutrition while you recover.
Bay Shore, New YorkAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,916 recruiting gastroenterology studies from the U.S. registry right now, out of 12,516 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.