Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,877 recruiting studies in this area right now.
By phase
- Not applicable4,908
- Phase 21,181
- Phase 1583
- Phase 3466
- Phase 1/Phase 2391
- Phase 4235
- Phase 2/Phase 3113
Top conditions
- Colorectal Cancer495
- Gastric Cancer297
- Pancreatic Cancer293
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer174
- Breast Cancer145
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer113
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)105
- Liver Cancer99
- Lung Cancer98
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas146
- Florida134
- Massachusetts128
- New York123
- Alabama121
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,877 total
- NCT06406062Recruiting
AI-assisted colonoscopy study
This trial tests an artificial intelligence (AI) system during colonoscopy to help doctors see polyps or other issues more clearly. It may help improve detection of problems in the colon.
Wuhan, HubeiAges 50 years+ - NCT06951503RecruitingPhase 3
AK112 plus chemo for first-line metastatic colorectal cancer
This trial tests a new drug called AK112 combined with chemotherapy as a first treatment for people with metastatic colorectal cancer. The goal is to see if the combination helps shrink tumors and improve survival better than chemotherapy alone.
Guanzhou, GuangdongAges 18–75 - NCT06317727Recruiting
Pulsed field ablation for removing colon polyps
This study tests a new way to remove colon polyps using short bursts of energy (pulsed field ablation) instead of standard methods. It may help people with polyps in the lower part of the colon that are not too large or complex.
LondonAges 18 years+ - NCT05342233Recruiting
Compare watchful care versus catheter treatment for a bowel artery tear
This study compares two ways to treat an isolated tear in the superior mesenteric artery (a blood vessel that supplies the intestines): conservative (watchful care) versus endovascular (catheter-based) treatment. It may help doctors figure out which approach works best for people whose condition is confirmed on a CT angiogram and who are stable enough for either plan.
Changsha, HunanAges 18 years+ - NCT06406426RecruitingPhase 2
New drug combo for advanced stomach cancer after first treatment fails
This trial tests a combination of three drugs—cadonilimab, fruquintinib, and albumin-bound paclitaxel—as a second treatment for advanced stomach cancer. It may be an option if your first treatment stopped working and you have not had certain types of prior therapy.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT05643859Recruiting
Fiber supplement study for bowel health and gut bacteria
This study tests whether adding a dietary fiber supplement can change the bacteria in your colon (gut microbiome). You may be asked to take the fiber supplement during evaluation for a non-cancer rectal condition.
Portland, OregonAges 18 years+ - NCT06829355RecruitingPhase 2
Thymalfasin plus triple therapy for advanced colorectal cancer
This trial tests a combination of three drugs plus thymalfasin, an immune-boosting medicine, for people whose advanced colorectal cancer has not responded to at least two prior treatments. It's designed specifically for the common type of colorectal cancer (pMMR/MSS) to see if adding this immune therapy can help.
Beijing, ChinaAges 18–75 - NCT07629323Enrolling by invitation
Spinal Pain Relief During Hiatal Hernia Surgery
This trial tests whether injecting pain medication directly into the spinal fluid during a minimally invasive stomach surgery (called fundoplication) helps reduce pain after the operation. Fundoplication is used to treat severe acid reflux.
Karlstad, Värmland CountyAges 18 years+ - NCT06335420Recruiting
Can carrot juice prevent colon polyps from coming back?
This study tests whether drinking carrot juice every day can lower the chance that large colon polyps or early colon cancers will come back. Researchers want to see if the nutrients in carrot juice help protect the lining of the colon.
OdenseAges 18 years+ - NCT06212921Recruiting
Biomarkers to predict acute mesenteric ischemia
This trial is looking for biomarkers (clues in your blood) that can help doctors predict acute mesenteric ischemia, a condition where blood flow to your gut is suddenly blocked. It may help find better ways to diagnose this serious condition early.
TartuAges 18 years+ - NCT06446440Recruiting
Keyhole surgery for scar tissue blocking the intestine
This study tests a keyhole surgery (laparoscopy) to cut away scar tissue (adhesiolysis) that is blocking the intestine. It is for people whose blockage is caused by scar tissue and who have not gotten better with non-surgical care.
AsyutAges 18 years+ - NCT07307027Recruiting
Feeding plan for children in intensive care
This study tests a step-by-step feeding plan (enteral nutrition) for children in the pediatric ICU to see if it improves their recovery. It might help if your child is critically ill and can receive nutrition through a tube.
Cairo, AbbasiaAges 1 month–16 years - NCT06754514Recruiting
Organ retractor device study for weight loss surgery
This trial is testing a device that helps surgeons perform weight loss surgery through small incisions. It may be for you if you are scheduled for minimally invasive bariatric surgery.
Raleigh, North CarolinaAges 18 years+ - NCT06816914RecruitingPhase 2
Perioperative chemo for resectable pancreatic cancer
This trial tests a combination of chemotherapy drugs (liposomal irinotecan with fluorouracil, leucovorin, and oxaliplatin) given before and after surgery for pancreatic cancer that can be fully removed. It aims to see if this approach improves outcomes for patients with stage I or II disease.
Kaohsiung CityAges 20–75 - NCT06221722Recruiting
Brain scan study for treating constipation
This trial uses brain scans to see if doctors can predict how well constipation treatments will work. It is for adults with functional constipation, but only if they have no other digestive problems or medical implants.
Yinchuan, NingxiaAges 18–45 - NCT06104215RecruitingEarly Phase 1
BGT007H cells for advanced digestive cancer
This trial tests a new cell therapy called BGT007H for people with advanced digestive tract cancers (esophagus, stomach, pancreas, or colon) that have not responded to or stopped working after at least two prior treatments. The goal is to see if this therapy can help shrink tumors or slow the disease.
Xuzhou, JiangsuAges 18–70 - NCT06353854Recruiting
Study of biomarkers in MSI-high colorectal cancer patients on immunotherapy
This trial is studying people with a specific type of advanced colorectal cancer (MSI-high/dMMR) who are starting immunotherapy with pembrolizumab. The goal is to find out which markers in the tumor might predict whether the treatment works well.
BayonneAges 18 years+ - NCT06739174Recruiting
Study of new colostomy bags with improved filter
This trial tests a new type of colostomy bag that has a special filter system to reduce problems like ballooning, odor, and leakage. If you use a flat, closed bag and have at least one filter-related issue a week, this study might help find a better option for you.
Birmingham, EnglandAges 18 years+ - NCT06387745Recruiting
Checking liver health with a new device
This study tests a new device called Hepatoscope that measures your liver health without a needle. It may be a good option if you have liver problems, diabetes, or metabolic syndrome and want a simple, noninvasive check.
Edegem, AntwerpAges 18–80 - NCT06431048Enrolling by invitation
Does pausing tube feeding affect recovery?
This study looks at whether briefly pausing tube feedings during certain procedures (like placing a tracheostomy or PEG tube) affects patient outcomes. The goal is to find out if it's safe to continue feeding without stopping, which might prevent delays in nutrition.
Columbia, MissouriAges 18 years+ - NCT07084441RecruitingPhase 4
Steroid treatment for bowel blockage management
This trial studies whether a steroid medicine (dexamethasone) helps people with a bowel blockage get better faster and avoid surgery. If you have a blockage from scar tissue and are being watched in the hospital, this could be an option.
New York, New YorkAges 18 years+ - NCT06347120Recruiting
Nasogastric tube for bowel obstruction
This trial compares the effectiveness of placing a nasogastric tube versus not placing one for treating small bowel obstructions caused by adhesions. It aims to see if the tube is really needed for patients who do not have complications.
AmiensAges 18–85 - NCT07083076Recruiting
Regular diet vs low residue diet after colon surgery
This study compares a regular diet to a low residue diet (a diet low in fiber) after colon surgery to see if patients can eat normally without issues. It may help determine if a regular diet is safe and better for recovery.
Manhasset, New YorkAges 18 years+ - NCT06729944Recruiting
Genetic testing study for bile duct cancers
This trial looks at how well a modern genetic test (next-generation sequencing) works when analyzing tissue samples from people with bile duct cancer. The goal is to see if this test can help doctors better understand these tumors.
BolognaAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,877 recruiting gastroenterology studies from the U.S. registry right now, out of 12,321 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.