Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,607 recruiting studies in this area right now.
By phase
- Not applicable4,687
- Phase 21,190
- Phase 1566
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer480
- Pancreatic Cancer289
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer147
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Ovarian Cancer90
- Pancreas Cancer90
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis76
Leading sponsors
- Fudan University100
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)50
- National Taiwan University Hospital45
Where studies are running
- California443
- Arizona189
- Texas140
- Alabama129
- Florida127
- Massachusetts120
- New York120
- Maryland88
- Ohio80
- Illinois69
Recruiting studies7,607 total
- NCT07812155Recruiting
AI-assisted bowel prep for colonoscopy
This trial tests whether an AI-assisted app can help hospitalized patients prepare better for a colonoscopy. It may make the bowel-cleansing process easier and more effective.
Chiayi City, TaiwanAges 20 years+ - NCT07814027Recruiting
Trial comparing two surgeries for achalasia
This trial compares two surgeries to treat achalasia, a condition where the esophagus fails to push food into the stomach. Both procedures aim to relax the muscle at the bottom of the esophagus, and the study will see which one works better for improving your symptoms.
Minya, Minya GovernorateAges 18–75 - NCT07816094RecruitingPhase 4
Comparing two doses of entecavir for hepatitis B cirrhosis
This study tests two daily doses of the medicine entecavir to see which one better controls the hepatitis B virus in people with advanced liver scarring (cirrhosis). It aims to find the most effective dose to improve liver health.
Dhaka, Dhaka DivisionAges 18 years+ - NCT07817199Recruiting
Comparing bowel care timing in spinal cord injury rehab
This study compares two different care schedules for managing bowel movements in people with spinal cord injury, to see which is faster and more effective. If bowel care takes you a long time, this trial might help make daily routines easier and more consistent.
Pomona, CaliforniaAges 18 years+ - NCT07809867RecruitingPhase 4
How Trikafta moves through the body in cystic fibrosis
This study looks at how the medicine elexacaftor/tezacaftor/ivacaftor (often called Trikafta) works in the body in people with cystic fibrosis. It helps doctors understand the right dose and how the drug is processed, which may improve treatment for children and adults.
GenovaAges 6 years+ - NCT07814014Recruiting
Systemic therapy options for liver cancer
This trial studies which systemic treatments (medicines that travel through the blood to reach cancer cells) work best for patients with advanced liver cancer. It aims to find the most effective approach to slow tumor growth and improve quality of life.
Al Mansurah, Dakahlia GovernorateAges 18 years+ - NCT07810309RecruitingPhase 1
Easing the pancreatic duct to help chronic pancreatitis
This study tests whether draining the main pancreatic duct (the tube that carries digestive enzymes) can help patients with chronic pancreatitis who have mild symptoms. It aims to see if this procedure improves how the pancreas works without causing harm.
Rochester, MinnesotaAges 18 years+ - NCT07817147Recruiting
Microwave ablation treatment for advanced cancer
This study tests a procedure called microwave ablation (using heat to destroy cancer cells) for tumors that are hard to remove with surgery. It aims to see if the procedure is safe and effective when done through a scope in the stomach.
Gilbert, ArizonaAges 18 years+ - NCT07816263Recruiting
Guaraná supplement for cancer-related fatigue
This trial tests whether a natural supplement called guaraná can help reduce fatigue in people undergoing cancer treatment. Guaraná contains caffeine and other compounds that may boost energy and improve well-being.
Bogotá, Bogota D.C.Ages 18 years+ - NCT07811752RecruitingPhase 2
Combination treatment for advanced esophageal cancer
This trial tests a combination of two drugs for advanced esophageal cancer that has grown despite earlier treatment. The goal is to see if this combination can help shrink tumors and slow the disease.
ShanghaiAges 18 years+ - NCT07816809Recruiting
Phage therapy for gut discomfort
This trial tests whether taking special capsules with friendly viruses (phages) can help reduce stomach pain, bloating, constipation, or diarrhea by balancing the bacteria in your gut.
Fort Collins, ColoradoAges 18–75 - NCT07814456RecruitingPhase 2
Fecal transplant for ulcerative colitis comparing donor types
This trial tests fecal microbiota transplantation (a procedure that puts healthy donor bacteria into your gut) for left-sided ulcerative colitis. It compares results using donors from two different backgrounds to see if one works better.
Kunming, YunnanAges 18–60 - NCT07809711Recruiting
Ultrasound check after surgery for chronic anal fissure
This trial uses ultrasound to check how well the anal muscle heals after surgery for a chronic anal fissure. It may help doctors understand what to expect after the operation and guide treatment decisions.
ValenciaAges 18 years+ - NCT07809620Recruiting
Acid reflux surgery: Who is likely to feel better?
This study looks at patients who are planning to have surgery for severe acid reflux (called fundoplication). It aims to find out which patients are most likely to see their symptoms improve after the operation, so doctors can better choose who will benefit.
Minya, Minya GovernorateAges 18 years+ - NCT06243393RecruitingPhase 2/Phase 3
Sacituzumab govitecan for advanced colorectal cancer
This study tests a drug called sacituzumab govitecan for people with metastatic colorectal cancer who have already tried several standard treatments. It may be an option if your cancer is not MSI-H or dMMR and you haven't had irinotecan recently.
Heidelberg, Baden-WurttembergAges 18 years+ - NCT01882205Recruiting
Testing new camera methods to find precancer in ulcerative colitis
This study compares different special camera techniques during colonoscopy to see which best finds early abnormal (pre-cancer) changes in people with long-term ulcerative colitis. It may help doctors improve how they screen and monitor your colon over time.
LeuvenAges 18 years+ - NCT06494514Recruiting
New chemo combo with immunotherapy and radiation for advanced pancreatic cancer
This trial compares two different chemotherapy combinations, each paired with immunotherapy and radiation, as the first treatment for locally advanced pancreatic cancer. It aims to see which combination works better.
Nanjing, JiangsuAges 18 years+ - NCT05733130Recruiting
Registry study for chronic pancreatitis symptoms
This study keeps a medical registry of people with chronic pancreatitis (long-term pancreas inflammation), starting soon after the diagnosis. It helps doctors better understand how the condition begins and progresses in real life.
MilanAges 12 years+ - NCT06509126RecruitingPhase 3
Panitumumab with Chemo: Continuous or Intermittent for Advanced CRC
This trial compares giving panitumumab plus FOLFIRI (two chemotherapy drugs) either continuously or with breaks, as a first treatment for left-sided colorectal cancer that has spread. It's for people whose tumors have certain genetic markers (RAS/BRAF wild-type) and haven't had treatments for advanced disease before.
NaplesAges 18–100 - NCT06205862RecruitingPhase 2
Fecal transplant for preventing colon polyp return
This study tests whether taking capsules of healthy bacteria (fecal microbiota transplant) can help prevent colon polyps from coming back after they have been removed. It might be an option for people who have had an adenoma polyp removed and want to reduce the chance of recurrence.
Guangzhou, GuangdongAges 18–75 - NCT06498622RecruitingPhase 2
Liver cancer relapse prevention after surgery
This trial tests a combination of two drugs (Donafenib and Envafolimab) after surgery to lower the risk of liver cancer coming back in people who have high-risk features. It may help if you qualify based on your tumor(s) and overall health.
Fuyang, AnhuiAges 18–80 - NCT06341270Recruiting
Electric acupressure for pain after liver surgery
This trial tests if a gentle electric stimulation on the skin (TEAS) can reduce pain and speed up recovery after liver surgery. The treatment is non-invasive and may be an alternative to pain medicines.
Chengdu, SichuanAges 18–80 - NCT02021604RecruitingPhase 1
Fluorodopa scan for congenital hyperinsulinism and insulinoma
This Phase 1 study tests a special imaging medicine (fluorodopa F 18) to help doctors better understand congenital hyperinsulinism (HI) patterns in the body. It may help guide treatment decisions to prevent dangerous low blood sugar and protect brain function.
Fort Worth, TexasAges Up to 18 years - NCT06517407Recruiting
Comparing two stoma placement methods to reduce complications
This trial is comparing two ways to place a stoma (a new opening for waste) during abdominal surgery, to see which method leads to fewer problems like leaking or skin issues.
AsyutAges Any age
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,607 recruiting gastroenterology studies from the U.S. registry right now, out of 11,926 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.