Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,877 recruiting studies in this area right now.
By phase
- Not applicable4,908
- Phase 21,181
- Phase 1583
- Phase 3466
- Phase 1/Phase 2391
- Phase 4235
- Phase 2/Phase 3113
Top conditions
- Colorectal Cancer495
- Gastric Cancer297
- Pancreatic Cancer293
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer174
- Breast Cancer145
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer113
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)105
- Liver Cancer99
- Lung Cancer98
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas146
- Florida134
- Massachusetts128
- New York123
- Alabama121
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,877 total
- NCT07622940RecruitingPhase 1/Phase 2
CAR-NK Cell Therapy for Advanced Esophageal Cancer
This trial tests a new immunotherapy using specially engineered natural killer cells (a type of immune cell) designed to target two proteins found on esophageal cancer cells. It's for patients with advanced esophageal adenocarcinoma that has spread or returned after prior treatment.
Shenzhen, GuangdongAges 18–75 - NCT06430372RecruitingPhase 1
Dye-guided endoscopy to see gut blood vessels
This trial tests a new dye that lights up blood vessels in the gut during an endoscopy, using a special camera. It may help doctors see abnormal areas more clearly.
Beijing, Beijing MunicipalityAges 18–75 - NCT07417514Recruiting
Tolerance test of an oral nutrition supplement for kidney patients
This study tests how well kidney patients tolerate a new oral nutrition supplement taken by mouth or through a feeding tube. It aims to see if it is acceptable for daily use over 28 days.
LondonAges 18 years+ - NCT06250803Recruiting
Early pancreatic stent for PEP prevention
This trial tests placing a small plastic tube (stent) in your pancreatic duct early during ERCP to try to prevent pancreatitis (inflammation of the pancreas). It’s for people having their first ERCP to get into their bile duct.
Hefei, AnhuiAges 18 years+ - NCT06251700Recruiting
AI-assisted colonoscopy and long-term polyp prevention
This study checks if using AI during colonoscopy helps prevent growths from coming back. You'd need to have been in an earlier AI-colonoscopy study and be willing to come back for a follow-up colonoscopy 3 years later.
Hong KongAges 18 years+ - NCT06252948Recruiting
Gut bacteria study for POEMS and related plasma cell disorders
This study looks at the gut microbiome (the bacteria living in your digestive system) in people with POEMS syndrome, multiple myeloma, MGUS, amyloidosis, and healthy household members. It may help researchers understand how gut health relates to these conditions.
Rochester, MinnesotaAges 18 years+ - NCT07413549RecruitingPhase 1/Phase 2
Stem cell injection for hepatitis B cirrhosis
This trial tests an injection of stem cells from donated umbilical cords to see if it can help people with advanced liver scarring from hepatitis B. You may be able to join if standard treatments haven’t helped enough and you aren’t able to get a liver transplant.
WuhanAges 18–75 - NCT07032376Enrolling by invitation
Quick care pathway for chronic constipation
This study tests a faster care plan for people with chronic constipation. It will see if a simplified approach helps patients get the right treatment sooner.
Ann Arbor, MichiganAges 18 years+ - NCT07261228Recruiting
Comparing carbon footprint of diagnostic vs. therapeutic upper endoscopy
This study looks at how much carbon dioxide is released during upper endoscopy, comparing people having a diagnostic procedure for stomach discomfort versus those having treatment for a bleeding ulcer. It may help understand which type of procedure has a bigger environmental impact.
BangkokAges 20–80 - NCT06803628Recruiting
Ultrasound to rule out bowel blockage in ER
This study tests if an ER doctor can use a bedside ultrasound to quickly rule out a bowel blockage, so you might avoid a CT scan. You'll get the ultrasound plus a CT scan to compare how well the ultrasound works.
Clermont-Ferrand, FranceAges 18 years+ - NCT03720262RecruitingPhase 2/Phase 3
Prevent hernia after reversing a temporary ileostomy
This trial studies ways to lower the chance of getting a hernia after your temporary ileostomy is reversed. It may help patients who are planning stoma reversal after rectal cancer surgery.
SödertäljeAges 18–90 - NCT06801665RecruitingPhase 2
Fecal transplant plus immunotherapy and chemotherapy for colon cancer with liver spread
This trial tests a combination of fecal microbiota transplant (FMT), an immunotherapy drug (QL1706), a targeted therapy (bevacizumab), and chemotherapy (XELOX) as a first treatment for advanced colon cancer that has spread to the liver. The goal is to see if this mix can help shrink tumors and improve outcomes.
ChangzhouAges 18–75 - NCT03789383Recruiting
Living donor liver transplant and biliary complication outcomes study
This study looks at what factors lead to “biliary complications” (problems involving the bile ducts that help move bile from the liver) after an adult living-donor liver transplant. It’s aimed at people who had this specific type of transplant at the study hospital in Egypt.
AsyutAges 18–65 - NCT07608120Recruiting
Electrolyte drink with bowel cleansing solution for colonoscopy prep
This study tests whether combining an electrolyte beverage (a drink with salts and minerals) with polyethylene glycol—a standard bowel-cleaning solution—helps prepare your colon better for colonoscopy. The goal is to see if this combination makes the preparation easier to tolerate while still cleaning your bowel effectively.
Guangzhou, GuangdongAges 18–75 - NCT05630443Recruiting
Prone position after major abdominal cancer surgery
This study looks at whether placing you in a face-down (prone) position after major abdominal cancer surgery can improve recovery. You may be offered this positioning approach after your operation if it’s safe for you.
GothenburgAges Any age - NCT03148743Recruiting
Fecal transplant for gut graft-versus-host disease
This study tests whether a fecal transplant (FMT) can help treat gut graft-versus-host disease (gut GVHD), a condition where donated immune cells attack the intestines. If you have gut GVHD and meet age requirements, you may be eligible to receive this treatment in the trial.
Suzhou, JiangsuAges 10–60 - NCT01912313Recruiting
Testing nerve signals in gut samples from IBS patients
This study looks at how nerves behave in small gut tissue samples (biopsies) from people with irritable bowel syndrome (IBS) and healthy volunteers. The goal is to better understand IBS symptoms and what might be driving them.
Leuven, Vlaams-BrabantAges 18–99 - NCT07616245Recruiting
Special feeding to prevent fluid leaks after esophageal surgery
This study tests whether a special type of nutritional feeding through a tube placed in your small intestine can reduce complications (fluid leaks) after surgery to remove your esophagus for cancer. Researchers hope this approach may help you recover faster and spend less time in the hospital.
Beaumont, DublinAges 18 years+ - NCT06289374Recruiting
Long-term breath & blood study after stomach or esophagus cancer surgery
This study is for people who have had surgery for stomach or esophagus adenocarcinoma and are already part of a larger study called BIORESOURCE 1. It looks at certain substances in your breath and blood over time to learn more about recovery.
LondonAges 18–90 - NCT04415983RecruitingPhase 3
Nitazoxanide for stomach infection in children
This trial studies nitazoxanide to treat Helicobacter pylori, a common stomach infection, in children. If you test positive for this infection and haven’t been treated for it before, you may be able to join.
TantaAges Up to 18 years - NCT06241170Recruiting
Surgical margin study for Crohn's disease recurrence
This trial tests a specific way of cutting the bowel during surgery for Crohn's disease to see if it lowers the chance of the disease coming back. It is for people with Crohn's in the ileocecal area who are having their first surgery to remove that section.
Guangzhou, GuangdongAges 14–65 - NCT07607158Recruiting
How Blueberries Work in Your Body
This study explores how your gut bacteria (the healthy microbes in your digestive system) affect how your body processes beneficial compounds in blueberries. Researchers want to understand this natural process by studying healthy adults.
Fort Collins, ColoradoAges 18 years+ - NCT02594813Recruiting
Bleeding risk check for endoscopy in people on blood thinners
This trial looks at how often bleeding happens after an upper scope (EGD) or colonoscopy in people who keep taking blood-thinning medicines during the procedure. The results may help doctors choose safer prep plans to lower bleeding risk.
KomaganeAges 20–90 - NCT07492134RecruitingPhase 2
Antibiotics vs placebo for mild diverticulitis
This study tests whether antibiotics are necessary for mild diverticulitis or if a placebo works just as well. Participants are treated in the emergency department and followed using a smartphone app.
Nashville, TennesseeAges 18–90
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,877 recruiting gastroenterology studies from the U.S. registry right now, out of 12,321 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.