Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,607 recruiting studies in this area right now.
By phase
- Not applicable4,687
- Phase 21,190
- Phase 1566
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer480
- Pancreatic Cancer289
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer147
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Ovarian Cancer90
- Pancreas Cancer90
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis76
Leading sponsors
- Fudan University100
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)50
- National Taiwan University Hospital45
Where studies are running
- California443
- Arizona189
- Texas140
- Alabama129
- Florida127
- Massachusetts120
- New York120
- Maryland88
- Ohio80
- Illinois69
Recruiting studies7,607 total
- NCT06500403Recruiting
Non-invasive tools for liver injury after chemotherapy
This study tests non-invasive methods to diagnose a liver condition called PSVD in people who have received platinum chemotherapy. It may help find liver problems early without a biopsy.
Guangzhou, GuangdongAges 18–80 - NCT06272214RecruitingPhase 2
Adjuvant radiotherapy for esophageal cancer after immunotherapy
This trial tests if adding radiation therapy after surgery improves outcomes for people with esophageal squamous cell cancer who received immunotherapy and chemotherapy before surgery but did not achieve a complete response. It aims to see if this approach can lower the chance of the cancer coming back.
Hangzhou, ZhejiangAges 18–75 - NCT06086457RecruitingPhase 3
Immunotherapy plus chemo with or without radiation for esophageal cancer
This trial tests whether adding radiation therapy to a standard treatment (immunotherapy plus chemotherapy) can help people with advanced esophageal cancer that has spread to up to two organs. The goal is to see if the combination improves outcomes.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05844046RecruitingPhase 2
Triple drug treatment for advanced liver cancer that can’t be removed
This Phase 2 trial tests three medicines together (durvalumab, tremelimumab, and bevacizumab) to treat non-surgical (non-resectable) liver cancer. It may help shrink tumors and slow disease progression by boosting the immune system and blocking tumor blood supply.
MunichAges 18 years+ - NCT06413342RecruitingPhase 2
Sintilimab after chemoradiation for older adults with esophageal cancer
This trial tests whether the immunotherapy drug Sintilimab can help prevent esophageal cancer from returning after standard chemotherapy and radiation. It is for patients aged 70-85 who cannot have or choose not to have surgery.
Hangzhou, ZhejiangAges 70–85 - NCT07802379Recruiting
Tube feeding tolerance with different blood pressure medications in the intensive care unit
This study looks at how critically ill patients on a breathing tube and receiving nutrition through a tube tolerate their feeding, depending on the dose of medications given to manage their blood pressure. It aims to see if feeding works well while patients are on these medications.
IstanbulAges 18 years+ - NCT07801508RecruitingPhase 1
Trial of a new imaging agent for people with advanced solid tumors
This trial tests a radioactive imaging agent that may help doctors see tumors more clearly using a special scan. It is designed for adults with certain breast, lung, or stomach cancers that have spread.
Darlinghurst, New South WalesAges 18 years+ - NCT07803965RecruitingPhase 2
Study of an injection for severe acute pancreatitis
This trial tests an investigational medicine called SGC001 given as an injection to people with severe acute pancreatitis, a serious inflammation of the pancreas. The study aims to see if the drug is safe and helpful, and to gather early information on how it works.
ChengduAges 18–75 - NCT07807059RecruitingPhase 1
Study of HRS-4729 injection in healthy people and those with kidney problems
This study is testing a new injectable medicine (HRS-4729) to see how the body processes it in people with healthy kidneys and in those with kidney problems. If you join, you will receive a single dose and have your blood and urine checked over time to measure the drug levels.
Chengdu, SichuanAges 18–65 - NCT07805551RecruitingPhase 1/Phase 2
HDM2017 combination therapy for advanced colorectal cancer
This study tests a new drug called HDM2017 in combination with other treatments for advanced colorectal cancer that cannot be removed by surgery or has spread. The goal is to see if this combination can help shrink tumors or slow the disease.
Beijing, Beijing MunicipalityAges 18–75 - NCT05688176Recruiting
Testing blood RNA markers for esophagus cancer and Barrett’s
This study looks for helpful “RNA markers” found in blood to improve diagnosis in people with Barrett’s esophagus or esophageal cancer. It may help doctors spot disease more reliably, but it requires specific health and treatment conditions and a planned biopsy blood sample process.
Ghent, Oost-VlaanderenAges 18 years+ - NCT06354140RecruitingPhase 2
Tislelizumab plus S-1 for esophageal cancer after surgery
This trial tests a combination of the immunotherapy drug tislelizumab and the chemotherapy drug S-1 for people with a specific type of esophageal cancer that still has some cancer cells in the main tumor but no cancer in lymph nodes after surgery. The goal is to see if this treatment can help prevent the cancer from coming back.
Chongqing, Chongqing MunicipalityAges 18–75 - NCT06506292RecruitingPhase 2
Study of adebrelimab plus chemo before and after stomach cancer surgery
This trial tests combining adebrelimab (an immunotherapy) with chemotherapy (XELOX) before and after surgery for stomach cancer that hasn't spread. The goal is to see if this approach helps shrink tumors and improves outcomes.
Tianjin, Tianjin MunicipalityAges 18–75 - NCT07807319Recruiting
Seton before surgery for anal fistula
This study tests whether placing a temporary seton (a soft thread) before surgery helps improve healing for people with a single anal fistula, compared to going straight to surgery. It aims to see if this approach leads to better outcomes and fewer problems.
Amstelveen, North HollandAges 18 years+ - NCT07808853RecruitingPhase 2
Short radiation plus chemo-immunotherapy before esophageal cancer surgery
This trial tests a new approach before surgery: a short course of radiation (5 treatments) combined with chemotherapy and immunotherapy. The goal is to shrink the tumor and increase the chance of successful removal, while hopefully reducing side effects and improving long-term outcomes.
Guanzhou, GuangdongAges 18–75 - NCT07803978Enrolling by invitationEarly Phase 1
Study of Amimaitosai plus steroids for gut graft-versus-host disease
This study tests whether adding an investigational drug called Amimaitosai to standard steroids helps control gut symptoms caused by graft-versus-host disease after a stem cell transplant. It may offer a new option to reduce these symptoms and improve recovery.
Beijing, Beijing MunicipalityAges 14 years+ - NCT07808879Recruiting
Comparing two PET scans to find insulinoma tumors
This trial compares two similar PET/CT scan agents to see which one better finds insulinomas — small tumors in the pancreas that cause low blood sugar. If you're scheduled for surgery, the results might help your doctor pinpoint the tumor before the operation.
Beijing, Beijing MunicipalityAges 18–70 - NCT07801287RecruitingPhase 2
Combination treatment before and after surgery for intermediate-stage liver cancer
This trial tests a combination of immunotherapy drugs, radiation therapy, and a targeted therapy drug before and after surgery for people with intermediate-stage liver cancer that can be surgically removed. The goal is to see if this approach can shrink tumors and improve outcomes.
TianjinAges 18 years+ - NCT07802002Recruiting
Dietary supplement to prevent bowel injury during radiation for rectal cancer
This trial tests whether a special dietary supplement can help protect the rectum from radiation damage during chemoradiation for locally advanced rectal cancer. If it works, it may reduce painful bowel symptoms like frequent stools and cramping.
Guangzhou, GuangdongAges 18–75 - NCT07808164Recruiting
Protein markers in solid tumors: a Vietnamese tissue study
This study looks at tissue samples from Vietnamese patients with solid tumors to understand the presence of certain proteins (ENPP1, cGAS, and FAP). The goal is to learn more about these tumors, which might help develop better treatments in the future.
Hanoi, HanoiAges 18 years+ - NCT07802197Recruiting
Radiation before surgery for advanced rectal cancer
This trial compares giving radiation therapy before surgery versus going straight to surgery for people with advanced rectal cancer that has not spread to other parts of the body. It aims to see which approach may be better for controlling the cancer.
IstanbulAges 18 years+ - NCT07801716Recruiting
Low-calorie diet before liver surgery
This trial tests whether eating a low-calorie diet for 7 days before liver surgery helps reduce complications after the operation. It may help you recover more easily after surgery.
LundAges 18 years+ - NCT06500754Recruiting
Persistent intestinal damage in celiac disease on strict diet
This study looks at why some adults with celiac disease still have damage to their small intestine even after strictly avoiding gluten. It aims to understand persistent villous atrophy and could help improve long-term care for people like you.
Terrassa, BarcelonaAges 20–80 - NCT06507683Recruiting
Radiation plus ripretinib for advanced GIST
This trial tests whether adding radiation therapy to the drug ripretinib can help people with advanced gastrointestinal stromal tumors (GIST) that can't be removed by surgery and have stopped responding to other treatments. It aims to see if this combination is safe and effective.
Chongqing, Chongqing MunicipalityAges 18–75
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,607 recruiting gastroenterology studies from the U.S. registry right now, out of 11,926 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.